Journal of Bone and Mineral Metabolism
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368 records returned
High pressure may inhibit periprosthetic osteogenesis
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Abstract Mechanical effects have been demonstrated to activate periprosthetic osteoclasts and hence to promote bone resorption. However,
the periprosthetic mechanical effect on osteoblast function is not clearly understood. The purpose of this study was to explore
whether the high pressure on bone caused by a prosthesis affects periprosthetic osteoblast function. We applied static pressure
of various magnitudes to SV40-transfected human fetal osteoblast cells, then assayed bioactivities compared to cells cultured
without pressure (control). The results showed that osteoblast proliferation, differentiation, a...
Source: Journal of Bone and Mineral Metabolism - November 17, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Lengthening of mouse hindlimbs with joint loadingEmail this article to a colleague.
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This report addresses the following question: does knee loading increase bone length of the loaded
hindlimb? Knee loading has been shown to induce anabolic responses on the periosteal and endosteal surfaces, but its effects
on longitudinal bone growth have not yet been examined. In the present studies, loads were applied to the left hindlimb (5-min
bouts at 0.5 N) of C57/BL/6 mice (21 mice, ~8 weeks old). Compared to the contralateral and age-matched control groups, knee
loading increased the length of the femur by 2.3 and 3.5%, together with the tibia by 2.3 and 3.7% (all P < 0.001), respectivel...
Source: Journal of Bone and Mineral Metabolism - November 4, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
List of Reviewers 2008–2009Email this article to a colleague.
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Content Type Journal ArticleCategory List of Reviewers 2008-2009DOI 10.1007/s00774-009-0132-0
Journal Journal of Bone and Mineral MetabolismOnline ISSN 1435-5604Print ISSN 0914-8779
Journal Volume Volume 27
Journal Issue Volume 27, Number 6 / November, 2009 (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 3, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in miceEmail this article to a colleague.
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In conclusion, our data suggest that ZOL delays wound healing of the tooth extraction socket by inhibiting
osteogenesis and angiogenesis. Our data also suggest that ZOL alters oral bacterial behaviors. These actions of ZOL may be
relevant to the pathogenesis of BRONJ.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00774-009-0128-9Authors
Yasuyoshi Kobayashi, Osaka University Graduate School of Dentistry Department of Molecular and Cellular Biochemistry 1-8 Yamadaoka, Suita Osaka 565-0871 JapanToru Hiraga, Matsumoto Dental University Department of Histology and Cell Biology Nagano JapanAkimi Ueda, ...
Source: Journal of Bone and Mineral Metabolism - October 30, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Antitumor necrotic factor agent promotes BMP-2-induced ectopic bone formationEmail this article to a colleague.
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Abstract Etanercept (ETN), which is a recombinant human soluble tumor necrosis factor (TNF) receptor that inhibits TNF activity, is
effective in the treatment of rheumatoid arthritis. We investigated the effect of ETN on recombinant human bone morphogenetic
protein-2 (rhBMP-2)-induced ectopic bone formation in vivo. A block copolymer composed of poly-d,l-lactic acid with random insertion of p-dioxanone and polyethylene glycol (PLA–DX–PEG polymer) was used as the delivery system. Polymer discs (6 mm, 30 mg) containing
5 μg rhBMP-2 were implanted into the left dorsal muscle pouch of mice (n&...
Source: Journal of Bone and Mineral Metabolism - October 29, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Erratum to: A pilot investigation of load-carrying on the head and bone mineral density in premenopausal, black African womenEmail this article to a colleague.
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Content Type Journal ArticleCategory ErratumDOI 10.1007/s00774-009-0133-zAuthors
Ray Lloyd, University of Abertay Dundee DD1 1HG UKKaren Hind, Leeds Metropolitan University Carnegie Research Institute Headingley Campus Leeds LS6 3QS UKLisa K. Micklesfield, University of Cape Town Newlands 7725 South AfricaSean Carroll, Leeds Metropolitan University Carnegie Research Institute Headingley Campus Leeds LS6 3QS UKJohn G. Truscott, University of Leeds Division of Medical Physics, Worsley Building Leeds LS2 9JT UKBridget Parr, Cape Peninsula University of Technology Cape Town South AfricaSimeon Davies, Cape Peninsula Univers...
Source: Journal of Bone and Mineral Metabolism - October 28, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Infusion of ibandronate once every 3 months effectively decreases bone resorption markers and increases bone mineral density in Chinese postmenopausal osteoporotic women: a 1-year studyEmail this article to a colleague.
