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CorrectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Tags: PostScript Source Type: journals

Paediatric forensic medicine and pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Dada, M A Tags: PostScript Source Type: journals

Adult hepatic epitheloid haemangioendothelioma presenting with Kasabach-Merrit syndrome: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Ozturk, B, Coskun, U, Yaman, E, Cakir, A, Akdemir, U O, Yildiz, R, Akyol, G, Demirci, U, Buyukberber, S, Tezel, E, Benekli, M Tags: PostScript Source Type: journals

To study the effect of the sequence of seven pranayama by Swami Ramdev on gene expression in leukaemia patients and rapid interpretation of gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Kumar, A, Balkrishna, A Tags: PostScript Source Type: journals

Revised national guidelines for the analysis of cerebrospinal fluid for bilirubin in suspected subarachnoid haemorrhage: interpret with cautionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Griffiths, M J, Ford, C, Gama, R Tags: PostScript Source Type: journals

Sensitivity and specificity in diagnostic accuracy: ROC solid or lost in translation?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Soreide, K. Tags: PostScript Source Type: journals

Receiver-operating characteristic curve analysis in diagnostic, prognostic and predictive biomarker research: trade-off between sensitivity and specificity with change of test cut-offsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Bharti, B., Bharti, S. Tags: PostScript Source Type: journals

Snippets in surgical pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Cooper, K., Chetty, R. Tags: Immunology (including allergy), Colon cancer, Skin cancer, Prostate cancer, Urological cancer, Morbid anatomy / surgical pathology, Dermatology, Clinical diagnostic tests Snippets in pathology Source Type: journals

Detection of PCR products using self-reporting duplex mutation primersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel oligonucleotide probe, with duplex mutation primers, which comprised a normal reverse primer labelled with a fluorophore at its 5'-end and a single-base mismatched complementary oligonucleotide labelled with a quencher at its 3'-end, was designed. Its application in the detection of hepatitis B virus (HBV) DNA of serum was investigated; results were compared with those obtained using a commercial TaqMan kit. There was a good linear correlation in the range of 102~107 copies/ml (r2 = 0.999) with the method. Intra-experimental coefficients of variation (CVs) were 0.70%~7.80%, and inter-experimental CVs were 0.78%~9.0...
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Xia, Q-F, Tu, Z-G, Liu, J-B, Qin, X, Qian, S-Y, Li, P Tags: Liver disease, Hepatitis and other GI infections, Hepatitis (sexual health) Short reports Source Type: journals

Werner syndrome as a possible cause of non-alcoholic steatohepatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Non-alcoholic steatohepatitis (NASH) is characterised by steatosis, liver cell injuries, the presence of a mixed inflammatory lobular infiltrate, and variable degrees of fibrosis. Werner syndrome (WS) is a rare autosomal recessive disease characterised by the premature onset of multiple age-related disorders. Central obesity and insulin resistance are common symptoms of both NASH and WS. Three cases were studied to evaluate the association between WS and NASH. NASH was diagnosed by liver biopsies and imaging studies following the exclusion of alcohol consumption, viral disease or autoimmune liver disease. Liver histology w...
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Hashizume, H, Sato, K, Takagi, H, Kanda, D, Kashihara, T, Kiso, S, Mori, M Tags: Liver disease, Clinical diagnostic tests, Lipid disorders Short reports Source Type: journals

Titrimetric immunohistochemical evaluation of DNA hypomethylation in uterine tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A simple titrimetric immunohistochemical method has been developed for quantitative evaluation of ligands. This method should be further employed in follow-up studies, in order to establish the prognostic value of DNA hypomethylation in uterine cancer. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Wolk, M, Martin, J E Tags: Immunology (including allergy), Gynecological cancer Short reports Source Type: journals

