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Differential expression of miRNA patterns in renal cell carcinoma and nontumorous tissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Quantitative real-time PCR analysis confirmed microarray data. The report supports that many miRNA expressions were altered in renal carcinoma, whose expression profiling may provide a useful clue for the pathophysiology research. However, further longer-term researches are required to investigate the relationship between miRNA and renal carcinoma as well as their role in carcinogenesis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0726-xAuthors Zhengjun Yi, Weifang Medical University Department of Laboratory Medicine of Clinical Faculty Weifang ChinaYurong Fu,...
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

The effect of endostatin mediated by human mesenchymal stem cells on ovarian cancer cells in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We found that MSCs possessed great migratory capacity in vitro and the human ovarian adenocarcinoma cell line SKOV3 could significantly induce the migration of MSCs. Our results provided evidence that MSCs could be utilized as a powerful delivery system of endostatin. The endostatin produced by MSC-EN cells could inhibit the proliferation of SKOV3 cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0728-8Authors Jing Jiang, The Second Affiliated Hospital of Harbin Medical University Department of Obstetrics and Gynecology No. 246, Xue Fu Road, Nan Gang District ...
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

A new staging system is more discriminant than conventional staging systems for unresectable hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The new staging system, accounting for both liver function and tumor characteristics, can accurately identify patients with different prognoses, particularly in the advanced phases of HCC. It should be useful as the only tool that can be applied for patients with unresectable HCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0722-1Authors Bai-Hong Zhang, General Hospital of People’s Liberation Army Department of Oncology 730050 Lanzhou ChinaXiang-Hui Wang, General Hospital of People’s Liberation Army Department of Oncology 730050 Lanzhou ChinaHong-Yun Yue, G...
Source: Journal of Cancer Research and Clinical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Changes in expression, and/or mutations in TGF-β receptors (TGF-β RI and TGF-β RII) and Smad 4 in human ovarian tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggest that mutations and/or alterations in expression of TGF-β receptors and loss of Smad 4 are frequent in human ovarian cancers and may potentially explain the frequent loss of TGF-β responsiveness that typically occurs in human ovarian cancer. Content Type Journal ArticleCategory Orginal PaperDOI 10.1007/s00432-009-0703-4Authors Marie Lue Antony, Rajiv Gandhi Center for Biotechnology Division of Cancer Biology Thiruvananthapuram Kerala 695014 IndiaRema Nair, Regional Cancer Center Department of Surgical Oncology Thiruvananthapuram Kerala 695011 IndiaPaul Sebastian, Regio...
Source: Journal of Cancer Research and Clinical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions From our findings we conclude that bacoside A is effective to prevent DEN-induced hepatocellular carcinoma by quenching lipid peroxidation and enhancing antioxidant status through free radical scavenging mechanism and having potential of protecting endogenous enzymatic and non-enzymatic antioxidant activity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0715-0Authors Panneerselvam Janani, Presidency College Department of Zoology Chennai 600005 Tamil Nadu IndiaKanakarajan Sivakumari, Presidency College Department of Zoology Chennai 600005 Tamil Nadu IndiaArumugam...
Source: Journal of Cancer Research and Clinical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Expression of metalloproteases and their inhibitors in different histological types of breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We found variations in MMP/TIMP expressions among the different histological subtypes of breast carcinomas suggesting differences in their tumor pathophysiology Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0721-2Authors J. M. Del Casar, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 Gijón Asturias SpainS. González-Reyes, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 Gijón Asturias SpainL. O. González, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 ...
Source: Journal of Cancer Research and Clinical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Expression of IL-13Rα2 in liver cancer cells and its effect on targeted therapy of liver cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We reported the expression of IL-13Rα2 in liver cancer cell lines and tissues as well as investigated the cytotoxin (DT389-hIL13-13E13K) targeted killing efficiency of liver cancer cells and potential role of IL-13Rα2 in the cancer treatment. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0724-zAuthors Lingling Hou, Beijing Jiaotong University College of Life Sciences and Bioengineering 100044 Beijing People’s Republic of ChinaJuan Du, Beijing Jiaotong University College of Life Sciences and Bioengineering 100044 Beijing People’s Republic of ChinaJianwei Wan...