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Abstract The efficacy and safety of intravenous ibandronate were evaluated in postmenopausal osteoporosis women in China. In this multicenter,
positive drug-controlled study, 158 postmenopausal osteoporotic women were randomized to receive 2 mg ibandronate given intravenously
once every 3 months or 70 mg alendronate given orally once per week. All women also received supplemental calcium (500 mg)
and vitamin D (200 IU) daily. One hundred fifty-one patients completed the 1-year study. Ibandronate produced mean increases
in bone mineral density (BMD) by 4.27% at the lumbar spine, 3.48%...
Source: Journal of Bone and Mineral Metabolism - October 23, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
The relationships among bone health, insulin-like growth factor-1 and sex hormones in adolescent female athletesEmail this article to a colleague.
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Abstract The aim of this study was to determine the relationships of bone mineral density (BMD) and content (BMC) with insulin-like
growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3) and estradiol in pubertal female athletes. The participants were
170 healthy adolescent girls (13–15 years) who participated in competitive extramural athletic programs, i.e., sports games
(n = 49), track sprinting (n = 24), rhythmic gymnastics (n = 23), swimming (n = 24) and cross-country skiing (n = 17). The control group (n = 33) consisted of girls who to...
Source: Journal of Bone and Mineral Metabolism - October 21, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Serum homocysteine, folate and vitamin B12 in patients with Paget’s disease of bone: the effect of zoledronic acidEmail this article to a colleague.
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Abstract High serum homocysteine (HCY) and indirectly deficiency of folate and/or vitamin B12 stimulate bone resorption and adversely affect collagen cross-linking. The aim of this study was the evaluation of serum
levels of HCY, folate and vitamin B12 in patients with Paget’s disease of bone (PDB) and the effect of zoledronic acid (ZOL) on their serum levels. Nine consecutive
patients with polyostotic PDB (median age 66 years) received a single 5-mg ZOL infusion. Blood samples for HCY, folate, vitamin
B12, 25-hydroxyvitamin D (25-OH-D), total serum alkaline phosphatase (TSAP), bone-specific serum alka...
Source: Journal of Bone and Mineral Metabolism - October 20, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Smoking among premenopausal women is associated with increased risk of low bone status: the JPOS StudyEmail this article to a colleague.
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We examined how smoking exposure influences
bone mineral density (BMD) or the risk of low bone status in premenopausal women. We conducted a baseline survey with a representative
sample of Japanese women in 1996. The effect of current and former smokers (ever-smoker) was investigated with 789 premenopausal
women aged 20–40 years. The multiple regression with stepwise method was used to identify significant determinants for BMD
or the risk of low bone status (T-score < −1) with age, height, weight, calcium intake, coffee consumption, exercise habits, level of daily activity, parity ≥ 1,...
Source: Journal of Bone and Mineral Metabolism - October 14, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Validation of the Japanese Osteoporosis Quality of Life QuestionnaireEmail this article to a colleague.
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Abstract The Japanese Society for Bone and Mineral Research developed the Japanese Osteoporosis Quality of Life Questionnaire (JOQOL)
to evaluate the disease-specific Health-Related QOL, which is specific for osteoporosis of Japanese patients. JOQOL was revised
in 2000; it consisted of 38 items with the scale graded from 0 to 4 and a total full score of 152. To elucidate the reliability
and validity of the revised JOQOL, we enrolled 193 postmenopausal women as subjects and diagnosed them as having osteoporosis
or osteopenia. The mean age of the subjects was 68.2 ± 8 years; 58 subjects (30.1%)...
Source: Journal of Bone and Mineral Metabolism - October 13, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Teriparatide is safe and effectively increases bone biomarkers in institutionalized individuals with osteoporosisEmail this article to a colleague.
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In conclusion, teriparatide is safe and effective
in developmentally disabled institutionalized adults. Serial calcium measurements are warranted, particularly during the first
three months of therapy.
Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00774-009-0123-1Authors
Kathryn M. Ryder, The University of Tennessee Health Science Center Department of Medicine Memphis TN USAS. Bobo Tanner, Vanderbilt University School of Medicine Nashville TN USALaura Carbone, The University of Tennessee Health Science Center Department of Medicine Memphis TN USAJohn E. Williams, Greenville Hospital System Gar...
Source: Journal of Bone and Mineral Metabolism - October 6, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese womenEmail this article to a colleague.
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Abstract HTRA1 (high-temperature requirement A1) has been implicated in the modulation of various disease pathologies. HTRA1 expression
is upregulated in osteoarthritic joints, suggesting that it may contribute to the development of this debilitating disease.