Primary myxoid liposarcoma of the thyroid glandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes such a case. A 59-year-old woman was admitted for evaluation of a 6x6x5 cm nodule in the left lobe of the thyroid gland. Left thyroid lobectomy was performed without any postoperative treatment except for follow-up. Osseous and pulmonary metastasis developed 1 year later and the patient died 15 months after the surgery. The clinical course and treatment choice are discussed. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Huang, G W, Li, Y X, Hu, Z L Tags: Case reports Source Type: journals

Mucosal prolapse syndrome presenting as rectal polyposisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a patient initially diagnosed with a colorectal polyposis syndrome consisting of multiple rectal hyperplastic and adenomatous polyps. But after careful review of medical history and histopathology, the patient was found to have a rare variant of solitary rectal ulcer syndrome presenting as rectal polyposis. The recognition of rectal polyposis as a manifestation of solitary rectal ulcer syndrome/mucosal prolapse syndrome will improve diagnosis and treatment and prevent inappropriate management of this condition. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Brosens, L A A, Montgomery, E A, Bhagavan, B S, Offerhaus, G J A, Giardiello, F M Tags: Histopathology Case reports Source Type: journals

An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 60-year old man with a 10-year history of multiple system atrophy (MSA) was found in respiratory arrest. After 4 months of respiratory support with two episodes of septic shock, he died. Autopsy disclosed severe atrophy of the mesencephalon, brainstem, medulla oblongata and cerebellum. Gallyas–Braak, -synuclein and ubiquitin-positive inclusions in the cytoplasm of glial cells were evident, despite the severe ischaemic damage due to respiratory arrest and subsequent respiratory support for 4 months. The cause of respiratory arrest was not identified, but could be explained by the natural history of MSA. The bereaved...
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Nakajima, M, Kojima, H, Takazawa, Y, Yahagi, N, Harada, K, Takahashi, K, Unuma, K, Yoshida, K Tags: Legal and forensic medicine Case reports Source Type: journals

Intestinal intussusception in adults due to acute enterovirus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Three adult cases of intussusceptions, associated with enteroviruses occurring within a 3-week period, are reported. Virological studies include viral RNA detection in stool samples and staining for enterovirus protein by immunoperoxidase staining of the resected intestinal tissues. A new mechanism for intussusception associated with enterovirus is proposed. Tap water was implicated in the outbreak. Better monitoring of drinking-water may prevent other cases of non-polio enterovirus infection. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Chia, A Y, Chia, J K Tags: Case reports Source Type: journals

Use of an elastic stain to show venous invasion in colorectal carcinoma: a simple technique for detection of an important prognostic factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pathologists should look for morphological clues of VI in H&E stained sections; when VI is not apparent, an elastic tissue stain on all tumour blocks significantly improves identification of VI. Morphological clues include the "unaccompanied artery" and "protruding tongue" signs. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Howlett, C J, Tweedie, E J, Driman, D K Tags: Immunology (including allergy), Colon cancer Original articles Source Type: journals

Proteins from the Wnt pathway are involved in the pathogenesis and progression of mammary phyllodes tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Results suggest that alterations in the Wnt pathway are important in the progression and in the epithelial and stromal interactions in PTs. They have important implications for understanding the pathogenesis of these uncommon but clinically important tumours. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Karim, R Z, Gerega, S K, Yang, Y H, Horvath, L, Spillane, A, Carmalt, H, Scolyer, R A, Lee, C S Tags: Original articles Source Type: journals

The significance of tumour cell immunophenotype in myeloma and its impact on clinical outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Immunophenotype impacts on clinical outcome in MM. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Ngo, N-T, Brodie, C, Giles, C, Horncastle, D, Klammer, M, Lampert, I A, Rahemtulla, A, Naresh, K N Tags: Immunology (including allergy), Clinical diagnostic tests Original articles Source Type: journals

The clinicopathological significance of BUBR1 overexpression in hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: BUBR1 was overexpressed in about 45% HCCs, and its overexpression may be a relative lately event in HCC progression. Overexpression of BUBR1 was associated with worse prognosis and is a potential prognostic factor for patients with HCC. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Liu, A-W, Cai, J, Zhao, X-L, Xu, A-M, Fu, H-q, Nian, H, Zhang, S-H Tags: Immunology (including allergy), Breast cancer, Hepatic cancer Original articles Source Type: journals

Clinical evaluation of NucliSENS magnetic extraction and NucliSENS analytical specific reagents for the real-time detection of respiratory syncytial virus (RSV) in paediatric respiratory specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NRSVA is sensitive and specific for RSV detection in respiratory samples. The R-IC monitored the test process, including NA extraction, target amplification and detection. The rapid detection of respiratory pathogens can foster appropriate patient management. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Manji, R, Lotlikar, M, Zhang, F, Ginocchio, C C Tags: TB and other respiratory infections Original articles Source Type: journals

New time-dependent approach to analyse the prognostic significance of immunohistochemical biomarkers in colon cancer and diffuse large B-cell lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Time-dependent ROC curve analysis is a novel tool for identifying potential immunohistochemical prognostic markers across varying follow-up times. Use of this tool could facilitate the identification of high-risk patients not only with colon cancer and DLBCL but with a range of other tumour types. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Adams, H, Tzankov, A, Lugli, A, Zlobec, I Tags: Immunology (including allergy), Breast cancer, Colon cancer Original articles Source Type: journals

Micro-RNAs in thyroid neoplasms: molecular, diagnostic and therapeutic implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Micro-RNAs (miRNAs) belong to a class of small non-coding messenger RNA species that have emerged as potent regulators of a variety of biological processes including oncogenesis. They serve as master regulators with a single miRNA capable of regulating as many as 100 different target genes. Thyroid carcinomas encompass a wide spectrum ranging from well-differentiated thyroid carcinomas to poorly differentiated and anaplastic carcinoma. Currently, a considerable degree of interobserver variability exists in the morphological diagnosis of certain types of thyroid carcinomas especially the follicular pattern neoplasm. The pre...
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Menon, M P, Khan, A Tags: Reviews Source Type: journals

EGFR fluorescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses the consensus outcomes of a global workshop convened to discuss key technical issues and standardise reading strategies for the EGFR FISH assay of NSCLC tumour tissue. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Varella-Garcia, M, Diebold, J, Eberhard, D A, Geenen, K, Hirschmann, A, Kockx, M, Nagelmeier, I, Ruschoff, J, Schmitt, M, Arbogast, S, Cappuzzo, F Tags: Reviews Source Type: journals

The cytological diagnosis of paediatric renal tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fine needle aspiration cytology (FNAC) is used for preoperative diagnosis of paediatric renal tumours, especially in centres where preoperative chemotherapy is advocated in Wilms’ tumour. This review focuses on salient cytological features in specific paediatric renal tumours, the approach to resolving a differential diagnosis and the role of ancillary methods in diagnosis of paediatric renal tumours. Crucial differential diagnoses include distinguishing: Wilms’ tumour from benign tumours in the kidney like multicystic nephroma or congenital mesoblastic nephroma; aggressive non-Wilms’ tumours of kidney li...
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Shet, T, Viswanathan, S Tags: Cytogenetics, Immunology (including allergy), Urological cancer, Paediatric oncology, Clinical diagnostic tests My approach Source Type: journals

Atlas of gross pathology with histologic correlation [PostScript]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Jamali, M Tags: PostScript Source Type: journals

Ode to a pathologist or red and blue [PostScript]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Connolly, C E Tags: PostScript Source Type: journals

Anticipating the Redfern inquiry: a historical note about tissue retention and consent [PostScript]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: McNeish, A S Tags: PostScript Source Type: journals

Minimal added value of further blocks in negative appendicectomy for acute appendicitis [PostScript]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Ipadeola, O, Gulmann, C Tags: PostScript Source Type: journals

Staphylococcus pasteuri bacteraemia in a patient with leukaemia [PostScript]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Savini, V, Catavitello, C, Carlino, D, Bianco, A, Pompilio, A, Balbinot, A, Piccolomini, R, Di Bonaventura, G, D'Antonio, D Tags: PostScript Source Type: journals

Snippets in surgical pathology [Snippets in pathology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Cooper, K., Chetty, R. Tags: Inflammatory bowel disease, Neurogastroenterology, Immunology (including allergy), Cranial nerves, Neurooncology, Peripheral nerve disease, Morbid anatomy / surgical pathology, Clinical diagnostic tests Snippets in pathology Source Type: journals

Enteral Clostridium difficile, an emerging cause for high-output ileostomy [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes two cases of high-output ileostomy associated with enteric C difficile infection and proposes that the management algorithm of a high-output ileostomy should include exclusion of small bowel C difficile. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Williams, R N, Hemingway, D, Miller, A S Tags: Small intestine, Acute renal failure Short reports Source Type: journals

Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: There are rare cyclin D1-negative cases of MCL overexpressing cyclin D2. Anti-cyclin D1 antibodies with low specificity can bind both cyclin D1 and cyclin D2, thus providing false cyclin D1-positive signals in immunohistochemical analysis. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Stefancikova, L, Moulis, M, Fabian, P, Falkova, I, Vasova, I, Kren, L, Macak, J, Smardova, J Tags: Immunology (including allergy) Short reports Source Type: journals

Sarcomatous transformation in a cellular angiofibroma: a case report [Case reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes the case of a patient with a 3.5 cm subcutaneous mass, 2 cm below the left anterior superior iliac spine. Grossly, the mass had tan-white cut surface with a 1.5 cm tan-yellow, whorled, well-delineated nodule. Histologically, the tumour was composed primarily of cytologically bland spindle cells set in a collagenous stroma, with multiple dilated vessels. Other areas showed an abrupt transition to hypercellular sarcomatous elements, including pleomorphic cells with high mitotic activity. The tumour cells were diffusely positive for vimentin and factor XIIIa, and weakly positive for CD34. The patient did...
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Kandil, D H, Kida, M, Laub, D R, Cooper, K Tags: Immunology (including allergy) Case reports Source Type: journals

Uterine adenosarcomas overgrown by sex-cord-like tumour: report of two cases [Case reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Müllerian adenosarcomas are tumours of low malignant potential with proliferation of benign glands and low grade endometrial stromal sarcoma (LGESS). Unusually, the latter may include foci of uterine tumours resembling ovarian sex-cord tumours (UTROSCT). Two cases of uterine adenosarcomas massively overgrown by UTROSCT are reported, for the first time. The patients, aged 71 and 64, one receiving tamoxifen, presented with intracavitary polypoid adenosarcomas; each was overgrown by an immunopathologically characteristic UTROSCT that constituted more than 75% of its volume. Periglandular CD10+LGESS represented less than ...
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Stolnicu, S, Balachandran, K, Aleykutty, M A, Loghin, A, Preda, O, Goez, E, Nogales, F F Tags: Immunology (including allergy) Case reports Source Type: journals

Diagnosis of conjunctivitis in primary care: comparison of two different culture procedures [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The Stuart medium detected more bacteria than direct inoculation. The lower 90% CI, testing non-inferiority at p = 0.05, indicates that it is unlikely that the Stuart medium misses any positive cultures compared with direct inoculation. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Tellegen, E, ter Riet, G, Sloos, J H, van Weert, H C P M Tags: Eye Diseases Original articles Source Type: journals

Utilisation of laboratory services by health workers in a district hospital in Malawi [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 25% of commonly requested laboratory tests were not utilised effectively; because of the high volume, interventions to improve their use are likely to be cost effective. Although 68% of low-volume tests were not used efficiently, the cost of providing support for these tests in a resource-poor setting needs to be balanced against their clinical usefulness. In contrast to published information, this study shows significant under-requesting of laboratory tests that were available. Measures to increase appropriate test requests will have implications for clinician education as well as laboratory space, budgets an...
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Mepham, S O, Squire, S B., Chisuwo, L, Kandulu, J, Bates, I Tags: Tropical medicine (infectious diseases) Original articles Source Type: journals

The role of laboratory processing in determining diagnostic conclusiveness of breast fine needle aspirations: conventional smearing versus a monolayer preparation [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Patients presenting with breast lesions can more often be offered a same-day, conclusive cytopathological diagnosis when FNA are prepared by a manual MP processing technique. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Wauters, C A P, Kooistra, B, Strobbe, L J A Tags: Clinical diagnostic tests Original articles Source Type: journals

Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriers [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although the number of cases studied was low, DCIS lesions in BRCA1 and BRCA2 mutations carriers are usually of the basal and luminal molecular type, respectively, similar to their accompanying invasive cancers, thereby providing evidence that DCIS is a direct precursor lesion in these hereditary predisposed patients. This also suggests that crucial carcinogenetic events leading to these phenotypes in hereditary predisposed patients occur before the stage of invasion. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: van der Groep, P, van Diest, P J, Menko, F H, Bart, J, de Vries, E G E, van der Wall, E Tags: Breast cancer Original articles Source Type: journals

Prevalence of haemoglobinopathies in 34 030 healthy adults in Tehran, Iran [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In comparison with other parts of world, there is a different pattern of haemoglobinopathy with a high prevalence of Hb D, which appears to be Hb D Iran. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Ashtiani, M T H, Monajemzadeh, M, Sina, A H, Berenji, F, Abdollahi, M, Said, M G, Alam, M Tags: Original articles Source Type: journals

Investigation of outpatients referred to a chemical pathologist with potential pseudohyperkalaemia [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Before a problem can be treated, it must be confirmed and its aetiology identified. A systematic approach to investigate potential pseudohyperkalaemia has been presented. This confirmed the clinician’s suspicion of pseudohyperkalaemia and in the majority of patients the aetiology was also identified. The use of serum and plasma potassium with an FBC in the initial investigation will identify whether clotting or a haematological abnormality is the cause in about half of the cases. Assay of whole-blood potassium is less important as centrifugation is a rare cause. Time to centrifugation is likely to play a ...
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Kapoor, A K, Ravi, A, Twomey, P J Tags: Original articles Source Type: journals

Primary cutaneous Ewing sarcoma/primitive neuroectodermal tumour: a clinicopathological analysis of seven cases highlighting diagnostic pitfalls and the role of FISH testing in diagnosis [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although rare, primary cutaneous ES/PNET should be considered in the differential diagnosis of cutaneous "small blue cell tumours". Immunostaining for FLI-1 and molecular testing for evidence of an EWS rearrangement are useful ancillary investigations to confirm the diagnosis. The prognosis of primary cutaneous ES/PNET appears to be more favourable than extracutaneous ES/PNET. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Shingde, M V, Buckland, M, Busam, K J, McCarthy, S W, Wilmott, J, Thompson, J F, Scolyer, R A Tags: Immunology (including allergy), Skin cancer, Dermatology, Clinical diagnostic tests Original articles Source Type: journals

Loss of ALX4 expression in epithelial cells and adjacent stromal cells in breast cancer [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data show a distinct pattern of expression of ALX4 in the human breast relative to the murine mammary gland. Furthermore, characterisation of ALX4 in breast cancer showed that loss of ALX4 in tumours and the surrounding untransformed stroma is a basic characteristic of DCIS and IDC. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Chang, H, Mohabir, N, Done, S, Hamel, P A Tags: Immunology (including allergy), Breast cancer Original articles Source Type: journals

BCL2 gene aberration as an IPI-independent marker for poor outcome in non-germinal-centre diffuse large B cell lymphoma [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cases of DLBCL of the non-GC type with BCL2 gene aberration are accompanied by a significantly worse prognosis as opposed to cases without such gene abnormalities. It may be helpful to asses BCL2 gene abnormalities by FISH in addition to assessing established parameters for individual risk estimation in DLBCL. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Obermann, E C, Csato, M, Dirnhofer, S, Tzankov, A Tags: Immunology (including allergy) Original articles Source Type: journals

Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Results suggest that FOXP1 demonstrates different expression patterns in familial breast cancers than sporadic tumours, even in tumours showing similar phenotypes. They also suggest a different role of FOXP1 as a tumour suppressor in familial tumours, which is unrelated to ER expression and may impact on therapeutic options. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Rayoo, M, Yan, M, Takano, E A, Bates, G J, Brown, P J, Banham, A H, Fox, S B Tags: Immunology (including allergy), Breast cancer Original articles Source Type: journals

Trisomy 7 and 17 mark papillary renal cell tumours irrespectively of variation of the phenotype [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Trisomies of chromosomes 7 and 17 are specific genetic alterations in papillary RCTs irrespective of their size, grade and cellular differentiation. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Balint, I, Szponar, A, Jauch, A, Kovacs, G Tags: Original articles Source Type: journals

Detection of KRAS mutations in colorectal cancer by high-resolution melting analysis [Original articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HRM analysis is a sensitive method of detecting KRAS mutation on FFPE tumour tissue to guide cetuximab treatment and is applicable to routine molecular diagnostic service. Utilisation of HRM to screen for mutations upfront economises the resource used in the sequencing reaction. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Ma, E S K, Wong, C L P, Law, F B F, Chan, W-K, Siu, D Tags: Molecular genetics, Immunology (including allergy), Colon cancer Original articles Source Type: journals

Bioinformatics and breast cancer: what can high-throughput genomic approaches actually tell us? [Reviews]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
High-throughput genomic technology has rapidly become a major tool for the study of breast cancer. Gene expression profiling has been applied to many areas of research from basic science to translational studies, with the potential to identify new targets for treatment, mechanisms of resistance and to improve on current tools for the analysis of prognosis. However, the sheer scale of the data generated along with the number of different protocols, platforms and analysis methods can make these studies difficult for clinicians to comprehend. Similarly, computational scientists and statisticians that may be called upon to ana...
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Sims, A H Tags: Reviews Source Type: journals

Human papillomavirus prevalence and type distribution in penile carcinoma [Reviews]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: About half of the penile tumours were associated with HPV 16–18 with little presence of other genotypes. Research on the mechanisms behind penile carcinogenesis is warranted. Available HPV vaccines are likely to be effective in penile tumours. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Miralles-Guri, C, Bruni, L, Cubilla, A L, Castellsague, X, Bosch, F X, de Sanjose, S Tags: Reviews Source Type: journals

{alpha}1-Antitrypsin deficiency: best clinical practice [Best practice]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
1-Antitrypsin (AAT), a 52 kDa plasma protein, is produced mainly in the liver. It is the most abundant circulating serine proteinase inhibitor (serpin). It has also previously been called protease inhibitor to reflect its function as a general inhibitor of serine proteases. Its main physiological role is to inhibit neutrophil elastase and it contributes to the innate immune system as an anti-inflammatory protein. Severe AAT deficiency is most prevalent in northern Europeans affecting about 1 in 3000 of the population. AAT deficiency predisposes individuals who smoke to developing pulmonary emphysema in the fourth–fif...
Source: Journal of Clinical Pathology - September 25, 2009 Category: Pathology Authors: Kalsheker, N A Tags: Liver disease, Immunology (including allergy), Biological agents Best practice Source Type: journals

[PostScript] Atlas of gross pathology with histologic correlationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 24, 2009 Category: Pathology Authors: Jamali, M Tags: PostScript Source Type: journals