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Recent cardiovascular trials: What are the drivers of benefit and adverse effect?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - October 28, 2009 Category: Endocrinology Authors: Zachary Bloomgarden Tags: Editorial Source Type: journals

Journal of Diabetes NEWSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - October 27, 2009 Category: Endocrinology Tags: Journal of Diabetes NEWS Source Type: journals

Long-term effects of a carbohydrate-rich diet on fasting blood sugar, lipid profile, and serum insulin values in rural BengalisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The effects of increased carbohydrate on FBS, serum insulin, triglycerides and VLDL-C indicate that a proper nutritional policy needs to be implemented for this population of rural, low-income Bengalis. (Source: Journal of Diabetes)
Source: Journal of Diabetes - September 3, 2009 Category: Endocrinology Authors: Sutapa MUKHERJEE, Goutam THAKUR, Balasubramaniam Dinesh KUMAR, Analava MITRA, Chandan CHAKRABORTY Tags: Original Articles Source Type: journals

Cancer mortality and insulin glargineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - August 27, 2009 Category: Endocrinology Authors: Zachary Bloomgarden, Yehuda Handelsman Tags: Editorial Source Type: journals

Diabetes and skeletal healthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteoporosis and diabetes affect a large proportion of the elderly population. The prevalence of diabetes and osteoporosis is increasing. Compared with individuals without diabetes, both men and women with diabetes have a higher risk of fractures, particularly at the hip, with consequent significant morbidity and mortality. Type 1 diabetes is associated with decreased bone mass and although bone mass data for Type 2 diabetes may or may not be decreased, there is evidence of altered bone quality in diabetes. The mechanisms involved include effects of insulin, insulin-like growth factor 1, cytokines, advanced glycation end p...
Source: Journal of Diabetes - August 17, 2009 Category: Endocrinology Authors: Subhashini YATURU Tags: Reviews Source Type: journals

Serum concentrations of vitamin D and parathyroid hormone and prevalent metabolic syndrome among adults in the United StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Some reports suggest that concentrations of vitamin D are inversely, whereas concentrations of parathyroid hormone (PTH) are directly, associated with prevalent metabolic syndrome. Because of lingering uncertainty about these associations, we examined the cross-sectional associations between serum concentrations of 25-hydroxyvitamin D3 and PTH with metabolic syndrome in a representative sample of adults in the US.Methods: We used data from 1705 participants in the 2005[ndash]2006 National Health and Nutrition Examination Survey. Vitamin D was measured by radioimmunoassay, whereas PTH was measured using an elect...
Source: Journal of Diabetes - July 21, 2009 Category: Endocrinology Authors: Earl S. FORD, Guixiang ZHAO, Chaoyang LI, William S. PEARSON Tags: Original Articles Source Type: journals

Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Genistein activates the antioxidant profile, decreases IL-6 and TNF-[alpha] concentrations, prevents oxidative damage, and ameliorates fatty liver in insulin-resistant rats. (Source: Journal of Diabetes)
Source: Journal of Diabetes - July 21, 2009 Category: Endocrinology Authors: Sumiyabanu MOHAMED SALIH, Palanisamy NALLASAMY, Pooranaperundevi MUNIYANDI, Viswanathan PERIYASAMI, Anuradha CARANI VENKATRAMAN Tags: Original Articles Source Type: journals

Antecedent caloric intake and glucose excursion following a subsequent meal in Type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: For optimal postprandial glucose control, people with Type 1 diabetes may need to consider not only anticipated meal calories, but also prior food intake, a practice not commonly recommended based on currently used insulin dosing algorithms. (Source: Journal of Diabetes)
Source: Journal of Diabetes - July 18, 2009 Category: Endocrinology Authors: Rinku MEHRA, Ramesh RAMAN, Margaret L. BAYLESS, William I. SIVITZ Tags: Original Articles Source Type: journals

Journal of Diabetes NEWSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - July 8, 2009 Category: Endocrinology Tags: Journal of Diabetes NEWS Source Type: journals

Glucose represses PPARαgene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic β-cellEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results indicate that glucose represses PPAR[alpha] gene expression via AMPK, but not via p38 MAPK in the [beta]-cell. (Source: Journal of Diabetes)
Source: Journal of Diabetes - July 8, 2009 Category: Endocrinology Authors: Erik JOLY, Raphaël RODUIT, Marie-Line PEYOT, Susan Amy HABINOWSKI, Neil Bertrand RUDERMAN, Lee Alan WITTERS, Marc PRENTKI Tags: Original Articles Source Type: journals