Source: Journal of Cancer Research and Clinical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Macrophage migration inhibitory factor expression in cervical cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions MIF has been shown to promote tumor immune escape mechanisms in other cancer entities, which makes it an interesting target for cancer therapy, given the known significance of immune mechanisms for uterine cervical cancer. The overexpression of MIF on the protein and mRNA level, as well as its secretion by cervical cancer cells points to a critical role of the protein for the pathogenesis of uterine cervical cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0702-5Authors Mathias Krockenberger, University of Wuerzburg Department of Obstetrics and Gynecology ...
Source: Journal of Cancer Research and Clinical Oncology - November 13, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Cathepsins B, L and cystatin C in cyst fluid of ovarian tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Further studies are warranted to investigate cathepsins as possible prognostic biomarkers for the aggressiveness of ovarian cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0716-zAuthors Eva Kolwijck, Radboud University Nijmegen Medical Centre Department of Obstetrics and Gynecology Nijmegen The NetherlandsLeon F. A. G. Massuger, Radboud University Nijmegen Medical Centre Department of Obstetrics and Gynecology Nijmegen The NetherlandsChris M. G. Thomas, Radboud University Nijmegen Medical Centre Department of Chemical Endocrinology Nijmegen The NetherlandsPa...
Source: Journal of Cancer Research and Clinical Oncology - November 13, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Genetic and protein changes of E-cadherin in meningiomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggest that genetic instabilities of the E-cadherin gene have a role in meningioma development and progression. Detected microsatellite instability indicates that mismatch repair may also be targeted in meningioma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0708-zAuthors Nives Pećina-Šlaus, University of Zagreb Laboratory of Neurooncology, Croatian Institute for Brain Research, School of Medicine Šalata 12 10000 Zagreb CroatiaTamara Nikuševa Martić, University of Zagreb Laboratory of Neurooncology, Croatian Institute for Brain Research, Schoo...
Source: Journal of Cancer Research and Clinical Oncology - November 11, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions XRCC1 genotype independently predicted overall survival in metastatic colorectal carcinoma patients treated with irinotecan-based chemotherapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0720-3Authors Mehmet Artac, Selcuk University Department of Medical Oncology, Meram Medical Faculty Meram 42080 Konya TurkeyHakan Bozcuk, Akdeniz University Department of Medical Oncology, Medical Faculty Antalya TurkeySacide Pehlivan, Gaziantep University Department of Medical Biology, Medical Faculty Gaziantep TurkeySongül Akcan, Akdeniz University Department of Internal Me...
Source: Journal of Cancer Research and Clinical Oncology - November 11, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Circulating IL-1β levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Functional IL-1B genotypes may modify plasma IL-1β concentrations to contribute to the etiology of cervical cancer in Chinese women; however, further perspective studies are warranted to test the causal effects of IL-1β concentration in cervical carcinogenesis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0710-5Authors Nianfeng Qian, Nanjing Medical University Laboratory of Reproductive Medicine 210029 Nanjing ChinaXiaojun Chen, Nanjing Medical University Laboratory of Reproductive Medicine 210029 Nanjing ChinaSuping Han, Nanjing Medical University Laboratory o...
Source: Journal of Cancer Research and Clinical Oncology - November 10, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

The importance of −460 C/T and +405 G/C single nucleotide polymorphisms to the function of vascular endothelial growth factor A in colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The results indicate that the two SNPs have a functional influence on the VEGF-A protein levels in normal colorectal tissue. The possible clinical implications of the findings need further investigation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0714-1Authors Torben F. Hansen, Vejle Hospital Vejle DenmarkKaren-Lise G. Spindler, Vejle Hospital Vejle DenmarkKaren A. Lorentzen, Vejle Hospital Vejle DenmarkDorte A. Olsen, Vejle Hospital Vejle DenmarkRikke F. Andersen, Vejle Hospital Vejle DenmarkJan Lindebjerg, Vejle Hospital Vejle DenmarkIvan Brandslund, Vejle Ho...
Source: Journal of Cancer Research and Clinical Oncology - November 10, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In medically fit older patients, bevacizumab provides similar PFS and OS benefits as in younger patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0712-3Authors James Cassidy, Cancer Research UK Glasgow UKLeonard B. Saltz, Memorial Sloan-Kettering Cancer Center New York NY USABruce J. Giantonio, University of Pennsylvania Philadelphia PA USAFairooz F. Kabbinavar, UCLA School of Medicine Los Angeles CA USAHerbert I. Hurwitz, Duke University Medical Center Durham NC USAUlrich-Peter Rohr, F. Hoffmann-La Roche Basel Switzerland Journal Journal of Cancer Re...
Source: Journal of Cancer Research and Clinical Oncology - November 10, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Features of senescence and cell death induced by doxorubicin in A549 cells: organization and level of selected cytoskeletal proteinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions G-actin stability may imply its potential usefulness for permanent senescence detection. Along with slight to moderate cytoskeletal alterations, the obtained results suggest transient senescence-like state induction, followed by morphology typical of mitotic catastrophe in part of the A549 cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0711-4Authors Anna Litwiniec, Nicolaus Copernicus University in Toruń Department of Histology and Embryology, Ludwik Rydygier Collegium Medicum in Bydgoszcz Karłowicza 24 85-092 Bydgoszcz PolandAlina Grzanka, Nicolaus Cope...
Source: Journal of Cancer Research and Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Analysis of the expression of hyaluronan in intraductal and invasive carcinomas of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our study indicates a proportionally higher area of hyaluronan expression in DCIS with a microinvasive component than in pure DCIS, suggesting a key role of this glycosaminoglycan in the early invasive phase of breast carcinomas. Thus, hyaluronan could play an important function in determining the migratory phenotype of cancer cells. Larger size tumors appear to demonstrate an intricate balance between hyaluronan synthesis and degradation, thus conditioning intratumoral heterogeneity in the hyaluronan metabolism. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-071...
Source: Journal of Cancer Research and Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Overexpression of high-mobility group box 1 correlates with tumor progression and poor prognosis in human colorectal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggest that HMGB1 protein is a valuable marker for progression of CRC patients. High HMGB1 expression is associated with poor overall survival in patients with CRC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0706-1Authors Xingjun Yao, The First Affiliated Hospital of Jilin University Department of Surgery 130021 Changchun People’s Republic of ChinaGang Zhao, The First Affiliated Hospital of Jilin University Department of Surgery 130021 Changchun People’s Republic of ChinaHongfa Yang, The First Affiliated Hospital of Jilin University Department...
Source: Journal of Cancer Research and Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Tetrandrine prevents acquired drug resistance of K562 cells through inhibition of mdr1 gene transcriptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In summary, tetrandrine can prevent doxorubicin-induced mdr1 mRNA/P-gp expression and P-gp functions in a dose-dependent manner through a mechanism that may involve inhibition of doxorubicin-induced NF-κB mRNA expression and protein activity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0704-3Authors Huiling Shen, Jiangsu University The Affiliated People’s Hospital Zhenjiang Jiangsu ChinaWenlin Xu, Jiangsu University The Affiliated People’s Hospital Zhenjiang Jiangsu ChinaQiaoyun Chen, Jiangsu University The Affiliated People’s Hospital Zhenjiang Jiangsu C...
Source: Journal of Cancer Research and Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Vascular endothelial growth factor and endoglin expression in colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our results support that VEGF and endoglin act as two valuable indicators of prognosis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0709-yAuthors Konstantinos Dassoulas, “Tzaneion” Hospital First Surgical Department Piraeus GreeceMaria Gazouli, University of Athens Department of Biology, School of Medicine Michalakopoulou 176, Goudi 11527 Athens GreeceGeorge Theodoropoulos, Hippocration University Hospital 1st Propaideutic Surgical Department Athens GreeceZoi Christoni, University General Hospital “Attikon” Department of Cytopathology Athens GreeceSpyros ...
Source: Journal of Cancer Research and Clinical Oncology - November 4, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

TNF superfamily gene polymorphism as prognostic factor in early breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The TNFSF10 (rs1131532) polymorphism was identified as a possible prognostic factor of survival in patients with operated invasive breast cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0707-0Authors Jin Hyang Jung, Kyungpook National University School of Medicine Department of Surgery, Kyungpook National University Hospital 50 Samduk 2-Ga, Jung-Gu Daegu 700-721 KoreaYee Soo Chae, Kyungpook National University School of Medicine Department of Oncology/Hematology, Kyungpook National University Hospital 50 Samduk 2-Ga, Jung-Gu Daegu 700-721 KoreaJoon Ho Moon, ...
Source: Journal of Cancer Research and Clinical Oncology - November 4, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Oroxylin A inhibits angiogenesis through blocking vascular endothelial growth factor-induced KDR/Flk-1 phosphorylationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Oroxylin A possessed antiangiogenic activities in vitro and in vivo, which could be an underlying mechanism of its anticancer effect. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0705-2Authors Ying Gao, China Pharmaceutical University Jiangsu Key Laboratory of Carcinogenesis and Intervention P.O. Box 209 24 Tongjia Xiang 210009 Nanjing Jiangsu ChinaNa Lu, China Pharmaceutical University Jiangsu Key Laboratory of Carcinogenesis and Intervention P.O. Box 209 24 Tongjia Xiang 210009 Nanjing Jiangsu ChinaYun Ling, China Pharmaceutical University Jiangsu Key Laborator...
Source: Journal of Cancer Research and Clinical Oncology - November 4, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Clinical study of recombinant adenovirus-p53 combined with fractionated stereotactic radiotherapy for hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results suggest that rAd-p53 combined with fSRT is a relatively safe and effective method for treating primary hepatocellular carcinoma compared with only fSRT. Thus, rAd-p53 combined with fractionated SRT may be preferred as a choice of local treatment for primary HCC when the patients are inoperable or when the patients refuse operation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0701-6Authors Zhi-xiang Yang, Third Military Medical University Cancer Center, Daping Hospital and Institute of Surgery Research 400042 Chongqing ChinaDong Wang, Third Militar...
Source: Journal of Cancer Research and Clinical Oncology - October 31, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Procalcitonin as a predictive marker of infections in chemoinduced neutropeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These findings suggest that PCT is not a useful predictive marker of infection in oncohematologic neutropenic patients, even though higher serum PCT concentrations are associated with hematological tumors as well as in-hospital admission. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0699-9Authors Luisa Carnino, San Giovanni Battista University Hospital Oncohematological Center Turin ItalySilvia Betteto, San Giovanni Battista University Hospital Clinical Biochemistry Laboratory Corso Bramante, 88 10126 Turin ItalyMaria Loiacono, San Giovanni Battista University H...
Source: Journal of Cancer Research and Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Long-term follow-up and a detailed prognostic analysis of patients with oropharyngeal cancer treated with radiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Primary radiotherapy was recommended for OPC patients with the lateral wall at the primary site because of good LRC. The treatment method to the older population and T4 tumor is future tasks. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0700-7Authors Natsuo Tomita, Aichi Cancer Center Hospital Department of Radiation Oncology 1-1 Kanokoden, Chikusaku Nagoya 464-8681 JapanTakeshi Kodaira, Aichi Cancer Center Hospital Department of Radiation Oncology 1-1 Kanokoden, Chikusaku Nagoya 464-8681 JapanKazuhisa Furutani, Aichi Cancer Center Hospital Department of Radiati...
Source: Journal of Cancer Research and Clinical Oncology - October 26, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Erratum to: Lenalidomide in patients with cisplatin-refractory and multiply relapsed germ cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00432-009-0697-yAuthors Karin Oechsle, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg GermanyCarsten Bokemeyer, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg GermanyFriedemann Honecker, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg Germany Journal Journal of Cancer ...
Source: Journal of Cancer Research and Clinical Oncology - October 26, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Genomic aberrations in hepatocellular carcinoma related to osteopontin expression detected by array-CGHEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions There is a significant intratumor genomic heterogeneity between the OPN-positive and negative HCC cells, and OPN-positive HCC cells play a more important role in the development of HCC malignancy than their OPN-negative counterparts. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0695-0Authors Jin-Cai Wu, Fudan University Liver Cancer Institute and Zhongshan Hospital, Institutes of Biomedical Sciences 180 Feng Lin Road 200032 Shanghai People’s Republic of ChinaBing-Sheng Sun, Fudan University Liver Cancer Institute and Zhongshan Hospital, Institutes of Biomedica...
Source: Journal of Cancer Research and Clinical Oncology - October 15, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Urokinase expression in course of benign and malignant mammary lesions: comparison between nodular and healthy tissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In conclusion, although uPA overexpression is typical of cancer tissues, it could be considered as a feature of the whole organism affected by cancer. On the basis of these first results, uPA could be considered for further studies as a possible useful therapeutic target in breast cancer. Content Type Journal ArticleCategory Rapid CommunicationDOI 10.1007/s00432-009-0694-1Authors Francesca Ceccarelli, Sapienza University of Rome UOC Medicina territoriale chirurgica e prevenzione oncologica, Department of Surgery “P. Valdoni” C.so Vittorio Emanuele II, 244 00186 Rome ItalyAndrea Fuso, S...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Expression of Nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The upregulation of NS, EGF and EGFR mRNA frequently occurs in ESCC tissues and is associated with malignancy of human esophageal squamous tumors. NS is required for EGF and EGFR expression. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0693-2Authors Gongyuan Zhang, Zhengzhou University Department of Histology and Embryology, College of Basic Medical Sciences 100 Kexue Boulevard 450001 Zhengzhou People’s Republic of ChinaQiao Zhang, Zhengzhou University College of Public Health 450001 Zhengzhou People’s Republic of ChinaQinxian Zhang, Zhengzhou University Depa...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Expression profiling of formalin-fixed paraffin embedded primary human uveal melanomas using DASL matricesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions To the best of our knowledge, this is the first time that a successful retrospective analysis has been done with UM FFPE RNA. This data may lead to future customized therapeutic targets, which may improve the now unchanged mortality rate of this particular malignancy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0692-3Authors Sebastian Di Cesare, McGill University Health Center The Henry C. Witelson Ophthalmic Pathology Laboratory and Registry 3775 University St., Lyman Duff Building, Room 216 Montreal QC H3A 2B4 CanadaAndre Nantel, National Research Council of...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Erratum to: RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00432-009-0696-zAuthors Qiang Lin, Shanghai Jiaotong University Department of General Thoracic Surgery, Shanghai Chest Hospital 200030 Shanghai ChinaJunfeng Geng, Shanghai Jiaotong University Department of General Thoracic Surgery, Shanghai Chest Hospital 200030 Shanghai ChinaKelong Ma, Shanghai Jiaotong University Cancer Epigenetics and Gene Therapy Program, The State-Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute LN 2200/25, Xietu Road 200032 Shanghai ChinaJian Yu, Shanghai Jiaotong University Cancer Epigenetics and Gene Therapy Progr...
Source: Journal of Cancer Research and Clinical Oncology - October 9, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggested that cucurbitacin E may be an effective regimen for the chemotherapy of pancreatic cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0698-xAuthors Chunyan Sun, China Medical University Department of Clinical Pharmacology 92 Bei’er Road 110001 Shenyang ChinaMeixia Zhang, China Medical University Department of Clinical Pharmacology 92 Bei’er Road 110001 Shenyang ChinaXiaolei Shan, China Medical University Department of Clinical Pharmacology 92 Bei’er Road 110001 Shenyang ChinaXueying Zhou, China Medical University Department of Clinic...
Source: Journal of Cancer Research and Clinical Oncology - October 9, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

The similar survival benefits of stable disease and partial response to pemetrexed in previously treated non-small cell carcinoma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Pemetrexed has comparable survival benefits in NSCLC patients that show objective response or stable disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0687-0Authors Hye-Ryoun Kim, Korea Cancer Center Hospital Department of Internal Medicine 215-4, Gongneung-dong Nowon-gu, Seoul 139-706 KoreaMin Soo Kang, Korea Cancer Center Hospital Department of Internal Medicine 215-4, Gongneung-dong Nowon-gu, Seoul 139-706 KoreaIm Il Na, Korea Cancer Center Hospital Department of Internal Medicine 215-4, Gongneung-dong Nowon-gu, Seoul 139-706 KoreaSung Hyeon Yang, Korea Ca...
Source: Journal of Cancer Research and Clinical Oncology - September 29, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Age as a prognostic factor for patients with osteosarcoma: an analysis of 438 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Age at diagnosis does not appear to be a significant independent prognostic variable for overall survival or disease-free survival in patients with osteosarcoma. Although our data indicate that patients in the fifth decade and older fare worse than younger patients, other variables such as tumor necrosis, tumor extension, and tumor location are likely responsible for the observed decline in overall survival and disease-free survival. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0690-5Authors Matthew T. Harting, University of Michigan Department of Surgery Ann ...
Source: Journal of Cancer Research and Clinical Oncology - September 29, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Loss of GDF-15 abolishes Sulindac chemoprevention in the ApcMin/+ mouse model of intestinal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results demonstrate in a murine model that GDF-15 does not significantly regulate heritable in vivo intestinal carcinogenesis but does mediate sulindac chemoprevention in heritable colon cancer. These data suggest that the use of GDF-15 activated signaling pathways may allow improved chemoprevention and therapies for colorectal cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0691-4Authors Teresa A. Zimmers, University of Miami Miller School of Medicine Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery Miami FL USAJuan C. Gut...
Source: Journal of Cancer Research and Clinical Oncology - September 29, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Expression status of Zic family member 2 as a prognostic marker for oral squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results suggested that ZIC2 expression is correlated with the differentiation type of OSCC and diagnosis and might be a potential prognostic indicator and therapeutic target for OSCCs. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0689-yAuthors Kentaro Sakuma, Chiba University Department of Clinical Molecular Biology, Graduate School of Medicine 1-8-1 Inohana, Chuo-ku Chiba 260-8670 JapanAtsushi Kasamatsu, Chiba University Department of Clinical Molecular Biology, Graduate School of Medicine 1-8-1 Inohana, Chuo-ku Chiba 260-8670 JapanMasanobu Yamatoji, Chib...
Source: Journal of Cancer Research and Clinical Oncology - September 29, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Aberrant p16INK4a methylation is a frequent event in colorectal cancers: prognostic value and relation to mRNA expression and immunoreactivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We conclude that p16INK4a methylation results in transcriptional silencing and defines a group of CRCs with a poor prognosis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0688-zAuthors Hiroyuki Mitomi, Juntendo University School of Medicine Department of Human Pathology 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 JapanNaoshi Fukui, National Hospital Organization, Sagamihara Hospital Department of Pathomechanisms, Clinical Research Center Sagamihara JapanNobuho Tanaka, National Hospital Organization, Sagamihara Hospital Department of Pathomechanisms, Clinical Research C...
Source: Journal of Cancer Research and Clinical Oncology - September 25, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Association of clinicopathological features with UbcH10 expression in colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our study suggests that the overexpression of UbcH10 gene plays a critical role in the carcinogenesis and tumor progression of colorectal cancer. It may be a new marker in diagnosis and prognosis of colorectal cancer, and the inhibition of UbcH10 may be a therapeutic potential for the treatment of colorectal cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0672-7Authors Shimin Chen, Shandong University School of Medicine Institute of Biochemistry and Molecular Biology 44#, Wenhua Xi Road 250012 Jinan Shandong ChinaYingjian Chen, General Hospital of Jinan Mi...
Source: Journal of Cancer Research and Clinical Oncology - September 25, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Clinical outcomes of advanced non-small cell lung cancer patients screened for epidermal growth factor receptor gene mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion EGFR mutation-positive patients benefit from either first- or second-line gefitinib monotherapy. Further large-scale prospective studies to confirm this finding are needed. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0685-2Authors Kimihide Yoshida, Aichi Cancer Center Hospital Department of Thoracic Oncology 1-1 Kanokoden, Chikusa-ku Nagoya 464-8681 JapanYasushi Yatabe, Aichi Cancer Center Hospital Department of Pathology and Molecular Diagnostics 1-1 Kanokoden, Chikusa-ku Nagoya 464-8681 JapanJangchul Park, Aichi Cancer Center Hospital Department of Thoracic On...
Source: Journal of Cancer Research and Clinical Oncology - September 24, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

US-guided interstitial chemotherapy using paclitaxel temperature-responsive gel for breast cancer treatment in ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Interstitial chemotherapy mediated by PTRG appeared to be a safe and effective treatment for breast cancer in rats. It might have clinical applications for treating human breast cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0686-1Authors Chen Zhi-kui, Affiliated Union Hospital of Fujian Medical University Department of Ultrasonography Fuzhou ChinaLin Li-wu, Affiliated Union Hospital of Fujian Medical University Department of Ultrasonography Fuzhou ChinaYang Ying-hong, Affiliated Union Hospital of Fujian Medical University Department of Pathology Fuzhou Ch...
Source: Journal of Cancer Research and Clinical Oncology - September 24, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Phase II study of capecitabine plus oxaliplatin (XELOX) as first-line treatment and followed by maintenance of capecitabine in patients with metastatic colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions XELOX is a highly effective first-line treatment for Chinese mCRC patients. The response rate, TTP, and overall survival of patients treated with this regimen are similar to those treated with FU/leucovorin/oxaliplatin. Furthermore, our preliminary data show maintenance therapy with capecitabine for those patients without progressive disease after at least six cycles of XELOX can significantly improve DDC; and further prospective randomized control trial is warranted. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0682-5Authors Yu Hong Li, Sun Yat-Sen University...
Source: Journal of Cancer Research and Clinical Oncology - September 24, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

The clinical significance of ascitic fluid CEA in advanced gastric cancer with ascitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results suggest that aCEA levels can be used as a prognostic marker for advanced gastric cancer patients with ascites. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0684-3Authors Minkyu Jung, Yonsei University College of Medicine Division of Medical Oncology, Department of Internal Medicine 250 Seongsanno, Seodaemun-gu Seoul 120-752 KoreaHei-Cheul Jeung, Yonsei University College of Medicine Division of Medical Oncology, Department of Internal Medicine 250 Seongsanno, Seodaemun-gu Seoul 120-752 KoreaSung Sook Lee, Yonsei University College of Medicine Divisio...
Source: Journal of Cancer Research and Clinical Oncology - September 23, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Modified apical dissection of the prostate improves early continence in laparoscopic radical prostatectomy: technique and initial resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In this preliminary study, the technique of simplified apical dissection of the prostate in LRP appears to be an easy and feasible technique in early recovery of urinary continence. Further long-term and larger sample studies are necessary to elucidate the modified technique in LRP on early restoration of urinary continence. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0683-4Authors Xin Gao, Sun Yat-Sen University Department of Urology, The Third Affiliated Hospital Number 600, Tianhe Road 510630 Guangzhou Guangdong ChinaKe-Bing Wang, Sun Yat-Sen University Dep...
Source: Journal of Cancer Research and Clinical Oncology - September 23, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Current status and developments in diagnosis and therapy of multiple myelomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Meeting ReportDOI 10.1007/s00432-009-0676-3Authors Jens Hillengass, University of Heidelberg Department of Hematology and Oncology Im Neuenheimer Feld 410 Heidelberg GermanyKai Neben, University of Heidelberg Department of Hematology and Oncology Im Neuenheimer Feld 410 Heidelberg GermanyHartmut Goldschmidt, University of Heidelberg Department of Hematology and Oncology Im Neuenheimer Feld 410 Heidelberg Germany Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 17, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Transglutaminase 2 as a cisplatin resistance marker in non-small cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We showed that good responders of cisplatin in NSCLC could be identified by the promoter methylation of TGM2 and that TGase 2 inhibition appears to be an effective cisplatin-sensitizing modality in NSCLC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0681-6Authors Kang-Seo Park, National Cancer Center Research Institute 111 Jungbalsan-ro, Ilsandong-gu Goyang 410-769 KoreaHyun-Kyoung Kim, National Cancer Center Research Institute 111 Jungbalsan-ro, Ilsandong-gu Goyang 410-769 KoreaJung-Hwa Lee, National Cancer Center Research Institute 111 Jungbalsan-ro, Ilsandong-...
Source: Journal of Cancer Research and Clinical Oncology - September 17, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1αEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions It suggests that HIF-1α, stimulated by hypoxia, exerts a pivotal role in chemoresistance by G0/G1 arrest. Eliminating hypoxic conditions or silencing HIF-1α by siRNA might provide a potent tool to enhance paclitaxel effectiveness in treatment of human ovarian cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0675-4Authors Lei Huang, Huazhong University of Science and Technology Cancer Biology Center, Tongji Hospital, Tongji Medical College 1095 Jiefang Ave. 430030 Wuhan Hubei People’s Republic of ChinaQilin Ao, Department of Pathology, Tongji Hospital, T...
Source: Journal of Cancer Research and Clinical Oncology - September 17, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Adenocarcinoma of the small bowel at a single Korean institute: management and prognosticatorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Early diagnosis is crucial to improve outcomes of SBA with respect to increasing resectability. Distant metastasis as a dominant pattern of recurrence suggests a potential role for adjuvant chemotherapy. Newer antitumor agents in advanced SBA should be evaluated considering the poor efficacy of current palliative chemotherapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0668-3Authors Yong Wha Moon, Yonsei University College of Medicine Department of Internal Medicine, Yonsei Cancer Center 250 Seongsanno, Seodaemun-gu Seoul 120-752 KoreaSun Young Rha, Yonsei Un...
Source: Journal of Cancer Research and Clinical Oncology - September 17, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Lenalidomide in patients with cisplatin-refractory and multiply relapsed germ cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Lenalidomide was well tolerated and showed efficacy in heavily pretreated patients with cisplatin-refractory and multiply relapsed germ cell tumors. Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00432-009-0677-2Authors Karin Oechsle, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg GermanyCarsten Bokemeyer, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg GermanyFriedemann Honeck...
Source: Journal of Cancer Research and Clinical Oncology - September 17, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Serum CA 125 expression as a tumor marker for diagnosis and monitoring the clinical course of epithelioid sarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We concluded that epithelioid sarcoma cells produce and secrete CA 125 into the blood serum and that the elevation of serum CA 125 correlates with disease progression. Therefore, measuring the serum CA 125 level should provide an useful index for diagnosing and monitoring the course of epithelioid sarcoma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0678-1Authors Makiko Hoshino, Niigata University Graduate School of Medical and Dental Sciences Division of Orthopedic Surgery 1 Asahimachi-dori, Chuo-ku Niigata 951-8510 JapanHiroyuki Kawashima, Niigata University ...
Source: Journal of Cancer Research and Clinical Oncology - September 16, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Mina53, a novel c-Myc target gene, is frequently expressed in lung cancers and exerts oncogenic property in NIH/3T3 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our results suggest that Mina53 plays an important role in carcinogenesis and may be a target for cancer prevention. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0679-0Authors Kazutoshi Komiya, Saga University Department of Internal Medicine, Faculty of Medicine Saga JapanNaoko Sueoka-Aragane, Saga University Department of Internal Medicine, Faculty of Medicine Saga JapanAkemi Sato, Saga University Department of Internal Medicine, Faculty of Medicine Saga JapanTakashi Hisatomi, Saga University Department of Internal Medicine, Faculty of Medicine Saga JapanToru Sak...
Source: Journal of Cancer Research and Clinical Oncology - September 16, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results indicate that the co-expression score has independent prognostic value for endometrial cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0673-6Authors Maria Lambropoulou, Democritus University of Thrace Laboratory of Histology-Embryology 68 100 Alexandroupolis GreeceNikolaos Papadopoulos, Democritus University of Thrace Laboratory of Histology-Embryology 68 100 Alexandroupolis GreeceGrigoris Tripsianis, Democritus University of Thrace Medical Statistics 68 100 Alexandroupolis GreeceGeorge Alexiadis, Democritus University of Thrace Laboratory of His...
Source: Journal of Cancer Research and Clinical Oncology - September 16, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals