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360 records returned

Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Quadruple therapy including ecabet sodium is useful as second-line eradication treatment for H. pylori. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - November 4, 2009 Category: Drugs & Pharmacology Authors: W. Koizumi, S. Tanabe, K. Nakatani, K. Ishido, K. Nishimura, M. Azuma, T. Ae, T. Sasaki, K. Higuchi, C. Katada, N. Nakayama, K. Saigenji Source Type: journals

Pharmacokinetics and safety of bromotetrandrine (BrTet, W198) after single-dose intravenous administration in healthy Chinese volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study suggested that bromotetrandrine was well tolerated in healthy volunteers within the dose range evaluated. The pharmacokinetics parameters of bromotetrandrine indicated that the compound was rapidly distributed and accumulated in the tissues, and slowly cleared from plasma, which supported the use of BrTet for a once or twice dosing per chemotherapy cycle. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - October 21, 2009 Category: Drugs & Pharmacology Authors: L. Zheng, Y.-p. Qing, N. Xu, Q. Yu, Y. Wang, F.-p. Wang, Z.-y. Li Source Type: journals

Psycholeptic use in aged care homes in Tasmania, AustraliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In comparison with other recent Australasian studies, the current level of benzodiazepine use in Tasmanian aged care homes is of major concern, at approximately three times that reported in Sydney and New Zealand. There is also substantial use of multiple psycholeptic agents. Interventions to reduce benzodiazepine use and improve psycholeptic utilization in Tasmania need to be developed urgently. The results demonstrate the value of regular auditing of prescribing to highlight problem areas in prescribing. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - October 11, 2009 Category: Drugs & Pharmacology Authors: J. L. Westbury, S. Jackson, G. M. Peterson Source Type: journals

CYP2C19 genotype-based (R)-warfarin disposition assessment – some views on data analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - October 4, 2009 Category: Drugs & Pharmacology Authors: N. R. Srinivas Source Type: journals

Relationship of CYP2D6 genetic polymorphisms and the pharmacokinetics of tramadol in Chinese volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CYP2D6*2 does not alter the pharmacokinetics of tramadol, whereas CYP2D6*10 did with homozygotes showing a more pronounced reduction than heterozygotes. The 32-h metabolic ratio of tramadol to M1 were (mean ± SD) 2·05 ± 1·01, 2·13 ± 0·83, 4·24 ± 2·75 and 6·85 ± 2·78, respectively, in CYP2D6*1/*1, CYP2D6*2/*2, CYP2D6*2/*10 and CYP2D6*10/*10 subjects, respectively. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - October 1, 2009 Category: Drugs & Pharmacology Authors: Q. Li, R. Wang, Y. Guo, S. Wen, L. Xu, S. Wang Source Type: journals

Proton pump inhibitors: predisposers to Alzheimer disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The abnormal processing of amyloid-[beta] peptide (A[beta]) and resultant formation of fibrillar A[beta] (fA[beta]) are major events in the pathogenesis of Alzheimer disease (AD). Microglia as the phagocytic cells of the brain can engulf and digest fA[beta] within their acidic lysosomes. The lysosomes of AD patients are less acidic and therefore less capable of clearance of fA[beta]. Vacuolar proton pumps (V-ATPases) which are found abundantly in microglia and macrophages, acidify lysosomes by pumping protons into these structures. Proton pump inhibitors (PPIs) can inhibit V-ATPases of the lysosomes. These drugs are shown ...
Source: Journal of Clinical Pharmacy and Therapeutics - September 10, 2009 Category: Drugs & Pharmacology Authors: M. K. Fallahzadeh, A. Borhani Haghighi, M. R. Namazi Source Type: journals

A systematic review and meta-analysis on the therapeutic equivalence of statinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study will use systematic review to compare the efficacy and safety profiles of different statins at different doses and determine the therapeutically equivalent doses of statins to achieve a specific level of low-density lipoprotein cholesterol (LDL-C) lowering effect.Methods: Publications of head-to-head randomized controlled trials (RCTs) of statins were retrieved from the Oregon state database (1966[ndash]2004), MEDLINE (2005-April of 2006), EMBASE (2005-April of 2006), and the Cochrane Controlled Trials Registry (up to the first quarter of 2006). The publications were evaluated with predetermined criteria by a re...
Source: Journal of Clinical Pharmacy and Therapeutics - August 13, 2009 Category: Drugs & Pharmacology Authors: T.-C. Weng, Y.-H. Kao Yang, S.-J. Lin, S.-H. Tai Source Type: journals

A phase I trial assessing the safety, tolerability, pharmacokinetic and pharmacodynamic characteristics of single-dose Auron Misheil therapy in healthy male subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data provide important PK, PD and safety data for AMT, and support further controlled clinical investigation in patients with different types of cancer as an option for supportive care. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 13, 2009 Category: Drugs & Pharmacology Authors: J. Scheele, K. Diergarten, J. Drevs, F. R. Niazi Source Type: journals

Architecture of the drug–drug interaction networkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study demonstrated that drug interaction information can be viewed and analysed as a connecting, growing network. As with many real-world networks, the drug interaction network was scale free, indicating that drug interaction information has been dominated by a relatively small number of highly interacting drugs. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 12, 2009 Category: Drugs & Pharmacology Authors: T.-M. Hu, W. L. Hayton Source Type: journals

Prophylactic use of aspirin does not induce anaemia among adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results may help in minimizing concerns about the development of anaemia among patients on aspirin. They highlight the importance of age, gender, smoking and ulcer medication in determining the incidence of anaemia among those patients. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: S. I. Al-Azzam, F. AlMahasneh, N. Mhaidat, K. H. Alzoubi, Y. S. Khader Source Type: journals

Comparing the cumulative incidences of add-on therapy among the major antihypertensive classes in 2531 Asian patients: a cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The incidence of add-on therapy among first-time antiypertensives appear to be significantly different between drug classes. This deserves further investigation. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: M. C. S. Wong Source Type: journals

Body weight gain induced by atypical antipsychotics: an extension of the monocygotic twin and sib pair studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results of the present and our previous report suggest a contribution of genetic factors in antipsychotic-induced weight gain of 60[ndash]80%. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: S. Gebhardt, F. M. Theisen, M. Haberhausen, M. Heinzel-Gutenbrunner, P. M. Wehmeier, J.-C. Krieg, W. Kühnau, J. Schmidtke, H. Remschmidt, J. Hebebrand Source Type: journals

Doxycycline vs. levofloxacin in the treatment of community-acquired pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study supports doxycycline as an effective and economical alternative therapy for levofloxacin in the empirical treatment of CAP in general medical wards. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: R. Mokabberi, A. Haftbaradaran, K. Ravakhah Source Type: journals

Prescription trends for treatment of paediatric gastroenteritis at a Japanese hospital between 1997 and 2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although experimental evidence upon which to base recommendations is lacking, Japanese evidence-based guidelines are critical for improving the quality of treatment of paediatric gastroenteritis. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: F. Kita, Y. Shibata, T. Yorifuji, T. Nakahata, J. Kawakami, K. Kawakami Source Type: journals

Using explicit criteria to evaluate the quality of prescribing in elderly Italian outpatients: a cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Via the developed criteria, the study corroborates that PIP among elderly outpatients is a substantial issue in Parma Local Health Unit, Italy. Knowledge of the prevalence of PIP and associated factors should gear efforts to develop strategies to reduce PIP in outpatient settings in Italy. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: V. Maio, S. Del Canale, S. Abouzaid Source Type: journals

The effect of high dose of N-acetylcysteine in lupus nephritis: a case report and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 46-year-old lupus nephritis patient who received 1800 mg of NAC orally. After NAC, this patient showed a higher glutathione level, and a normal level of malondialdehyde, a lipid peroxidation product. In addition, the urinary protein levels, the complete blood counts and physical examination of the affected organs showed improvement. However, a well-controlled trial is needed to confirm the value of high-dose NAC in lupus nephritis patients. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: K. Tewthanom, S. Janwitayanujit, K. Totemchockcyakarn, D. Panomvana Na Ayudhya Source Type: journals

Effect of plasma uric acid on pharmacokinetics of cyclosporine A in living-related renal transplant recipients and pharmacokinetic study in rats with experimental hyperuricaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The absorption of CyA was affected by plasma UA in transplant recipients and experimental rats. The contribution of intestinal metabolism by CYP3A to decreasing CyA absorption in HU rats was significant. These results suggest that transplant recipients with high UA may have poor absorption of CyA. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: N. Sugioka, M. Takai, K. Yoshida, K. Yasuda, K. Fukushima, T. Kokuhu, M. Okamoto, N. Yoshimura, K. Takada Source Type: journals

Resistance to low-dose aspirin therapy among patients with acute coronary syndrome in relation to associated risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There is inter-individual variability in response to the antiplatelet effect of standard doses of aspirin (150, 300 mg/day). The response to aspirin 300 mg/day is enhanced in resistant patients when compared to 150 mg/day. There was a significant association between aspirin resistance and atherothrombotic risk factors (diabetes, hyperlipidaemia and obesity). (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: M. M. Salama, A.-R. Mohamed Morad, M. A. Saleh, N. A. Sabri, M. M. Zaki, L. A. ElSafady Source Type: journals

Solubilization of vorinostat by cyclodextrinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CDs, particularly RM-[beta]-CD and HP-[beta]-CD, increased vorinostat's solubility. Future studies could be focused on the application of HP-[beta]-CD in parenteral delivery of vorinostat or using RM-[beta]-CD as an oral absorption enhancer. Molecular simulation appeared to be a useful tool for the selection of appropriate CD as excipient for drug delivery. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 7, 2009 Category: Drugs & Pharmacology Authors: Y. Y. Cai, C. W. Yap, Z. Wang, P. C. Ho, S. Y. Chan, K. Y. Ng, Z. G. Ge, H. S. Lin Source Type: journals

Assessment of CYP2C19 genetic polymorphisms in a korean population using a simultaneous multiplex pyrosequencing method to simultaneously detect the CYP2C19*2, CYP2C19*3, and CYP2C19*17 allelesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The multiplex pyrosequencing method to detect CYP2C19*2, CYP2C19*3, and CYP2C19*17 concurrently, seems to be a rapid and reliable genotyping method for the detection of important CYP2C19 genetic polymorphisms. Similar to studies conducted on other Asian populations, this study reported that in the Korean population tested, the CYP2C19*2 and CYP2C19*3 alleles were relatively frequently found, whereas the frequency of CYP2C19*17 was very low. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 6, 2009 Category: Drugs & Pharmacology Authors: K.-A. Kim, W.-K. Song, K.-R. Kim, J.-Y. Park Source Type: journals

Effect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The decreased plasma concentrations of the metabolite are presumably caused by metabolic inhibition of CYP3A4 by fluconazole. Although the therapeutic consequences of this interaction are not clear caution should be exercised when co-administering both drugs to avoid accumulation and subsequent cardiotoxic effects of halofantrine. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 6, 2009 Category: Drugs & Pharmacology Authors: C. P. Babalola, Y. T. Kolade, A. A. Olaniyi, A. Adedapo, G. K. E. Scriba Source Type: journals

Effects of voriconazole on tacrolimus metabolism in a kidney transplant recipientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report presents a case of drug[ndash]drug interaction between voriconazole and tacrolimus in a kidney transplant recipient. Voriconazole treatment led to a dramatic increase in tacrolimus concentration that required its discontinuation in spite of the manufacturer's guidelines that recommend a reduction of tacrolimus dosage by one-third. The present drug[ndash]drug interaction can be attributed to a strong inhibitory effect on cytochrome P450-3A4 activity by voriconazole. When voriconazole and tacrolimus are coadministered, close monitoring of tacrolimus blood levels is recommended as the rule-of-thumb reduction of ta...
Source: Journal of Clinical Pharmacy and Therapeutics - July 6, 2009 Category: Drugs & Pharmacology Authors: D. Capone, G. Tarantino, A. Gentile, M. Sabbatini, G. Polichetti, M. Santangelo, R. Nappi, A. Ciotola, V. D'Alessandro, A. Renda, V. Basile, S. Federico Source Type: journals

OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The OATP 388A>G polymorphism causes significant alterations in the pharmacokinetics of pitavastatin in healthy Chinese volunteers and this may well be clinically significant. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 6, 2009 Category: Drugs & Pharmacology Authors: J. Wen, Y. Xiong Source Type: journals

Evaluation of inosin-5'-monophosphate dehydrogenase activity during maintenance therapy with tacrolimusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Inosin-5'-monophosphate dehydrogenase activity in cell lysates could be reliably determined by HPLC. A 25[ndash]40% inhibition of IMPDH activity may be an appropriate range for preventing rejection with MPF but this requires further validation using larger studies with harder outcomes such as rejection episodes. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 6, 2009 Category: Drugs & Pharmacology Authors: T. Maiguma, T. Yosida, K. Otsubo, Y. Okabe, A. Sugitani, M. Tanaka, R. Oishi, D. Teshima Source Type: journals

The role of carbamazepine and oxcarbazepine in alcohol withdrawal syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Carbamazepine has demonstrated safety, tolerability and efficacy in treatment of moderate to severe symptoms of alcohol withdrawal in the inpatient setting. However, trials of carbamazepine provide inconclusive evidence for prevention of alcohol withdrawal seizures and DTs in comparison with benzodiazepines. Benzodiazepines remain the primary treatment of moderate to severe AWS. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 6, 2009 Category: Drugs & Pharmacology Authors: R. Barrons, N. Roberts Source Type: journals

The pharmacokinetics of fluconazole in healthy Chinese adult volunteers: influence of ethnicity and genderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Ethnicity (Chinese Han, Mongolian, Korean, Hui and Uygur) influences the pharmacokinetics of fluconazole tablet. However, there were statistically significant gender differences in AUC, Cmax, Vd and CL. But these could be accounted for by weight differences. If fluconazole dose-adjustment is deemed necessary, this can be done on a weight basis rather than gender basis. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 6, 2009 Category: Drugs & Pharmacology Authors: T. Guo, W-J. Sun, D-Y. Xia, L-S. Zhao Source Type: journals

Phytotherapeutics: an evaluation of the potential of 1000 plantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present review provides a baseline on the level of evidence available on many herbal preparations and should be of help to those intending to research further on these topics. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 6, 2009 Category: Drugs & Pharmacology Authors: G. Cravotto, L. Boffa, L. Genzini, D. Garella Source Type: journals

PPI use in patients commenced on clopidogrel: a retrospective cross-sectional evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that PPIs may only lower the probability of major bleeding in patients treated with dual antiplatelet therapy, who possess additional risk factor(s) for bleeding. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 6, 2009 Category: Drugs & Pharmacology Authors: M. Luinstra, M. Naunton, G. M. Peterson, L. Bereznicki Source Type: journals

Comparison of genetic polymorphisms of the NAT2 gene between Korean and four other ethnic groupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Ethnic differences in the NAT2 genotype frequencies may be one of the important factors explaining variability in cancer incidence and drug toxicity. Our observations could be useful in assessing the susceptibility of different populations to cancer and contribute to better predictions of the pharmacokinetics and pharmacodynamics of drugs that are metabolized by NAT2, in different populations. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - July 4, 2009 Category: Drugs & Pharmacology Authors: T. S. Kang, S. K. Jin, J. E. Lee, S. W. Woo, J. Roh Source Type: journals

Influence of the placebo effect on oxidative stress in healthy older adults of Mexico CityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings suggest that the placebo has a significant effect on OxS. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 30, 2009 Category: Drugs & Pharmacology Authors: R. Retana-Ugalde, L. A. Vargas, M. Altamirano-Lozano, V. M. Mendoza-Núñez Source Type: journals

Effect of telmisartan, valsartan and candesartan on mycophenolate mofetil pharmacokinetics in Japanese renal transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The degree of drug interaction between MPA and telmisartan was significantly greater than that between MPA and valsartan or candesartan. Uridine diphosphate-glucuronosyltransferase (UGT) 1A9 has been identified as a PPAR-[gamma] target gene. UGT induction by telmisartan might stimulate MPA glucuronidation. A combination of telmisartan and mycophenolate mofetil might require periodic monitoring of MPA. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 30, 2009 Category: Drugs & Pharmacology Authors: M. Miura, S. Satoh, H. Kagaya, M. Saito, T. Inoue, T. Ohkubo, T. Habuchi, T. Suzuki Source Type: journals

Rivastigmine for cognitive impairment after spontaneous subarachnoid haemorrhage: a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The use of rivastigmine was safe in patients with spontaneous subarachnoid haemorrhage and persistent cognitive impairment. A prospective double-blind placebo-controlled trial is required to establish the efficacy of rivastigmine for patients with spontaneous subarachnoid hemorrhage and persistent cognitive impairment and whether it can be translated to improvement in instrumental activity of daily living and quality of life. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 30, 2009 Category: Drugs & Pharmacology Authors: G. K.-C. Wong, R. Wong, V. Mok, A. Wong, D. Fan, G. Leung, A. Chan, W. S. Poon Source Type: journals

The M5 muscarinic receptor as possible target for treatment of drug abuseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two reports published in the latter 1980s are generally given credit for being the first to announce the discovery of a new subtype of muscarinic acetylcholine receptor (mAChR), designated m5 or M5, and now officially M5 (1). Both identifications were assigned using molecular biology techniques. Then [ndash] as now [ndash] no selective high-affinity ligands or toxins were available. In situ hybridization and reverse-transcriptase PCR have found M5 AChR expression in brain to be distinct from that of the four other G protein-coupled mAChR subtypes and primarily localized to the substantia nigra, ventral tegmental area, hipp...
Source: Journal of Clinical Pharmacy and Therapeutics - June 30, 2009 Category: Drugs & Pharmacology Authors: R. B. Raffa Source Type: journals

Impact of ALLHAT publication on antihypertensive prescribing patterns in Regione Emilia-Romagna, ItalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We found little evidence that the ALLHAT study had an impact on antihypertensive prescribing patterns in RER in the year following their publication. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 30, 2009 Category: Drugs & Pharmacology Authors: V. Maio, J. J. Gagne Source Type: journals

Pharmacokinetics and pharmacodynamics of prasugrel in subjects with moderate liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Moderate hepatic impairment appears to have no effect on exposure to prasugrel's active metabolite. Furthermore, MPA results suggest that moderate hepatic impairment has little or no effect on platelet aggregation relative to healthy controls. Overall, these results suggest that a dose adjustment would not be required in moderately hepatically impaired patients taking prasugrel. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 16, 2009 Category: Drugs & Pharmacology Authors: D. S. Small, N. A. Farid, Y. G. Li, C. S. Ernest II, K. J. Winters, D. E. Salazar, C. D. Payne Source Type: journals

Prasugrel pharmacokinetics and pharmacodynamics in subjects with moderate renal impairment and end-stage renal diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There was no difference in pharmacokinetics or PD responses between subjects with moderate renal impairment and healthy subjects. Despite significantly lower exposure to prasugrel's active metabolite in subjects with ESRD, MPA did not differ between healthy subjects and those with ESRD. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 16, 2009 Category: Drugs & Pharmacology Authors: D. S. Small, R. E. Wrishko, C. S. Ernest II, L. Ni, K. J. Winters, N. A. Farid, Y. G. Li, J. T. Brandt, D. E. Salazar, A. G. Borel, K. A. Kles, C. D. Payne Source Type: journals

Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive KoreansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We found no significant links between polymorphisms of the ACE gene or bradykinin B2 receptor gene with ACE inhibitor-induced coughing in hypertensive Koreans. But, the topic remains controversial and requires more study. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 7, 2009 Category: Drugs & Pharmacology Authors: S. W. Woo, S. Bang, M. W. Chung, S. K. Jin, Y. S. Kim, S. H. Lee Source Type: journals

Poor applicability of estimation method for adults to calculate unbound serum concentrations of valproic acid in epileptic neonates and infantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Since the relationship between the VPA concentrations of epileptic neonates and infants is noticeably different from the reference, the unbound serum VPA concentrations of these patients are not adequately estimated using the same method as that for grown-ups. The unbound VPA concentrations of neonates and infants should be explicitly determined via TDM activities. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: S. Ueshima, T. Aiba, N. Ishikawa, T. Sato, H. Kawasaki, Y. Kurosaki, Y. Ohtsuka, T. Sendo Source Type: journals

Insulin pumps: from inception to the present and toward the futureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As an alternative to the usual insulin injections, insulin pumps have been introduced as an advanced method of insulin delivery for managing type 1 diabetes mellitus patients. This review documents the history of insulin pump development and the production of 'smart pumps' that offer patients greater dosing accuracy, flexibility, and ease of use. This has resulted in an increase in the number of insulin pump users around the world. This paper also provides a comprehensive survey of the pumps currently available on the market and their specifications. Unique features of each product and the drawbacks are addressed in the re...
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: F. M. Alsaleh, F. J. Smith, S. Keady, K. M. G. Taylor Source Type: journals

Prescribed medications and pharmacy interventions for acute respiratory tract infections in Swiss primary careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Prescription rates of antibiotics for ARTI in this trial were low and patients were treated mainly with non-antibiotic symptomatic medications. Efforts to reduce antibiotic prescribing may induce higher rates of use of medications for intensive symptomatic treatment. Considerable differences between prescribed and dispensed medications were noted. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: K. E. Hersberger, A. Botomino, R. Sarkar, P. Tschudi, H. C. Bucher, M. Briel Source Type: journals

Comparison of SSRIs and SNRIs in major depressive disorder: a meta-analysis of head-to-head randomized clinical trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Serotonin and norepinephrine reuptake inhibitors showed statistical but not clinical significance when compared with SSRIs in treating MDD. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: M. Machado, T. R. Einarson Source Type: journals

Improvement of restless legs syndrome and trichotillomania with aripiprazoleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The case report describes a 39-year-old woman with restless legs syndrome (RLS) and trichotillomania (TTM). She was treated with venlafaxine and clonazepam with partial remission of RLS and no response for TTM. When aripiprazole was added to the clonazepam both RLS and TTM fully remitted. We suggest that aripiprazole might be worth investigating for treatment of these disorders. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: O. Virit, S. Selek, H. A. Savas, H. Kokaçya Source Type: journals

Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that NK2R G231E G>A and TBX21 H33Q C>G are genetic predictors of response to ICS, at least with respect to asthma control status and changes in FEV1%, in Korean patients with asthma. Further prospective validation of those associations is necessary. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: Y-M. Ye, H-Y. Lee, S-H. Kim, Y-K. Jee, S-K. Lee, S-H. Lee, H-S. Park Source Type: journals

Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background and Objective: Carbamazepine (CBZ) is metabolized mainly by the CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. Several studies have suggested that the CYP3A5*3 genotype influences the pharmacokinetics of CYP3A substrates. The present study aimed to assess the effect of the CYP3A5*3 genotype on serum concentration of CBZ at the steady-state in Korean epileptic patients.Method: The serum concentrations of CBZ in 35 Korean epileptic patients were measured and their CYP3A5 genotype was determined. Fourteen patients were CYP3A5 expressors (two for CYP3A5*1/*1 and 12 for CYP3A5*1/*3) and 21 patients were C...
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: P.-W. Park, Y. H. Seo, J. Y. Ahn, K.-A. Kim, J.-Y. Park Source Type: journals

Thiopurine S-methyltransferase (TPMT) genetic polymorphisms in Mexican newbornsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data suggest that approximately 1 in 180 persons born in Mexico City might have low or undetectable TPMT enzyme activity, a frequency that, overall, is somewhat higher than that reported for Caucasian populations generally (1 in 300). (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: A. González-del Angel, C. Bermúdez-López, M. A. Alcántara-Ortigoza, M. Vela-Amieva, R. A. Castillo-Cruz, V. Martínez, L. Torres-Espíndola Source Type: journals

Problems associated with prophylactic use of erythromycin in 1566 staff to prevent hospital infection during the outbreak of pertussisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results indicate that EM appears to cause adverse effects more frequently than reported in the package insert in Japan. The prophylactic use of EM for pertussis infection is recognized in the guideline of the Centers for Disease Control and Prevention. However, this study suggests that attention should be paid to EM non-compliance during a pertussis outbreak, which could extend the duration of the outbreak and increase the number of affected patients. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: H. Tanaka, M. Kaji, K. Higuchi, N. Shinohara, M. Norimatsu, H. Kawazoe, M. Ninomiya, N. Fukuoka, N. Ishii, J. Fujita, A. Okabe, H. Houchi Source Type: journals

Clinical outcomes of lung-transplant recipients treated by voriconazole and caspofungin combination in aspergillosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background and objective: Invasive pulmonary aspergillosis (IPA) is a serious cause of death among immune-compromised patients such as organ-transplant recipients. Recently, voriconazole has been approved for first-line therapy in IPA. Theoretically, optimal voriconazole blood level (superior to 1 mg/L according to recent studies) should be reached within 24 h. In practice, a significantly longer time seems to be needed in lung-transplant recipients. Therefore, caspofungin is now used in combination with voriconazole to provide cover against Aspergillus spp. infection during this gap. The first aim of this study was to inv...
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: A. Thomas, V. Korb, R. Guillemain, T. Caruba, V. Boussaud, E. Billaud, P. Prognon, D. Begué, B. Sabatier Source Type: journals

CYP2C19 genotype-based (R)-warfarin disposition assessment: some views on data analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: Takenori Niioka, Tsukasa Uno Source Type: journals

Beta-2 adrenergic receptor genetic polymorphisms and asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Beta-2-Adrenergic receptors ([beta]2AR) participate in the physiologic responses of the lung, including bronchodilation and bronchoprotection, through mechanisms such as mucociliary clearance, fluid accumulation and mediator release from mast cells and basophils. Thus, these receptors may also play an important role in the pathophysiology of asthma. The gene encoding [beta]2AR (ADRB2) is extremely polymorphic, and studies of this gene improves our understanding of asthma and possibly lead to new methods to prevent, diagnose and treat it. This review summarizes results from various studies on the possible relationship of AD...
Source: Journal of Clinical Pharmacy and Therapeutics - June 2, 2009 Category: Drugs & Pharmacology Authors: N. Hizawa Source Type: journals

Tolerability and safety profile of posaconazole: evaluation of 18 controlled studies in healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background and objectives: Antifungal agent utility can be limited by safety and tolerability concerns. Posaconazole is an extended-spectrum triazole antifungal agent for the treatment and prophylaxis of invasive fungal infection. The aim was to analyse the overall safety profile of posaconazole in healthy volunteers.Methods: Safety data from all 18 clinical pharmacology single- and multiple-dose trials of posaconazole conducted in healthy volunteers plus 2 additional healthy subsets from other pharmacology trials were pooled and analysed. Four hundred and forty-nine healthy volunteers (354 men; 95 women) were enrolled. Th...
Source: Journal of Clinical Pharmacy and Therapeutics - April 17, 2009 Category: Drugs & Pharmacology Authors: A. Moton, G. Krishna, Z. Wang Source Type: journals