Metabolic syndrome and chronic kidney diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prevalence of metabolic syndrome (MetS) is increasing worldwide in both developing and developed countries. Experimental and clinical studies have revealed that MetS plays an important role in the development of chronic kidney disease (CKD), which leads to end-stage renal disease. Emerging evidence also suggests that CKD may actually cause MetS since the kidney is an important organ of glucose and lipid homeostasis. Although multiple mechanisms have been shown to be involved in the pathogenesis of MetS, insulin resistance appears to be a central pathophysiological factor contributing to MetS. In this review we will dis...
Source: Journal of Diabetes - July 8, 2009 Category: Endocrinology Authors: Xiongzhong RUAN, Youfei GUAN Tags: Reviews Source Type: journals

Ethnic difference in patients with type 2 diabetes mellitus in inter-East Asian populations: A systematic review and meta-analysis focusing on gene polymorphismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results of this study and our previous studies suggest that behavioral and environmental risk factors have a more significant impact on ethnic difference in East Asian patients with T2DM compared with genetic predispositions. (Source: Journal of Diabetes)
Source: Journal of Diabetes - July 2, 2009 Category: Endocrinology Authors: Masakazu TAKEUCHI, Kousuke OKAMOTO, Tatsuya TAKAGI, Hitoshi ISHII Tags: Original Articles Source Type: journals

Journal of Diabetes EBMEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - July 1, 2009 Category: Endocrinology Tags: Journal of Diabetes EBM Source Type: journals

Early life factors and Type 2 diabetes in south India: Do the associations change with age?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Short birth length remains a risk factor for diabetes. Changes in the effects of birth length and maternal weight on diabetes risk with age may indicate different causal pathways. These findings require replication in studies with more accurate dating of the onset of diabetes. (Source: Journal of Diabetes)
Source: Journal of Diabetes - June 29, 2009 Category: Endocrinology Authors: Sargoor R. VEENA, Andrew K. WILLS, David J. FISHER, Claudia E. STEIN, Kalyanaraman KUMARAN, Ghattu V. KRISHNAVENI, Krishnarajasagara N. KIRAN, Patsy J. COAKLEY, Caroline H.D. FALL Tags: Original Articles Source Type: journals

Progress in diabetes research in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prevalence of diabetes, especially Type 2 diabetes mellitus (T2DM), is increasing markedly throughout the world, including in China. Because T2DM and its complications are associated with considerable socioeconomic burden and mortality, there is increasing interest in developing strategies to prevent or delay progression of the disease. In recent decades, many researchers have focused on the mechanism of onset of diabetes, as well as examining the benefits of various interventions in subjects with different glucose tolerance status to prevent or delay development of the disease. In the present article, we focus on five...
Source: Journal of Diabetes - June 29, 2009 Category: Endocrinology Authors: Guang NING, Jie HONG, Yufang BI, Weiqiong GU, Yifei ZHANG, Zhiguo ZHANG, Yun HUANG, Weiqing WANG, Xiaoying LI Tags: Review Source Type: journals

Indian diabetes risk score according to menopausal status in Asian Indian women: The Santiniketan Women studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - June 29, 2009 Category: Endocrinology Authors: Arnab GHOSH, Minakshi BHAGAT Tags: Research Letter Source Type: journals

Randomized clinical trial of standard dietary treatment versus a low-carbohydrate/high-protein diet or the LighterLife Programme in the management of obesity*Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Greater weight loss and improved CV risk were achieved with the LL, which mostly reflects the patient support provided for each dietary treatment. (Source: Journal of Diabetes)
Source: Journal of Diabetes - June 25, 2009 Category: Endocrinology Authors: Catherine ROLLAND, Michelle HESSION, Susan MURRAY, Alan WISE, Iain BROOM Tags: Original Articles Source Type: journals

Dietary fiber improves lipid homeostasis and modulates adipocytokines in hamstersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Reductions in plasma cholesterol and triglyceride levels were correlated with a decrease in plasma leptin and an increase in adiponectin. These results suggest that adipocytokines are regulated by HPMC and may play a pivotal role in the hypocholesterolemic effect. (Source: Journal of Diabetes)
Source: Journal of Diabetes - June 25, 2009 Category: Endocrinology Authors: Shao-Ching HUNG, Glenn BARTLEY, Scott Andrew YOUNG, David Robert ALBERS, Demetrius Richard DIELMAN, William Henry Kerr ANDERSON, Wallace YOKOYAMA Tags: Original Articles Source Type: journals

Journal of Diabetes EBMEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - June 22, 2009 Category: Endocrinology Tags: Journal of Diabetes EBM Source Type: journals

Journal of Diabetes NEWSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - June 22, 2009 Category: Endocrinology Tags: Journal of Diabetes NEWS Source Type: journals