Moreover, recent reports have shown that the rs11200638, a single nucleotide polymorphism (SNP) in the promoter region of
the HTRA1 gene, is strongly associated with an increased prevalence of age-related macular degeneration (AMD). In the present
study, we examined the expression of the HTRA1 in human primary chondrocytes and an association between the...
Source: Journal of Bone and Mineral Metabolism - October 1, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Gene expression profiles of disc tissues and peripheral blood mononuclear cells from patients with degenerative discsEmail this article to a colleague.
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The objective of this study was to analyze gene expression profiles of intervertebral disc samples and peripheral blood mononuclear
cells (PBMCs) from patients with degenerative discs using Agilent’s Human 1A Oligo microarray. RNA samples from disc tissue
and PBMCs were obtained from patients with degenerative discs and from subjects in a control group. RNA samples were reverse-transcribed
into Cy5-labeled cRNA, combined with a Cy3-labeled reference and hybridized to oligonucleotide microarrays. Microarrays were
scanned by Gene-Pix 4000B and data were analyzed using GenePixPro 3.0 software. The microarray data were v...
Source: Journal of Bone and Mineral Metabolism - October 1, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Effects of transgenic Pit-1 overexpression on calcium phosphate and bone metabolismEmail this article to a colleague.
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In conclusion, transgenic Pit-1 overexpression in rats affected bone and calcium
phosphate metabolism. It also decreased alkaline phosphatase activity in osteoblasts without influencing bone matrix mineralization
as well as skeletal development.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00774-009-0121-3Authors
Atsushi Suzuki, Fujita Health University Division of Endocrinology and Metabolism, Department of Internal Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake Aichi 470-1192 JapanPatrick Ammann, University Hospital of Geneva Service of Bone Diseases, Department of Rehabilitation and Geri...
Source: Journal of Bone and Mineral Metabolism - September 30, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Vitamin E exhibits bone anabolic actions in normal male ratsEmail this article to a colleague.
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Abstract Recently, vitamin E has been found to promote the bone structure of nicotine-treated rats well above their baseline values,
thus suggesting that vitamin E may have some anabolic action. A bone anabolic agent acts by improving the bone structure leading
to stronger bone. To assess the possible anabolic action vitamin E on bone, we supplemented α-tocopherol (ATF) or γ-tocotrienol
(GTT) at 60 mg/kg or vehicle [normal control (NC) group] for 4 months to normal male rats and measured their bone structure
and biomechanical properties. Histomorphometric analysis revealed that vitamin E-suppleme...
Source: Journal of Bone and Mineral Metabolism - September 24, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
A review of drug-induced hypocalcemiaEmail this article to a colleague.
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Abstract Hypocalcemia (defined as total serum calcium lower than 8.5 mg/dl or as ionized serum calcium lower than 4.7 mg/dl) is a relatively
common metabolic abnormality observed in hospitalized patients. Although it is associated with certain pharmacological agents
such as bisphosphonates and cisplatin, hypocalcemia may occasionally develop in the course of treatment with drugs used in
everyday clinical practice, including antiepileptics, aminoglycosides, and proton pump inhibitors. Hypocalcemia associated
with drug treatment can be easily missed as a consequence of coexistence of multiple factors...
Source: Journal of Bone and Mineral Metabolism - September 18, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosisEmail this article to a colleague.
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We examined a possible correlation between osteoporosis and ER stress response. Bone specimens from 8 osteoporosis
patients and 8 disease-controls were used for immunohistochemical analysis. We found that ER molecular chaperones, such as
BiP (immunoglobulin heavy-chain binding protein) and PDI (protein-disulfide isomerase) are down-regulated in osteoblasts from
osteoporosis patients. Based on this result, we hypothesized that up-regulation of ER molecular chaperones in osteoblasts
could restore decreased bone formation in osteoporosis. Therefore, we investigated whether treatment of murine model for osteoporosis
with ...
Source: Journal of Bone and Mineral Metabolism - September 17, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Impact of dietary intake, education, and physical activity on bone mineral density among North Indian womenEmail this article to a colleague.
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Abstract The aim of the study was to determine the relationship of dietary nutrients and bone mineral density (BMD) in North Indian
women. This cross-sectional study was conducted from April 2006 to March 2008. Subjects included 255 healthy women, aged 20–69 years,
who were relatives of patients being admitted in the hospital. Various demographic characteristics including socioeconomic
status and serum parameters in relationship to BMD were evaluated. In addition, the daily dietary intake of energy, protein,
fat, and calcium and the amount of physical activity were assessed. BMD at the lumbar spine, f...
