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2+ HER-2/neu IHC results: positively equivocalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 19, 2009 Category: Pathology Authors: Jean D. Kemp, Michael C. Royer Source Type: journals

Lymphoepitelioma-like carcinoma of the skin: report of three casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe three new cases of this entity that support an epidermic origin. López V, Martín JM, Santonja N, Molina I, Ramón D, Monteagudo C, Jordá E. Lymphoepitelioma-like carcinoma of the skin: report of three cases (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: Verónica López, José M. Martín, Nuria Santonja, Inmaculada Molina, Dolores Ramón, Carlos Monteagudo, Esperanza Jordá Source Type: journals

Borderline CD30+ cutaneous lymphoproliferative disorder: report of a case with expression of cytotoxic markers and response to clarithromycinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of borderline CD30+ CLPD with cytotoxic phenotype, presenting in a 22-year-old male patient as an ulcer on the forearm. He reported having had similar ulcers on the buttock and thigh that spontaneously regressed over the course of 1 year. The lesion resolved with a single course of clarithromycin; a subsequent lesion, too, responded to clarithromycin, and no recurrences or systemic involvement have been documented in the 9-month follow-up. A conservative approach in the management of CD30+ CLPD is recommended. We believe that the anti-inflammatory and apoptotic effects of clarithromycin on T cells may ha...
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: Pedro Ponte, Vasco Serrão, Isabel Viana, Esmeralda Vale, Alexandre João, Lorenzo Cerroni Source Type: journals

De novo intraepidermal epithelioid melanocytic dysplasia: an emerging entityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
De novo intraepidermal epithelioid melanocytic dysplasia represents a distinctive form of intraepidermal melanocytic dysplasia. Although these lesions are atypical, they are not diagnostic of melanoma. They are considered a part of the atypical mole phenotype and may define a point in the natural course of melanomagenesis. Magro CM, Crowson AN, Mihm MC, Kline M. De novo intraepidermal epithelioid melanocytic dysplasia: an emerging entity of diagnostic and clinical importance. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: Cynthia M. Magro, A. Neil Crowson, Martin C. Mihm, Mitchell Kline Source Type: journals

Comparison between PAS and GMS stains for the diagnosis of onychomycosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PAS and GMS stains are quantitatively similar. Sensitivity of both methods can be increased by preparing two slides from different levels in the paraffin block. Reza Kermanshahi T, Rhatigan R. Comparison between PAS and GMS stains for the diagnosis of onychomycosis. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: Taher Reza Kermanshahi, Ronald Rhatigan Source Type: journals

DNIEMD and other acronymsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: François Milette Source Type: journals

Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe two further cases of this rare entity and review the literature on the subject. Our first case additionally has a plexiform multinodular pattern, a feature described in only one previous report. Suchak R, Luzar B, Bacchi CE, Maguire B, Calonje E. Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 17, 2009 Category: Pathology Authors: Ravi Suchak, Bostjan Luzar, Carlos E. Bacchi, Brigid Maguire, Eduardo Calonje Source Type: journals

Skin metastasis: a pathologist's perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study presents a literature review concerning these issues as well as this author's experience encountered throughout 19 years of surgical pathology and dermatopathology practice. Several conclusions are evident. Generally, skin metastases are encountered in 0.7[ndash]9% of all patients with cancer and as such the skin is an uncommon site of metastatic disease when compared to other organs. There is usually a long-time lag between the diagnosis of the primary malignancy and the recognition of the skin metastases. However, these metastases may be the first indication of the clinically silent visceral malignancies. The ...
Source: Journal of Cutaneous Pathology - November 17, 2009 Category: Pathology Authors: Mahmoud Rezk Abdelwahed Hussein Source Type: journals

Atypical lymphoid proliferation in capillary hemangioma: a finding related to bacterial infection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 17, 2009 Category: Pathology Authors: Anna M. Cesinaro, Reggiani B. Luca Source Type: journals

FoxP3 expression is increased in cutaneous squamous cell carcinoma with perineural invasionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 17, 2009 Category: Pathology Authors: Ben Tallon, Jag Bhawan Source Type: journals

Fibrillar IgA deposition in dermatitis herpetiformis — an underreported pattern with potential clinical significanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dermatitis herpetiformis has characteristic clinical and histopathologic findings. A fibrillar pattern of IgA deposition on direct immunofluorescence in dermatitis herpetiformis is underreported. Here, we describe three patients with the fibrillar pattern of IgA deposition on direct immunofluorescence examination that initially misled diagnosis in one of the three. Interestingly, two of the three patients lacked anti-transglutaminase and anti-endomysial antibodies but had a clinical course typical of dermatitis herpetiformis. Dermatitis herpetiformis may have a fibrillar rather than granular pattern of IgA deposition on di...
Source: Journal of Cutaneous Pathology - November 17, 2009 Category: Pathology Authors: Christine J Ko, Oscar R Colegio, Jeremy E Moss, Jennifer M McNiff Source Type: journals

Superficially invasive transitional cell carcinoma of the bladder associated with distant cutaneous metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cutaneous metastases from transitional cell carcinoma of the bladder are rare and most often associated with a deeply invasive primary tumor. This case report describes a 69-year-old male with previously resected superficially invasive primary transitional cell carcinoma of the bladder who presented with distant cutaneous and central nervous system metastases associated with recurrent bladder cancer. In addition, this case highlights the differential diagnosis of metastatic carcinomas that display a CK7/CK20 positive immunophenotype including transitional cell carcinoma, pancreatic carcinoma, cholangiocarcinoma and rare ga...
Source: Journal of Cutaneous Pathology - November 16, 2009 Category: Pathology Authors: Brian L. Swick, Jennifer R.S. Gordon Source Type: journals

Desmoplastic fibroblastoma (collagenous fibroma) of the tongueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 10, 2009 Category: Pathology Authors: Cassiano Francisco Weege Nonaka, Marianne de Vasconcelos Carvalho, Maiara de Moraes, Ana Miryam Costa de Medeiros, Roseana de Almeida Freitas Source Type: journals

Cutaneous presentation of post-renal transplant lymphoproliferative disorder: a series of four casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report detailed histological and molecular characteristics of four post transplant lymphoproliferative disorders (PTLD) presenting in the skin of renal transplant patients, and their clinical outcome. Three had B-cell lymphomas (cases 1[ndash]3), and one had a T-cell lymphoma (case 4). All B-cell lymphomas showed Epstein-Barr virus (EBV) by immunohistochemistry (IHC) or in situ hybridization (ISH). Cases 1 and 2 were large cell lymphomas, and case 3 a plasmacytoma. Case 1 showed light chain restriction and heavy chain gene rearrangement by polymerase chain reaction (PCR). The patient was then diagnosed with an abdominal...
Source: Journal of Cutaneous Pathology - November 9, 2009 Category: Pathology Authors: Samih Salama, Stanley Todd, Davide Pietro Cina, Peter Margetts Source Type: journals

Extragenital lichen sclerosus et atrophicus mimicking cutaneous T-cell lymphoma: report of a caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of extragenital LSA in which both histological patterns were present in the same clinically homogenous and stable lesion. A 27-year-old man presented with a history of white atrophic plaques on the trunk. A biopsy of an abdominal lesion revealed epidermal thinning, a superficial perivascular lymphoid cell infiltrate with focal epidermotropism, mild nuclear atypia and perinuclear halos. Immunophenotyping showed decreased CD5 and CD7, with a slight predominance of CD8-positive T-lymphocytes. All these changes were suggestive of MF. However, a repeat biopsy 3 months later from the same stable plaque revealed ...
Source: Journal of Cutaneous Pathology - November 9, 2009 Category: Pathology Authors: Ravi Suchak, Roberto Verdolini, Alistair Robson, Catherine M. Stefanato Source Type: journals

Necrotizing palisaded granulomatous dermatitis as a manifestation of familial hemophagocytic lymphohistiocytosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 9, 2009 Category: Pathology Authors: Michael J. Murphy Source Type: journals

Palisaded neutrophilic granulomatous dermatitis with leukocytoclastic vasculitis in a patient without any underlying systemic disease detected to dateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report presents the case of a 60-year-old female patient with multiple erythematous nodules on the extremities. She had no underlying systemic disease detected to date, although transient, abnormal liver function tests were seen. The histopathological examination of an erythematous nodule revealed the features of PNGD in the acute stage. The patient presented the characteristic features of LCV including palisaded granulomatous pattern, and the interstitial granulomatous pattern was seen together, suggesting that PNGD with LCV can show an interstitial granulomatous pattern. The present case also suggested that PNGD in ...
Source: Journal of Cutaneous Pathology - November 9, 2009 Category: Pathology Authors: Noriyuki Misago, Yohsuke Shinoda, Masaki Tago, Yutaka Narisawa Source Type: journals

Indolent CD8-positive lymphoid proliferation on the face: part of the spectrum of primary cutaneous small-/medium-sized pleomorphic T-cell lymphoma or a distinct entity?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of a CD8-positive lymphoid proliferation presenting as solitary lesions on the ear and nose, respectively. Histopathologically, both cases were characterized by a diffuse non-epidermotropic dermal proliferation of clonal medium-sized CD8-positive T-lymphocytes with a lymphoblast-like appearance, having cells with large folded nuclei, prominent nucleoli and ample amphophilic or pale eosinophilic cytoplasm. Staging procedures excluded systemic involvement, and both lesions were successfully treated with localised radiotherapy without evidence of recurrence after 12 and 24 months' follow up, respectively. ...
Source: Journal of Cutaneous Pathology - November 5, 2009 Category: Pathology Authors: Ravi Suchak, Simon O'Connor, Christopher McNamara, Alistair Robson Source Type: journals

Expression of Ras homologous B protein in the human scalp skin and hair follicles: hair follicle cycle stages-associated changesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Here we report, for the first time, the distribution of RhoB protein in the human scalp skin and hair follicles. We also provide the first indication that there are variations in the expression of this protein in the different stages of the hair cycle. Adly M.A, Assaf H.A, Hussein M.R.A. Expression of Ras homologous B protein in the human scalp skin and hair follicles: hair follicle cycle stages-associated changes (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 4, 2009 Category: Pathology Authors: Mohamed A. Adly, Hanan A. Assaf, Mahmoud Rezk A. Hussein Source Type: journals

Transient iatrogenic immunodeficiency-related B-cell lymphoproliferative disorder of the skin in a patient with mycosis fungoides/Sézary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immunodeficiency-related lymphoproliferative disorders (IR-LPD) may occur in the setting of immunosuppressive therapy with methotrexate and TNF-[alpha] antagonists. As far as we are aware, this is the first report of an Epstein-Barr virus-associated B-cell lymphoproliferative disorder, secondary to methotrexate therapy in a patient with mycosis fungoides/Sézary syndrome. Curry JL, Prieto VG, Jones DM, Vega F, Duvic M, Diwan AH. Transient iatrogenic immunodeficiency-related B-cell lymphoproliferative disorder of the skin in a patient with mycosis fungoides/Sézary syndrome. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 4, 2009 Category: Pathology Authors: Jonathan L. Curry, Victor G. Prieto, Dan M. Jones, Franscisco Vega, Madeleine Duvic, A. Hafeez Diwan Source Type: journals

Pseudolymphomatous reaction to varicella zoster virus vaccination: role of viral in situ hybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 61-year-old female on immunosuppressant medications for rheumatoid arthritis who presented with a subcutaneous nodule at the site of a recent herpes zoster vaccination. Histopathological examination revealed a dense nodular and interstitial mononuclear infiltrate throughout the mid and deep dermis with extension into the superficial subcutaneous fat. Immunohistochemical staining revealed an admixture of T-cells and B-cells, with a predominance of T-cells. These findings are consistent with a pseudolymphoma (PL), a reactive inflammatory disorder that can resemble cutaneous lymphoma and has rarely been described ...
Source: Journal of Cutaneous Pathology - November 4, 2009 Category: Pathology Authors: Dennis A. Porto, Nneka I. Comfere, Laura M. Myers, Jared J. Abbott Source Type: journals

The phenotypic profile of dermatomyositis and lupus erythematosus: a comparative analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: An interferon-[alpha]-inducible cytokine milieu is common in SLE, DLE, SCLE and DM. In addition, there are phenotypic differences as alluded to above that may be of some practical value in separating these distinctive subsets. Features not previously emphasized such as MXA endothelial cell staining in DM and the lack of staining for CD83 and CLA in lesions of collagen vascular disease may be of diagnostic value. Magro CM, Segal JP, Crowson AN, Chadwick P. The phenotypic profile of dermatomyositis and lupus erythematosus: a comparative analysis. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 4, 2009 Category: Pathology Authors: Cynthia M. Magro, Jeremy P. Segal, A. Neil Crowson, Paul Chadwick Source Type: journals

Multiple myeloma and cutaneous anaplastic large T-cell lymphoma in the same patient: Is there a causal relation?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of 49-year-old man, with 2-year history of multiple myeloma, presented with a raised, erythematous and ulcerated nodule in the anterior aspect of his right thigh. Histologic examination of biopsy specimen showed a dense dermic infiltrate made of large balastic cells displaying anaplastic morphology with no epidermotropism. Immunohistochemical study showed that tumor cells stained positive with CD30, EMA and CD4, and negative for CD3, CD8, CD5, CD20, CD79a, CD138 and anaplastic lymphoma kinase 1 (ALK or Ki-1). Tangour M, Chelly I, Haouet S, Zitouna M, Kchir N. Multiple myeloma and cutaneous anaplastic large...
Source: Journal of Cutaneous Pathology - November 4, 2009 Category: Pathology Authors: Monia Tangour, Ines Chelly, Slim Haouet, Moncef Zitouna, Nidhameddine Kchir Source Type: journals

C3d immunohistochemistry on formalin-fixed tissue is a valuable tool in the diagnosis of bullous pemphigoid of the skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: C3d immunohistochemistry is a valuable tool in the diagnosis of BP and PG of the skin with a sensitivity of at least 97%. Mixed forms of linear IgA dermatosis, and BP, DHD and linear IgA dermatosis can only be identified by DIF. A positive result may prompt serologic confirmation of BP without further need for DIF. Pfaltz K, Mertz K, Rose C, Scheidegger P, Pfaltz M, Kempf W. C3d immunohistochemistry on formalin-fixed tissue is a valuable tool in the diagnosis of bullous pemphigoid of the skin. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 27, 2009 Category: Pathology Authors: Katrin Pfaltz, Kirsten Mertz, Christian Rose, Paul Scheidegger, Madeleine Pfaltz, Werner Kempf Source Type: journals

Cytokeratin expression patterns in multiple infundibulocystic basal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of multiple IBCC which developed on a patient's scalp by performing histopathological and immunohistochemical examinations, using monoclonal antibodies against cytokeratins (CKs). A 76-year-old female had noticed multiple small papules on her scalp. She noticed that the tumors were growing when she underwent systemic chemotherapy for metastatic lung cancer. Routine histopathological specimens from skin biopsies revealed findings typical of IBCC. The tumor cells expressed CK14 and CK17. However, CK1 and CK10 were expressed only in a few cells in the inner area of the tumors. The present case is unique in tw...
Source: Journal of Cutaneous Pathology - October 27, 2009 Category: Pathology Authors: Tokimasa Hida, Kenji Saga, Tetsunori Kimura Source Type: journals

Myxoid intravascular fasciitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nodular fasciitis is a common reactive proliferation of soft tissue. It is composed of high density of fibroblasts and myofibroblasts, and sometimes shows a sarcomatoid appearance histologically. A rare variant of nodular fasciitis, intravascular fasciitis can be found in the veins or arteries. Histologically, intravascular fasciitis has been described that resembles nodular fasciitis with a less prominent mucoid matrix. Here, we report a case of intravascular fasciitis with prominent mucin deposition. Clinically, it presented as multiple nodules on the leg of the patient. Histologically, it showed proliferation of spindle...
Source: Journal of Cutaneous Pathology - October 26, 2009 Category: Pathology Authors: Lei Wang, Gang Wang, Lin Wang, Tianwen Gao Source Type: journals

Granulomas induced by subcutaneous injection of a luteinizing hormone-releasing hormone analog: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 26, 2009 Category: Pathology Authors: Tessin Watanabe, Nanako Yamada, Yuichi Yoshida, Osamu Yamamoto Source Type: journals

Intradermal proliferative fasciitis in childhood: a potential diagnostic pitfallEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of PF in the dermis of a 13-year-old boy. This is the first case of PF primarily arising in the dermis. Apart from the unusual site, another intriguing finding was the presence of rare atypical mitoses, a feature which has not been previously emphasized in PF. Awareness that PF may occur in the dermis, exhibiting occasional atypical mitoses, is crucial to avoid a misdiagnosis of malignancy. Magro G, Michal M, Alaggio R, Amore ED. Intradermal proliferative fasciitis in childhood: a potential diagnostic pitfall. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 26, 2009 Category: Pathology Authors: Gaetano Magro, Michal Michal, Rita Alaggio, Emanuele D' Amore Source Type: journals

Fibrofolliculoma with ancient/pseudosarcomatous featuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a case of solitary fibrofolliculoma arisen on the nose of a 63-year-old woman, with peculiar histological and immunohistochemical features. The lesion was characterized by the presence of bizarre multinucleated perifollicular stromal cells, positive for factor XIIIa, in a background of CD34-positive cells, and by a peripheral population of CD34-positive spindle cells organized in fascicles haphazardly infiltrating the deep dermis, and surrounded by scattered factor XIIIa-positive dendrocytes. We consider the bizarre perifollicular cellular component as an 'ancient' feature of fibrofolliculoma, hypothesis corro...
Source: Journal of Cutaneous Pathology - October 14, 2009 Category: Pathology Authors: Anna Maria Cesinaro, Borislav Chavdarov Rusev, Heinz Kutzner Source Type: journals

Early-onset lichenoid graft-vs.-host disease: a unique variant of acute graft-vs.-host disease occurring in peripheral blood stem cell transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Early-onset lichenoid GvHD is exclusive to the PBSCT setting and appears to be mediated by donor lymphocytes, reflecting the higher numbers of donor T cells encountered in PBSCT. We consider this reaction pattern a distinctive subtype of acute GvHD. Magro CM, Kerns MJ, Votava H, Vasil KE, Dyrsen ME, Morrison CD. Early-onset lichenoid graft-vs.-host disease: a unique variant of acute graft-vs.-host disease occurring in peripheral blood stem cell transplant recipients. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 14, 2009 Category: Pathology Authors: Cynthia M. Magro, Mary Jo Kerns, Henry Votava, Katherine E. Vasil, Molly E. Dyrsen, Carl D. Morrison Source Type: journals

Melkersson Rosenthal syndrome: a histopathologic mystery and dermatologic challengeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Melkersson Rosenthal syndrome (MRS) is rare disease of unknown etiology characterized by orofacial edema, facial nerve palsy and fissured tongue. Microscopically, it shows epithelioid non-caseous granulomas; however, edema and perivascular lymphocytic infiltrates have been described. Two different clinical forms of MRS are presented in this report. In the complete form (Case 1), the main histopathologic finding was a non-necrotizing granulomatous inflammation with 56% of the total number of cells composed of B cells (CD 20+) principally located in the granuloma's center and 33% being T cells predominating in the surroundin...
Source: Journal of Cutaneous Pathology - October 14, 2009 Category: Pathology Authors: Estela Kaminagakura, Jacks Jorge Jr. Source Type: journals

CD30 positive anaplastic large-cell lymphoma mimicking Langerhans cell histiocytosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the case of a 56-year-old female with a solitary nodule on the chin whose case was referred to our institution for confirmation of the diagnosis of LCH. Skin biopsy showed an ulcerated nodule containing a wedge-shaped infiltrate comprised of large atypical cells and cells with prominent grooved nuclei. The constellation of histologic and immunologic features favored a CD30 lymphoproliferative disorder of T-cell lineage even though there were accompanying numerous dendritic histiocytes and CD1a positive Langerhans cells. The sheets of CD30 positive atypical lymphoid cells which express T-cell markers were consist...
Source: Journal of Cutaneous Pathology - October 8, 2009 Category: Pathology Authors: Navid Ezra, Gregory S. Van Dyke, Scott W. Binder Source Type: journals

Proliferative nodules in a giant congenital melanocytic nevus–case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a newborn infant with large proliferative nodules and multiple satellite nevi in a GCN of the bathing suit type. The diagnosis in our patient was based on the smooth transition of the pre-existing lesion and the nodule, the absence of strong atypical nuclei, the atypical mitotic figures, the ascension of melanocytes in the epidermis and the absence of necrosis. A review of the literature showed that the clinical and the histological features of benign (proliferative) nodules are variable. The awareness and the identification of this entity by clinicians and pathologist are imperative to prevent diagnostic errors....
Source: Journal of Cutaneous Pathology - October 8, 2009 Category: Pathology Authors: Annemarie H. van Houten, Marcory C. R. F. van Dijk, Marie-Louise A. Schuttelaar Source Type: journals

Primary cutaneous myxoid spindle cell squamous cell carcinoma: a clinicopathologic study and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mucocutaneous squamous cell carcinoma (SCC) may rarely exhibit intracellular mucin production. Extracellular mucin production is an even rarer finding in SCC that is not well documented in the literature. Here, we report six cases of primary cutaneous and mucocutaneous SCC with prominent extracellular stromal mucin deposition and an epithelial spindle cell component. We propose the term 'yxoid spindle cell SCC' (MSC SCC) to describe the histologic characteristics of these six cases. We also propose a set of histologic and immunohistochemical findings for distinguishing MSC SCC from primary cutaneous and metastatic spindle ...
Source: Journal of Cutaneous Pathology - October 7, 2009 Category: Pathology Authors: Aparche Yang, Andrew Hanley, Elsa F. Velazquez, David S. Cassarino Source Type: journals

Morphological and immunohistochemical characteristics of atypical fibroxanthoma with a special emphasis on potential diagnostic pitfalls: a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A diagnosis of AFX is still made by exclusion of other malignant neoplasms with similar morphology. Immunohistochemistry plays a crucial role in this distinction, but can also be misleading. This study expands the spectrum of non-vascular CD31 positive tumors. Luzar B, Calonje E. Morphological and immunohistochemical characteristics of atypical fibroxanthoma with a special emphasis on potential diagnostic pitfalls. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 5, 2009 Category: Pathology Authors: Bo[scaron]tjan Luzar, Eduardo Calonje Source Type: journals

Histopathology and immunohistochemistry of depigmented lesions in lupus erythematosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The DL still fulfill histological criteria for lupus. In the absence of a precise histological diagnosis, thickening of basement membrane, hyperkeratosis, cellular infiltration, epidermal atrophy and elastosis are the most common features. Loss of melanocytes and the dermal fibrosis suggests that DL in cutaneous LE behave as post-inflammatory scars. França AFEC, de Souza EM. Histopathology and immunohistochemistry of depigmented lesions in lupus erythematosus. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 5, 2009 Category: Pathology Authors: Andrea Fernandes Eloy da Costa França, Elemir Macedo de Souza Source Type: journals

Pitfalls of Melan-A stainingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 4, 2009 Category: Pathology Authors: Christian Andres, Michael J. Flaig Source Type: journals

A case of porocarcinoma arising in pigmented hidroacanthoma simplex with multiple lymph node, liver and bone metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Porocarcinoma is a rare skin appendage carcinoma that may arise de novo or be associated with pre-existing poroma and hidroacanthoma simplex (HAS). Here, we report a case of porocarcinoma arising in pigmented HAS, which led to death from multiple lymph node, liver and bone metastases. A 72-year-old Japanese man presented with a brown to focal black flat plaque, measuring 17 × 12 mm, on the posterior region of his right thigh. Histopathological study of the tumor revealed that there was intraepidermal proliferation of small-sized basaloid cells, and it exhibited the 'Jadassohn phenomenon', with dendritic melanocytes, and a...
Source: Journal of Cutaneous Pathology - September 25, 2009 Category: Pathology Authors: Mitsuaki Ishida, Machiko Hotta, Ryoji Kushima, Hidetoshi Okabe Source Type: journals

Expression of survivin and human telomerase reverse transcriptase in extramammary Paget's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Over-expression of survivin and hTERT correlated strongly with recurrence and local invasion of EMPD lesions. EMPD has male gender predominance in Oriental population. Shan S-J, Zhang N, Geng S-L, Zhou Z, Chen X, Nie T, Guo Z, Li C, Liu Q, Guo Y, Wei H, Chen H-D. Expression of survivin and human telomerase reverse transcriptase in extramammary Paget's disease. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 24, 2009 Category: Pathology Authors: Shi-Jun Shan, Naiqin Zhang, Shi-Ling Geng, Zhihai Zhou, Xu Chen, Tingfen Nie, Zhe Guo, Changping Li, Quanzhong Liu, Ying Guo, Huachen Wei, Hong-Duo Chen Source Type: journals

IMP-3 expression in melanocytic lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A malignant circumstance, such as non-desmoplastic melanoma or atypical Spitz tumor, can be inferred when IMP-3 is expressed, suggesting potential diagnostic value of IMP-3 in melanocytic lesions. Yu L, Xu H, Wasco MJ, Bourne PA, Ma L. IMP-3 expression in melanocytic lesions. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 23, 2009 Category: Pathology Authors: Limin Yu, Haodong Xu, Matthew J. Wasco, Patricia A. Bourne, Linglei Ma Source Type: journals

Myxofibrosarcoma mimicking cutaneous myxomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 23, 2009 Category: Pathology Authors: Mi Ri Kim, Eui Hyung Lee, Sang Eun Lee, Ji Eun Kwon, Kwang Gil Lee, You Chan Kim, Soo-Chan Kim Source Type: journals

Oncogenic BRAF and the tumor suppressor IGFBP7 in the genesis of atypical spitzoid nevomelanocytic proliferationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rare reports indicate that the frequency of BRAFV600E mutations is high in atypical Spitz nevi. The purpose of this study was to ascertain the utility of the RAF/RAS mutational status as a diagnostic adjunct in lesions with histologic features that deviate from a typical Spitz nevus and, to examine expression of Insulin growth factor binding protein 7 (IGFBP7), a tumor suppressor acting through autocrine/paracrine pathways to inhibit BRAF-MEK-ERK signaling, in the same. Genomic DNA for genotyping was isolated from 6 regular Spitz nevi and 14 atypical spitzoid nevomelanocytic proliferations (including 1 melanoma with spitzo...
Source: Journal of Cutaneous Pathology - September 23, 2009 Category: Pathology Authors: Andrew Emley, Shi Yang, Narendra Wajapeyee, Michael R Green, Meera Mahalingam Source Type: journals

Blimp-1: a marker of terminal differentiation but not of sebocytic progenitor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The reported expression pattern is difficult to reconcile with a function of Blimp-1 as a marker for sebocytic progenitor cells but indicates a major role in terminal differentiation. Within the interfollicular epidermis, its exclusive localization to the granular layer suggests a central function in skin barrier homeostasis in the human. Sellheyer K, Krahl D. Blimp-1: a marker of terminal differentiation but not of sebocytic progenitor cells. A comparative analysis of embryonic and adult human skin with sebaceous neoplasms. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 23, 2009 Category: Pathology Authors: Klaus Sellheyer, Dieter Krahl Source Type: journals

Immunohistochemical techniques to compare primary vs. metastatic mucinous carcinoma of the skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In a small subset of mucinous carcinomas (20% in this series), positive labeling for CK5/6 indicated primary cutaneous tumor. Staining with p63 also favored primary over metastatic disease. Myoepithelial cell layers were not consistently identified to enable the identification of primary disease. Levy G, Finkelstein A, McNiff JM. Immunohistochemical techniques to compare primary vs. metastatic mucinous carcinoma of the skin (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 23, 2009 Category: Pathology Authors: Gillian Levy, Alexander Finkelstein, Jennifer M. McNiff Source Type: journals

Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfallEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A case of cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma is described. The patient was a 60-year-old man who presented with a painless nodule on his chest. Thorough clinical examination did not reveal any evidence of tumor elsewhere. A punch biopsy was performed which showed a benign spindle cell neoplasm with focal cellular pleomorphism that had smooth muscle differentiation and was clearly originating from the arrector pili muscle, consistent with a cutaneous symplastic pilar leiomyoma. Immunohistochemical studies were performed and the tumor cells were strongly positive for smooth muscle actin (SMA...
Source: Journal of Cutaneous Pathology - September 22, 2009 Category: Pathology Authors: Mark E. Fons, Thomas Bachhuber, Jose A. Plaza Source Type: journals

The cellular component of the mucinous nevus consists of CD34-positive fibroblastsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 17, 2009 Category: Pathology Authors: Juan C. Tardío, Rosario Granados Source Type: journals

The histopathologic spectrum of regression in atypical fibroxanthomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Fibrosis with prominent sclerosis and hyalinization replacing the tumor is rare in AFX. Advanced fibrosis, in the absence of a history of prior trauma or surgery, may indicate spontaneous regression. These cases emphasize the importance of recognizing this subset of AFX in order to avoid misinterpretation, particularly in cases with few residual atypical cells. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 16, 2009 Category: Pathology Authors: Catherine M. Stefanato, Alistair Robson, J. Eduardo Calonje Source Type: journals

De novo intraepidermal epithelioid melanocytic dysplasia: a review of 263 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Most of these DNIEMD lesions are found on the lower extremities of women and men, and they have an increased association with MM, DN and NMSC. Jessup CJ, Cohen LM. De novo intraepidermal epithelioid melanocytic dysplasia: a review of 263 cases. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 16, 2009 Category: Pathology Authors: Chad J. Jessup, Lisa M. Cohen Source Type: journals

Syringocystadenocarcinoma papilliferum in a linear nevus verrucosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the 12th case of SCACP, the first case of SCACP on the arm and the first case of SCACP arising from pre-existing SCAP, in what appeared to be an epidermal nevus. Hoekzema R, Leenarts MFE, Nijhuis EWP. Syringocystadenocarcinoma papilliferum in a linear nevus verrucosus. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 15, 2009 Category: Pathology Authors: Rick Hoekzema, Marjolein F.E. Leenarts, Erik W.P. Nijhuis Source Type: journals

Oral lesions in lupus erythematosus–cytokines profiles of inflammatory infiltrateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Oral LE lesions are associated with both type 1 and type 2 cytokines, characterized by stronger expression of INF- [gamma], TNF- [alpha] and IL-10. These findings suggest that although ultraviolet (UV) light is involved in the induction of LE lesions, mechanisms of lesions formation may be similar in sun-exposed as well as sun-covered areas. Marques ERMC, Lourenço SV, Lima DM, Nico MMS. Oral lesions in lupus erythematosus[ndash]cytokines profiles of inflammatory infiltrate. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - September 14, 2009 Category: Pathology Authors: Elisa R. M. C. Marques, Silvia Vanessa Lourenço, Dirce M. Lima, Marcello Menta S. Nico Source Type: journals