Journal of Cellular and Molecular Medicine 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Exosomes from mesenchymal stem cells expressing miR ‐125b inhibit neointimal hyperplasia via myosin IE
AbstractIntercellular communication between mesenchymal stem cells (MSCs) and their target cells in the perivascular environment is modulated by exosomes derived from MSCs. However, the potential role of exosome ‐mediated microRNA transfer in neointimal hyperplasia remains to be investigated. To evaluate the effects of MSC‐derived exosomes (MSC‐Exo) on neointimal hyperplasia, their effects upon vascular smooth muscle cell (VSMC) growth in vitro and neointimal hyperplasia in vivo were assessed in a m odel of balloon‐induced vascular injury. Our results showed that MSC‐Exo were internalised by VSMCs and inhibited...
Source: Journal of Cellular and Molecular Medicine - November 28, 2018 Category: Molecular Biology Authors: Dongqing Wang,
Bin Gao,
Jianing Yue,
Fei Liu,
Yifan Liu,
Weiguo Fu,
Yi Si Tags: ORIGINAL ARTICLE Source Type: research
O ‐GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5
This study not on ly reveals the novel functional of O‐GlcNAcylation in regulating DDX5, but also reveals the carcinogenic effect of the OGT‐DDX5 axis in colorectal cancer. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - November 28, 2018 Category: Molecular Biology Authors: Nan Wu,
Mingzuo Jiang,
Yuying Han,
Haiming Liu,
Yi Chu,
Hao Liu,
Jiayi Cao,
Qiuqiu Hou,
Yu Zhao,
Bing Xu,
Xin Xie Tags: ORIGINAL ARTICLE Source Type: research
Identification of a 4 ‐mRNA metastasis‐related prognostic signature for patients with breast cancer
AbstractMetastasis ‐related mRNAs have showed great promise as prognostic biomarkers in various types of cancers. Therefore, we attempted to develop a metastasis‐associated gene signature to enhance prognostic prediction of breast cancer (BC) based on gene expression profiling. We firstly screened and identified 5 6 differentially expressed mRNAs by analysing BC tumour tissues with and without metastasis in the discovery cohort (GSE102484, n = 683). We then found 26 of these differentially expressed genes were associated with metastasis‐free survival (MFS) in the training set (GSE20685, n = 319). A meta stasis‐...
Source: Journal of Cellular and Molecular Medicine - November 28, 2018 Category: Molecular Biology Authors: Xinhua Xie,
Jianwei Wang,
Dingbo Shi,
Yutian Zou,
Zhenchong Xiong,
Xing Li,
Jianhua Zhou,
Hailin Tang,
Xiaoming Xie Tags: ORIGINAL ARTICLE Source Type: research
Disabled ‐1 is down‐regulated in clinical breast cancer and regulates cell apoptosis through NF‐κB/Bcl‐2/caspase‐9
In this study, we examined the expression of Dab1 in 38 breast cancer paraffin sections, as well as 60 paired frozen breast cancer and their adjacent tissues. Our results showed that Dab1 was reduced in breast cancer, and its compromised expression correlated with triple negative breast cancer phenotype, poor differentiation, as well as lymph node metastasis. Functional analysis in breast cancer cell lines demonstrated t hat Dab1 promoted cell apoptosis, which, at least partially, depended on its regulation of NF‐κB/Bcl‐2/caspase‐9 pathway. Our study strongly suggests thatDab1 may be a potential tumour suppressor ge...