Source: Journal of Bone and Mineral Metabolism - August 19, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Relationships between falls, spinal curvature, spinal mobility and back extensor strength in elderly peopleEmail this article to a colleague.
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Abstract Spinal mobility and back extensor strength (BES) are important in determining quality of life (QOL) for elderly people. However,
the impact of spinal factors on falls remains unclear. The purpose of this study was to clarify spinal factors related to
falls in elderly people, including deformity of spinal curvature, spinal mobility and BES. Subjects comprised 92 elderly people
divided into 3 groups: subjects without a history of falls or fear of falls (Non-falls group, n = 40); subjects with a history of fear of falls or requiring any support when walking (Fear of falls group, n = ...
Source: Journal of Bone and Mineral Metabolism - August 19, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Effect of alendronate on bone mineral density and bone turnover markers in post-gastrectomy osteoporotic patientsEmail this article to a colleague.
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The objective of the
present case series study was to examine the effect of alendronate on BMD and bone turnover markers in post-gastrectomy osteoporotic
patients. Sixteen patients (3 men and 13 postmenopausal women) with osteoporosis, who had undergone a gastrectomy (mean age:
69.1 years), were recruited in our outpatient clinic. All the patients were treated with alendronate (5 mg daily or 35 mg
weekly) for 24 months. The effects of alendronate on lumbar spine (women) or total hip (men) BMD and urinary NTX and serum
ALP levels were examined. A total or partial gastrectomy had been performed for e...
Source: Journal of Bone and Mineral Metabolism - August 19, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Effects of alcohol and nicotine on the mechanical resistance of bone and bone neoformation around hydroxyapatite implantsEmail this article to a colleague.
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Abstract The consumption of alcohol or nicotine is harmful to the integrity of bone tissue, hindering or even impeding the fixation
and maintenance of bone implants. The aim of the present work was to evaluate the effects of ethanol and nicotine, when consumed
alone and simultaneously, on both bone mechanical resistance and bone neoformation around hydroxyapatite implants. Twenty
rats were divided into four groups: control (CT), alcohol (A), nicotine (N) and nicotine + alcohol (N + A). After 4 weeks
of alcohol and/or nicotine consumption, dense (HAD) and porous (HAP) bodies were resp...
Source: Journal of Bone and Mineral Metabolism - August 9, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Successful treatment of postsurgical hypoparathyroidism by intramuscular injection of vitamin D3 in a patient associated with malabsorption syndrome due to multiple abdominal surgeriesEmail this article to a colleague.
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Abstract A 56-year-old patient with postsurgical hypothyroidism and hypoparathyroidism associated with gastrointestinal malabsorption
syndrome was prescribed with l-thyroxine and 1α(OH)D3 at a massive daily dosage of 600 and 39 μg, respectively. Although the patient became nearly euthyroid, she had been hypocalcemic,
requiring frequent intravenous injection of calcium gluconate to prevent tetany. Because the serum level of 1,25(OH)2D hardly increased after an oral intake of 21 μg 1α(OH)D3, vitamin D3 was administered intramuscularly. After stoss therapy (600,000 IU), the patient has been rec...
Source: Journal of Bone and Mineral Metabolism - August 5, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Assessment of adherence to treatment of postmenopausal osteoporosis with raloxifene and/or alfacalcidol in postmenopausal Japanese womenEmail this article to a colleague.
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In this study we aimed to assess adherence to treatment with 1 μg alfacalcidol (D), 60 mg raloxifene (R) or a combination
of both (D + R) for 1 year in postmenopausal Japanese women with osteoporosis or osteopenia. We defined persistence of D and
R as continuing to take tablets for more than 7 of any 14 days immediately before the 1-year visit. A total of 137 subjects
aged 49–81 years [64.9 ± 7.0 years, 16.0 ± 12.7 years since menopause (YSM)] were randomly assigned to each treatment group.
The proportions persisting with each treatment group at 1&nb...
Source: Journal of Bone and Mineral Metabolism - August 5, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
An autosomal dominant hypophosphatemic rickets phenotype in a Tunisian family caused by a new FGF23 missense mutationEmail this article to a colleague.
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Abstract Autosomal dominant hypophosphatemic rickets (ADHR) is a rare disease, characterized by isolated renal phosphate wasting, hypophosphatemia,
and inappropriately normal 1,25-dihydroxyvitamin D3 (calcitriol) levels. This syndrome involves rickets with bone deformities in childhood and osteomalacia, osteoporosis, articular
and para-articular pain, and fatigue in adulthood. It is caused by mutations in a consensus sequence for proteolytic cleavage
of the FGF23 protein. Normally, this protein actively regulates phosphate homeostasis. Here we report a Tunisian family in
which one parent and three children s...
