Journal of Circadian RhythmsThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Impact of oral melatonin on the electroretinogram cone responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Oral melatonin appears to reach the eye through the circulation. When it is administered at a time of day when it is not usually present, melatonin appears to reduce input to retinal cones. We believe that the impact of melatonin on retinal function should be taken into consideration when used without supervision in chronic self-medication for sleep or circadian disorder treatment. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - November 19, 2009 Category: Biology Authors: Anne-Marie GagneKonstantin DanilenkoSerge RosolenMarc Hebert Source Type: journals

Sex and hand differences in circadian wrist activity are independent from sex and hand differences in 2D:4DEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Sex and hand differences for digit ratio and acrophase replicated previous findings. The lack of correlation between digit ratio and patterns of wrist activity suggests that sexually dimorphic circadian activity develops independently from the mechanisms of hormone exposure that cause sex differences in digit ratio. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - October 29, 2009 Category: Biology Authors: Camille ReuterDenise McQuade Source Type: journals

Restless Legs Syndrome in shift workers: A cross sectional study on male assembly workersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Rotational shift work acts as a risk or exacerbating factor for Restless Legs Syndrome. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - September 13, 2009 Category: Biology Authors: Akbar SharifianMarjan FiroozehGholamreza PouryaghoubMehran ShahryariMohsen RahimiMohammad HesamianAli Fardi Source Type: journals

Food anticipation in Bmal1-/- and AAV-Bmal1 rescued mice: a reply to Fuller et alEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence that circadian food-anticipatory activity and temperature rhythms are absent in Bmal1 knockout mice and rescued by restoration of Bmal1 expression selectively in the dorsomedial hypothalamus was published in 2008 by Fuller et al and critiqued in 2009 by Mistlberger et al. Fuller et al have responded to the critique with new information. Here we update our critique in the light of this new information. We also identify and correct factual and conceptual errors in the Fuller et al response. We conclude that the original results of Fuller et al remain inconclusive and fail to clarify the role of Bmal1 or the dorsomed...
Source: Journal of Circadian Rhythms - August 9, 2009 Category: Biology Authors: Ralph MistlbergerRuud BuijsEtienne ChalletCarolina EscobarGlenn LandryAndries KalsbeekPaul PevetShigenobu Shibata Source Type: journals

A possible connection between psychosomatic symptoms and daily rhythmicity in growth hormone secretion in healthy Japanese studentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Psychosomatic symptoms may be associated with circadian dysfunction, as inferred from blunted rhythmicity in growth hormone secretion. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - August 4, 2009 Category: Biology Authors: Mitsuo NaganeKazunori YoshimuraShu-Ichi WatanabeMasahiko Nomura Source Type: journals

Phase delaying the human circadian clock with a single light pulse and moderate delay of the sleep/dark episode: No influence of iris colorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A single 2-hour bright light pulse combined with a moderate delay of the sleep/dark episode delayed the circadian clock an average of ~1.5 hours. There was no evidence that iris color influenced the magnitude of the phase shift. Future studies are needed to replicate our findings that iris color does not impact the magnitude of light-induced circadian phase shifts, and that the previously reported differences may be due to race. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - July 16, 2009 Category: Biology Authors: Jillian CantonMark SmithHo-Sun ChoiCharmane Eastman Source Type: journals

Chronotypology and melatonin alterations in minimal hepatic encephalopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: "Minimal (subclinical) hepatic encephalopathy" is a term that describes impairment of every day life activities in cirrhosis patients without clinical neurologic abnormalities. Melatonin diurnal pattern disruption and metabolic changes due to liver insufficiency can affect the human biologic clock. Our study was conducted to measure plasma melatonin levels in an attempt to correlate plasma melatonin abnormalities with liver insufficiency severity, and describe chronotypology in cirrhosis patients with minimal encephalopathy. Methods: Twenty-six cirrhotic patients enrolled in the study and thirteen patients with...
Source: Journal of Circadian Rhythms - May 29, 2009 Category: Biology Authors: Dimitrios VelissarisVasilis KaramouzosPanagiotis PolychronopoulosMenelaos Karanikolas Source Type: journals

NPAS2 and PER2 are linked to risk factors of the metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings support the view that relevant relationships between circadian clocks and the metabolic syndrome in humans exist. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - May 26, 2009 Category: Biology Authors: Ani EnglundLeena KovanenSirkku SaarikoskiJari HaukkaAntti ReunanenArpo AromaaJouko LonnqvistTimo Partonen Source Type: journals

Effect of chronic ethanol exposure on the liver of Clock-mutant miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In humans, chronic ethanol consumption leads to a characteristic set of changes to the metabolism of lipids in the liver that is referred to as an "alcoholic fatty liver (AFL)". In severe cases, these metabolic changes result in the enlargement and fibrillization of the liver and are considered risk factors for cirrhosis and liver cancer. Clock-mutant mice have been shown to display abnormal lipid metabolism and alcohol preferences. To further understand the potential interactions between ethanol consumption, lipid metabolism, and the circadian clock, we investigated the effect of chronic ethanol intake on the lipid metabo...
Source: Journal of Circadian Rhythms - April 1, 2009 Category: Biology Authors: Takashi Kudo, Toru Tamagawa and Shigenobu Shibata Source Type: journals

Standards of evidence in chronobiology: Critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Daily feeding schedules generate food anticipatory rhythms of behavior and physiology that exhibit canonical properties of circadian clock control. The molecular mechanisms and location of food-entrainable circadian oscillators hypothesized to control food anticipatory rhythms are unknown. In 2008, Fuller et al reported that food-entrainable circadian rhythms are absent in mice bearing a null mutation of the circadian clock gene Bmal1 and that these rhythms can be rescued by virally-mediated restoration of Bmal1 expression in the dorsomedial nucleus of the hypothalamus (DMH) but not in the suprachiasmatic nucleus (site of ...
Source: Journal of Circadian Rhythms - March 26, 2009 Category: Biology Authors: Ralph E Mistlberger, Ruud M Buijs, Etienne Challet, Carolina Escobar, Andries Kalsbeek, Glenn J Landry, Paul Pevet and Shigenobu Shibata Source Type: journals

Is a purpose of REM sleep atonia to help regenerate intervertebral disc volumetric loss?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses a new hypothesis for complete core muscle relaxation in REM sleep, suggesting a bottom-up recuperative perspective. That is, does the atonia in REM sleep provide a utility to help restore the mechanobiology and respective diurnal intervertebral disc hydraulic loss? By combining the effects of gravity with current compressive concepts in spinal stability, this article looks at vertebral approximation as a deleterious experience with an intrinsic biological need to keep vertebrae separated. Methods using polysomnography and recumbent MRI are discussed. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - January 5, 2009 Category: Biology Authors: Jerome CJ Fryer Source Type: journals

A new approach to understanding the impact of circadian disruption on human healthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This paper provides a quantitative foundation for systematically studying the impact of light-induced circadian disruption in humans and in animal models. Ecological light and activity data are needed to develop the essential insights into circadian entrainment/disruption actually experienced by modern people. These data can now be obtained and analyzed to reveal the interrelationship between actual light exposures and markers of circadian rhythm such as rest-activity patterns, core body temperature, and melatonin synthesis. Moreover, it should now be possible to bridge ecological studies of circadian disrupti...
Source: Journal of Circadian Rhythms - May 29, 2008 Category: Biology Authors: Mark S Rea, Andrew Bierman, Mariana G Figueiro and John D Bullough Source Type: journals

Delayed sleep phase cases and controlsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate a DSPD phenotype is familial and associated with unipolar depression. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - April 29, 2008 Category: Biology Authors: Daniel F Kripke, Katharine M Rex, Sonia Ancoli-Israel, Caroline M Nievergelt, Walt Klimecki and John R Kelsoe Source Type: journals

SCN-AVP release of mPer1/mPer2 double-mutant mice in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that the circadian clock in these animals, although deficient in (most) behavioural and molecular rhythms, may still be (partially) functional, possibly as an hourglass mechanism. The level of perturbation of the clock in Per1/2 double mutants may therefore be less than was originally thought. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - March 20, 2008 Category: Biology Authors: Daan R van der Veen, Ellis GA Mulder, Henrik Oster, Menno P Gerkema and Roelof A Hut Source Type: journals

Period-2: a tumor suppressor gene in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous reports have suggested that the ablation of the Period 2 gene (Per 2) leads to enhanced development of lymphoma and leukemia in mice. Employing immunoblot analyses, we have demonstrated that PER 2 is endogenously expressed in human breast epithelial cell lines but is not expressed or is expressed at significantly reduced level in human breast cancer cell lines. Expression of PER 2 in MCF-7 breast cancer cells significantly inhibited the growth of MCF-7 human breast cancer cells, and, when PER 2 was co-expressed with the Crytochrome 2 (Cry 2) gene, an even greater growth-inhibitory effect was observed. The inhibito...
Source: Journal of Circadian Rhythms - March 11, 2008 Category: Biology Authors: Shulin Xiang, Seth B Coffelt, Lulu Mao, Lin Yuan, Qi Cheng and Steven M. Hill Source Type: journals

Structural insights into the function of the core-circadian factor TIMING OF CAB2 EXPRESSION 1 (TOC1)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The models we present should prove useful in future hypothesis-driven biochemical analyses to test the predictions that TOC1 is a multi-domain signaling component of the plant circadian clock. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - February 25, 2008 Category: Biology Authors: Elsebeth Kolmos, Heiko Schoof, Michael Pluemer and Seth J Davis Source Type: journals

Ovipositional periodicity of caged Anopheles gambiae individualsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Confined individual A. gambiae oviposit in a single ca. 2-4 h continuous bout per 24 h. Oviposition is most probable in early scotophase, mid scotophase, or early photophase. However, some oviposition can occur at any hour during 24 h, especially if females were previously deprived of ovipositional substrate. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - January 25, 2008 Category: Biology Authors: Megan L Fritz, Juan Huang, Edward D Walker, M NABIE Bayoh, John Vulule and James R Miller Source Type: journals

Circadian rhythm dysfunction in glaucoma: a hypothesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The absence of circadian zeitgebers in the social environment causes circadian misalignment, which is often associated with sleep disturbances. Circadian misalignment, defined as a mismatch between the sleep-wake cycle and the timing of the circadian system, can occur either because of inadequate exposure to the light-dark cycle, the most important synchronizer of the circadian system, or reduction in light transmission resulting from ophthalmic diseases (e.g., senile miosis, cataract, diabetic retinopathy, macular degeneration, retinitis pigmentosa, and glaucoma). We propose that glaucoma may be the primary ocular disease...
Source: Journal of Circadian Rhythms - January 10, 2008 Category: Biology Authors: Girardin Jean-Louis, Ferdinand Zizi, Douglass R Lazzaro and Arthur H Wolintz Source Type: journals

A QTL on mouse chromosome 12 for the genetic variance in free-running circadian period between inbred strains of miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We not only fine-mapped the QTL for circadian period on chromosome 12 but found a new QTL there as well: an association with the timing of the nocturnal activity-minimum. Candidate quantitative trait genes in this QTL are zinc finger protein 277 and arylhydrocarbon receptor. Arylhydrocarbon receptor is structurally related to Bmal1, a canonical clock gene. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - October 31, 2007 Category: Biology Authors: John R Hofstetter, Doreen A Svihla-Jones and Aimee R Mayeda Source Type: journals

Temporal variation in the recovery from impairment in adriamycin-induced wound healing in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It is concluded that adriamycin-induced impairment of wound healing in adult female rats exhibits nycthemeral variation. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - October 10, 2007 Category: Biology Authors: Haluk Alagol, Soykan Dinc, Bilgen Basgut and Nurettin Abacioglu Source Type: journals

Rapid phase adjustment of melatonin and core body temperature rhythms following a 6-h advance of the light/dark cycle in the horseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Aside from the temperature rhythm disruption, rapid resynchronization of the melatonin rhythm suggests that the central circadian pacemaker of the horse may possess a particularly robust entrainment response. The consequences for athletic performance remain unknown. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - August 24, 2007 Category: Biology Authors: Barbara A Murphy, Jeffrey A Elliott, Dawn R Sessions, Mandi M Vick, Erin L Kennedy and Barry P Fitzgerald Source Type: journals

Circadian phase response curves to light in older and young women and menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In these experimental conditions, 3000 lux light could shift the phase of circadian rhythms to about the same extent among older and young adults, but the optimal light timing for phase shifting differed. For an interval near 4 PM, bright light produced only negligible phase shifts for either age group. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - July 10, 2007 Category: Biology Authors: Daniel F Kripke, Jeffrey A Elliott, Shawn D Youngstedt and Katharine M Rex Source Type: journals

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results confirm GSK3 as a plausible target of lithium action in BPD therapeutics, and suggest the circadian clock mechanism as a significant modulator of lithium's clinical benefits. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - February 12, 2007 Category: Biology Authors: Sevag A Kaladchibachi, Brad Doble, Norman Anthopoulos, James R Woodgett and Armen S Manoukian Source Type: journals

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results confirm GSK3 as a plausible target of lithium action in BPD therapeutics, and suggest the circadian clock mechanism as a significant modulator of lithium's clinical benefits. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - February 12, 2007 Category: Biology Authors: Sevag A Kaladchibachi, Brad Doble, Norman Anthopoulos, James R Woodgett and Armen S Manoukian Source Type: journals

The effect of high correlated colour temperature office lighting on employee wellbeing and work performanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: High correlated colour temperature fluorescent lights could provide a useful intervention to improve wellbeing and productivity in the corporate setting, although further work is necessary in quantifying the magnitude of likely benefits. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - January 11, 2007 Category: Biology Authors: Peter R Mills, Susannah C Tomkins and Luc JM Schlangen Source Type: journals

Daily rhythm of salivary and serum urea concentration in sheepEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In sheep both salivary and serum urea concentrations showed daily fluctuations. Urea is synthesized in the liver and its production is strongly influenced by food intake. Future investigation should clarify whether daily urea rhythms in sheep are endogenous or are simply the result of the temporal administration of food. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - November 23, 2006 Category: Biology Authors: Giuseppe Piccione, Augusto Foà, Cristiano Bertolucci and Giovanni Caola Source Type: journals

Modeling biological rhythms in failure time dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this paper we have described a method for modeling failure time data with an underlying biological rhythm. The advantage of adapting a cosinor model to proportional hazards model is its ability to model right censored data. We have presented a method to provide an estimate and confidence interval of the day in the menstrual cycle where the minimum hazard is achieved. This method is not limited to breast cancer data, and may be applied to any biological rhythms linked to right censored data. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - November 7, 2006 Category: Biology Authors: Naser B Elkum and James D Myles Source Type: journals

Clock mutation affects circadian regulation of circulating blood cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that endogenous clock-regulated circadian corticosterone secretion from the adrenal gland is involved in the effect of a Clock mutation on daily profiles of circulating WBC. However, intact CLOCK seems unnecessary for generating the rhythm of corticosterone secretion in mice. Our results also suggest that CLOCK is involved in discharge of RBC from the spleen. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - October 2, 2006 Category: Biology Authors: Katsutaka Oishi, Naoki Ohkura, Koji Kadota, Manami Kasamatsu, Kentaro Shibusawa, Juzo Matsuda, Kazuhiko Machida, Shuichi Horie and Norio Ishida Source Type: journals

Relationship between nocturnal serotonin surge and melatonin onset in rodent pineal glandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that both 5-HT and melatonin could serve as reliable markers of the circadian clock because of their day-to-day precision of onset timings within the same animals or within individuals of the same strain or same species. The results also demonstrate that data for MT-on cannot be compared directly between different species, and that 5HT-on may be a more reliable circadian marker when data from animals of different species are compared. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - September 27, 2006 Category: Biology Authors: Tiecheng Liu and Jimo Borjigin Source Type: journals

Emergence of physiological rhythmicity in term and preterm neonates in a neonatal intensive care unitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Whereas circadian rhythmicity in neonates may result from maternal influence, the increase of amplitude indexes in PR with PCA may be related to physiological maturity. Further studies are needed to elucidate the effect of oxygenation on physiological rhythmicity in neonates. (Source: Journal of Circadian Rhythms)
Source: Journal of Circadian Rhythms - September 11, 2006 Category: Biology Authors: Esmot ara Begum, Motoki Bonno, Makoto Obata, Hatsumi Yamamoto, Masatoshi Kawai and Yoshihiro Komada Source Type: journals