Tanshinone IIA suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual‐like protein 1 and acyl‐coenzyme A synthetase long‐chain family member 4 signaling pathway
ConclusionTIIA treatment restrained HG-caused MPC5 cell injury and ferroptosis partly through targeting the ELAVL1 –ACSL4 axis, providing a promising therapeutic target for DN treatment. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 23, 2024 Category: Endocrinology Authors: Shuai Zhu,
Zhiqiang Kang,
Fengjiao Zhang Tags: Original Article Source Type: research
Risk factors and prediction score for new ‐onset diabetes mellitus after liver transplantation
ConclusionsAge at the time of transplantation, preoperative IFG, postoperative FPG, and length of hospital stay were independent predictive factors of NODALT. The use of a simple risk prediction score can identify the patients who have the highest risk of NODALT and interventions may start early. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 20, 2024 Category: Endocrinology Authors: Ruiping Bai,
Rui An,
Siyu Chen,
Wenkang Ding,
Mengwen Xue,
Ge Zhao,
Qingyong Ma,
Xin Shen Tags: Original Article Source Type: research
Medical database analysis of the association between kidney function and achievement of glycemic control in older Japanese adults with type 2 diabetes who started with oral antidiabetic drugs
ConclusionsIn older Japanese adults with type 2 diabetes, those with a lower estimated glomerular filtration rate were more likely to achieve hemoglobin A1c of<7.0%. To safely manage blood glucose levels in older adults with chronic kidney disease, physicians should remain vigilant about the risk of iatrogenic hypoglycemia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 19, 2024 Category: Endocrinology Authors: Ryo Suzuki,
Kiyoyasu Kazumori,
Tatsuya Usui,
Masahiko Shinohara Tags: Original Article Source Type: research
Long ‐term efficacy of encapsulated xenogeneic islet transplantation: Impact of encapsulation techniques and donor genetic traits
ConclusionThe AC-PFD capsule, designed to ameliorate both hypoxia and inflammation, showed the highest long-term efficacy in xenogeneic islet transplantation. Genetic modifications of porcine islets with GTKO or GTKO with overexpression of membrane cofactor protein did not influence naked islet transplantation outcomes, but did delay graft failure when encapsulated. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 18, 2024 Category: Endocrinology Authors: Heon ‐Seok Park,
Eun Young Lee,
Young‐Hye You,
Marie Rhee,
Jong‐Min Kim,
Seong‐Soo Hwang,
Poong‐Yeon Lee Tags: Original Article Source Type: research
Plantar pressure measurement in diabetic foot disease: A scoping review
ConclusionsPlantar pressure measurement can and will play a major role in the prevention of DFU. There is already a strong, albeit limited, evidence base in place to prove its benefit in reducing DFU recurrence. More research is required in larger populations, using remote monitoring in real-world settings, and with improved technology. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 18, 2024 Category: Endocrinology Authors: Michael Lockhart,
Sean F Dinneen,
Derek T O'Keeffe Tags: Review Source Type: research
Implementation rate of diabetic self ‐management education and support for Japanese people with diabetes using the National Database
We investigated the implementation rates of diabetes self-management education and support in outpatients using the National Database of claims data. We showed that care related to diabetes self-management education and support might not be adequately provided for Japanese patients with diabetes. Nutrition guidance (5.6%) was the most frequently provided care type, and insulin users and patients visiting large medical institutions were associated with higher implementation rates of nutrition guidance. AbstractPeople with diabetes are encouraged to receive diabetes self-management education and support (DSMES) appropriately...
Source: Journal of Diabetes Investigation - April 17, 2024 Category: Endocrinology Authors: Noriko Ihana ‐Sugiyama,
Takehiro Sugiyama,
Kenjiro Imai,
Mitsuru Ohsugi,
Kohjiro Ueki,
Toshimasa Yamauchi,
Takashi Kadowaki Tags: Short Report Source Type: research
Corrigendum to “Leucine–glycine and carnosine dipeptides prevent diabetes induced by multiple low‐doses of streptozotocin in an experimental model of adult mice”
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 14, 2024 Category: Endocrinology Tags: Corrigendum Source Type: research
Associations of fasting plasma glucose with all ‐cause mortality and cardiovascular events in older Chinese diabetes patients: A population‐based cohort study
ConclusionsIn older Chinese diabetes patients, the FPG ranges related to the minimum death and CVD event rates were 5.50 –7.50 and 4.50–7.50 mmol/L, respectively. Patients with more cardiovascular risk factors had higher optimal blood glucose ranges than those with fewer risk factors. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 10, 2024 Category: Endocrinology Authors: Linan Wang,
Wei Zhang,
Juan Dai,
Qing Deng,
Yaqiong Yan,
Qing Liu Tags: Original Article Source Type: research
Nutrient quality in dietary therapy for diabetes and diabetic kidney disease
Diet therapy is crucial for treatment of diabetes and its complications, including diabetic kidney disease. Considering the diversification of the pathophysiology and comorbidities of diabetes, it might become crucial in the future to focus on the quality of nutrients in the diet rather than just the quantity. This suggests that individualized dietary therapy could be increasingly important. ABSTRACTDietary therapy is crucial for diabetes care with the aim of preventing the onset and progression of diabetes and its complications. The traditional approach to dietary therapy for diabetes has primarily focused on restricting ...
Source: Journal of Diabetes Investigation - April 9, 2024 Category: Endocrinology Authors: Hiroaki Tsuruta,
Sho Sugahara,
Shinji Kume Tags: REVIEW ARTICLE Source Type: research
The role of vascular adhesion protein ‐1 in diabetes and diabetic complications
Vascular adhesion protein-1 (VAP-1) has adhesive and enzymatic functions, aiding leukocyte migration to inflammation sites and producing by-products linked to diabetic complications. This review focuses on the impact of VAP-1 on diabetes and its complications, its association with related diseases, and the potential of soluble VAP-1 as a biomarker. ABSTRACTVascular adhesion protein-1 (VAP-1) plays a dual role with its adhesive and enzymatic properties, facilitating leukocyte migration to sites of inflammation and catalyzing the breakdown of primary amines into harmful by-products, which are linked to diabetic complications...
Source: Journal of Diabetes Investigation - April 7, 2024 Category: Endocrinology Authors: I ‐Weng Yen,
Hung‐Yuan Li Tags: REVIEW Source Type: research
Advances in diagnostic methods for early ‐stage diabetic polyneuropathy
Significant advancements have been made in diagnostic methods for early-stage diabetic polyneuropathy. Early and accurate diagnosis of diabetic polyneuropathy is crucial for preventing further complications and enabling timely intervention. Furthermore, there is a need for an objective numerical value to evaluate the early stage of diabetic polyneuropathy. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 6, 2024 Category: Endocrinology Authors: Keiko Naruse Tags: Update Source Type: research
An update of contemporary insulin therapy
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 4, 2024 Category: Endocrinology Authors: Yuan ‐Yu Tsai,
Yuh‐Shiou Gu,
Yi‐Der Jiang Tags: Update Source Type: research
What characteristics are most important in stratifying patients into groups with different risk of diabetic foot ulceration?
ConclusionsImpaired sensations to temperature, vibration and touch were shown to be the strongest factors in stratifying patients into two groups with one group having almost 5-fold risk of future foot ulceration compared to the other. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 4, 2024 Category: Endocrinology Authors: Roozbeh Naemi,
Nachiappan Chockalingam,
Janet K Lutale,
Zulfiqarali G Abbas Tags: Original Article Source Type: research
Remnant cholesterol, but not other traditional lipids or lipid ratios, is independently and positively related to future diabetes risk in Chinese general population: A 3 year cohort study
ConclusionsIt was RC, but not other lipid parameters, that was independently and positively related to a future risk of diabetes among the Chinese general population. Moreover, the relationship between RC and diabetes risk was stable, even with appropriate levels of HDL-C. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 3, 2024 Category: Endocrinology Authors: Binqi Li,
Yang Liu,
Xin Zhou,
Weijun Gu,
Yiming Mu Tags: Original Article Source Type: research
Gut microbiota dysbiosis as a novel pathogenic factor of diabetic peripheral neuropathy
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 2, 2024 Category: Endocrinology Authors: Naoko Niimi,
Kazunori Sango Tags: Commentary Source Type: research
