Journal of Dermatological ScienceThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Source Type: journals

Olopatadine hydrochloride inhibits scratching behavior induced by a proteinase-activated receptor 2 agonist in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Proteinase-activated receptors (PARs), a group of G protein-coupled receptors, are activated by the cleavage of their N-terminal domain by serine proteinases . The proteolytic cleavage of the N-terminal region of PARs unmasks a new N-terminal sequence that acts as a tethered ligand that binds and activates the receptor itself . The PAR2 subtype is highly expressed in the skin, is activated by trypsin and mast cell tryptase, and can be activated without the need for proteolysis by synthetic PAR2 agonists, such as SLIGRL-NH2 . Tryptase and PAR2 are up-regulated on sensory nerves in the skin from atopic dermatitis patients . ...
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Ayumi Yoshizaki, Shinichi Sato Tags: Letters to the Editor Source Type: journals

Expression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha with progression of keratinocytic neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Low oxygen levels are frequently encountered in solid tumors, and tumor growth, angiogenesis, invasion and metastasis are regulated by hypoxia-stimulated genes, such as hypoxia-inducible factors (HIFs) . Under low oxygen concentration, HIF-1alpha and HIF-2alpha translocate to the nucleus, heterodimerize with HIF-1beta, and activate target genes. High expression of HIFs has been correlated with frequent mutations of tumor suppressor genes such as p53 and PTEN, enhanced cellular proliferation, and decreased apoptosis . C-myc controls the G1-S cell-cycle transition and is overexpressed in many human tumors. HIF-1alpha is know...
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Xie Lining, Hiroshi Uchi, Sayaka Hayashida, Gaku Tsuji, Makiko Kido, Takeshi Nakahara, Satoshi Takeuchi, Masakazu Takahara, Yoichi Moroi, Masutaka Furue Tags: Letters to the Editor Source Type: journals

Morphological relationship between nerve fibers and Langerhans cells in the epidermis of psoriasis vulgaris and lichen simplex chronicusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is generally accepted that skin is a target organ of the stress reaction . There is a close correlation between psoriasis vulgaris (PV), lichen simplex chronicus (LSC) and certain psychoneural factors. Both PV and LSC are associated with psychologic disorders and can be aggravated by anxiety or depression. Quantitative analysis of nerve fibers in the lesions of PV provides morphological evidence for the functional role of nervous system in PV . However, quantitative analysis of nerve fibers in the lesions of LSC and morphological relationship between nerve fibers and LCs in the lesions of PV and LSC have not been report...
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Shaoshan Cui, Ting Xiao, Yan Wang, Hongguang Lu, Yakun Wang, Xing-Hua Gao, Huachen Wei, Hong-Duo Chen Tags: Letters to the Editor Source Type: journals

The first case report of a Chinese Hermansky–Pudlak syndrome patient with a novel mutation on HPS1 geneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hermansky–Pudlak syndrome (HPS; OMIM 203300) is an autosomal recessive and a genetically heterogeneous disorder characterized by oculocutaneous albinism (OCA), bleeding tendency, and ceroid deposition which may cause lung fibrosis, colitis, and cardiomyopathy. Patients with HPS often die in their middle ages . The hallmark of pathological features of HPS is the disrupted biogenesis of lysosome-related organelles (LROs), such as melanosomes and platelet dense granules . The identification of the first HPS gene, HPS1, in 1996 prompts the identification of seven other HPS genes (HPS2–HPS8) during the past decade . (Source...
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Aihua Wei, Shi Lian, Lejin Wang, Wei Li Tags: Letters to the Editor Source Type: journals

Endogenous expression of TRPV1 channel in cultured human melanocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The vanilloid receptor 1 (transient receptor potential vanilloid type 1, TRPV1) is a non-selective cation channel that binds vanilloids and was originally described to be activated by the naturally occurring lipophilic alkaloid capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a substance not synthesized in the human body . Recently, endogenous ligands including anandamide (arachidonylethanolamine) and lipoxygenases by-products such as 12-hydroperoxyeicosatetraenoic acid, N-arachidonyldopamine, and N-oleoyldopamine were also described to activate TRPV1 . Therefore, TRPV1 was suggested as a key integrator molecule of vari...
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Tae-Young Choi, Sang-Young Park, Ji Yoon Jo, Gun Kang, Jin Bong Park, Jin-Gu Kim, Seong-Geun Hong, Chang-Deok Kim, Jeung-Hoon Lee, Tae-Jin Yoon Tags: Letters to the Editor Source Type: journals

Histamine induces human β-defensin-3 production in human keratinocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It is suggested that histamine induces hBD-3 production in human keratinocytes through H1 receptors by activating STAT3 and AP-1 via JAK2 and MEK/ERK. Histamine may promote cutaneous antimicrobial defense, inflammation, and wound repair through hBD-3. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Takeko Ishikawa, Naoko Kanda, Carren S. Hau, Yayoi Tada, Shinichi Watanabe Tags: Regular articles Source Type: journals

Cultured human melanocytes express functional Toll-like receptors 2–4, 7 and 9Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Present study indicates human melanocytes express a panel of functional TLRs. The ligation of TLRs can turn these cells into active players of the skin innate immunity. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Ning Yu, Shujie Zhang, Fuguo Zuo, Kefei Kang, Ming Guan, Leihong Xiang Tags: Regular articles Source Type: journals

Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-κB and MAPK pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that nicotinamide inhibits IL-8 production through the NF-κB and MAPK pathways in an in vitro keratinocytes/P. acnes model of inflammation. Keratinocytes involved in the innate immune response may be a suitable target for treatment during the early phase of inflammation. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Philippe A. Grange, Joël Raingeaud, Vincent Calvez, Nicolas Dupin Tags: Regular articles Source Type: journals

Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Traffic-related air pollution (TAP) impairs respiratory health and could influence the development of allergies, as was demonstrated in urban areas with relatively high pollution. Whether eczema is affected by TAP was rarely investigated.Objective: To investigate whether exposure to TAP affects eczema and respiratory allergies also in small-town areas with lower concentrations of pollution.Methods: Between 1995 and 1999, we recruited 3390 newborns from small-town areas. Diagnoses and symptoms of eczema and respiratory allergies were recorded by annual questionnaires. Seventy-seven percent of families ...
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Ursula Krämer, Dorothea Sugiri, Ulrich Ranft, Jean Krutmann, Andrea von Berg, Dietrich Berdel, Heidrun Behrendt, Thomas Kuhlbusch, Matthias Hochadel, Heinz-Erich Wichmann, Joachim Heinrich, the GINIplus and LISAplus study groups Tags: Regular articles Source Type: journals

Effectiveness of different substrate materials for in vitro sunscreen testsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, several substrates have been fully characterized for in vitro sunscreen testing.Methods: The following different substrates have been utilised in the study: roughened PMMA plates, Transpore, Vitro-Skin, roughened quartz plate and a laboratory prepared roughened PTFE plate. The suitability of these substrates for SPF evaluation has been investigated by performing total absorbance measurements of seven sunscreen products with different SPF values produced by the same manufacturer.Results and conclusions: Application of sunscreen products on Transpore, roughened quartz plate, PMMA, PTFE and Vitro-Skin was perfo...
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Denis Garoli, Maria Guglielmina Pelizzo, Piergiorgio Nicolosi, Andrea Peserico, Elena Tonin, Mauro Alaibac Tags: Regular articles Source Type: journals

Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Rapamycin selectively blocks K6a expression in human keratinocytes. The improvement of symptoms in PC patients following rapamycin treatment suggests rapamycin (or rapamycin analogs) may be a therapeutic option, particularly if topical formulations can be developed that avoid the side effects associated with systemic administration. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Robyn P. Hickerson, Devin Leake, Lana N. Pho, Sancy A. Leachman, Roger L. Kaspar Tags: Regular articles Source Type: journals

DNA damage responses in skin biology—Implications in tumor prevention and aging accelerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: UV irradiation is the main etiological cause of most types of skin cancers and can accelerate skin photoaging. UV irradiation results in several types of DNA damage in eukaryotic cells, such as DNA single strand breaks, DNA interstrand cross-links, and nucleotide base modifications. In response to such DNA damages, mammalian cells exert DNA damage responses including cell cycle checkpoints, well-developed DNA repair, apoptosis and premature senescence to prevent genomic instability. Cell cycle checkpoints are important surveillance systems to maintain genomic integrity. Once checkpoint systems sense the abnormal ...
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Makoto Nakanishi, Hiroyuki Niida, Hiroshi Murakami, Midori Shimada Tags: Invited review article Source Type: journals

The international role of the Japanese Society for Investigative Dermatology (JSID): Secretary General's PerspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
After serving as the Editor-in-Chief of the Journal of Dermatological Science (JDS) for the past 5 years, I assumed the five-year Secretary Generalship of the JSID in 2008. With Prof. Yoshiki Tokura as the new president and Prof. Akimichi Morita as the new JDS Editor-in-Chief, I believe it is an appropriate time to consider the JSID's future. Together with increases in the quality and impact factor of the JDS, the JSID's international role on skin science has become clearer (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Hiroshi Shimizu Tags: Editorial Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Source Type: journals

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(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Source Type: journals

No involvement of the NOD1 polymorphism Glu266Lys in Japanese leprosy patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Leprosy (Hansen's disease) is a chronic infectious disease caused by Mycobacterium leprae (M. leprae) and primarily affects the skin and the peripheral nervous system. In Japan, occurrence of new patients is quite rare and most patients are already very old to live in or close to the leprosaria, although more than 200,000 patients newly arise per year in the whole world . Leprosy shows apparent phenotypic heterogeneity depending on the host's immunological response to the pathogen. One is the tuberculoid (T-) type, characterized by formation of epithelioid cell granuloma without apparent bacilli due to the host's strong ce...
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Hong-jin Li, Nobuo Kanazawa, Yumi Nakatani, Fukumi Furukawa, Motoaki Ozaki, Maki Kosaka, Norihisa Ishii Tags: Letters to the Editor Source Type: journals

Significance of cyclin D1-, product of retinoblastoma (pRb), p53, p63 and p73 expression in eccrine poroma and eccrine porocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eccrine porocarcinoma (EPC) is a rare malignant tumor arising from the intraepidermal portion of the eccrine sweat gland duct epithelium or from pre-existing eccrine poroma (EP) , and the precise pathogenesis remains unclear. We have previously reported that activating transcription factor-2- and signal transducer and activator of transcription-3 signaling pathways might contribute to the formation of both EP and EPC , but neither factor was able to dissect EPC from EP. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Si-Yuan Chen, Satoshi Takeuchi, Yoichi Moroi, Makiko Kido, Sayaka Hayashida, Yue Qian, Hiroto Tomoeda, Takeshi Uenotsuchi, Kazunori Urabe, Masutaka Furue, Ya-Ting Tu Tags: Letters to the Editor Source Type: journals

The compound heterozygote for new/recurrent COL7A1 mutations in a Japanese patient with bullous dermolysis of the newbornEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated COL7A1 gene pathology in an additional Japanese patient with BDN and identified compound heterozygous new/recurrent mutations. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Keiko Hashikawa, Takahiro Hamada, Norito Ishii, Shunpei Fukuda, Rie Kuroki, Takekuni Nakama, Shinichiro Yasumoto, Katsuto Tamai, Hajime Nakano, Daisuke Sawamura, Takashi Hashimoto Tags: Letters to the Editor Source Type: journals

Anti-inflammatory and barrier protecting effect of Lithospermum erythrorhizon extracts in chronic oxazolone-induced murine atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atopic dermatitis (AD) is a chronic inflammatory, and highly pruritic skin disease of which prevalence is steadily increasing along with industrialization . Corticosteroids are generally prescribed to control the symptoms of AD, yet the repeated use can cause severe skin atrophy, susceptibility to infection and adrenal suppression etc. Due to these profound side effects, chronic usages have been actively avoided, even arousing a strong antipathy against corticosteroid, so called “steroid phobia” . In this background, many attempts have been made to develop alternative therapies and in particular, much attention has bee...
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Ji Hae Lee, Kyoung-Mi Jung, Il-Hong Bae, SiYoung Cho, Dae-Bang Seo, Sang-Jun Lee, Young-Ho Park, Kyung-Min Lim Tags: Letters to the Editor Source Type: journals

Recurrent European missense mutation in the F12 gene in a British family with type III hereditary angioedemaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hereditary angioedema (HAE; OMIM 106100) is an autosomal dominant condition that is genetically heterogeneous (). The classic forms, types I and II HAE, both result from mutations in the gene encoding the C1 inhibitor (SERPING1) . A third type of inherited HAE has been described recently. Affected individuals have recurrent angioedema without wheals and have normal C1 inhibitor function . This new type of HAE (designated type III HAE) almost exclusively affects females, and appears to be associated with high estrogen levels (hence the previous name of estrogen-related HAE) . In 2006, Dewald and Bork identified the F12 gene...
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Nikoletta Nagy, Malcolm W. Greaves, Akio Tanaka, John A. McGrath, Clive E. Grattan Tags: Letters to the Editor Source Type: journals

Expression of selected ADAMs in bullous pemphigoid and dermatitis herpetiformisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are autoimmune diseases characterized by destruction of the basement membrane zone and anchoring fibers. Recent studies established biochemical properties of a disintegrin and metalloproteinase (ADAMs) and their high affinity to the basement membrane components, especially collagen type XVII and VII . Moreover, ADAMs are responsible for shedding of several proteins from the cells surface, for example TNFα . There is still no evidence on the expression and the possible function of ADAMs in blister formation. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Agnieszka Zebrowska, Malgorzata Wagrowska-Danilewicz, Marian Danilewicz, Karolina Wodz, Milena Sokolowska, Anna Erkiert-Polguj, Anna Sysa-Jedrzejowska, Elzbieta Waszczykowska, Rafal Pawliczak Tags: Letters to the Editor Source Type: journals

In vitro impact of a whey protein isolate (WPI) and collagen hydrolysates (CHs) on B16F10 melanoma cells proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It is suggested that a mechanism for tumorigenesis inhibition may involve the caspases cascade and apoptosis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: G.A. Castro, D.A. Maria, S. Bouhallab, V.C. Sgarbieri Tags: Regular articles Source Type: journals

Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochlorideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: GS–HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1β- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Hua Hong, Yu-Kyoung Park, Mi-Sun Choi, Nam-Hee Ryu, Dae-Kyu Song, Seong-Il Suh, Ki-Young Nam, Gy-Young Park, Byeong-Churl Jang Tags: Regular articles Source Type: journals

Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: YKS inhibited the development of AD-like skin lesions in socially isolated NC/Nga mice by suppressing scratching and infiltration of inflammatory cells in the skin. These results indicate that YKS possesses an anti-itching property, and its anti-itching may be partly through attenuation on social isolation stress. It is expected that YKS might provide an effective alternative therapy for AD in human patients. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Ju Jiang, Takuji Yamaguchi, Naoko Funakushi, Takatoshi Kuhara, Ping-shen Fan, Rie Ueki, Hajime Suto, Yoshio Kase, Shigaku Ikeda, Hideoki Ogawa Tags: Regular articles Source Type: journals

DNA demethylation of the perforin promoter in CD4+ T cells from patients with subacute cutaneous lupus erythematosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: DNA demethylation at the perforin locus contributes to perforin overexpression in SCLE CD4+ T cells. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Yongqi Luo, Xiujuan Zhang, Ming Zhao, Qianjin Lu Tags: Regular articles Source Type: journals

Mutations in the SLURP-1 gene underlie Mal de Meleda in three Pakistani familiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results expand the spectrum of mutations in SLURP-1 gene. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Muhammad Wajid, Mazen Kurban, Yutaka Shimomura, Angela M. Christiano Tags: Regular articles Source Type: journals

Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Slug is an important modulator of successful wound repair in adult tissue and may be critical for maintaining epidermal integrity in response to chronic injury. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Laurie G. Hudson, Kimberly M. Newkirk, Heather L. Chandler, Changsun Choi, Stacey L. Fossey, Allison E. Parent, Donna F. Kusewitt Tags: Regular articles Source Type: journals

Long-term follow-up of patients with recessive dystrophic epidermolysis bullosa in the Netherlands: Expansion of the mutation database and unusual phenotype–genotype correlationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Pseudosyndactyly occurs in approximately half of RDEB-O patients when type VII collagen is strongly reduced. The prognosis in RDEB cannot always be simply predicted from the COL7A1 genotype. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Peter C. van den Akker, Anthonie J. van Essen, Marian M.J. Kraak, Rowdy Meijer, Miranda Nijenhuis, Gonnie Meijer, Robert M.W. Hofstra, Hendri H. Pas, Hans Scheffer, Marcel F. Jonkman Tags: Regular articles Source Type: journals

Multiphoton microscopy in dermatological imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A minimally invasive imaging modality that provides both cellular and extracellular structural information with subcellular resolution is helpful for clinical diagnosis as well as basic laboratory research in dermatology. Multiphoton microscopy (MPM), using femtosecond laser as the light source, is efficient in non-linear excitation of endogenous fluorophores and induction of second harmonic generation signals from non-centrosymmetric biomolecules such as collagen. This imaging modality is minimally invasive in the sense that much of the traditional histological procedures can be bypassed en route to obtain morph...
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Authors: Tsung-Hua Tsai, Shiou-Hwa Jee, Chen-Yuan Dong, Sung-Jan Lin Tags: Invited review article Source Type: journals

The latest impact factor for Journal of Dermatological Science is now 2.97!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Tags: Editorial Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 31, 2009 Category: Dermatology Source Type: journals

AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Source Type: journals

Circulating levels of adiponectin, oxidized LDL and C-reactive protein in Portuguese patients with psoriasis vulgaris, according to body mass index, severity and duration of the diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Psoriasis vulgaris, a chronic inflammatory disease, associates with oxidative stress, dislipidaemia, overweight/obesity, low adiponectin levels and a high frequency in cardiovascular diseases (CVD) . However, there are no reports studying the relation of CVD risk factors with body mass index (BMI), severity and duration of psoriasis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Susana Coimbra, Hugo Oliveira, Flávio Reis, Luís Belo, Susana Rocha, Alexandre Quintanilha, Américo Figueiredo, Frederico Teixeira, Elisabeth Castro, Petronila Rocha-Pereira, Alice Santos-Silva Tags: Letters to the Editor Source Type: journals

SMAD3 as an atopic dermatitis susceptibility gene in the Japanese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atopic dermatitis (AD) is a hereditary, pruritic, inflammatory, and chronic skin disease that occurs most commonly in early childhood but can persist in or even begin in adulthood. AD is a common disease of complex inheritance, and twin and family studies have confirmed the existence of a genetic predisposition to the development of AD, with a heritability of 0.72 , although a clear Mendelian pattern of inheritance has not been established. Recent studies have emphasized the importance of skin barrier function in the development of AD. Loss-of-function mutations of the filaggrin gene (FLG) were found to be associated with ...
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Kenta Otsuka, Sayaka Takeshita, Hisako Enomoto, Takenori Takahashi, Tomomitsu Hirota, Mayumi Tamari, Kouji Ebe, Fujio Otsuka, Masanao Shibasaki, Tadao Arinami, Emiko Noguchi Tags: Letters to the Editor Source Type: journals

Abnormal collagen deposition in fibromas from patient with juvenile hyaline fibromatosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Juvenile hyaline fibromatosis (JHF [MIM #228600]) is a rare mesenchymal dysplasia that is inherited in an autosomal recessive manner. This disease is characterized by joint contracture, bone deformity, gingival hypertrophy and subcutaneous fibromatosis in the back, scalp and extremities. Fibromas of JHF are histologically characterized by the deposition of amorphous hyaline material in the extracellular milieu of the dermis and soft tissues . Recently, mutations in capillary morphogenesis gene 2 (CMG2) were identified in JHF patients . CMG2 was originally identified as a gene expressed at elevated levels in human umbilical...
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Keisuke Tanaka, Tetsuya Ebihara, Masashi Kusubata, Eijiro Adachi, Masami Arai, Noriyoshi Kawaguchi, Joji Utsunomiya, Yoshio Miki, Michiaki Hiramoto, Shunji Hattori, Shinkichi Irie Tags: Letters to the Editor Source Type: journals

The effect of proopiomelanocortin-derived peptides on the immune system of human hair folliclesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Proopiomelanocortin (POMC) is a prohormone produces various bioactive peptides via a series of enzymatic steps in a tissue-specific manner, including adrenocorticotropin (ACTH), α-melanocyte stimulating hormone (α-MSH), and β-endorphin. POMC is expressed not only in the pituitary gland, but also in a variety of non-pituitary organs, including the skin . The functions of POMC-derived peptides in immunomodulation are still under investigation. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Sanghoon Lee, Long-Quan Pi, Young-Lip Park, Kyu-Uang Whang, Soo-Young Jeon, Won-Soo Lee Tags: Letters to the Editor Source Type: journals

Xp22.3 microdeletions in three Chinese families with X-linked ichthyosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
X-linked ichthyosis (XLI), an inborn error of metabolism due to steroid sulfatase deficiency , is caused by mutations in STS encoding the steroid sulfatase. About 90% of the XLI cases have genomic microdeletions encompassing the STS locus . Occasionally, STS deletions can extend to the neighboring genes, leading to a contiguous gene syndrome that may combine the classical XLI with mental retardation, chondrodysplasia punctata, Kallmann syndrome (KAL1), short stature, and/or ocular albinism type 1 . (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Dan-Dan Shang, Xue Zhang, An Liu, Li Du, Wei-Ying Jiang, Sheng-Xiang Xiao Tags: Letters to the Editor Source Type: journals

Identification of the major allergen of Malassezia globosa relevant for atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: MGp42 may be a cleavage product of intact HSP70. This novel M. globosa allergen could be useful for the diagnosis of AD. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Yoshio Ishibashi, Hiroshi Kato, Yoko Asahi, Takashi Sugita, Akemi Nishikawa Tags: Regular articles Source Type: journals

Effects of hydroquinone and its glucoside derivatives on melanogenesis and antioxidation: Biosafety as skin whitening agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Deoxyarbutin exerts potent tyrosinase inhibition, lessened cytotoxicity, and certain antioxidation potential, may serve as an effective and safe alternative to hydroquinone for use in skin whitening. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Zhi-Ming Hu, Qiong Zhou, Tie-Chi Lei, Shen-Feng Ding, Shi-Zheng Xu Tags: Regular articles Source Type: journals

HB-EGF-induced VEGF production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results demonstrate that HB-EGF-induced eNOS activation depends on p42/p44 MAPK, PI3K/Akt pathways and endogenous VEGF in HaCaT cells. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Kozo Nakai, Kozo Yoneda, Tetsuya Moriue, Junske Igarashi, Hiroaki Kosaka, Yasuo Kubota Tags: Regular articles Source Type: journals

Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing compoundsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The topical application of P-334+SH protected against UV-induced skin damage in mice and contributed to maintaining the antioxidant defence system of the skin as well as Hsp70 expression. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: F. de la Coba, J. Aguilera, M.V. de Gálvez, M. Álvarez, E. Gallego, F.L. Figueroa, E. Herrera Tags: Regular articles Source Type: journals

The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-cultureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study indicates the advantage of using a new skin equivalent model incorporating a small fraction of MSCs to develop biologically useful tissues for maintaining homeostasis during skin regeneration and wound healing process. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Filip Laco, Ma Kun, Hans Joachim Weber, S. Ramakrishna, Casey K. Chan Tags: Regular articles Source Type: journals

Gender-linked differences in human skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The knowledge of gender-linked cutaneous differences might help in preparing male-specific products for more appropriate dermatological treatments or cosmetic interventions. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Authors: Paolo U. Giacomoni, Thomas Mammone, Matthew Teri Tags: Review article Source Type: journals

34th Annual Meeting of the Japanese Society of Investigative Dermatology (JSID) and the JSID-Asia-Oceania-Forum on Hair Research and Stem Cells December 4-6, 2009, in Fukuoka City, Kyushu, JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Tags: Editorial Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 28, 2009 Category: Dermatology Source Type: journals

AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 10, 2009 Category: Dermatology Source Type: journals

Prevalence of atopic dermatitis in Japanese adults and community validation of the U.K. diagnostic criteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this current study was to confirm these results by evaluating the prevalence of adult AD in other areas of Japan, because there have been few studies in adults. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 10, 2009 Category: Dermatology Authors: Hidehisa Saeki, Naoki Oiso, Masaru Honma, Hajime Iizuka, Akira Kawada, Kunihiko Tamaki Tags: Letters to the Editor Source Type: journals

Analysis of variation in the IL7RA and IL2RA genes in atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex genetic background. It belongs to the group of atopic disorders that are characterized by a T helper (Th) type 2-dominated immune response. Recent evidence suggested that atopic diseases and autoimmune disorders (which are mainly Th1-driven) may not be mutually exclusive, but rather share certain risk factors that increase the development of either Th1- or Th2-immune responses to non-pathogenic antigens . (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 10, 2009 Category: Dermatology Authors: S. Hoffjan, J. Beygo, D.A. Akkad, Q. Parwez, E. Petrasch-Parwez, J.T. Epplen Tags: Letters to the Editor Source Type: journals

Extensive genetic polymorphism in the haplotype STR-TNF and HLA class I with the onset and evolution of psoriasis vulgarisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Psoriasis is an inflammatory and autoimmune disease, clinically characterized by hyperproliferation of epidermis. The cause of the disease is unknown, but one of its most consistent associations involves the Major Histocompatibility Complex (MHC) and triggering factors . Many genes are located in the MHC region and the most important is the tumor necrosis factor-alpha (TNF-α). Several polymorphisms, including microsatellites (Short Tandem Repeats – STR), were identified in the TNF-α gene found in the MHC class III region. Some studies point out that those polymorphisms are related to the production level of the TNF-α ...
Source: Journal of Dermatological Science - July 10, 2009 Category: Dermatology Authors: A.C. Biral, R.F. Magalhaes, I.J. Wastowski, R. Simoes, E.A. Donadi, A.L. Simoes, C.T. Mendes-Junior, M.H.S. Kraemer Tags: Letters to the Editor Source Type: journals