Source: Journal of Bone and Mineral Metabolism - August 4, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Age curves of bone mineral density at the distal radius and calcaneus in KoreansEmail this article to a colleague.
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This study evaluated age-related changes in bone mineral density (BMD) and identified the peak bone mineral density (PBMD)
in Koreans. We recruited 2929 subjects, ranging in age from 5 to 86 years, from three regions: Seoul, Siwha, and Gwangyang.
The BMD at the distal radius and calcaneus were measured with dual-energy X-ray absorptiometry, and anthropometric measures
were also obtained. PBMD was calculated from the highest mean in each age group. The PBMD at the distal radius was 0.514 ± 0.06 g/cm2 in females and 0.598 ± 0.07 g/cm2 in males. Peak ages for both sexes were the thirtie...
Source: Journal of Bone and Mineral Metabolism - July 27, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Changes in distribution of bone densitometry equipment from 1996 to 2006 in JapanEmail this article to a colleague.
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Abstract Many types of bone densitometry equipment are available in Japan, but the numbers of such machines and the numbers of institutions
that offer bone densitometry have not been clarified. We analyzed the data from annual surveys conducted by the Japan Osteoporosis
Foundation from 1996 to 2006, and we obtained the following results on the use of densitometry equipment: (1) In 1996 there
were 6,687 units of bone densitometry equipment in 6,483 institutions in Japan; in 2006 there were 16,371 units in 15,020
institutions. (2) In 2006, of the types of institutions with bone densitometry equipment, the numb...
Source: Journal of Bone and Mineral Metabolism - July 25, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Impact of bisphosphonate wash-out prior to teriparatide therapy in clinical practiceEmail this article to a colleague.
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This study confirms that beneficial effects of teriparatide on intermediate bone endpoints can be translated into clinical
practice with less constringent methodological circumstances than in RCTs. Furthermore, as bisphosphonate wash-out does not
appear to influence the treatment effect, teriparatide therapy can be started immediately after ceasing bisphosphonate therapy
and wash-out.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00774-009-0101-7Authors
Christina Keel, University Hospital Basel Division of Endocrinology, Diabetes and Clinical Nutrition Missionsstrasse 24 4055 Basel SwitzerlandMa...
Source: Journal of Bone and Mineral Metabolism - July 25, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
A pilot investigation of load-carrying on the head and bone mineral density in premenopausal, black African womenEmail this article to a colleague.
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Abstract Although the influence of weight-bearing activity on bone mass has been widely investigated in white women, few studies have
been conducted in black, African populations. We investigated bone mineral density (BMD) in black South African women, with
and without a history of load-carrying on the head. We also investigated whether load carrying may offer protection against
low BMD in users of injectable progestin contraception (IPC). Participants were 32 black, South African women (22.4 ± 3.2 years).
Load carrying history was determined by questionnaire and interview; participants were ...
Source: Journal of Bone and Mineral Metabolism - July 25, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
The morphology and lattice structure of bone crystal after strontium treatment in goatsEmail this article to a colleague.
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In this study, eight osteopenic goats were divided into two groups: Ca + 40Sr (five goats) and controls (three
goats). Controls were fed with low calcium feeds. Ca phosphate was supplied at 100 mg/(kg day), and Sr phosphate at 40 mg/(kg day)
in the Ca + 40Sr group. The newly formed bone at the outer cortical area of the femur with Sr deposition was identified from
tetracycline labels, and the morphology and lattice structure of the crystals in these regions were investigated. Results
showed that Sr concentrations of bone tissue significantly increased 144.37% for Sr administratio...
Source: Journal of Bone and Mineral Metabolism - July 15, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
The effect of thiazolidinediones on bone mineral density in Chinese older patients with type 2 diabetesEmail this article to a colleague.
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Abstract The effect of thiazolidinediones (TZDs) on bone mineral density (BMD) and bone metabolism in patients with type 2 diabetes
is still in debate. Accumulating evidence has emerged that long-term administration of TZDs may increase the occurrence of
osteoporosis, at least in postmenopausal women. Because little clinical data has been reported on Chinese people, a retrospective
study was performed. One-hundred ninety-eight Chinese people, all from our inpatients, were selected for a 24–28 month review
(26 ± 0.5 m). Four groups divided according to gender and TZD use were designated...
Source: Journal of Bone and Mineral Metabolism - July 15, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Secular change of the incidence of four fracture types associated with senile osteoporosis in Sado, Japan: the results of a 3-year surveyEmail this article to a colleague.
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Abstract We conducted a three-year survey of fracture incidences associated with senile osteoporosis—compression fractures of the spine,
femoral neck fractures, distal radius fractures, and fractures of the proximal end of the humerus—to examine secular change.
The survey was conducted between 2004 and 2006 on patients in Sado City. We calculated the incidence of each fracture based
on the population of Sado City (per 100,000 person-years). Only clinical or incident fractures were diagnosed as new fractures
for compression fractures of the spine. Incidence of compression fracture of the spine was the hig...
Source: Journal of Bone and Mineral Metabolism - July 7, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Normochromic normocytic anemia in a postmenopausal woman with severe osteoporosis treated with intermittent parathyroid hormoneEmail this article to a colleague.
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Abstract Intermittent exogenous parathyroid hormone (PTH) is a potent osteoanabolic agent used for the treatment of severe osteoporosis.
Two molecules of recombinant PTH are commercially available: the full-length PTH (PTH 1–84) and teriparatide (PTH 1–34). We
present the first report of PTH-induced mild, asymptomatic, normochromic normocytic anemia in a postmenopausal woman treated
sequentially with PTH 1–84 and PTH 1–34. Anemia was more pronounced with PTH 1–84 compared to PTH 1–34 and was reversed with
each regimen discontinuation. We suggest monitoring of hematocrit and hemoglobin in PTH-trea...
Source: Journal of Bone and Mineral Metabolism - July 6, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
High weight or body mass index increase the risk of vertebral fractures in postmenopausal osteoporotic womenEmail this article to a colleague.
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In conclusion, among
postmenopausal women with osteoporosis, body weight and BMI are associated with a higher likelihood of having a vertebral
fracture, irrespective of the positive association between weight and BMD.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00774-009-0108-0Authors
Matteo Pirro, University of Perugia, Hospital “Santa Maria della Misericordia” Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Clinical and Experimental Medicine Piazzale Menghini 1 06129 Perugia ItalyGianluigi Fabbriciani, University of Perugia, Hospital “Santa Maria della ...
Source: Journal of Bone and Mineral Metabolism - July 6, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability studyEmail this article to a colleague.
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This study
involved the collection of clinical information from three cohorts composed of participants located in urban, mountainous,
and coastal areas. KOA and LS were radiographically defined as a grade of ≥2 by the Kellgren–Lawrence scale; OP was defined
by the criteria of the Japanese Society for Bone and Mineral Research. The 3,040 participants in total were divided into six
groups based on their age: ≤39, 40–49, 50–59, 60–69, 70–79, and ≥80 years. The prevalence of KOA in the age groups ≤39, 40–49,
50–59, 60–69, 70–79, and ≥80 years 0, 9.1, 24.3, 35.2, 48.2, and 51.6%, respe...
Source: Journal of Bone and Mineral Metabolism - July 1, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Journal of Bone and Mineral Metabolism Best Paper Award 2008Email this article to a colleague.
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Content Type Journal ArticleCategory AnnouncementDOI 10.1007/s00774-009-0106-2
Journal Journal of Bone and Mineral MetabolismOnline ISSN 1435-5604Print ISSN 0914-8779
Journal Volume Volume 27
Journal Issue Volume 27, Number 4 / July, 2009 (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 29, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Local delivery of rolipram, a phosphodiesterase-4-specific inhibitor, augments bone morphogenetic protein-induced bone formationEmail this article to a colleague.
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Abstract Recombinant human bone morphogenetic protein (rhBMP) is a promising therapeutic cytokine for the induction of bone formation,
but a weak response in humans remains a major hurdle in its therapeutic application. We have previously reported an rhBMP-2-induced
increase in the bone mass of mice receiving systemic rolipram, a specific inhibitor of phosphodiesterase-4. To overcome the
side effects of systemic administration of rolipram, we examined the effects of its local release. Polyethylene glycol discs
were used as a delivery system. The discs were impregnated with rhBMP-2 and rolipram and implanted ...
Source: Journal of Bone and Mineral Metabolism - June 25, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
The effects of recombinant human TSH on bone turnover in patients after thyroidectomyEmail this article to a colleague.
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Abstract Thyrotropin receptors are expressed in several extrathyroidal tissues including bone. We investigated whether the increase
of thyroid-stimulating hormone (TSH) levels, under stable thyroid hormone levels, affects the bone markers. Thirty-two postmenopausal
women, with papillary thyroid carcinoma, previously treated with near-total thyroidectomy and I131 remnant ablation underwent routine evaluation for residual disease by using injections of recombinant human TSH (rhTSH) without
withdrawal from thyroxine therapy. Changes in TSH levels and various serum and urine markers of bone metabolism were follow...