Additional value of carotid artery intima-media thickness in cardiovascular risk assessment by Framingham risk-score in Type 2 diabetes: a retrospective cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although FRS predicts 10-year risk for cardiovascular mortality and morbidity in T2DM, we suggest that UAE and carotid artery IMT should also be considered in risk assessments. (Source: Journal of Diabetes)
Source: Journal of Diabetes - June 1, 2009 Category: Endocrinology Authors: Hayriye Esra ATAOGLU, Tayyibe SALER, Isil UZUNHASAN, Mustafa YENIGUN, Zehra YIGIT, Levent Umit TEMIZ, Zuhal SAGLAM, Faik CETIN, Baki KUMBASAR, Fuat SAR Tags: Original Articles Source Type: journals

Diabetic foot ulcer burden may be modified by high-dose atorvastatin: A 6-month randomized controlled pilot trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Diabetic foot ulcers (DFUs) are common complications of diabetes mellitus (DM), with a complex pathogenesis. Treatment is difficult and no single treatment with measurable clinical impact is available. In the present clinical pilot trial, we investigated whether statins could be of use against some of the pathogenic factors in DFUs.Methods: Thirteen diabetic patients (10 men; 11 with Type 2 DM; mean age 64 years; mean duration of DM 18 years) with neuropathic DFUs (Source: Journal of Diabetes)
Source: Journal of Diabetes - June 1, 2009 Category: Endocrinology Authors: Odd Erik JOHANSEN, Kåre Inge BIRKELAND, Anders Palmstrøm JØRGENSEN, Elsa ORVIK, Beate SØRGÅRD, Bjørn Rino TORJUSSEN, Thor UELAND, Pål AUKRUST, Lars GULLESTAD Tags: Original Articles Source Type: journals

Reactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vascular complications are an important pathological issue in diabetes that lead to the further functional deterioration of several organs. The balance between endothelium-dependent relaxing factors and endothelium-dependent contracting factors (EDCFs) is crucial in controlling local vascular tone and function under normal conditions. Diabetic endothelial dysfunction is characterized by reduced endothelium-dependent relaxations and/or enhanced endothelium-dependent contractions. Elevated levels of oxygen-derived free radicals are the initial source of endothelial dysfunction in diabetes. Oxygen-derived free radicals not on...
Source: Journal of Diabetes - June 1, 2009 Category: Endocrinology Authors: Yi SHI, Paul Michel VANHOUTTE Tags: Review Source Type: journals

What is the evidence base for the randomized controlled trial?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - May 31, 2009 Category: Endocrinology Authors: Zachary Bloomgarden, Guang Ning Tags: Editorial Source Type: journals

Smoking, diabetes and cardiovascular diseases in men in the Asia Pacific regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The effects of cigarette smoking and smoking cessation are broadly similar in men with and without diabetes. In Asia, where there are high rates of smoking and a rapidly increasing prevalence of diabetes, strategies that encourage smokers to quit are likely to have huge benefits in terms of reducing the burden of CVD in men with diabetes. (Source: Journal of Diabetes)
Source: Journal of Diabetes - May 4, 2009 Category: Endocrinology Authors: Andre Pascal KENGNE, Koshi NAKAMURA, Federica BARZI, Tai Hing LAM, Rachel HUXLEY, Dongfeng GU, Anushka PATEL, Hyeon Chang KIM, Mark WOODWARD Tags: Original Articles Source Type: journals

CommitteesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - April 1, 2009 Category: Endocrinology Tags: Abstracts of the 3rd International Congress on Prediabetes and the Metabolic Syndrome, 1-4 April, 2009, Nice, France Source Type: journals

Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: Possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results suggest the following molecular etiopathophysiology of DN: (i) hyperglycemia upregulates IGF2, which initiates PTEN, a regulator of IGF2 signaling; (ii) loss of this IGF2[ndash]PTEN feedback loop causes changes that are characteristic of DN; and (iii) lowered expression of the repair modulator SPARC results in the development and/or progression of DN. Hence, targeting relevant modulators, such as like IGF2, PTEN, and SPARC, may be important in the management of DN. (Source: Journal of Diabetes)
Source: Journal of Diabetes - March 26, 2009 Category: Endocrinology Authors: Movva SIREESHA, Venkatasubramanian SAMBASIVAN, Vattam Kiran KUMAR, Sistla RADHA, Ahuja Yog RAJ, Hasan QURRATULAIN Tags: Original Articles Source Type: journals

Insulin secretory function in Type 2 diabetes: Does it matter how you measure it?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The following estimates of insulin secretory function have been used widely to evaluate the role of pancreatic [beta]-cells in the pathogenesis and treatment of patients with type 2 diabetes (2DM): (i) Homeostatic Model Assessment (HOMA)-[beta], a calculation based on fasting plasma glucose and insulin concentrations; (ii) post-glucose acute insulin response (AIRg), the increment in insulin concentration measured in the 5 min after intravenous glucose; and (iii) [Delta]I/[Delta]G, the ratio of the increment in plasma insulin concentration (I)/increment in plasma glucose concentration (G) 30 min after the oral administratio...
Source: Journal of Diabetes - March 18, 2009 Category: Endocrinology Authors: Gerald M. REAVEN Tags: Review Source Type: journals