Source: Journal of Cellular and Molecular Medicine - November 28, 2018 Category: Molecular Biology Authors: Rang ‐Juan Cao,
Kai Li,
Wan‐Ying Xing,
Shuang Du,
Qiang Li,
Xiao‐Juan Zhu,
Shu‐Sen Cui Tags: SHORT COMMUNICATION Source Type: research
One method to establish Epstein ‐Barr virus‐associated NK/T cell lymphoma mouse models
AbstractNovel nude mice model of human NK/T cell lymphoma were established by subcutaneously injecting two NK/T cell lymphoma cell lines into the right axillary region of mice and successful passages were completed by injecting cell suspension which was obtained through a 70 ‐μm cell strainer. These mice models and corresponding cell clones have been successfully developed for more than 8 generations. The survival rates of both resuscitation and transplantation in NKYS and YT models were 90% and 70% correspondingly. Pathologically, the tumour cells in all passages of the lymphoma‐bearing mice and cell lines obtained f...
Source: Journal of Cellular and Molecular Medicine - November 28, 2018 Category: Molecular Biology Authors: Weili Xue,
Weiming Li,
Yufeng Shang,
Yanjie Zhang,
Xuan Lan,
Guannan Wang,
Zhaoming Li,
Xudong Zhang,
Yue Song,
Baopeng Wu,
Meng Dong,
Xinhua Wang,
Mingzhi Zhang Tags: ORIGINAL ARTICLE Source Type: research
Preconditioning strategies for improving the survival rate and paracrine ability of mesenchymal stem cells in acute kidney injury
AbstractAcute kidney injury (AKI) is a common, severe emergency case in clinics, with high incidence, significant mortality and increased costs. Despite development in the understanding of its pathophysiology, the therapeutic choices are still confined to dialysis and renal transplantation. Considering their antiapoptotic, immunomodulatory, antioxidative and pro ‐angiogenic effects, mesenchymal stem cells (MSCs) may be a promising candidate for AKI management. Based on these findings, some clinical trials have been performed, but the results are contradictory (NCT00733876, NCT01602328). The low engraftment, poor survival...
Source: Journal of Cellular and Molecular Medicine - November 28, 2018 Category: Molecular Biology Authors: Lingfei Zhao,
Chenxia Hu,
Ping Zhang,
Hua Jiang,
Jianghua Chen Tags: REVIEW Source Type: research
Up ‐regulation of SPINT2/HAI‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion
AbstractThe role of tumour microenvironment in neoplasm initiation and malignant evolution has been increasingly recognized. However, the bone marrow mesenchymal stromal cell (BMMSC) contribution to disease progression remains poorly explored. We previously reported that the expression of serine protease inhibitor kunitz ‐type2 (SPINT2/HAI‐2), an inhibitor of hepatocyte growth factor (HGF) activation, is significantly lower in BMMSC from myelodysplastic syndromes (MDS) patients compared to healthy donors (HD). Thus, to investigate whether this loss of expression was due to SPINT2/HAI‐2 methylation, BMMSC from MDS and...
Source: Journal of Cellular and Molecular Medicine - November 28, 2018 Category: Molecular Biology Authors: Fernanda Marconi Roversi,
Nathalia Moreno Cury,
Matheus Rodrigues Lopes,
Karla Priscila Ferro,
Jo ão Agostinho Machado‐Neto,
Marisa Claudia Alvarez,
Gabriela Pereira Santos,
Renata Giardini Rosa,
Ana Leda Longhini,
Adriana da Silva Santos Duar Tags: ORIGINAL ARTICLE Source Type: research
Protease ‐activated receptor‐1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy
AbstractEnd ‐stage renal disease, the final stage of all chronic kidney disorders, is associated with renal fibrosis and inevitably leads to renal failure and death. Transition of tubular epithelial cells (TECs) into mesenchymal fibroblasts constitutes a proposed mechanism underlying the progression of renal fibrosis and here we assessed whether protease‐activated receptor (PAR)‐1, which recently emerged as an inducer of epithelial‐to‐mesenchymal transition (EMT), aggravates renal fibrosis. We show that PAR‐1 activation on TECs reduces the expression of epithelial markers and simultaneously in duces mesenchymal...
Source: Journal of Cellular and Molecular Medicine - November 28, 2018 Category: Molecular Biology Authors: Maaike Waasdorp,
Dennis M. de Rooij,
Sandrine Florquin,
JanWillem Duitman,
C. Arnold Spek Tags: ORIGINAL ARTICLE Source Type: research
Plasma levels of soluble ST2, but not IL ‐33, correlate with the severity of alcoholic liver disease
AbstractAlcoholic liver disease (ALD) is a complication that is a burden on global health and economy. Interleukin ‐33 (IL‐33) is a newly identified member of the IL‐1 cytokine family and is released as an “alarmin” during inflammation. Soluble suppression of tumourigenicity 2 (sST2), an IL‐33 decoy receptor, has been reported as a new biomarker for the severity of systemic and highly inflammatory di seases. Here, we found the levels of plasma sST2, increased with the disease severity from mild to severe ALD. Importantly, the plasma sST2 levels in ALD patients not only correlated with scores for prognostic mode...
Source: Journal of Cellular and Molecular Medicine - November 27, 2018 Category: Molecular Biology Authors: Zijian Sun,
Binxia Chang,
Ang Huang,
Shuli Hao,
Miaomiao Gao,
Ying Sun,
Ming Shi,
Lei Jin,
Wei Zhang,
Jun Zhao,
Guangju Teng,
Lin Han,
Hui Tian,
Qingsheng Liang,
Ji ‐Yuan Zhang,
Zhengsheng Zou Tags: ORIGINAL ARTICLE Source Type: research
CXXC5: A novel regulator and coordinator of TGF ‐β, BMP and Wnt signaling
AbstractCXXC5 is a member of the CXXC ‐type zinc‐finger protein family. Proteins in this family play a pivotal role in epigenetic regulation by binding to unmethylated CpG islands in gene promoters through their characteristic CXXC domain. CXXC5 is a short protein (322 amino acids in length) that does not have any catalytic domain, but is able to bind to DNA and act as a transcription factor and epigenetic factor through protein‐protein interactions. Intriguingly, increasing evidence indicates that expression of the CXXC5 gene is controlled by multiple signaling pathways and a variety of transcription factors, positi...
Source: Journal of Cellular and Molecular Medicine - November 27, 2018 Category: Molecular Biology Authors: Xiangyang Xiong,
Shuo Tu,
Jianbin Wang,
Shiwen Luo,
Xiaohua Yan Tags: REVIEW Source Type: research
Therapeutic effects of lentinan on inflammatory bowel disease and colitis ‐associated cancer
In this study, we investigated the therapeutic potential of lentinan in mouse models of inflammatory bowel disease (IBD) and colitis ‐associated cancer (CAC). Lentinan decreased the disease activity index and macroscopic and microscopic colon tissue damage in dextran sulphate sodium (DSS)‐induced or TNBS‐induced models of colitis. High‐dose lentinan was more effective than salicylazosulfapyridine in the mouse models of co litis. Lentinan decreased the number of tumours, inflammatory cell infiltration, atypical hyperplasia and nuclear atypia in azoxymethane/DSS‐induced CAC model. It also decreased the expression o...
Source: Journal of Cellular and Molecular Medicine - November 24, 2018 Category: Molecular Biology Authors: Yanrong Liu,
Jianmin Zhao,
Yali Zhao,
Shumin Zong,
Yixuan Tian,
Shuang Chen,
Meng Li,
Huijuan Liu,
Qiang Zhang,
Xueshuang Jing,
Bo Sun,
Hongzhi Wang,
Tao Sun,
Cheng Yang Tags: ORIGINAL ARTICLE Source Type: research
Plasma levels of miR ‐29b and miR‐200b in type 2 diabetic retinopathy
AbstractMicroRNAs (miRNAs/miRs) are involved in the pathogenesis of diabetes mellitus and its chronic complications, and their circulating levels have emerged as potential biomarkers for the development and progression of diabetes. However, few studies have examined the expression of miRNAs in diabetic retinopathy (DR) in humans. This case ‐control study aimed to investigate whether the plasma levels of miR‐29b and miR‐200b are associated with DR in 186 South Brazilians with type 2 diabetes (91 without DR, 46 with non‐proliferative DR and 49 with proliferative DR). We also included 20 healthy blood donors to determ...
Source: Journal of Cellular and Molecular Medicine - November 23, 2018 Category: Molecular Biology Authors: Maria Enoia Dantas da Costa e Silva,
Evelise Regina Polina,
Daisy Crispim,
Renan Cesar Sbruzzi,
Daniel Lavinsky,
Felipe Mallmann,
Nidiane Carla Martinelli,
Luis Henrique Canani,
Katia Gon çalves Santos Tags: ORIGINAL ARTICLE Source Type: research
Evaluation of serum exosomal LncRNA ‐based biomarker panel for diagnosis and recurrence prediction of bladder cancer
In this study, our aim was to identify a panel of lncRNAs in serum exosomes for the diagnosis and recurrence prediction of bladder cancer (BC). The expressions of 11 candidate lncRNAs in exosome were investigated in training set (n = 200) and an independent validation set (n = 320) via quantitative real‐time PCR. A three‐lncRNA panel (PCAT‐1, UBC1 and SNHG16) was finally identified by multivariate logistic regression model to provide high diagnostic accuracy for BC with an area under the receiver‐operating characteristic curve (AUC) of 0.857 and 0.826 in t raining set and validation set, respectively, which was...
Source: Journal of Cellular and Molecular Medicine - November 23, 2018 Category: Molecular Biology Authors: Shujun Zhang,
Lutao Du,
Lishui Wang,
Xiumei Jiang,
Yao Zhan,
Juan Li,
Keqiang Yan,
Weili Duan,
Yinghui Zhao,
Lili Wang,
Yunshan Wang,
Yuliang Shi,
Chuanxin Wang Tags: ORIGINAL ARTICLE Source Type: research
MiR ‐15a/16‐1 deficiency induces IL‐10‐producing CD19+ TIM‐1+ cells in tumor microenvironment
AbstractIL ‐10‐producing B cells (B10) are associated with autoimmune diseases, infection and tumours. MiR‐15a/16 as a tumour‐suppressive gene is down‐regulated in several tumours, such as chronic lymphocytic leukaemia, pituitary adenomas and prostate carcinoma. Here, increased frequency of IL‐10‐ producing CD19+ Tim ‐1+ cells was seen in both aged miR ‐15a/16−/− mice (15 ‐18 months) with the onset of B cell leukaemia and young knockout mice (8‐12 weeks) transplanted with hepatic cancer cells. CD19+ Tim ‐1+ cells down ‐regulated the function of effector CD4+CD25low T cells ex vivo dependent ...
Source: Journal of Cellular and Molecular Medicine - November 23, 2018 Category: Molecular Biology Authors: Xiaoqin Jia,
Hao Liu,
Chong Xu,
Sen Han,
Yating Shen,
Xin Miao,
Xiangyu Hu,
Zhijie Lin,
Li Qian,
Zhengbing Wang,
Weijuan Gong Tags: ORIGINAL ARTICLE Source Type: research
ADIPOQ, KCNJ11 and TCF7L2 polymorphisms in type 2 diabetes in Kyrgyz population: A case ‐control study
This study demonstrated some association of 276T allele andADIPOQ gene G276T heterozygous genotype as well asKCNJ11 gene 23Lys allele with T2D in ethnic Kyrgyz, but study results should be interpreted with caution because of the limited statistical power. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - November 23, 2018 Category: Molecular Biology Authors: Jainagul Isakova,
Elnura Talaibekova,
Denis Vinnikov,
Iskender Saadanov,
Nazira Aldasheva Tags: SHORT COMMUNICATION Source Type: research