Source: Journal of Bone and Mineral Metabolism - June 23, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Bone metabolism after cinacalcet administration in patients with secondary hyperparathyroidismEmail this article to a colleague.
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Abstract Cinacalcet, an allosteric modulator of a calcium (Ca)-sensing receptor, significantly suppresses parathyroid hormone (PTH)
secretion and bone turnover rate in chronic hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT). In this
study, bone metabolism after cinacalcet treatment was examined, because hungry bone syndrome is sometimes experienced after
parathyroidectomy in severe SHPT. We conducted a prospective observational study in 17 HD patients with SHPT. Cinacalcet was
started at 25 mg/day, and the dose was increased step by step based on serum calcium level. A significant d...
Source: Journal of Bone and Mineral Metabolism - June 23, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
The relationship between body composition and the urinary excretion of deoxypyridinoline and galactosyl-hydroxylysine in children and adolescentsEmail this article to a colleague.
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Abstract The study intends to investigate the relationship of body composition (%fat, percent body fat; FM, fat mass; FFM, fat free
mass; FA and MA cross-sectional fat and muscle area) to the urinary excretion of deoxypyridinoline (DPD) and galactosyl-hydroxylysine
(Gal-Hyl). 231 healthy children and adolescents (age 5–19 years; 112 males) of the DONALD study were analyzed for FM and FFM
by measuring 4 skinfold thicknesses, for DPD and Gal-Hyl in urine samples and for bone parameters, FA and MA at the forearm
by peripheral quantitative computed tomography. In contrast to adrenarchal females, adrenarch...
Source: Journal of Bone and Mineral Metabolism - June 13, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Unipedal standing exercise and hip bone mineral density in postmenopausal women: a randomized controlled trialEmail this article to a colleague.
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In conclusion, unipedal standing exercise for 6 months did not improve hip BMD in Japanese postmenopausal
women. Effect of exercise on hip total BMD was age dependent. In participants aged ≥70 years, the exercise significantly increased
hip total BMD.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00774-009-0100-8Authors
Akinori Sakai, University of Occupational and Environmental Health Department of Orthopaedic Surgery, School of Medicine 1-1 Iseigaoka, Yahatanishi-ku Kitakyushu 807-8555 JapanToshihisa Oshige, University of Occupational and Environmental Health Department of Orthopaed...
Source: Journal of Bone and Mineral Metabolism - June 12, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Hypophosphatemia: the common denominator of all ricketsEmail this article to a colleague.
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Abstract Rickets is a disease of the hypertrophic chondrocytes in the growth plate and is caused by hypophosphatemia—a derived defect
in terminal chondrocyte apoptosis. This highlights the critical role of phosphorous in cartilage and bone metabolism. This
review shows the role of phosphorous metabolism, transport and function in maintaining phosphorous supply to the growth plate,
bone osteoblast and the kidney. Given that phosphorous is the common denominator of all rickets, this review proposes a new
classification for the differential diagnosis of rickets, which is based on the mechanisms leading to hyp...
Source: Journal of Bone and Mineral Metabolism - June 6, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized miceEmail this article to a colleague.
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Abstract Quercetin is a major dietary flavonoid found in onions and other vegetables, and potentially has beneficial effects on disease
prevention. In the present study, we demonstrate for the first time the effects of dietary quercetin on bone loss and uterine
weight loss by ovariectomy in vivo. Female mice were ovariectomized (OVX) and were randomly allocated to 3 groups: a control
diet or a diet with 0.25% (LQ) or 2.5% quercetin (HQ). After 4 weeks, dietary quercetin had no effects on uterine weight in
OVX mice, but bone mineral density of the lumbar spine L4 and femur measured by peripheral quantita...
Source: Journal of Bone and Mineral Metabolism - June 4, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Prostaglandin expression profile in hypoxic osteoblastic cellsEmail this article to a colleague.
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In this study, we investigated the role of hypoxia on prostaglandin release from osteoblastic cells cultured in 2% (hypoxia),
5% (potentially cellular normoxia), and 21% (normoxia for standard cell culture conditions) oxygen for up to 24 h. We quantified
the effects of reduced oxygen tension on the release of prostaglandin (PG)E2, PGF2α, PGD2, and PGI2. The mechanism by which hypoxia increases PG production was investigated by examining the various regulatory components of
the PG biosynthetic pathway. Our data show that PGE2 levels alone are significantly elevated under hypoxic conditions. Also, we show that cyclo...