Serum retinol-binding protein 4 is associated with insulin secretion in Chinese people with normal glucose toleranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Serum RBP4 is correlated with glucose-stimulated insulin secretion in NGT non-VO subjects, but not in NGT VO subjects and T2DM patients. (Source: Journal of Diabetes)
Source: Journal of Diabetes - March 18, 2009 Category: Endocrinology Authors: Ling LI, Chen WANG, Yuqian BAO, Haiya WU, Junxi LU, Kunsan XIANG, Weiping JIA Tags: Original Articles Source Type: journals

Mild and severe forms of tuberculosis in diabetic and non-diabetic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Severe pulmonary involvement in DM patients may be due to smoking status. (Source: Journal of Diabetes)
Source: Journal of Diabetes - March 18, 2009 Category: Endocrinology Authors: Serpil OCAL, Dilek SAKA, Mihriban OGRETENSOY Tags: Original Articles Source Type: journals

Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase-independent mannerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: On the basis of the results of the present study, we postulate that cinnamic acid isolated from the hydro-alcoholic extract of Cinnamomum cassia activates glucose transport by a PI3-K-independent pathway. However, the detailed mechanism of action requires further analysis. (Source: Journal of Diabetes)
Source: Journal of Diabetes - March 18, 2009 Category: Endocrinology Authors: Baddireddi Subhadra LAKSHMI, Sundaresan SUJATHA, Singaravelu ANAND, Kadapakkam Nandhabalan SANGEETHA, Rangarajan Badri NARAYANAN, Chandrakanth KATIYAR, Anil KANAUJIA, Rajeev DUGGAR, Yogendra SINGH, Konasubrahmanya SRINIVAS, Vinay BANSAL, Simi SARIN, Ruchi Tags: Original Articles Source Type: journals

Effects of systolic and diastolic blood pressures on incident coronary heart disease and all-cause death in Chinese women with Type 2 diabetes: The Hong Kong Diabetes RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We identified 130 mmHg as the threshold of SBP for increased risk of CHD in Chinese female patients with T2DM. It appears that 67[ndash]77 mmHg is the optimal range for diastolic BP, within which the risk of CHD is lowest. (Source: Journal of Diabetes)
Source: Journal of Diabetes - March 18, 2009 Category: Endocrinology Authors: Ronald Ching Wan MA, Xilin YANG, Gary Tin Choi KO, Wing Yee SO, Alice Pik Shan KONG, Chung Shun HO, Christopher Wai Kei LAM, Chun Chung CHOW, Peter Chun Yip TONG, Juliana Chung Ngor CHAN Tags: Original Articles Source Type: journals

Intensified multifactorial treatment of patients with Type 2 diabetes: What can be achieved and does it pay off?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
By influencing the standards of diabetes care and treatment guidelines throughout the world, the results of recent long-term risk factor interventions in Type 2 diabetes (T2D) have likely contributed to the improved health outcomes and induced a decline in mortality in people with T2D. Although we have a need for even more evidence to support early, individualized, and intensive management of all known modifiable risk factors, we have now reached an era in T2D care where the critical challenges appear to be to translate the insights, knowledge and benefits to patients in the community setting. Current surveys show slow pro...
Source: Journal of Diabetes - March 18, 2009 Category: Endocrinology Authors: Oluf PEDERSEN Tags: Review Source Type: journals

IndexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - February 25, 2009 Category: Endocrinology Tags: Index Source Type: journals

PostersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - February 25, 2009 Category: Endocrinology Tags: Posters Source Type: journals

Poster Discussion SessionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - February 25, 2009 Category: Endocrinology Tags: Poster Discussion Sessions Source Type: journals

Satellite SymposiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - February 25, 2009 Category: Endocrinology Tags: Satellite Symposia Source Type: journals

Lectures and Oral PresentationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Diabetes)
Source: Journal of Diabetes - February 25, 2009 Category: Endocrinology Tags: Lectures and Oral Presentations Source Type: journals

Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although previous reports suggest that higher levels of cholesterol absorption in T1DM potentially increase cardiovascular risk in this population, the present data suggest no differences in cholesterol absorption between T1DM individuals with and without CAD. (Source: Journal of Diabetes)
Source: Journal of Diabetes - January 27, 2009 Category: Endocrinology Authors: Christina Marie SHAY, Rhobert Wyn EVANS, Trevor John ORCHARD Tags: Original Articles Source Type: journals