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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Tags: Calendar of Events Source Type: journals

Renoprotective and Potassium Sparing Effects of Low Dose Dopamine in Acute Decompensated Heart Failure: Preliminary Results of the Dopamine in Acute Decompensated Heart Failure (DAD-HF) TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Worsening renal function (WRF) and hypokalemia related to diuretic use for acute decompensated heart failure (ADHF) are common and portend poor prognosis. Low dose dopamine infusion improves renal perfusion. Whether dopamine infusion improves diuresis and/or reduces renal complication in ADHF is not known. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: Gregory Giamouzis, Javed Butler, Randall C. Starling, Carsten Tschöpe, Dirk Westermann, Dimitrios Economou, George Karayannis, Charalambos Parisis, Dimitrios Rovithis, John Nastas, Themistoklis Kirlidis, Themistoklis Tsaknakis, John Skoularigis, Filippos Tags: Late-Breaking Clinical Trial Presentations Source Type: journals

MARVEL-1; A Double-Blind, Randomized, Controlled, Multicenter Study to Assess The Safety And Cardiovascular Effects of Myocell™ Implantation by a Catheter Delivery System in Congestive Heart Failure Patients Post Myocardial Infarction(s)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Despite the myriad advances in the treatment of myocardial infarction no therapies can regenerate lost contractile tissue. Myoblast administration is the most clinically advanced therapy aimed at prevention of left ventricular remodeling and improvement in contractile function in areas of myocardial scar; however, studies of myoblast administration have been largely uncontrolled, unblinded, or combined with concomitant surgical revascularization. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: Thomas J. Povsic, Timothy Henry, Andrew Taussig, Dean Kereiakis, F. David Fortuin, Alan Niederman, Richard Schatz, Richard Spencer, Douglas Owens, Missy Banks, Diane Joseph, Rhonda Roberts, Christopher M. O'Connor, Warren Sherman Tags: Late-Breaking Clinical Trial Presentations Source Type: journals

Relationship of Baseline Gated Rest SPECT Myocardial Perfusion Imaging to Death and Hospitalization in Heart Failure Patients: Results from the Nuclear Substudy of the HF-ACTION TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: There are currently limited data from large, prospective studies regarding the ability of single photon emission tomography (SPECT) myocardial perfusion imaging (MPI) variables to predict adverse outcomes in patients with heart failure (HF) and reduced left ventricular (LV) ejection fraction (EF). We hypothesize that the severity of resting perfusion defects (“myocardial scarring”) as measured by the summed rest score (SRS) by SPECT MPI will be associated with higher rates of adverse outcomes as defined by a composite primary endpoint of all-cause mortality and cardiovascular hospitalization in patients enr...
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: Allen E. Atchley, Dalane W. Kitzman, David J. Whellan, Ami E. Iskandrian, Stephen J. Ellis, Linda K. Shaw, Robert A. Pagnanelli, Andrew Kao, Khaled Abdul-Nour, Greg Ewald, Christopher M. O'Connor, William E. Kraus, Salvador Borges-Neto, HF-ACTION Trial In Tags: Late-Breaking Clinical Trial Presentations Source Type: journals

Clinical and Prognostic Value of Galectin-3, a Novel Fibrosis-Associated biomarker, in Patients with Chronic Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Biomarkers are increasingly being used in the management of patients with heart failure (HF). Galectin-3 (Gal-3) is a recently developed, novel biomarker that is related to fibrosis underlying cardiac adverse remodelling. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: Dirk J. van Veldhuisen, Dirk J.A. Lok, Kevin Damman, Rudolf A. de Boer, Peter van der Meer, Adriaan A. Voors, Tiny Jaarsma Tags: Late-Breaking Clinical Trial Presentations Source Type: journals

Effect of Rolofylline, a Selective Adenosine A1 Receptor Antagonist, in Patients Hospitalized for Acute Decompensated Heart Failure and Renal Impairment: Findings from the PROTECT StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Context: Patients with acute heart failure (AHF) often present with or develop worsening renal function (WRF) and diuretic resitance during treatment (often termed “cardiorenal syndromeâ€□), with poorer subsequent in-hospital and post-discharge outcomes. Experimental and clinical studies suggest that counter- regulatory responses mediated by adenosine are mechanistically involved. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: M. Christopher O'Connor, PROTET Study and Investigators Tags: Late-Breaking Clinical Trial Presentations Source Type: journals

Reduction in the Risk of Heart Failure with Preventive Cardiac Resynchronization Therapy: MADIT-CRT TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: The randomized Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) was designed to determine if prophylactic cardiac resynchronization therapy with defibrillator (CRT-D) would reduce the primary end point (all cause mortality or heart failure events [iv diuretic Rx or hospitalization Rx for HF], whichever occurred first, when compared to patients receiving only an implanted cardiac defibrillator (ICD-only). The study population involved patients with ischemic (NYHA I & II) and non-ischemic (NYHA II) cardiomyopathy with ejection fraction ≤0.30 and QRS ≥...
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: A.J. Moss, D.S. Cannom, H. Klein, W.J. Hall, M.W. Brown, J.P. Daubert, N.A.M. Estes, E. Foster, H. Greenberg, S.L. Higgins, M.A. Pfeffer, S.D. Solomon, D. Wilber, W. Zarebathe, MADIT-CRT Investigators Tags: Late-Breaking Clinical Trial Presentations Source Type: journals

Improving Evidence-Based Care for Heart Failure in Outpatient Cardiology Practices: Primary Results of IMPROVE HFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: A well-documented treatment gap exists between national heart failure (HF) guidelines and the clinical care of patients with HF. IMPROVE HF prospectively tested the effect of a practice-specific performance improvement intervention on quality measures in patients with HF in outpatient cardiology practices. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: G.C. Fonarow, C.W. Yancy, N.M. Albert, A.B. Curtis, W. Gattis Stough, M. Gheorghiade, J.T. Heywood, M.L. McBride, M.R. Mehra, C. O'Connor, D. Reynolds, M.N. Walsh Tags: Late-Breaking Clinical Trial Presentations Source Type: journals

Superior Performance of Intrathoracic Impedance-Derived fluid Index versus Daily Weight monitoring in Heart Failure Patients: Results of the Fluid Accumulation Status Trial (FAST)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Self-monitoring of daily weight is recommended for the management of heart failure (HF). Diagnostic parameters, such as intrathoracic impedance assessment, derived from implantable devices may offer an adjunctive tool for remote monitoring. We compared the relative sensitivity and unexplained detection rate of changes in daily weights versus intrathoracic impedance changes. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: William T. Abraham, Steven Compton, Garrie Haas, Blair Foreman, Robert C. Canby, Robert Fishel, Scott McRae, Gloria B. Toledo, Shantanu Sarkar, FAST investigators Tags: Late-Breaking Clinical Trial Presentations Source Type: journals

Transforming Health Care Through the Medical Home: The Example of Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Amid ongoing legislative efforts to achieve universal coverage and reduce costs while improving quality of care, heart failure represents a major public health problem, challenging us to restructure systems of reimbursement and care. The “medical home” represents the best option for aligning and incentivizing multidisciplinary groups of providers to optimize decision-making for individual patients and the population, at large, and to compete based on quality and cost. For the medical home to meet the needs of patients with heart failure, it must eliminate barriers and facilitate collaboration among specialist...
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: Marvin A. Konstam, Barry Greenberg Tags: Perspective Source Type: journals

Heart Failure in Swine Flu: A NoteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Influenza virus infection is a problematic respiratory tract infection. The increased rate of mortality and morbidity in infected patients with cardiovascular disorder is confirmed. Nevertheless, influenza infection can also induce cardiovascular disorder. Influenza-induced heart failure has been documented for a long time. The mechanism is believed to be due to cardiac and non cardiac origins. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - October 8, 2009 Category: Cardiology Authors: Viroj Wiwanitkit Tags: Letter to the Editor Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 28, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 28, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 28, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 28, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 28, 2009 Category: Cardiology Tags: Calendar of Events Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 26, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 26, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 26, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 26, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 26, 2009 Category: Cardiology Tags: Calendar of Events Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 30, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 30, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 30, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 30, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Letter to the Editor “Familial Amyloid Cardiomyopathy Due to TTR Mutations: An Underground Cause of Restrictive Cardiomyopathy” by Ruberg et al (J Card Fail 2009;15:464) was printed with the incorrect title. The correct title is “Familial Amyloid Cardiomyopathy Due to TTR Mutations: An Underdiagnosed Cause of Restrictive Cardiomyopathy.” (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 30, 2009 Category: Cardiology Tags: Erratum Source Type: journals

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(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 30, 2009 Category: Cardiology Tags: Calendar of Events Source Type: journals

Re: Decreased Immune Responses to Influenza Vaccination in Patients With Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We appreciate Dr. Shaw and colleagues’ interest in our work. We agree that an improved understanding of immune responses in heart failure (HF) patients is of critical importance. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 30, 2009 Category: Cardiology Authors: Orly Vardeny, John J.M. Moran, Mary S. Hayney, Nancy K. Sweitzer, Maryl R. Johnson, Michelle A. Detry Tags: Letters to the Editor Source Type: journals

Clinical Profile and Predictors of Complications in Peripartum CardiomyopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 1. PPCM may be associated with mortality or severe and lasting morbidity. 2. Incidence of MAE is higher in non-Caucasians and in women with left ventricular ejection fraction ≤25%. 3. Diagnosis of PPCM is often delayed and preceded by MAE. 4. Increased awareness of PPCM is required for early diagnosis and aggressive therapy in an attempt to prevent complications. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 16, 2009 Category: Cardiology Authors: Sorel Goland, Kalgi Modi, Fahed Bitar, Munir Janmohamed, James M. Mirocha, Lawrence S.C. Czer, Sandra Illum, Parta Hatamizadeh, Uri Elkayam Tags: Clinical Investigations Source Type: journals

Percutaneous Implantation of an Intraventricular Device for the Treatment of Heart Failure: Experimental Results and Proof of ConceptEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A significant reduction in LV volumes and corresponding improvement in LV function occurred after device implantation indicating a potential beneficial effect of this new device in treatment of post MI LV dilation. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 13, 2009 Category: Cardiology Authors: Serjan D. Nikolic, Alex Khairkhahan, Miho Ryu, Gerard Champsaur, Eugene Breznock, Michael Dae Tags: Basic Science and Experimental Studies Source Type: journals

Antibodies to Oxidized LDL as Predictors of Morbidity and Mortality in Patients With Chronic Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Ox LDL Abs level maybe a useful parameter for monitoring and planning better management of patients with HF. It was superior to pro-BNP as a predictor of clinical course as expressed by time to hospitalization. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 6, 2009 Category: Cardiology Authors: Gideon Charach, Jacob George, Arnon Afek, Dov Wexler, David Sheps, Gad Keren, Ardon Rubinstein Tags: Clinical Investigations Source Type: journals

The Lowest VE/VCO2 Ratio During Exercise as a Predictor of Outcomes in Patients With Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The lowest VE/VCO2 ratio adds to the prognostic power of conventional CPX responses in HF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 6, 2009 Category: Cardiology Authors: Jonathan Myers, Ross Arena, Ricardo B. Oliveira, Daniel Bensimhon, Leon Hsu, Paul Chase, Marco Guazzi, Peter Brubaker, Brian Moore, Dalane Kitzman, Mary Ann Peberdy Tags: Clinical Investigations Source Type: journals

Levels of Circulating Pro-angiogenic Cells Predict Cardiovascular Outcomes in Patients With Chronic Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The level of circulating PACs is an independent predictor of cardiovascular death and hospitalization in patients with chronic HF, it can be assessed in blood samples collected in a multicenter setting, and may offer an accessible tool to assess the role of vascular regeneration in patients with HF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 6, 2009 Category: Cardiology Authors: Giovanna Balconi, Ralf Lehmann, Fabio Fiordaliso, Birgit Assmus, Stefanie Dimmeler, Patrizio Sarto, Emanuele Carbonieri, Alessandra Gualco, Carlo Campana, Laura Angelici, Serge Masson, Salman Aa Mohammed, Elisabetta Dejana, Marco Gorini, Andreas M. Zeiher Tags: Clinical Investigations Source Type: journals

Anti-Alzheimer's Drug, Donepezil, Markedly Improves Long-Term Survival After Chronic Heart Failure in MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Oral donepezil improves survival of CHF mice through prevention of pumping failure and cardiac remodeling. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 29, 2009 Category: Cardiology Authors: Takemi Handa, Rajesh G. Katare, Yoshihiko Kakinuma, Mikihiko Arikawa, Motonori Ando, Shiro Sasaguri, Fumiyasu Yamasaki, Takayuki Sato Tags: Basic Science and Experimental Studies Source Type: journals

Role of Ischemic Preconditioning and Inflammatory Response in the Development of Malignant Ventricular Arrhythmias After Reperfused ST-Elevation Myocardial InfarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Lack of ischemic preconditioning, enhanced inflammatory response, and subsequent LV dysfunction are related to the development of VT/VF after STEMI. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 29, 2009 Category: Cardiology Authors: Hidehiro Kaneko, Toshihisa Anzai, Kotaro Naito, Takashi Kohno, Yuichiro Maekawa, Toshiyuki Takahashi, Akio Kawamura, Tsutomu Yoshikawa, Satoshi Ogawa Tags: Clinical Investigations Source Type: journals

In-hospital Testing for Sleep-disordered Breathing in Hospitalized Patients With Decompensated Heart Failure: Report of Prevalence and Patient CharacteristicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Similar to stable chronic heart failure, ADHF is associated with a high prevalence of SDB. The prevalence of predominantly obstructive SDB exceeded that of predominantly central SDB in ADHF patients. The presence of obstructive SDB during hospitalization predicted a diagnosis of OSA on polysomnography. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 29, 2009 Category: Cardiology Authors: Rami N. Khayat, David Jarjoura, Brian Patt, Todd Yamokoski, William T. Abraham Tags: Clinical Investigations Source Type: journals

A Pilot Evaluation of the Long-term Effect of Combined Therapy With Intravenous Iron Sucrose and Erythropoietin in Elderly Patients With Advanced Chronic Heart Failure and Cardio-Renal Anemia Syndrome: Influence on Neurohormonal Activation and Clinical OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Long-term combined therapy with IV iron and rHuEPO may increase Hb, reduce NT-proBNP, and improve functional capacity and cardiovascular hospitalization in elderly patients with advanced CHF and CRAS with mild to moderate renal dysfunction. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 29, 2009 Category: Cardiology Authors: Josep Comín-Colet, Sonia Ruiz, Mercè Cladellas, Marcelo Rizzo, Adriana Torres, Jordi Bruguera Tags: Clinical Trial Source Type: journals

Trastuzumab-Induced Cardiomyopathy: Not as Benign as it Looks? A Retrospective StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: One of the recent advances in the treatment of breast cancer is trastuzumab. However, a major side effect of this medication is cardiomyopathy. Our objective was to determine the incidence of trastuzumab-induced cardiomyopathy and the rate of discontinuation of trastuzumab in a clinical setting.Methods and Results: We retrospectively reviewed the records of all women treated with trastuzumab at the Moffitt Cancer Center between 2003 and 2007. Cardiomyopathy was defined as symptomatic heart failure or a decrease of ejection fraction by ≥10% from baseline or to (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 28, 2009 Category: Cardiology Authors: Maya Guglin, Gregory Hartlage, Christopher Reynolds, Ren Chen, Vinod Patel Tags: Clinical Investigations Source Type: journals

Digitoxin Prolongs Survival of Female Rats With Heart Failure Due to Large Myocardial InfarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, long-term digitoxin administration reduced cardiac impairment after myocardium infarction, attenuated myocardial dysfunction, reduced pulmonary congestion, and provided the first evidence regarding the efficiency of digitoxin in prolonging survival in experimental cardiac failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 26, 2009 Category: Cardiology Authors: Izo Helber, Alexandra A. Dos Santos, Ednei L. Antonio, Ronald L.G. Flumignan, Danilo S. Bocalini, Camila Piccolo, Mihai Gheorghiade, Paulo J.F. Tucci Tags: Basic Science and Experimental Studies Source Type: journals

Improvement in Health-related Quality of Life After Hospitalization Predicts Event-free Survival in Patients With Advanced Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In patients hospitalized with severe HF decompensation, HRQOL is seriously impaired but improves substantially within 1 month for most patients and remains improved for 6 months. Patients for whom HRQOL does not improve by 1 month after hospital admission merit specific attention both to improve HRQOL and to address high risk for poor event-free survival. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 26, 2009 Category: Cardiology Authors: Debra K. Moser, Laura Yamokoski, Jie Lena Sun, Ginger A. Conway, Karen A. Hartman, Judith A. Graziano, Cynthia Binanay, Lynne W. Stevenson, Escape Investigators Tags: Clinical Investigations Source Type: journals

Evidence of Left Ventricular Systolic Dysfunction Detected by Automated Function Imaging in Patients With Heart Failure and Preserved Left Ventricular Ejection FractionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Deteriorated LV systolic function is demonstrated by decreased global PSLS in HFPEF patients. AFI is an effective and facile method for assessing LV systolic abnormalities. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 25, 2009 Category: Cardiology Authors: Yen-Wen Liu, Wei-Chuan Tsai, Chi-Ting Su, Chin-Chan Lin, Jyh-Hong Chen Tags: Clinical Investigations Source Type: journals

Atorvastatin Modulates Th1/Th2 Response in Patients With Chronic Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We congratulate Cheng et al for their interesting paper suggesting that atorvastatin can modulate the Th1/Th2 response in heart failure (HF) through inhibition of Th1 cytokine production. It is well known that in addition to lipid lowering effects, statins confer pleiotropic immunomodulatory, anti-atherogenic properties and a number of anti-tumor activities. We agree with Cheng et al that the pathophysiological importance of Th1/Th2 imbalance may potentially be transferable to a broader spectrum of clinical conditions beyond classical inflammatory or autoimmune diseases. However, the inherent complexity an...
Source: Journal of Cardiac Failure - June 24, 2009 Category: Cardiology Authors: Gábor Földes, Stefan D. Anker, Stephan von Haehling Tags: Letters to the Editor Source Type: journals

Decreased Immune Responses to Influenza Vaccination in Patients With Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Research into influenza vaccination in patients with heart failure is of clear importance. We were therefore encouraged to read the recent article by Vardeny and colleagues. However, we have to express reservations with the study findings and the conclusions provided by the authors. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 21, 2009 Category: Cardiology Authors: Steven M. Shaw, Simon G. Williams, Nizar Yonan, James E. Fildes Tags: Letters to the Editor Source Type: journals

4-Hydroxy-2-nonenal Induces Calcium Overload via the Generation of Reactive Oxygen Species in Isolated Rat Cardiac MyocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: HNE induces the formation of ROS, especially H2O2 and ·OH, in cardiomyocytes and subsequently ROS cause intracellular Ca2+ overload. HNE formation may play an important role as a mediator of oxidative stress in heart failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 18, 2009 Category: Cardiology Authors: Kazufumi Nakamura, Daiji Miura, Kengo Fukushima Kusano, Yoshihisa Fujimoto, Wakako Sumita-Yoshikawa, Soichiro Fuke, Nobuhiro Nishii, Satoshi Nagase, Yoshiki Hata, Hiroshi Morita, Hiromi Matsubara, Tohru Ohe, Hiroshi Ito Tags: Basic Science and Experimental Studies Source Type: journals

A Multicenter Study of Noninvasive Cardiac Output by Bioreactance During Symptom-limited ExerciseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Bioreactance-based noninvasive measurements of CO at rest and during exertion identified abnormalities of cardiovascular function consistent with those identified by pVO2 and in prior studies using invasive CO measurements. This technique might therefore be useful for indexing disease severity, prognostication, and for tracking responses to treatment in clinical practice and in clinical trials. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 18, 2009 Category: Cardiology Authors: Mathew M. Maurer, Daniel Burkhoff, Simon Maybaum, Veronica Franco, Timothy J. Vittorio, Paula Williams, Leah White, Gayathri Kamalakkannan, Jonathan Myers, Donna M. Mancini Tags: Methods Source Type: journals

Regional Distribution of Mitochondrial Dysfunction and Apoptotic Remodeling in Pacing-Induced Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Abnormal activity of several mitochondrial enzymes and increased apoptogenic pathway appear to be mediated, at least in part, by an orchestrated shift in expression (both nuclear and mitochondrial DNA) of respiratory chain subunits (eg, cyt b, ATP-β), mitochondrial bioenergetic enzymes (eg, mitochondrial creatine kinase), global transcription factor (eg, PGC-1), and apoptotic proteins (eg, p53, p21) with distinct differences in their regional distribution and in the subpopulations of mitochondria affected. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 16, 2009 Category: Cardiology Authors: José Marín-García, Michael J. Goldenthal, Shirish Damle, Yeqing Pi, Gordon W. Moe Tags: Basic Science and Experimental Studies Source Type: journals