Source: Journal of Bone and Mineral Metabolism - May 27, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescentsEmail this article to a colleague.
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In conclusion, our data support the hypothesis that leptin, insulin and HOMA-IR are inversely associated with
BMD and play a significant direct role in bone metabolism.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00774-009-0082-6Authors
Wagner Luiz do Prado, Pernambuco University Physical Education High School Pernambuco BrazilAline de Piano, São Paulo Federal University Nutrition Post-Graduation Program, Paulista Medicine School Rua Marselhesa, 535, Vila Clementino São Paulo SP 04020-060 BrazilMarise Lazaretti-Castro, São Paulo Federal University Nutrition Post-Graduation Program, Paulista M...
Source: Journal of Bone and Mineral Metabolism - May 25, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Differential effect of age, gender and puberty on bone formation rate assessed by measurement of bone-specific alkaline phosphatase in healthy Italian children and adolescentsEmail this article to a colleague.
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Abstract Bones undergo intensive modeling during growth, a process involving both formation and resorption processes. Bone formation
can be accurately monitored by measurements of bone-specific alkaline phosphatase (BAP) in serum. The lack of appropriate
reference values has hampered the use of BAP in pediatric subjects. The purposes of the present study were to verify the effect
of age, gender, and puberty on BAP concentration in healthy children, and to generate reference curves. Morning blood samples
were collected from 239 healthy children and adolescents (113 boys), aged 4.5–20.9 years. Anthropom...
Source: Journal of Bone and Mineral Metabolism - May 20, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Osteoclasts and the immune systemEmail this article to a colleague.
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Abstract Investigation into arthritis as well as the numerous bone phenotypes found in mice lacking immune-related genes has highlighted
the importance of the dynamic interplay between the bone and immune systems. It has recently led to both the emergence and
subsequent rapid evolution of the field of osteoimmunology. Receptor activator of nuclear factor-κB ligand (RANKL) stimulates
osteoclastogenesis through the nuclear factor of activated T cells, cytoplasmic 1 (NFATc1), which is well known as a crucial
regulator of immunity. Studies on RANKL signaling revealed various immune-related genes which are invol...
Source: Journal of Bone and Mineral Metabolism - May 20, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Long-term rugby practice enhances bone mass and metabolism in relation with physical fitness and playing positionEmail this article to a colleague.
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Abstract We attempted to clarify whether rugby was able to enhance bone mineral density (BMD) and content (BMC) of weight-bearing bones
by modifying bone remodelling in relation to physical fitness in male rugby players compared to controls. 22 male international
rugby players aged 20–31 years (forwards, n = 12 and backs, n = 10) were compared to 14 age-matched controls of the same ethnic origin aged 21–33 years. BMD and BMC were measured by DEXA
and bone metabolism was evaluated by specific makers. Physical fitness level was analysed in parallel. Both forwards and backs
exh...
Source: Journal of Bone and Mineral Metabolism - May 20, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
The effects of Acanthopanax senticosus extract on bone turnover and bone mineral density in Korean postmenopausal womenEmail this article to a colleague.
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This study suggests that AS extract supplementation may have beneficial effects on bone remodeling in Korean postmenopausal
women and that it has no significant adverse events.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00774-009-0093-3Authors
You-Cheol Hwang, Kyung Hee University School of Medicine Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee East-West Neo Medical Center #149, Sangil-dong, Kangdong-ku Seoul 134-727 KoreaIn-Kyung Jeong, Kyung Hee University School of Medicine Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee East-West Neo...
Source: Journal of Bone and Mineral Metabolism - May 19, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
Passage-affected competitive regulation of osteoprotegerin synthesis and the receptor activator of nuclear factor-κB ligand mRNA expression in normal human osteoblasts stimulated by the application of cyclic tensile strainEmail this article to a colleague.
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Abstract Mechanical stress application is a unique method for bone studies. We have reported regulation via the p38 mitogen-activated
protein kinase (MAPK) pathway in osteoblasts under application of cyclic tensile strain (CTS), among many reports on the extracellular
signal-regulated kinase (ERK) 1/2 pathway during mechanical stress, and questions remain as to the differences between our
findings and those of others regarding types of MAPK activation. In the present study, osteoblasts were used after the third
passage and stimulated by the application of 7%, 0.25 Hz CTS for 3 days, 4 h/day. C...
Source: Journal of Bone and Mineral Metabolism - May 18, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals
