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131 records returned

Long-term plasma exchange for severe refractory hypertriglyceridemia: A decade of experience demonstrates safety and efficacyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypertriglyceridemia (hyperTG) is a common form of dyslipidemia and is frequently associated with premature coronary disease, and when severe, recurrent events of pancreatitis may occur. The management of hyperTG is generally medical (life style modification, medications). Plasma exchange (PE) has been reported to be useful in emergency situations particularly when acute pancreatitis results from extreme hyperTG. To our knowledge, there is only one report on long-term use of PE for hyperTG. We here report our results of long-term treatment of hyperTG in 6 patients with Frederickson Type V hyperlipidemia who had recurrent a...
Source: Journal of Clinical Apheresis - November 20, 2009 Category: Hematology Authors: Michal Schaap-Fogler, Daniel Schurr, Tova Schaap, Eran Leitersdorf, Deborah Rund Source Type: journals

Immunoadsorption apheresis and immunosuppressive drug therapy in the treatment of complicated HCV-related cryoglobulinemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The immunosuppressive drug therapy (IDT) is not always effective to avoid the development of complications in hepatitis C virus-related cryoglobulinemia (HCV-Cr). Removal of cryoglobulins by therapeutic plasmapheresis is currently accepted. In this randomized, parallel group study, 17 male and female patients aged 43-79 years, with complicated HCV-Cr, were submitted for 12 weeks (initial immunosuppressive therapy) to IDT ([alpha]-interferon, pegylated-interferon [alpha]-2a, cyclophosphamide, methylprednisolone, prednisone, cyclosporine, ribavirin, and melphalan). Then, they were randomly assigned to two parallel groups: A ...
Source: Journal of Clinical Apheresis - November 19, 2009 Category: Hematology Authors: Claudia Stefanutti, Antonio Vivenzio, Serafina Di Giacomo, Giancarlo Labbadia, Fabio Mazza, Giovanna D'Alessandri, Pietro M. Ferraro, Cesare Masala Source Type: journals

Different inflammatory responses induced by three LDL-lowering apheresis columnsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, three LDL-apheresis devices with equal cholesterol-lowering effect differed significantly with respect to the inflammatory response. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - November 19, 2009 Category: Hematology Authors: Anders Hovland, Randolf Hardersen, Joe Sexton, Tom Eirik Mollnes, Knut Tore Lappegård Source Type: journals

Feasibility and safety of triple dose platelet collection by apheresisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Blood cell separators of the newest generation allow for the collection of high-dose platelet concentrates. The aim of this study was to evaluate triple dose platelet collection with respect to feasibility and safety.Four hundred eighty plateletphereses were performed targeting to collect a triple platelet dose. Platelet counts were performed before and after apheresis and in platelet concentrates. Furthermore, donors were monitored for adverse events.Triple dose platelet collection was achieved in 96% according to European and national guidelines. Mean donor platelet count before apheresis was 303 ± 64/nl and decreased t...
Source: Journal of Clinical Apheresis - November 12, 2009 Category: Hematology Authors: Rainer Moog Source Type: journals

Postthaw clotting of peripheral blood stem cell products due to insufficient anticoagulantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The amount of acid citrate dextrose formula A (ACD-A), which is a commonly used anticoagulant in leukopheresis, has to ensure both the safety of the donor and guarantee the integrity of the peripheral blood stem cell (PBSC) product until its transplant. Two recent consecutive cases of postthaw PBSC product clotting initiated a look-back investigation of the ACD-A percentage in leukopheresis products collected in our facility. The data indicated a significant difference between the average amount of ACD-A in prefreezing products collected during 2006 (11.4%) and in products collected during 2007 and 2008 (8.8% and 8.7%, res...
Source: Journal of Clinical Apheresis - November 11, 2009 Category: Hematology Authors: Ronit Reich-Slotky, Nita Patel, Shatrina Dael, Mildred Semidei-Pomales, Hannah Stephens, Michael Reich, Joseph Schwartz Source Type: journals

Homozygous familial hypercholesterolemia: Long term clinical course and plasma exchange therapy for two individual patients and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Familial hypercholesterolemia (FH) is an autosomal dominant disease. Homozygous FH (HFH) manifests with severe hypercholesterolemia since birth (cholesterol levels >5-6 the upper normal limit), which, if untreated, leads to early onset accelerated atherosclerosis and premature coronary death, usually before the 2nd or 3rd decades of life. Various invasive procedures (iliocecal bypass, porto-caval shunt, liver transplant, and gene therapy) have been introduced for lowering low density lipoprotein (LDL) aiming at reducing atherosclerosis and improving survival of HFH patients. Of all the various methods, LDL apheresis has be...
Source: Journal of Clinical Apheresis - November 10, 2009 Category: Hematology Authors: Roy Beigel, Yitzhak Beigel Source Type: journals

Appropriate timing of G-CSF use after mobilization chemotherapy significantly increases the yield of CD34+ cells in autoPBSCTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The yield of CD34+ cells collected by apheresis for autologous peripheral blood stem cell (PBSC) transplantation was greatly increased when the appropriate timing was determined to begin using G-CSF after COAEP (Cytoxan, Vinblastine, Arabinosylcytosin, Etoposide and Prednisone) mobilization. Twenty-nine patients with lymphoma or multiple myeloma (MM) received the same mobilization chemotherapy, including cytoxan (CTX) 400 mg/m2 d1; vinblastine (VLB) 2 mg/m2 d1; Ara-C 60 mg/m2 × 5d; vp-16 60 mg/m2 × 5d; and prednisone 40 mg/m2 × 5d. The historical control group (12 cases) received subcutaneous G-CSF (filgrastim) at the f...
Source: Journal of Clinical Apheresis - November 7, 2009 Category: Hematology Authors: Li Xu, Chunkang Chang, Xiao Li, Weijin Gan Source Type: journals

Low CD34 collection from a healthy blood progenitor cell donor: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transplantation of hematopoietic progenitor cells is widely used to ameliorate the consequences of bone marrow failure. In allogeneic transplantation, peripheral blood progenitor cells (PBPCs) from an HLA-matched donor are collected by apheresis and then identified using flow cytometric methods as being CD34 marker positive cells.A 25-year-old healthy male was matched with an obese 106 kg 23-year-old female diagnosed with acute lymphoblastic lymphoma. After a routine course of G-CSF induction, a 2-day PBPC collection procedure with a collection volume of 12 L/day was planned. All samples for CD34 estimation were shipped, s...
Source: Journal of Clinical Apheresis - November 6, 2009 Category: Hematology Authors: Majed A. Refaai, Robin M. Cusick, Geeta Paranjape, Laurie J. Sutor Source Type: journals

Predictors of complications in therapeutic plasma exchangeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Plasma exchange (PE) is used for blood purification to modulate proteins involved in pathological processes. As the number of patients receiving PE treatment and the heterogeneity of the underlying diseases is steadily increasing, we evaluated the most frequent complications and analyzed causes leading to adverse reactions. 883 PE procedures in 113 patients between the years 2000 to 2006 were retrospectively analyzed with respect to complications. Additionally, underlying diseases and settings of PE procedure were analyzed to identify high-risk patients and respective PE settings. A total of 226 adverse reactions were reco...
Source: Journal of Clinical Apheresis - November 4, 2009 Category: Hematology Authors: Carsten P. Bramlage, Katharina Schröder, Peter Bramlage, Katharina Ahrens, Antonia Zapf, Gerhard Anton Müller, Michael J. Koziolek Source Type: journals

Thrombotic microangiopathy during peripheral blood stem cell mobilizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 58-year-old female with vasculitis and renal impairment. She was found to have an underlying monoclonal gammopathy of unknown significance (MGUS). The monoclonal protein was felt to play a role in her underlying renal disease and peripheral neuropathy. She was considered a candidate for peripheral blood stem cell transplantation to manage the monoclonal protein. During stem cell mobilization with GCSF, she developed worsening of anemia; thrombocytopenia and worsening of renal function. She was diagnosed with thrombotic microangiopathy (TMA) which was successfully treated with therapeutic plasma exchange and rit...
Source: Journal of Clinical Apheresis - October 30, 2009 Category: Hematology Authors: Harris V.K. Naina, Morie A. Gertz, Michelle A. Elliott Source Type: journals

Postdonation platelet counts are safe when collecting platelets with the Trima Accel using a postdonation platelet count target of [ge]50,000 platelets/[mu]LEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In December 2007, the FDA issued a guidance document recommending that apheresis cell separators be configured with a postdonation platelet count target of [ge]100,000 platelets/[mu]L. Currently, our Trima Accel apheresis cell separators are configured with a postdonation platelet count target of [ge]50,000 platelets/[mu]L. To determine the safety of our current procedure, we analyzed the postdonation platelet counts of 115 donors collected using our current procedure. All of 115 donors had postdonation platelet counts [ge]100,000 platelets/[mu]L. On the basis of predonation platelet counts, we calculated that raising the ...
Source: Journal of Clinical Apheresis - October 8, 2009 Category: Hematology Authors: Jessie Alex, Beverly Roberts, Thomas Raife Source Type: journals

The clinical significance of tumor cells in bone marrow or apheresis product and the efficacy of CD34+ selection and high-dose chemotherapy in patients with Stage III breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the presence of tumor cells in bone marrow or apheresis product decreases DFS in patients with Stage III breast cancer who underwent high-dose chemotherapy. CD34+ selection does not change survivals, but it may decrease the distant metastases. J. Clin. Apheresis 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 7, 2009 Category: Hematology Authors: Fikret Arpaci, Mukerrem Safali, Ahmet Ozet, Ali U. Ural, Turker Cetin, Mustafa Ozturk, Selmin Ataergin, Okan Kuzhan, Seref Komurcu, Bekir Ozturk, Cengizhan Acikel Source Type: journals

Alteration of adipokines during peripheral blood stem cell mobilization induced by granulocyte colony-stimulating factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adipokines, soluble mediators produced by adipocytes, have been shown to play a role in various physiological and pathological conditions. We investigated the involvement of adipokines in granulocyte colony-stimulating factor (G-CSF)-induced mobilization of hematopoietic stem cells in 21 healthy donors. We found that serum visfatin and resistin levels, but not leptin and adiponectin levels, were significantly elevated by G-CSF treatment. G-CSF treatment activated signaling proteins like extracellular signal-regulated kinase and stimulated secretion of visfatin from 3T3-L1 adipocytes. These findings suggest that some adipok...
Source: Journal of Clinical Apheresis - October 7, 2009 Category: Hematology Authors: Yoshinori Tanaka, Toshiaki Yujiri, Mayumi Tanaka, Noriyuki Mitani, Atsuko Tanimura, Yukio Tanizawa Source Type: journals

Is therapeutic plasma exchange indicated for patients with gemcitabine-induced hemolytic uremic syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atypical hemolytic uremic syndrome (aHUS) has been described as an uncommon complication of gemcitabine. In this review, we discuss the diagnosis of gemcitabine-induced aHUS (GiHUS) and the published experience with therapeutic plasma exchange (TPE). To illustrate GiHUS, we present a patient who developed hypertension and peripheral edema while receiving gemcitabine and subsequently was found to have thrombocytopenia, hemolytic anemia, renal failure, and normal ADAMTS-13 activity. Although laboratory parameters improved on suspending gemcitabine, they worsened after reinstitution of the drug. Thrombocytopenia and hemolysis...
Source: Journal of Clinical Apheresis - October 7, 2009 Category: Hematology Authors: Ethan McCaleb Gore, Benjamin Scott Jones, Marisa B. Marques Source Type: journals

Iron depletion before HCV antiviral therapy: A pilot, randomized, controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is not known whether iron depletion before pegylated IFN or combination treatment improves sustained virological response (SVR) rate in patients with chronic hepatitis C, despite its use in clinical practice in this setting. We aimed to investigate whether blood letting improves the efficacy (SVR) and tolerability of PEG-IFN[alpha]2b + Ribavirin in chronic hepatitis C patients. Patients with chronic hepatitis C and ferritin >100 ng/mL were randomized to: (1) repeated phlebotomies to obtain a ferritin level (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - September 16, 2009 Category: Hematology Authors: Ivan Gentile, Chiara Viola, Luigi Paesano, Marcello D'Onofrio, Elio D'Agostino, Raimondo Cerini, Francesco Borrelli, Marcello Piazza, Guglielmo Borgia Source Type: journals

Granulocyte transfusion therapy in abdominal organ transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We observed temporal increases in ANC to levels above 1,000/[mu]l in 15/18 (83.3%) courses of GT. We observed a clinical response to infection in 5/12 (42%) patients, the remaining infected patients had no clinical response. Our results suggest that GT therapy in neutropenic solid organ transplant recipients can boost peripheral blood neutrophil counts. Additional studies areneeded to document an independent clinical benefit for GT in this patient population. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - September 14, 2009 Category: Hematology Authors: Nikhil R. Oak, Darrell J. Triulzi Source Type: journals

Mobilization effects of G-CSF, GM-CSF, and darbepoetin-[alpha] for allogeneic peripheral blood stem cell transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the triple regimen did not seem to be superior to G-CSF alone in terms of the CD34+ cell dose, hemoglobin recovery, and GVHD. However, the CD8+ cell count was significantly lower in the triple regimen group. The role of a lower CD8+ cell count in the graft may need to be elucidated in the future. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - September 13, 2009 Category: Hematology Authors: Shi Nae Kim, Joon Ho Moon, Jong Gwang Kim, Yee Soo Chae, Yoon Young Cho, Soo Jung Lee, Yun Jeong Kim, Yoo Jin Lee, Jang Soo Suh, Kun Soo Lee, Sang Kyun Sohn Source Type: journals

LDL lipid apheresis rapidly increases peripheral endothelial progenitor cell competenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endothelial progenitor cells (EPCs) have been shown to promote neovascularization under physiologic and pathologic conditions. Statins have been documented to increase the total number of circulating EPCs in long-term treated patients. Lipid apheresis is used to treat patient with refractory hyperlipidemia. The aim of our study was to evaluate whether lipid apheresis is associated with EPC mobilization.Thirteen patients with refractory hyperlipidemia (analysis at the beginning and at the end of a single lipid apheresis treatment) and 10 healthy controls were included into the study. For quantifying total peripheral EPCs, C...
Source: Journal of Clinical Apheresis - September 13, 2009 Category: Hematology Authors: Daniel Patschan, Susann Patschan, Elvira Henze, Johannes T. Wessels, Michael Koziolek, Gerhard A. Müller Source Type: journals

Therapeutic plasma exchange for desensitization prior to transplantation in ABO-incompatible renal allograftsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The desensitization protocol used by our institution allowed for successful ABOi renal transplantation. Although there were incidents of AMR and DGF, the majority of the transplants resulted in viable grafts. A larger patient study group may be needed to fully evaluate the efficacy and safety of this protocol. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - August 5, 2009 Category: Hematology Authors: Praveen Sivakumaran, Ashley A. Vo, Rafael Villicana, Alice Peng, Stanley C. Jordan, Samuel H. Pepkowitz, Ellen B. Klapper Source Type: journals

Effects of protein A immunoadsorption in patients with advanced chronic dilated cardiomyopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, on severely limited heart failure patients with nonfamilial DCM, IA therapy moderately improved markers of heart failure severity in a limited subgroup of patients. This may be due to the selected study population with end-stage heart failure patients and the lower reduction of IgG3 compared to previous studies. Future blinded multicenter studies are necessary to identify those patients that benefit most. J. Clin. Apheresis 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - July 9, 2009 Category: Hematology Authors: Andreas O. Doesch, Mathias Konstandin, Sultan Celik, Arnt Kristen, Lutz Frankenstein, Stefan Hardt, Stefan Goeser, Ziya Kaya, Hugo A. Katus, Thomas J. Dengler Source Type: journals

Peripheral blood stem cell collection in multiple myeloma: A retrospective analysis of 6 years leukapheresis activity in 109 patients treated at the Istituto Nazionale dei Tumori of MilanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Double autologous stem cell transplantation is the standard treatment in newly diagnosed multiple myeloma (MM) patients younger than 65 years; therefore, optimization of leukapheresis is crucial. We performed a retrospective analysis of 297 leukaphereses comparing semiautomated (V4.7 in 20% of collections) versus automated (V6.0 in 80%) Caridian (COBE) Spectra versions and analyzing the influence of M-protein on the outcome. Both methods gave comparable collection efficiencies (CE%) (53.4% vs. 55.7% in V6.0 and V4.7, respectively) with similar leukapheresis time and processed volume. Harvest volume was higher in V4.7 (P < ...
Source: Journal of Clinical Apheresis - July 8, 2009 Category: Hematology Authors: Paola Coluccia, Vittorio Montefusco, Sara Tunesi, Mario Avella, Alvaro Bompadre, Paolo Longoni, Marco Milanesi, Adriano De Carli, Fernando Ravagnani Source Type: journals

Elevated procalcitonin and C-reactive protein as potential biomarkers of sepsis in a subpopulation of thrombotic microangiopathy patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombotic microangiopathy (TMA) comprises a group of microvascular thrombosis syndromes associated with multiple pathogenic factors. Deficient activity of ADAMTS13 is a pathogenic factor in a subset of TMA patients that provides a strong rationale for plasma exchange treatment. However, the subset of TMA patients with normal ADAMTS13 activity remains a heterogeneous group of patients in which the appropriate treatment is not well understood. In addition to the common forms of TMA thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome, the differential diagnosis of TMA may include sepsis, autoimmune disorder...
Source: Journal of Clinical Apheresis - July 8, 2009 Category: Hematology Authors: Yasuko O. Erickson, Noelle I. Samia, Bruce Bedell, Kenneth D. Friedman, Bonnie S. Atkinson, Thomas J. Raife Source Type: journals

Effect of blood group on idiopathic thrombotic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a retrospective analysis of 74 patients presenting from 1993 to 2008 with idiopathic TTP. We studied the incidence across various blood groups and also estimated the recurrence and mortality in each group. The incidence of various blood groups were as follows: O 36%, A 36%, B 25%, and AB 2%, compared with expected frequencies in the Detroit area: O 44%, A 33% B 20%, and AB 3%. There was a trend of lower than expected frequency of blood group O. There were 24 recurrences and 14 deaths, uniform across blood groups. We hypothesized that there may be an association between blood groups and the risk of TTP; however th...
Source: Journal of Clinical Apheresis - July 8, 2009 Category: Hematology Authors: Lara Zuberi, Durga Yerasuri, Philip Kuriakose Source Type: journals

Successful weaning after plasma exchange for polyneuropathy related to POEMS syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe a 47-year-old male patient with polyneuropathy related to POEMS syndrome who suffered from hypercapnic respiratory failure due to progressive weakness of the respiratory muscles. His respiratory muscle strength significantly improved after plasma exchange and was extubated successfully. To our knowledge, this is the first case of POEMS syndrome with aggressive polyneuropathy that was successful treated by plasma exchange and our experience provides insight regarding the optimal management of such patients. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - June 24, 2009 Category: Hematology Authors: Shang-Gin Wu, Ping-Hung Kuo, Pan-Chyr Yang Source Type: journals

Photopheresis therapy for problematic renal allograft rejectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Photopheresis may have a role as an adjuvant or salvage antirejection therapy in solid organ transplantation. Furthermore, evaluation in randomized controlled clinical trials is required to evaluate its potential. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - June 16, 2009 Category: Hematology Authors: Meg J. Jardine, Sunil Bhandari, Kate R. Wyburn, Ashish K. Misra, Paul R. McKenzie, Josette M. Eris Source Type: journals

Preoperative therapeutic plasma exchange in patients with thyrotoxicosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this report was to determine the effectiveness of therapeutic plasma exchange (TPE) in preoperative preparation of patients with thyrotoxicosis scheduled for either thyroid or nonthyroid surgery. We retrospectively reviewed 11 patients with thyrotoxicosis and those who prepared surgery with plasmapheresis between 1999 and 2008 at our institution. Ten patients underwent thyroid surgery and one patient was operated for femur fracture during antithyroid drug treatment. The indications for plasmapheresis in all patients with severe thyrotoxicosis were poor response to medical treatment (seven patients), agronulo...
Source: Journal of Clinical Apheresis - May 30, 2009 Category: Hematology Authors: Ali Ezer, Kenan Caliskan, Alper Parlakgumus, Sedat Belli, Ilknur Kozanoglu, Sedat Yildirim Source Type: journals

TRALI risk reduction: Donor and component management strategiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transfusion-related lung injury (TRALI) occurs in [sim]1 in 5,000 transfusions and may cause considerably more morbidity and mortality that is not recognized in clinical practice. Based on the current understanding of the etiology of TRALI, blood centers have implemented or are evaluating various donor and component management strategies in an effort to mitigate the risk of TRALI. Many cases of TRALI are likely caused by antibodies to leukocyte antigens (HLA or HNA) in blood components. Approximately 10 to 20% of female blood donors with a history of pregnancy and 1 to 5% of male blood donors harbor these antibodies. Alter...
Source: Journal of Clinical Apheresis - April 18, 2009 Category: Hematology Authors: Anne F. Eder, Richard J. Benjamin Source Type: journals

Red cell exchange transfusion for babesiosis in Rhode IslandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report four cases of clinically severe tick borne babesiosis treated with chemotherapy and adjunctive red cell exchange (RCE) at two Rhode Island hospitals from 2004 to 2007. All RCE procedures were performed using a Cobe Spectra device and were well tolerated without complications. The volume of allogeneic red cells used in the exchange was determined using the algorithm in the apheresis device with the input variables of preprocedure hematocrit, weight, height, an assumed allogeneic red cell hematocrit of 55 and a desired post procedure hematocrit of 27. The preprocedure level of parasitemia varied between 2.4% and 24...
Source: Journal of Clinical Apheresis - March 17, 2009 Category: Hematology Authors: Joshua Spaete, Eleni Patrozou, Josiah D. Rich, Joseph D. Sweeney Source Type: journals

Abstracts from the American Society for Apheresis 30th Annual Meeting, May 20-23, 2009, San Diego, CaliforniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - March 6, 2009 Category: Hematology Source Type: journals

Is it quinine TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine "hypersensitivity." When schistocytes are present it is frequently termed "quinine-associated TTP/HUS." A severe deficiency of the vWF-cleaving protease, ADAMTS13, is associated with idiopathic TTP. A previous study of patients with "quinine-associated TTP/HUS" found that ADAMTS13 activities were not abnormal in 12/12 patients. A retrospective review of TTP patients with quinine-associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed. Six patients were identified. All we...
Source: Journal of Clinical Apheresis - March 4, 2009 Category: Hematology Authors: Yara A. Park, Shauna N. Hay, Karen E. King, Karen Matevosyan, Jessica Poisson, Amy Powers, Ravindra Sarode, Beth Shaz, Mark E. Brecher Source Type: journals

Value of ADAMTS13 activity and inhibitor in the postmortem diagnosis of thrombotic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of fulminant TTP in a woman who died before receiving plasma exchange. An autopsy plasma sample was analyzed for ADAMTS13 activity and inhibitor for correlation with the diagnosis of TTP. Recognizing that hemolysis in postmortem blood samples could interfere with ADAMTS13 activity, plasma samples from four additional decedents not suspected of having TTP were analyzed and correlated with their autopsy results. The purpose of this study was to assess whether testing postmortem samples for ADAMTS13 is useful in the postmortem diagnosis of TTP.Plasma samples from the index case and four non-TTP decedents were...
Source: Journal of Clinical Apheresis - February 28, 2009 Category: Hematology Authors: Denis M. Dwyre, Bryce Dursteler, Marcus Nashelsky, Kenneth D. Friedman, Thomas J. Raife Source Type: journals

Peripheral blood stem cell recovery following early termination of apheresis due to hypotension in a 4.8-kg infantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case in which peripheral blood stem cells (PBSC) were successfully recovered following early termination of a collection procedure due to hypotension in a 7-month-old patient. The patient was diagnosed at 4 months of age with neuroblastoma stage IV-S with favorable Shimada histology. She had completed two cycles of chemotherapy before the PBSC collection (PSCC). The procedure was performed on the Cobe Spectra in manual mode, and terminated after 35 min due to severe hypotension. Etiologies considered for the hypotensive episode included a transfusion reaction to the unit of red blood cells (RBC) used for primin...
Source: Journal of Clinical Apheresis - February 27, 2009 Category: Hematology Authors: Jessie Alex, Matthew J. Bahl, Annette J. Schlueter Source Type: journals

Large-volume-apheresis facilitates autologous transplantation of hematopoietic progenitors in poor mobilizer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Given that pre-apheresis CD34+ cell count (PA-CD34) predicts the apheresis' yield, a minimum of 5 to 20 PA-CD34/ml is required in many institutions to initiate cell collection. The aim of this study was to clarify whether large-volume-apheresis (LVA) could facilitate progenitor cell transplantation in patients with low PA-CD34. Apheresis was initiated in 226 patients, disregarding PA-CD34, at days: +5 in G-CSF, +10 in cyclophosphamide+G-CSF, and +15 to +20 in other chemotherapy+G-CSF mobilization, when leucocytes >2.5 × 109/l. Four times the blood volume was processed. Patients were grouped according to their PA-CD34: [ge...
Source: Journal of Clinical Apheresis - January 24, 2009 Category: Hematology Authors: Maria Juliana Majado, Alfredo Minguela, Consuelo González-García, Eduardo Salido, Miguel Blanquer, Consuelo Funes, Carmen Luisa Insausti, Ana María García-Hernández, José María Moraleda, Alfonso Morales Source Type: journals

Management of familial hypertriglyceridemia during pregnancy with plasma exchangeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the successful use of therapeutic plasma exchange (TPE) in the management of hypertriglyceridemia during pregnancy resulting in avoidance of pancreatitis and delivery of a healthy term infant. Thirteen TPEs were performed from 19 to 36 weeks gestation to maintain tight control of triglyceride levels. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - January 23, 2009 Category: Hematology Authors: Praveen Sivakumaran, Steven W. Tabak, Kimberly Gregory, Samuel H. Pepkowitz, Ellen B. Klapper Source Type: journals

Immunoadsorption with tryptophan columns: A therapeutic option for the treatment of rheumatoid arthritis with septic complicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, immunoadsorption is a safe and effective therapeutic alternative, which should be considered to bridge infectious complications in patients with severe RA. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - January 21, 2009 Category: Hematology Authors: Thomas Thomaidis, Corinna Schorn, Wolfram Flaig, Gerwinn Lingg, Elke Schönhals, Reinhard Klingel, Peter R. Galle, Andreas Schwarting Source Type: journals

Plasmapheresis therapy for rare but potentially fatal reaction to rituximabEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a near-fatal reaction to rituximab, which started 30 min after infusion and worsened over 24 to 48 h, resulting in hemodynamic and respiratory compromise that necessitated both intubation and high-dose vasopressors. Subsequent treatment with plasmapheresis helped stabilize and improve the patient's clinical condition, and the patient was discharged home on hospital day 5. There is no specific treatment for these severe and sometimes fatal reactions except supportive care with plasmapheresis. With the increased use of rituximab therapy in the medical management of numerous diseases, those in the medical community ...
Source: Journal of Clinical Apheresis - January 20, 2009 Category: Hematology Authors: Deborah Hastings, Bhavesh Patel, Antonio Sergio Torloni, Farouk Mookadam, Jeffrey Betcher, Adyr Moss, Raymond Heilman, Marek Mazur, Khaled Hamawi, David Mulligan, Kunam Reddy, Kristin Mekeel, Harini Chakkera Source Type: journals

ADAMTS13 activity levels in patients with human immunodeficiency virus-associated thrombotic microangiopathy and profound CD4 deficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombotic microangiopathy (TMA) encompasses a number of disorders with hemolytic anemia and thrombocytopenia, including thrombotic thrombocytopenic purpura (TTP). A deficiency in ADAMTS13 enzyme levels, along with an inhibitory antibody, is found in most patients with idiopathic TTP. Patients with human immunodeficiency virus (HIV) infection can have a TTP-like illness; however, it appears to have a different etiology.A retrospective review of patients who had an ADAMTS13 activity level performed from 2005 through 2007 was completed. Patients with a diagnosis of HIV infection with TMA were investigated.Two patients were i...
Source: Journal of Clinical Apheresis - January 20, 2009 Category: Hematology Authors: Yara A. Park, Shauna N. Hay, Mark E. Brecher Source Type: journals

Multiple myeloma patients receiving large volume leukapheresis efficiently yield enough CD34+ cells to allow double transplantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current protocols for myeloma patients require more than one autologous transplant. We performed a retrospective study to determine the cost-effectiveness of large volume leukapheresis (LVL) compared with standard volume leukapheresis (SVL) collection when two transplants are required. We evaluated 87 patients who underwent a cumulative total of 260 LVL and SVL collections. The median product volume per collection was 356 ml for LVL, and this was significantly higher than the median product volume per collection for SVL (median 149.5 ml, P < 0.001). The median total CD34+ cell yield/kg was 6.4 × 106 for LVL and 5.2 × 106...
Source: Journal of Clinical Apheresis - January 20, 2009 Category: Hematology Authors: A.C. Zubair, R. Rymer, J. Young, U. Keeton, R. Befort, B. Nolot, C. Evans, T. Bleach, A. Torloni Source Type: journals

Clinical improvement of a patient with severe Wilson's disease after a single session of therapeutic plasma exchangeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Here, we report a case of a 17-year old female with Wilson's disease presenting with progressive Coombs' negative hemolytic anemia and hepatic cirrhosis who was treated with one session of therapeutic plasma exchange (TPE) and clinically improved. In clinical situations where multiple sessions of TPE may not be possible, the use of a single session of TPE in conjunction with conventional therapy may be of benefit in preventing further clinical deterioration. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - January 20, 2009 Category: Hematology Authors: Mehmet Hursitoglu, Osman Kara, Mehmet A. Cikrikcioglu, Tahsin Celepkulu, Sengul Aydin, Tufan Tukek Source Type: journals

Treatment of severe amitriptyline intoxication with plasmapheresisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tricyclic antidepressant poisoning is one of the most common causes of serious intoxication. Here, we report a 2-year-old girl with severe amitriptyline (70 mg/kg) intoxication. She was in comatose, had generalized tonic clonic seizure, ventricular tachycardia, and wide QRS complexes. Although she did not respond to classical therapies, very good clinical response to plasmapheresis was obtained and she developed no complications. Thus, plasmapheresis may be an effective treatment modality in poisoning with drugs, which bind to plasma proteins with high affinity. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: J...
Source: Journal of Clinical Apheresis - January 14, 2009 Category: Hematology Authors: Ebru Kolsal, Ishak Özel Tekin, Etem Piskin, Cumhur Aydemir, Mehmet Akyüz, Hasan Çabuk, Nilüfer Eldes, Varim Numanoglu Source Type: journals

The Italian registry of pediatric therapeutic apheresis: A report on activity during 2005Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The results of the 2005 Survey of the Italian Society for Apheresis and Cell Manipulation (SIdEM) reporting on the pediatric procedures carried out in 18 Italian Apheresis Units are presented here. Utilizing a standardized questionnaire, the survey collected data on techniques, types of blood separators, clinical indications, and adverse events. A total of 1,693 apheresis procedures were carried out in 355 pediatric patients: 219 plasma-exchange, 291 peripheral blood stem cell collections, 791 extracorporeal photochemotherapy (ECP), 265 LDL-apheresis, 71 erythro-exchange, 9 cytoreductive apheresis, 47 immunoadsorption sess...
Source: Journal of Clinical Apheresis - December 16, 2008 Category: Hematology Authors: Giustina De Silvestro, Tiziana Tison, Maria Vicarioto, Paola Bagatella, Claudia Stefanutti, Piero Marson Source Type: journals

Atypical presentations of thrombotic thrombocytopenic purpura: A reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombotic thrombocytopenic purpura (TTP) is diagnosed by the presence of microangiopathic hemolytic anemia and thrombocytopenia in a patient who frequently presents with central nervous system involvement and, to a lesser extent, renal dysfunction. Recent understanding of the pathophysiology of TTP due to severe deficiency of von Willebrand factor cleaving protease, known as ADAMTS13, has improved diagnosis of TTP. Once the diagnosis is suspected, life-saving therapeutic plasma exchange therapy is initiated. Occasionally, an unusual clinical presentation makes TTP diagnosis difficult, thus resulting in a delay in the mana...
Source: Journal of Clinical Apheresis - December 15, 2008 Category: Hematology Authors: Ravi Sarode Source Type: journals

Hypersensitivity to plasma exchange in a patient with thrombotic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case report of a patient with TTP and idiopathic thrombocytopenic purpura (ITP) who had an elevated inhibitor level after plasma exchange. After instituting plasma exchange, patient improved clinically with a platelet count in the normal range. Subsequently, she developed an elevated ADAMTS antibody titer accompanied by a decline in platelet count despite continued exchange. She was successfully treated with a combination of steroids, rituximab and increased dose plasmapheresis. Based on this experience, we conclude that a drop in platelet count while patient is undergoing plasma exchange especially in an init...
Source: Journal of Clinical Apheresis - December 15, 2008 Category: Hematology Authors: Judy Lalmuanpuii, Kiran Yalamanchili, Sophia Fircanis, John C. Nelson Source Type: journals

A retrospective review of the outcome of plasma exchange and aggressive medical therapy in antibody mediated rejection of renal allografts: A single center experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antibody-mediated rejection (AMR) has been recognized as a major cause of renal allograft loss. Protocols using plasma exchange (PE) to reverse rejection have mixed results. Methods: A retrospective chart review was performed to determine the clinical response to PE inpatients with AMR of renal allograft. A good response to treatment was defined as a decline in serum creatinine (SCr) to within 25% above the prerejection value or discontinuation of dialysis with a SCr (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - November 15, 2008 Category: Hematology Authors: Wisam Al-Badr, Dorina Kallogjeri, Kamel Madaraty, Dana Oliver, Bahar Bastani, J. Grossman Source Type: journals

Plasmapheresis and intravenous immune globulin for the treatment of D alloimmunization in pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case report of an Rh(D) alloimmunized pregnancy, in which successful management consisted of initial therapeutic plasmapheresis (TPE) followed by intravenous immunoglobulin (IVIG) administration until delivery at 37 weeks gestation without the need for intrauterine transfusion. J. Clin. Apheresis, 2008. © 2008 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - November 12, 2008 Category: Hematology Authors: Deborah J. Novak, Lisa N. Tyler, Ramakrishna L. Reddy, Michael J. Barsoom Source Type: journals

Predictive parameters for granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the CD34+ cell numbers in the PB steady state may be a useful parameter selecting allogeneic PBSC donors. J. Clin. Apheresis, 2008. © 2008 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - November 7, 2008 Category: Hematology Authors: Akira Okano, Eishi Ashihara, Chihiro Shimazaki, Hitoji Uchiyama, Tohru Inaba, Kyoko Taniguchi, Taira Maekawa, Masafumi Taniwaki Source Type: journals

Is it HIV TTP or HIV-associated thrombotic microangiopathy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews emerging concepts of HIV associated microangiopathies. It concludes that the pathophysiology, in many cases seems to be distinct from idiopathic TTP (particularly with advanced HIV disease - (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 30, 2008 Category: Hematology Authors: Mark E. Brecher, Shauna N. Hay, Yara A. Park Source Type: journals

Preparing for inspection: Managing regulations and practices surrounding donors with positive infectious disease testingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Federal and local regulatory agencies mandate that all blood collection facilities test each allogeneic blood donation for evidence of infectious diseases. When a donation tests positive or reactive for any of the required screening tests, facilities are required to take appropriate action by deferring donors and removing potentially infectious products from inventory. Each required action must be performed in accordance with posted regulations and documented for record retention. Donor deferral records related to positive or reactive infectious disease testing are particularly vulnerable targets of inspection. There are c...
Source: Journal of Clinical Apheresis - October 29, 2008 Category: Hematology Authors: Jillian Ferschke Source Type: journals

Therapeutic apheresis in neurological disorders: A survey of the evidence in support of current category I and II indications for therapeutic plasma exchangeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides a critical look at the evidence in support of the assignment by ASFA of Category I or II indications to neurologic disorders in its most recent (2007) evaluation of therapeutic apheresis. J. Clin. Apheresis, 2008. © 2008 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 29, 2008 Category: Hematology Authors: Robert Weinstein Source Type: journals

Starch and albumin mixture as replacement fluid in therapeutic plasma exchange is safe and effectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: TPE with a mixture of 3% HES and 5% human albumin is as effective and safe as 5% human albumin alone for patients with these diseases. J. Clin. Apheresis, 2008. © 2008 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - September 26, 2008 Category: Hematology Authors: Gladys P. Agreda-Vásquez, Irma Espinosa-Poblano, Sergio A. Sánchez-Guerrero, Erick Crespo-Solís, Siram Cabrera-Vásquez, Josefa López-Salmorán, Josefina Barajas, Paula Peñaloza-Ramírez, Nelly Tirado-Cárdenas, Antonio Velázquez Source Type: journals