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Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Tags: Frontmatter Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Tags: Frontmatter Source Type: journals

Ranitidine is unable to maintain gastric pH levels above 4 in septic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Intravenous ranitidine was unable to maintain gastric pH above 4 in septic patients. All cases in the ranitidine group in whom pH remained above 4 had gastric hypotrophy or atrophy. Pantoprazole successfully maintained pH levels above 4. (Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Cristina B. Terzi Coelho, Desanka Dragosavac, João S. Coelho Neto, Ciro G. Montes, Fábio Guerrazzi, Nelson Adami Andreollo Tags: Electronic Articles Source Type: journals

Reviewers 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Michelle Rizoli Source Type: journals

Retractions: Guidance from the Committee on Publication EthicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal editors should consider retracting a publication if: They have clear evidence that the findings are unreliable, either as a result of misconduct (eg, data fabrication) or honest error (eg, miscalculation or experimental error) (Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Elizabeth Wager, Virginia Barbour, Steven Yentis, Sabine Kleinert, on behalf of COPE Council Source Type: journals

Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors of this book have taken it upon themselves to present many of the controversial issues that physicians treating the critically ill patient are often faced with. The sections are nicely organized by organ systems and address topics including support of failing organ systems, ventilator management, fluid resuscitation, and sepsis. More recent topics, such as tight glucose control and end-of-life issues, are discussed. Chapters are included on organizational, technological, and ethical considerations. Each chapter has been written by internationally renowned experts in their area and is presented in a clear, conci...
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Peter Roffey Tags: Book Review Source Type: journals

Effects of propofol and dexmedetomidine on indocyanine green elimination assessed with LİMON to patients with early septic shock: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In our study, we found that neither propofol nor dexmedetomidine infusion affected hepatic blood flow. (Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Dilek Memiş, M. Kargi, N. Sut Tags: Sepsis/Infection Source Type: journals

World Federation Update: Strategic Initiatives from Florence to DurbanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 10th Quadrennial Meeting of the World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM) was held in Florence, Italy, last August 28 to September 1, 2009. Hosted by the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Therapy and led by the steering committee chaired by Luciano Gattinoni (Milan), and his associates A Raffaelo De Gaudio (Florence), Antonino Gullo (Catania), and Rosalba Tufano (Naples), the delegates represented 96 countries and numbered more than 2000. The meeting was co-sponsored by the World Federation of Critical Care Nurses and the World Federation of Pedi...
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Philip D. Lumb Tags: Editorial Source Type: journals

Instruction for AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - November 7, 2009 Category: Gastroenterology Source Type: journals

On the second European Panel on the Appropriateness of Crohn's disease Therapy (EPACT-II)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In an era of evidence based medicine, what constitutes “evidence”? For aficionados, a large, statistically powered clinical trial that enrolls a specific type of patient, randomized to receive one of several alternative therapies, being evaluated in a blinded fashion would achieve that status. Even better, if multiple trials examined the same therapy in the same way, then a meta-analysis synthesizing those data provides even better “evidence” for patients and providers. In contrast, the second European Panel on the Appropriateness of Crohn's disease Therapy (EPACT-II) – reported in this issue of the JCC – uses ...
Source: Journal of Critical Care - November 7, 2009 Category: Gastroenterology Authors: Robert W. Dubois Tags: Editorial Source Type: journals

Issue Contents listEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - November 7, 2009 Category: Gastroenterology Source Type: journals

Prescription of physical exercise in Crohn's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Some basic guidelines about how to prescribe physical exercise in Crohn's disease can be provided. However, more research is needed as few studies have been carried out so far. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 12, 2009 Category: Gastroenterology Authors: Carlos Ayán Pérez Tags: Review article Source Type: journals

How can we really reduce the morbidity of inflammatory bowel disease — Research on genes and cytokines, or find out the causative factors in the environment?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dear Sir, Right now, millions of patients all over the world are suffering from the devastating inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC), both of which have very high incidences in children and adolescence and are still regarded as incurable. Currently, the main efforts of research on IBD remain largely on genes, cytokines, and other cellular and molecular changes, with the utmost finding by the recent genome-wide association study that more than 30 distinct susceptibility loci are associated with CD. It revealed the complex in the pathogenesis of IBD. However, all these ...
Source: Journal of Critical Care - October 9, 2009 Category: Gastroenterology Authors: Xiaofa Qin Tags: Letters to the editor Source Type: journals

IBD care in Europe: A comparative audit of the inpatient management of Crohn's disease and ulcerative colitis using the national UK IBD audit toolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Consistent procedural differences between Oxford and Milan identified by audits of both UC and CD could be resolved by organisational change, with an improvement in the service. The UK IBD audit tool is an easy instrument to assess the processes and outcomes of care delivery in IBD and can be applied also outside UK. (Source: Journal of Critical Care)
Source: Journal of Critical Care - September 18, 2009 Category: Gastroenterology Authors: Andrea Cassinotti, Satish Keshav, Sandro Ardizzone, Neil Mortensen, Gianluca Sampietro, Paolo Fociani, Piergiorgio Duca, Bruce George, Marco Lazzaroni, Gianpiero Manes, Brian Warren, Diego Foschi, Gianluca Vago, Gabriele Bianchi Porro, Simon Travis Tags: Regular papers Source Type: journals

Does the endoscopic appearance of the ileocecal valve suggest the severity of Crohn's disease in the terminal ileum?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Our results suggest that ileal exploration should be attempted in every suspected CD patients, because, although the appearance of the ICV correlates with the severity of the ileal inflammation, a normal-looking ICV does not correspond to normal ileal mucosa in almost one third of the cases. (Source: Journal of Critical Care)
Source: Journal of Critical Care - September 7, 2009 Category: Gastroenterology Authors: Tamás Molnár, Klaudia Farkas, Ferenc Nagy, Zoltán Szepes, László Tiszlavicz, István Németh, Tibor Nyári, Tibor Wittmann Tags: Regular papers Source Type: journals

Pneumatosis intestinalis and hepatic portal venous gas in Crohn's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 44-year-old man with a 16-year history of ileal-colonic Crohn's disease (CD) presented with acute onset severe abdominal pain and vomiting. On examination, he was febrile and a distended and generalized tender abdomen was noted with signs of peritoneal irritation. Laboratory tests revealed increased white blood cell count of 12,500/mm3. The other laboratory values were within normal range. Computed tomography (CT) scan disclosed pneumoperitoneum and dilated loops of the small intestine with diffuse intramural gas collections (), and intrahepatic gas with linear branching at the periphery (). Definite mesenteric ischemia ...
Source: Journal of Critical Care - September 1, 2009 Category: Gastroenterology Authors: Akira Hokama, Masayoshi Nagahama, Kazuto Kishimoto, Yasushi Ihama, Hiroshi Chinen, Fukunori Kinjo, Tadashi Nishimaki, Jiro Fujita Tags: Letters to the editor Source Type: journals

Instruction for AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - August 31, 2009 Category: Gastroenterology Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - August 31, 2009 Category: Gastroenterology Source Type: journals

The role of capsule endoscopy in small bowel Crohn's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Capsule endoscopy more accurately determines the severity and extent of the Crohn's disease in the small bowel than traditional imaging modalities. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 28, 2009 Category: Gastroenterology Authors: S. O'Donnell, A. Qasim, B.M. Ryan, H.J. O'Connor, N. Breslin, C.A. O`Morain Tags: Regular papers Source Type: journals

A new dosing protocol reduces dexmedetomidine-associated hypotension in critically ill surgical patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We found that use of a protocol that increases the time interval between dosage adjustments may reduce dexmedetomidine-associated hypotension. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 17, 2009 Category: Intensive Care Authors: Anthony T. Gerlach, Joseph F. Dasta, Steven Steinberg, Larry C. Martin, Charles H. Cook Tags: Sedation Source Type: journals

Azathioprine induced pneumonitis in a patient with ulcerative colitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of a young woman with ulcerative colitis (UC) who developed respiratory symptoms and fever combined with nodular densities and ground glass areas in both lungs on CT scan. An infection was ruled out and the diagnosis azathioprine induced pneumonitis was made. The drug was stopped and within one week her fever and respiratory symptoms resolved. Clinicians should be alert to this serious adverse event when treating patients with thiopurines. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 17, 2009 Category: Gastroenterology Authors: Alexander G.L. Bodelier, Ad A.M. Masclee, Jaap A. Bakker, Wim H. Hameeteman, Marie J. Pierik Tags: Short reports Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Tags: Frontmatter Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Tags: Frontmatter Source Type: journals

Effects of inhalational bronchodilator treatment during noninvasive ventilation in severe chronic obstructive pulmonary disease exacerbationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Short-term cessation of NIV for nebulization treatment did not result in distress, discomfort, or physiologic instabilities. The only detectable changes were increase in SBP and HR, probably due to the systemic adrenergic effects of salbutamol. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Amartya Mukhopadhyay, Eleanor Dela Pena, Brian Wadden, Mark Procyshyn, Tow Keang Lim Tags: Electronic Articles Source Type: journals

The abstracted biological computational unit: Introduction of a recursive descriptor for multiscale computational modeling of biological systemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The multiscale, hierarchical organization of biological systems is well recognized. The complex, nonlinear relationship between the underlying mechanisms at one level and the phenomenological behavior observed at a higher one, which in turn produces downward causation, represents the greatest epistemological barrier to effective translational research. Dynamic computational modeling has been proposed as a means of bridging this gap, particularly as a means of dynamically visualizing mechanistic hypotheses, thereby providing an additional tool for verifying the inferred causality in these mental models. However, there are m...
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Ricardo Colasanti, Gary An Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Assessing the prediction potential of an in silico computer model of intracranial pressure dynamicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Traumatic brain injury (TBI) frequently results in poor outcome, suggesting that new approaches are needed. We hypothesized that a patient-specific in silico computer model of intracranial pressure (ICP) dynamics may predict the ICP response to therapy. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Wayne Wakeland, Rachel Agbeko, Kevin Vinecore, Mark Peters, Brahm Goldstein Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Changes in temporal structure of heart rate variability during clinical stress testingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biology is modular. The modules are structural (eg, genes, cells, tissues, organs, organisms) and evolutionary adaptation typically occurs when environmental pressure leads to reuse of a duplicate or near duplicate of an existing module. We hypothesized (1) that within-lifetime adaptation also occurs by module reuse and (2) that the complex variability observed in biological time series reflects reuse of temporal modules across multiple scales. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Timothy G. Buchman, Robert E. Karsch Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

A multi-reservoir model of influenza evolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The work by Koelle et al introduced the idea that the influenza virus type A (IVA) may evolve on neutral networks. A neutral network is a collection of genotypes that map (in some way) to the same phenotype even if there may be significant evolutionary change in the genotype. The virus experiences no evolutionary pressure until it enters a new neutral network. This allows the IVA genotype to diffuse over the entire neutral network. This diffusion can bring the current IVA cluster (phenotype) in contact with many other neutral networks (phenotypes). Upon entering a new network, the phenotype can change either moderately or ...
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: David W. Dreisigmeyer, Roni Rosenfeld, Jay V. DePasse, Elodie Ghedin, Ian Price, Gilles Clermont Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Immune response to influenza AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In mammals, Influenza A virus triggers innate immunity before adaptive immunity; however, an exaggerated innate response is harmful to tissue and does not further the elimination of virus. This project seeks to model the immune response and identify methods of preventing lung failure and improving recovery. The model introduces a dynamic innate immune response with relevant biological compartments, expanding upon existing models of adaptive immune response to Influenza A virus. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Ian Price, David Swigon, Bard Ermentrout, Frank Toapanta, Ted Ross, Gilles Clermont Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

An agent-based model of epithelial cell cystogenesis implemented with a cellular Potts modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We created an in silico model of Madin-Darby canine kidney (MDCK) cell cystogenesis. We used agent-based modeling techniques to discover a set of operating principles that allowed the model to reproduce behaviors of MDCK cystogenesis within in vitro culture. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Jesse A. Engelberg, Minji Kim, Keith E. Mostov, C. Anthony Hunt Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Combination of dynamic analysis and data mining for stability prediction after cardiac surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to develop an early warning monitor that predicts the probability that a patient can be disconnected from mechanical ventilation within the first hours after cardiac surgery and to investigate whether dynamic information of the first 4 hours of ICU stay of individual patients can improve predictions based on static admission data. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: K. Van Loon, F. Guiza, G. Meyfroidt, J.-M. Aerts, H. Blockeel, G. Van den Berghe, D. Berckmans Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Dynamic information improves discharge prediction after cardiac surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To predict the probability of ICU discharge the day after scheduled cardiac surgery and to examine the independent contributions of data available upon ICU admission and dynamic data of the first 4 hours of ICU stay. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: K. Van Loon, F. Guiza, G. Meyfroidt, J.-M. Aerts, H. Blockeel, G. Van den Berghe, D. Berckmans Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Fluctuation-dissipation theorem provides a simple analytical relationship between post-stress heart rate recovery and heart rate variability during the stressEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The autonomic nervous system modulates both the dynamics of heart rate (HR) recovery (HRR) after a cardiac stress test (eg, treadmill exercise test) and the HR variability (HRV) under steady-state (“free-running”) conditions. Also, both reduced HRV and prolonged HRR are believed to be predictors of mortality. Thus, we hypothesized that there is a relationship between post-stress HRR time constant (Toff) and an HRV measure. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Anton Burykin, Yan Lu, Michael W. Deem, Timothy G. Buchman Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

An agent-based modeling framework for ontology integration: Toward formal executable knowledge representationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In today's high throughput, data-rich environment, technology has been able to augment various aspects of the scientific process. However, to date, there has been sparse work on technological enhancement of the intuitive processes of hypothesis formulation and conceptual model verification. These “discovery” steps can be augmented via the instantiation of thought experiments in a “virtual sandbox” where researchers can both formally represent their conceptual models and instantiate them dynamically such that the behavioral consequences of their beliefs can be examined and communicated. This has most recently been t...
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Gary An, Miles Parker, Scott Christley Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

A compartmental model reveals a mechanism for misregulation of neutrophil trafficking in sepsisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sepsis is a medical condition defined by systemic inflammation and the presence of infection. Systemic inflammation may progress to multiple-organ dysfunction and eventual death. Animal models of lethal sepsis have demonstrated defective neutrophil recruitment to the site of infection, accompanied by high levels of recruitment to healthy organs. We propose that a compartmental model of sepsis will provide insight into misregulation of neutrophil trafficking in sepsis. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Justin S. Hogg, James R. Faeder, Robert S. Parker, Gilles Clermont Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Are we listening to music or noise? Use of the Lyapunov exponent for comprehensive assessment of heart rate complexity during hemorrhage in sedated conscious miniature swineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Application of tools from nonlinear dynamics for calculation of changes in heart rate complexity assumes presence of deterministic chaotic trends in the investigated data. Calculation of the largest Lyapunov exponent (LLE) is a standard method for confirmation of whether such trends are present and is used to characterize the level of chaos in complex physiologic systems. We sought to evaluate the utility of LLE for that purpose during severe pump-controlled exponential hemorrhagic shock. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: A.I. Batchinsky, J. Ward, C. Necsoiu, K. Walker, R. Nguyen, L. Baer, J. Burns, E. Hagerman, C.E. Wade, L.C. Cancio Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Using statistical model selection criteria to discriminate nonsubjectively between hypotheses about physiologic mechanisms underlying experimental observations: a practical exampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Statistical model selection criteria have found widespread use in many areas of science because they essentially provide a quantitative implementation of Occam's razor by balancing the ability of an explanation/model to describe experimental data (goodness of fit) and its complexity (number of parameters). Their use in macroscopic physiologic investigations relevant to critical illness has been limited, however. We therefore aim to demonstrate, using a practical example, how statistical model selection criteria can serve to discriminate, quantitatively, between different hypotheses about physiologic mechanisms if these can...
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Sven Zenker, Andreas Hoeft Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Injury, stress, and dysregulation: A complex adaptive systems approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This presentation advances a complex adaptive systems view of injury and stress. Tissue trauma generates a normally adaptive, multisystem stress response. This response consists of immediate, coordinated activation in nervous (autonomic, sensory, and motor), endocrine, and immune systems followed by an extended recovery process. The various facets of the adaptive stress response, response patterns over time, and dysregulation are quantifiable. A complex adaptive systems perspective accounts for this response as well as systemic dysregulation and therefore has strong implications for patient management. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: C. Richard Chapman Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

The role of weak internal noise in biological systemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The interplay between reliability and variability of biological systems has been at the center of research in systems biology. The variability in a biological system is often referred to as internal noise, meaning that the noise is inherent and cannot be switched on or off by the system. Thus, a biological system often is modeled as a network with internal noise that can sophisticatedly perform tasks. Hence, an emerging notion is that biological networks are designed for computation in a noisy environment (Barkai and Shilo. Molecular Cell 2007;28:755-759). We suggest that whereas high levels of noise can disrupt the functi...
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Dawei Hong, Steven Hollenberg, Michael Palis, Joseph Procell, Sergio Zanotti, Joseph Martin Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

A multiscale model for the assessment of autonomic dysfunction in human endotoxemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Severe injury and infection are associated with autonomic dysfunction. The realization that a dysregulation in autonomic function may predispose a host to excessive inflammatory processes has renewed interest in dissecting the role of central nervous system in modulating systemic inflammatory processes. Assessment of heart rate variability (HRV) has been extensively used to evaluate autonomic activity and as a predictor of the severity of illness. As a potential surrogate marker for system decomplexification, diminished HRV has received increasing attention in the mathematical modeling of critical illness. Understanding th...
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: P.T. Foteinou, S.E. Calvano, S.F. Lowry, I.P. Androulakis Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Data-driven modeling approaches for predicting outcomes following traumatic brain injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammation induced by traumatic brain injury (TBI) can lead to both morbidity and mortality. A systems analysis of this process is lacking. The goal of the present study was to develop data-driven models to predict outcomes post-TBI. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Gregory Constantine, Erin Susick, Qi Mi, Alexey Solovyev, David Okonkwo, Yoram Vodovotz Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Principal component analysis delineates both subgroup- and patient-specific insights into acute inflammation in trauma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The human inflammatory response to trauma is a multidimensional, complex process. We used multiplexing cytokine analysis coupled with statistical modeling (principal component analysis [PCA]) followed by clustering analysis to gain insights into the inflammatory responses of trauma patients. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Ali Ghuma, Rajaie Namas, Cordelia Ziraldo, Juan Ochoa, Timothy R. Billiar, Ruben Zamora, Qi Mi, Yoram Vodovotz Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Integer heart rate complexity, mechanical ventilation, and mortality: Effect of pressure and rate in 527 trauma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reduced heart rate (HR) complexity is associated with trauma patient mortality. We sought to determine how ventilation parameters of positive end expiratory pressure (PEEP), maximum pressure during the breathing cycle (Pmax), and respiration rate (RR) affect integer HR complexity, and the degree to which these relationships modulate associations between HR complexity and mortality. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: William P. Riordan, Patrick R. Norris, Judith M. Jenkins, John A. Morris Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Porcine endotoxemia: Multiplexed cytokine analysis and mathematical modelingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously created a series of mathematical models to address the complexity of acute inflammation in mice, rats, and humans. Swine represent an attractive preclinical species because of their physiologic similarity to humans and because of the ease of obtaining serial blood samples as well as continuous physiologic measurements. Herein, we sought to determine the principal drivers of inflammation in porcine endotoxemia and to model the process mathematically. We also sought to determine and model the time evolution of matrix metalloproteinases (MMPs). (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Yoram Vodovotz, Steve Chang, Derek Barclay, Brian Kubiak, Chris Vieau, Louis Gatto, Kris Maier, Cordelia Ziraldo, Qi Mi, Ruben Zamora, Gary Nieman Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Dynamics of mitotic exitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cell cycle events in eukaryotes are regulated by periodic activation and inactivation of a family of cyclin-dependent kinases (Cdk's). Entry into mitosis is initiated by accumulation of Cdk in complexes with B-type cyclins, and exit from mitosis requires inactivation of these Cdk-cyclin complexes and dephosphorylation of Cdk targets. The Cdks are inactivated by Cdc20- and Cdh1-dependent proteolysis, and dephosphorylation is carried out by Cdc14, an essential phosphatase promoting mitotic exit. Understanding how Cdc14 is regulated is crucial to model and explore the dynamics of mitotic exit. How Cdc5 promotes exit from mito...
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Baris Hancioglu, John J. Tyson Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Simulation of lung alveolar type II epithelial wound healing in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In vitro wound healing studies have shown that alveolar type II (AT II) cells in 2-dimensional environment recapitulate features of early-stage alveolar epithelial repair after acute lung injury. Similar to in vivo repair, cell migration and spreading are primarily responsible for initial wound closure; cell proliferation plays no significant role. Mechanisms that enable and regulate the process in vitro and in vivo are unknown. Our objective is to explore, characterize, and understand plausible mechanisms, using an agent-based, discrete event simulation approach. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Sean H.J. Kim, C. Anthony Hunt Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

A parallel implementation of an agent-based modeling platform with application in modeling calcium releases in cardiomyocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We recently developed a novel agent-based modeling platform: SPARK (Simple Platform for Agent-based Representation of Knowledge) for multiscale biomedical agent-based modeling (ABM). The initial version of SPARK used a sequential execution algorithm that restricts the size of simulation and that cannot take full advantage of the computational power of multicore PCs and cluster machines. Herein, we report on a parallel implementation of SPARK. We demonstrate an initial application in modeling Ca2+ release in cardiomyocytes. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Maxim Mikheev, Alexey Solovyev, Anna Maltsev, John Bartels, Steven Chang, Qi Mi, Yoram Vodovotz Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Modeling the immune rheostat of macrophages in the lung in response to infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the lung, alternatively activated macrophages (AAM) form the first line of defense against microbial infection. Because of the highly regulated nature of AAM, the lung can be considered as an immunosuppressive organ for respiratory pathogens. However, as infection progresses in the lung, another population of macrophages, known as classically activated macrophages (CAM), enters; these cells are typically activated by IFN-γ. CAM are far more effective than AAM in clearing the microbial load, producing proinflammatory cytokines and antimicrobial defense mechanisms necessary to mount an adequate immune response. The prese...
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Judy Day, Avner Friedman, Larry Schlesinger Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to use a mathematical model to predict the conditions under which probiotics may be successful in promoting the health of infants susceptible to NEC. The model is simulated in the presence and absence of probiotic treatment, and the effects of breast-feeding are considered. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Julia Arciero, Bard Ermentrout, Jonathan Rubin, Yoram Yodovotz Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals

Patient-specific mathematical models of traumatic brain injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Traumatic brain injury (TBI) induces an inflammatory cascade that drives not only the pathology of this type of trauma but is also likely necessary for eventual healing. Given the complexity of acute inflammation and failure of nearly 30 clinical trials in TBI, personalized medicine may offer a viable solution. The goals of the present study were to analyze cerebrospinal fluid (CSF) inflammatory cytokines for principal drivers and to develop, calibrate, and validate TBI patient-specific mathematical models. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2009 Category: Gastroenterology Authors: Qi M, Gregory Constantine, Alexey Solovyev, Erin Susick, David Okonkw, Yoram Vodovotz Tags: Meeting Abstracts for the SCAI 8th International Conference on Complexity in Acute Illness (ICCAI) Source Type: journals