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(Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 1, 2009 Category: Endocrinology Source Type: journals

Rapid effect of mosapride citrate, 5-HT4 receptor agonist, on fasting blood glucose in Type 2 diabetes patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously reported that mosapride citrate, 5-HT4 receptor agonist, improved glycemic control in Type 2 diabetes patients. Administration of mosapride citrate (15 mg/day) orally for 8 weeks decreased fasting blood glucose, HbA1c and serum insulin levels. Mosapride increased the glucose infusion rate during hyperinsulinemic–normoglycemic glucose clamp study and increased tyrosine autophosphorylation as well as the number of insulin receptors on the erythrocytes of the patients, and expression of 5-HT4 receptors was detected in muscles; therefore, we concluded that mosapride citrate improved insulin sensitivity in ...
Source: Journal of Diabetes and Its Complications - June 25, 2009 Category: Endocrinology Authors: Naohiko Ueno, Yoshiko Satoh Tags: Letter to the Editor Source Type: journals

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(Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 25, 2009 Category: Endocrinology Source Type: journals

The incidence of heart failure among nondiabetic patients with and without impaired fasting glucoseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: The purpose of this study was to elucidate the relationship between fasting plasma glucose (FPG), development of diabetes, and incident heart failure (HF) in a large, community sample of nondiabetic subjects.Research Design and Methods: From Kaiser Permanente Northwest medical records, we identified 10,113 subjects with an FPG level of 100–125 mg/dl in 1997 or 1998 who were free of diabetes and HF and matched them to an equal number of subjects with an FPG level of (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Gregory A. Nichols, Carol E. Koro, Nikheel S. Kolatkar Tags: Original Articles Source Type: journals

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) meeting summary: Advances toward measuring diabetic retinopathy and neuropathy: from the bench to the clinic and back again (April 4–5, 2007, Baltimore, Maryland)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The National Institute of Diabetes and Digestive and Kidney Diseases sponsored a meeting recently to explore new ways to assess diabetic retinopathy and neuropathy, both in diabetic patients and in diabetic mice. The workshop compared current gold standards for assessment of retinopathy and neuropathy, new improvements of existing techniques, and new functional biomarkers measured with nontraditional technologies. Since the anatomical changes that comprise diabetic retinopathy and neuropathy take long to develop and have proven difficult to arrest once initiated, some talks highlighted the value of methods that a...
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Timothy S. Kern, Bruce A. Berkowitz, Eva L. Feldman Tags: Original Articles Source Type: journals

The effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to observe the effect of simvastatin on the serum monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in diabetic rats.Methods: Twenty-four Wistar rats were randomly assigned to a normal control group (Group A, n=8), and STZ-induced diabetic group (Group B, n=8), or a simvastatin-treated diabetic group (Group C, n=8). Rats in Group C were treated with simvastatin (20 mg kg−1 day−1) 1 week after the establishment of the diabetic model. Groups A and B were treated with corresponding sodium chloride. Per...
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Yang Lin, Shandong Ye, Yan Chen, Xiucai Li, Guang-wei Yang, Aihong Fan, Yingxin Wang Tags: Original Articles Source Type: journals

The effects of sulfonylurea glyburide on superoxide dismutase, catalase, and glutathione peroxidase activities in the brain tissue of streptozotocin-induced diabetic ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we administrated GLY to streptozotocin-induced diabetic rats and determined the effects of such treatment on activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) from brain tissue.Results and Discussion: Brain CAT and GPx activities were not significantly different in the diabetic group compared to controls (P>.05), but the SOD activity was significantly reduced in the diabetic group compared to controls (P (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Namık K. Nazaroglu, Aylin Sepici-Dincel, Nilgun Altan Tags: Original Articles Source Type: journals

Westernized-like-diet-fed rats: effect on glucose homeostasis, lipid profile, and adipocyte hormones and their modulation by rosiglitazone and glimepirideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Wersternized diet, containing high fat diet intake combined with high consumption of softdrinks, is accused with the emerge of modern epidemic obesity and diabesity. Therefore, we aimed to study the effect of this diet combination on the homeostasis of glucose, lipids, and some adipohormones in rats and to simulate the metabolic perturbations induced by the unhealthy Westernized diet intake, leading to the development of type 2 diabetes. To achieve this, we divided male Wistar rats (80–120 g) into two main groups: the first was fed commercial normal fat diet and the second received an in-house-prepared high-fat...
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Mona Schaalan, Hanan S. El-Abhar, Maged Barakat, Ezzedin S. El-Denshary Tags: Original Articles Source Type: journals

Iron status in women with and without gestational diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, concentration of serum ferritin, iron, transferrin saturation and hemoglobin, MCV, and MCH was significantly higher in the GDM group and TIBC was significantly lower in this group (P (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Mohammad Afkhami-Ardekani, Maryam Rashidi Tags: Original Articles Source Type: journals

Incidence and progression of diabetic retinopathy in Hong Kong Chinese with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The incidence of DR in our study was similar to—but progression of DR was higher than—those reported in Caucasians. More frequent retinal screening should be offered to those with baseline DR, high HbA1c, or albuminuria. Good glycemic control is important in order to prevent the development and progression of DR, and can lead to regression of DR. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Vicki H.K. Tam, Ellen P.K. Lam, Benjamin C.Y. Chu, K.K. Tse, L.M. Fung Tags: Original Articles Source Type: journals

Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. Recent reports have shown that inflammation is one of potential pathogenic mechanisms for diabetic nephropathy. However, information on inflammation related with CXC chemokines in human Type 2 diabetic nephropathy still remains scarce. We measured urinary and serum levels of three CXC chemokines, CXCL5, CXCL8 and CXCL9, in 45 Type 2 diabetic patients (DM), 42 primary renal disease (PRD) patients and 22 healthy controls by enzyme-linked immunosorbent assay. Urinary levels of CXCL5, CXCL8 and CXCL9 in DM were significan...
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Mayumi Higurashi, Yoshiyuki Ohya, Kensuke Joh, Masahiro Muraguchi, Motonobu Nishimura, Hiroyuki Terawaki, Kazuo Yagui, Naotake Hashimoto, Yasushi Saito, Kenichi Yamada Tags: Original Articles Source Type: journals

Switching from pathogenetic treatment with α-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, switching from long-term treatment with α-lipoic acid to central analgesic drugs such as gabapentin in painful diabetic neuropathy was associated with considerably higher rates of side effects, frequencies of outpatient visits, and daily costs of treatment. The pathogenic treatment option represents for the practicing diabetologist an effective, safe, and cost-effective treatment option for the majority of patients with diabetic polyneuropathy. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Heinz–Jürgen Ruessmann, on behalf of the German Society of out patient diabetes centres AND (Arbeitsgemeinschaft niedergelassener diabetologisch tätiger Ärzte e.V.) Tags: Original Articles Source Type: journals

Influence of vitamin E supplementation on endothelial complications in type 2 diabetes mellitus patients who underwent coronary artery bypass graftEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study indicates that increased levels of the proinflammatory markers and AMs occur in type 2 DM. Vitamin E administration appears beneficial in lowering proinflammatory markers and their downstream effectors that played an important role in diabetic complications following CABG. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Nadia M. Hamdy, Salwa M. Suwailem, Hala O. El-Mesallamy Tags: Original Articles Source Type: journals

Cardiorespiratory capacity is associated with favourable cardiovascular risk profile in patients with Type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: The aim of this study was to examine the interaction between cardiorespiratory capacity and cardiovascular risk factors in patients with Type 2 diabetes mellitus (T2DM).Research Design/Methods: A total of 92 patients with T2DM (40 men, 52 women) performed a symptom-limited exercise test on ergocycle, with continuous gas exchange measurement. All patients were overweight or obese (body mass index >25 kg/m2), with poor glycemic control (hemoglobin A1c >7%), but free from overt diabetic vascular complications. Anthropometric parameters, blood pressure (BP), cardiorespiratory fitness, glycemic and lipid pr...
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Nikolaos P.E. Kadoglou, Fotios Iliadis, Nikoleta Angelopoulou, Nikolaos Sailer, Grigorios Fotiadis, Kleon Voliotis, Ioulia Vitta, Christos D. Liapis, Miltiadis Alevizos Tags: Original Articles Source Type: journals

The association between erectile dysfunction and cardiovascular risk in men with Type 2 diabetes in primary care: it is a matter of ageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The ED prevalence rate assessed by a single question was comparable to that assessed by questionnaires. ED neither did independently relate to patients' cardiovascular history nor to cardiovascular risk. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Authors: Frits G.W. Cleveringa, Margriet G.G. Meulenberg, Kees J. Gorter, Maureen van den Donk, Guy E.H.M. Rutten Tags: Original Articles Source Type: journals

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(Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 29, 2009 Category: Endocrinology Source Type: journals

Long-term benefits of insulin therapy and glycemic control in overweight and obese adults with type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Newer insulin formulations can effectively improve glycemic control without significant effects on patient weight and, therefore, may be particularly useful in patients who are overweight or obese. Implementation of comprehensive treatment regimens that emphasize dietary modification, physical activity, and exercise, and aggressive use of pharmacological agents to achieve tight glycemic control through physiological regimens offer the most promise for reducing long-term complications in obese patients with type 2 diabetes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: A. Enrique Caballero Tags: Review Article Source Type: journals

Case report: diabetic myonecrosis of the neck complicated by infection in an islet transplanted patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 38-year-old female Type 1 diabetic patient who developed acute neck pain 3 weeks following islet transplantation. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Payam Salehi, Margaret A. Stull, Joan Martellotto, Antonio Gangemi, Betul Hatipoglu, Enrico Benedetti, Josè Oberholzer Tags: Case Report Source Type: journals

Epidemiology of diabetic retinopathy in a Chinese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with interest the article by . They estimated the prevalence and incidence of diabetic retinopathy (DR) in a 4-year follow-up study of a Chinese population with type 2 diabetes mellitus attending a district hospital in Hong Kong (N=413). They reported the use of one pair of 45° stereo fundus photographs centered on the macula as their protocol for screening DR. This strategy seems to be appropriate for a country like China, where the ophthalmologist-to-population ratio might be low. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Enrique Soto-Pedre Tags: Letters to the Editor Source Type: journals

Candida albicans osteomyelitıs in a diabetic foot ulcerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteomyelitis complicates 50–60% of serious and 10–20% of less severe foot infections in diabetic patients. Cases may be mono- or polymicrobial and Staphylococcus aureus is the most commonly isolated agent (50%), while Staphylococcus epidermidis, streptococci, and Enterobacteriacea are also frequent isolates (). Fungal osteomyelitis is an uncommon disease and arises as a result of hematogenous dissemination, direct inoculation from an exogenous source, or direct extension from an adjacent focus that can be seen in diabetic foot lesions (). Candida osteomyelitis during the course of diabetic foot infections is a rare en...
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Serkan Yener, Alpaslan Topcu, Metin Manisali, Abdurrahman Comlekci, Sena Yesil Tags: Letters to the Editor Source Type: journals

Evaluation of the effect of oxidative stress and vitamin E supplementation on renal function in rats with streptozotocin-induced Type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that ROS may play an important role in diabetes-induced nephropathy in this rat model. Vitamin E supplementation in addition to insulin can have additive protective effects against deterioration of renal function in this model. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Mohamed A. Haidara, Dimitri P. Mikhailidis, Moshira A. Rateb, Zeinab A. Ahmed, Hanaa Z. Yassin, Ibrahim M. Ibrahim, Laila A. Rashed Tags: Original Articles Source Type: journals

Rosiglitazone protects diabetic rats against kidney disease through the suppression of renal moncyte chemoattractant protein-1 expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, rosiglitazone may have a potential therapeutic target in DN, which may be partly attributed to lowering of the expression of MCP-1 in the local kidney and the urinary excretion of MCP-1. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Mao Zheng, Shandong Ye, Zhimin Zhai, Yan Chen, Xiucai Li, Guangwei Yang, Aihong Fan, Yingxin Wang Tags: Original Articles Source Type: journals

Fast and low-cost analysis of heart rate variability reveals vegetative alterations in noncomplicated diabetic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The aim of the present preliminary study was to describe a simple protocol for the analysis of the heart rate variability (HRV) that can reveal the different autonomic control between noncomplicated diabetic patients and normal subjects within 15 min. The power spectrum of the HRV was evaluated on 5-min-long electrocardiographic recordings in both the supine and the seated positions in 30 noncomplicated non-insulin-dependent diabetic (NIDDM) patients and in 30 healthy volunteers. In healthy subjects the low-frequency (LF) value was higher in seated position than in supine position, while in diabetic patients the ...
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Andrea Viggiano, Claudia Vicidomini, Marcellino Monda, Diego Carleo, Renato Carleo, Giovanni Messina, Alessandro Viggiano, Emanuela Viggiano, Bruno De Luca Tags: Original Articles Source Type: journals

Racial differences in diabetes self-management and quality of care in TexasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hispanics have poorer access to care and poorer health status compared to Whites or Blacks. Controlling for socioeconomic and access to care variables eliminated disparities in self-management but did not eliminate disparities in quality of diabetes care. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Chiagozie Nwasuruba, Christie Osuagwu, Sejong Bae, Karan P. Singh, Leonard E. Egede Tags: Original Articles Source Type: journals

Oxidative stress pathway genes and chronic renal insufficiency in Asian Indians with Type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The nonreplication of association suggests differential genetic susceptibility of the two populations to diabetic chronic renal insufficiency. In the SI diabetic subjects, oxidative stress pathway genes might be an important predictor for the development of diabetic complications. Further, the association of wild-type alleles may suggest that they confer greater survival ability to comorbid complications and may be nephroprotective. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Arun K. Tiwari, Pushplata Prasad, Thelma B.K., K.M. Prasanna Kumar, A.C. Ammini, Arvind Gupta, Rajeev Gupta Tags: Original Articles Source Type: journals

Incidence and risk factors of hypertension among Saudi type 2 diabetes adult patients: an 11-year prospective randomized studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aims: Insofar as hypertension is a risk factor for cardiovascular morbidity and mortality in Type 2 diabetes mellitus (T2DM), this study investigated the incidence of hypertension and associated risk factors in Saudi T2DM patients.Methods: A hospital-based, 11-year (1993–2004) prospective study of 916 adult originally normotensive T2DM Saudi patients (488 male and 428 female). T2DM was diagnosed as per World Health Organization (WHO) criteria, while hypertension was assessed according to the Seventh Joint National Criteria for Hypertension Classification (JNVII). Risk factors were analyzed on those who develope...
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Rabha A. Salman, Khalid A. Al-Rubeaan Tags: Original Articles Source Type: journals

The relationship between glycemic control and platelet activity in type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggested a close relationship between poor glycemic control and increased platelet activity in patients with type 2 DM. Furthermore, platelet activity recovered through improved glycemic control, which may prevent the possible role of platelets in cardiovascular events in these patients. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Refik Demirtunc, Dursun Duman, Melih Basar, Mustafa Bilgi, Mehmet Teomete, Tayfun Garip Tags: Original Articles Source Type: journals

Postural blood pressure changes and associated factors in long-term Type 1 diabetes: Wisconsin Epidemiologic Study of Diabetic RetinopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Purpose: To describe the frequency of orthostatic hypotension and hypertension and associations with risk factors in a cohort of persons with long-term Type 1 diabetes (n=440) participating in the Wisconsin Epidemiologic Study of Diabetic Retinopathy.Methods: Evaluations included detailed medical history, electrocardiography (ECG), and laboratory tests. Blood pressure (BP) was measured in supine and standing positions. Standing decrease in systolic (SBP) or diastolic (DBP) BP of at least 20 or 10 mmHg, respectively, was defined as orthostatic hypotension; increase of SBP from (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Flavio E. Hirai, Scot E. Moss, Barbara E.K. Klein, Ronald Klein Tags: Original Articles Source Type: journals

Reductions in excess mortality rates among people with diabetes by selected cause of deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the probability (Pr) of a rate decrease in the age-adjusted excess rate and considered the evidence strong if the probability was 0.90 or higher. Among men with diabetes, the evidence was strong for a probable decrease in excess rate for heart disease (8.7 per 1000 to 6.5), cerebrovascular disease (1.2 per 1000 to 0.75) and arterial disease (0.24 per 1000 to 0.08). Among women with diabetes, the evidence was strong for a probable decrease in excess rates for the overall (total) rate (17.8 per 1000 to 12.6), for heart disease (6.1 per 1000 to 4.4), IHD (4.4 per 1000 to 3.1), cerebrovascular disease (1.4 per 1000 t...
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Authors: Edward F. Tierney, Betsy L. Cadwell, Theodore J. Thompson, James P. Boyle, Sherri L. Paxon, Kathy Moum, Michael M. Engelgau Tags: Original Articles Source Type: journals

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(Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 1, 2009 Category: Endocrinology Source Type: journals

The effect of 1α,25(OH)2D3 vitamin over oxidative stress and biochemical parameters in rats where Type 1 diabetes is formed by streptozotocinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The highness of insulin and c-peptide levels in the group that received treatment when compared to other groups and the lowness of oxidative markers such as SOD, catalase in this study can be explained by the fact that 1α,25(OH)2D3 treatment prevents the intervention of apoptosis mechanism. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 3, 2008 Category: Endocrinology Authors: Şevki Çetinkalp, Yasemin Delen, Muammer Karadeniz, Gül Yüce, Candeğer Yılmaz Tags: Original Articles Source Type: journals

Charcot arthropathy of the foot and ankle: modern concepts and management reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Charcot arthropathy (Charcot neuroarthropathy, diabetic neuropathic osteoarthropathy, or neuropathic arthropathy) remains a poorly understood disease, although recent research has improved our level of knowledge regarding its etiology and treatment. The effects of Charcot arthropathy are almost exclusively seen in the foot and ankle, and the diagnosis is commonly missed upon initial presentation. It has been well established that this complication of diabetes mellitus severely reduces the overall quality of life and dramatically increases the morbidity and mortality of patients. However, there are few high-level ...
Source: Journal of Diabetes and Its Complications - October 20, 2008 Category: Endocrinology Authors: Dane K. Wukich, Wenjay Sung Tags: Review Articles Source Type: journals

Efficacy of glimepiride/metformin combination versus glibenclamide/metformin in patients with uncontrolled type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aim: The aim of this study was to compare the efficacy of glimepiride/metformin combination versus glibenclamide/metformin for reaching glycemic control in patients with uncontrolled type 2 diabetes mellitus.Patients and Methods: A randomized, double-blind, multicenter clinical trial was performed in 152 uncontrolled type 2 diabetic patients. Serum fasting and postprandial glucose, hemoglobin A1c (A1C), high-density lipoprotein cholesterol, and triglycerides were measured. After random allocation, all patients received two pills of glimepiride (1 mg)/metformin (500 mg) or glibenclamide (5 mg)/metformin (500 mg) p...
Source: Journal of Diabetes and Its Complications - October 13, 2008 Category: Endocrinology Authors: Manuel González-Ortiz, Jesús F. Guerrero-Romero, Rafael Violante-Ortiz, Niels Wacher-Rodarte, Esperanza Martínez-Abundis, Carlos Aguilar-Salinas, Sergio Islas-Andrade, Rosario Arechavaleta-Granell, Jorge González-Canudas, Martha Rodríguez-Morán, Ete Tags: Original Articles Source Type: journals

Cardiovascular prevention in type 2 diabetes mellitus patients: the role of oral glucose-lowering agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Diabetes mellitus (DM) is a metabolic disorder that requires medical diagnosis and treatment. Type 2 DM is due to a combination of defective secretion of and responsiveness to insulin. In early stages, the predominant abnormality is reduced insulin sensitivity, and hyperglycemia can be reversed by a variety of measures and medications. In this stage, the cornerstone of glucose-lowering therapy is lifestyle modification, but when counseling does not adequately achieve the recommended glycemic targets, at least five classes of oral drugs are available. In general, α-glucosidase inhibitors delay carbohydrate absorp...
Source: Journal of Diabetes and Its Complications - September 3, 2008 Category: Endocrinology Authors: Matteo Anselmino Tags: Review Articles Source Type: journals

Plasminogen activator inhibitor-1 is associated with coronary artery calcium in Type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: PAI-1 levels are independently related to CAC in younger Type 1 diabetes participants. PAI-1 levels were not independently related to CAC in non-diabetes participants. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 3, 2008 Category: Endocrinology Authors: Katherine A. Pratte, Anna E. Barón, Lorraine G. Ogden, Kathryn L. Hassell, Marian Rewers, John E. Hokanson Tags: Original Articles Source Type: journals

Safety and tolerability of duloxetine treatment of diabetic peripheral neuropathic pain between patients with and without cardiovascular conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this analysis, the safety of duloxetine in patients with DPNP was not found to be significantly different between patients with and without historical or comorbid CV conditions. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 2, 2008 Category: Endocrinology Authors: Joachim F. Wernicke, Apurva Prakash, Daniel K. Kajdasz, John Houston Tags: Original Articles Source Type: journals

A rare complication of diabetes mellitus in a 65-year-old manEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Spontaneous diabetic myonecrosis is a rare complication of diabetes mellitus. It involves mostly the thigh and calf muscles. It presents with acute leg pain, without any evidence of systemic illness. Diagnosis can be difficult and delayed. Here, we report a case of a 65-year-old man presenting with this complication. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - August 7, 2008 Category: Endocrinology Authors: Talal Hussain Muzaffar, Fatma Jasim Muzaffar Tags: Case Reports Source Type: journals

Trends in cardiovascular risk factors and lifestyle behaviors among Spanish adults with diabetes (1993–2003)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The overall prevalence of cardiovascular risk factors and unhealthy lifestyle behaviors among diabetes patients has shown no improvement in the decade 1993–2003, and there have been significant setbacks, in particular the rise in obesity and HBP. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - August 7, 2008 Category: Endocrinology Authors: Rodrigo Jiménez-García, Valentin Hernández-Barrera, Isabel Jiménez-Trujillo, Pilar Carrasco Garrido, Ana López de Andrés, Angel Gil de Miguel Tags: Original Articles Source Type: journals

Glucose endothelial cytotoxicity and protection by Dan Gua-Fang, a Chinese herb prescription in huVEC in hyperglycemia mediumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There is a notable linear correlation between the endothelial cytotoxicities of Glu and its concentrations. The spinodal point concentration of statistical significance of hyperglycemia cytotoxicity is 22.2 mmol/l; 1/300 Dan Gua can reverse the endothelia cytotoxicity in different concentrations of hyperglycemia. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 27, 2008 Category: Endocrinology Authors: Heng Xian-pei, Chen Ke-ji, Hong Zheng-feng, He Wei-dong, Chu Ke-dan, Chen Wen-lie, Chen Xu-zheng, Zheng Hai-xia, Chen Ling, Yang Liu-qing, Guo Fang, Lin Mao-long Tags: Original Articles Source Type: journals

Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGPA) and anti-intrinsic factor antibodies were positive, confirming diagnosis of pernicious anemia. Thyroid and Addison's disease were excluded. Gastroscopy revealed atrophic gastritis without any evidence of carcinoid tumors. The aim of this case, which, to our knowledge, is the first one to describe ...
Source: Journal of Diabetes and Its Complications - July 9, 2008 Category: Endocrinology Authors: Thrasivoulos G. Tzellos, Dimitrios K. Tahmatzidis, Aimilios Lallas, Kiriaki Apostolidou, Dimitrios G. Goulis Tags: Case Reports Source Type: journals

Comparison of diabetic retinopathy phenotype between Latinos and BlacksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although Latinos and Blacks of comparable age and glycemic control are equally at risk for CSME and proliferative retinopathy, Latinos may be at greater risk for a specific phenotype of DR characterized by extravasation of intraretinal hemorrhages, which is associated with poor prognosis. Further prospective studies may uncover racial differences that may have implications for prognosis and therapy. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 4, 2008 Category: Endocrinology Authors: Jessica L. Chen, Damien M. Luviano, John C. Chen, Fei Yu, David Sarraf Tags: Original Articles Source Type: journals

A case report of an effective treatment for diabetic foot ulcers with integration of traditional Chinese medicine and Western medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report herein a case of a diabetic foot ulcer that was treated with integrated traditional Chinese and Western medicine, with desirable cost-effective results. Traditional Chinese medicine (TCM) therapeutic principles include improving the spleen, nourishing yin, regulating qi, and resolving dampness, as well as activating stagnant blood. Western medicine includes wound debridement, skin grafting, and use of insulin, antibiotics, and vasodilators. The patient was treated with a holistic multidisciplinary approach (i.e., a combination of TCM and Western medicine, surgical management, education for diabetic foot care, and...
Source: Journal of Diabetes and Its Complications - July 3, 2008 Category: Endocrinology Authors: Xi-Sheng Xie, Yu-Jao Wang, Chuan Zuo, Jun-Ming Fan, Xiu-Jun Li Tags: Case Report Source Type: journals

A single nucleotide polymorphism alters the sequence of SP1 binding site in the adiponectin promoter region and is associated with diabetic nephropathy among type 1 diabetic patients in the Genetics of Kidneys in Diabetes StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study thus provides the first evidence that SNP −11377C/G alters the sequence in one of the SP1 binding sites in the adiponectin promoter region. This polymorphism, together with another promoter SNP −11391G/A, may confer susceptibility to the development of DN in T1D patients among the GoKinD population. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 3, 2008 Category: Endocrinology Authors: Dongying Zhang, Jun Ma, Kerstin Brismar, Suad Efendic, Harvest F. Gu Tags: Original Articles Source Type: journals

The ischemic etiology of heart failure in diabetics limits reverse left ventricular remodeling after cardiac resynchronization therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aim of the Study: The aim of this study was to evaluate reverse volumetric left ventricular (LV) remodeling after cardiac resynchronization therapy (CRT) in patients with heart failure (HF) with vs. without diabetes mellitus (DM).Methods: The study comprised 130 consecutive patients with HF (mean age, 61±12 years) who underwent CRT. Thirty patients (23%) had DM [mean glycated haemoglobin (HbA1c), 7.2±3.4%; 13 (43%) on insulin therapy]. Echocardiography, including tissue Doppler measurements, was performed before CRT and between 3 and 6 months after CRT. Echocardiographic response was defined as a >15% reduction...
Source: Journal of Diabetes and Its Complications - June 23, 2008 Category: Endocrinology Authors: Osama I.I. Soliman, Bas M. van Dalen, Dominic A.M.J. Theuns, Folkert J. ten Cate, Attila Nemes, Luc J. Jordaens, Marcel L. Geleijnse Tags: Original Article Source Type: journals

Excess risk of diabetes in persons with hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All persons with hypertension, irrespective of age, sex, and BMI, are at elevated risk of developing diabetes. Men and women with hypertension who are overweight or obese are at substantially elevated risk of diabetes, regardless of age, and should be monitored especially closely for the development of this disease. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 2, 2008 Category: Endocrinology Authors: Derek Weycker, Gregory A. Nichols, Maureen O'Keeffe-Rosetti, John Edelsberg, Gabor Vincze, Zeba M. Khan, Gerry Oster Tags: Original Articles Source Type: journals

Advanced glycation end products in senile diabetic and nondiabetic patients with cataractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Advanced glycation end products (AGE) have been reported to contribute to aging and cataract formation in the lens. In the present study, AGE immunoreactivity in human serum samples of normal senile subjects (n=31), senile diabetic patients without cataract (n=33), senile diabetic patients with cataract (n=30), senile nondiabetic with cataract (n=30), and normal young subjects (n=31) was investigated.Methods: A noncompetitive ELISA with polyclonal anti-AGE antibody was performed. The patients were selected on clinical grounds from Eye Ward, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.Results...
Source: Journal of Diabetes and Its Complications - May 27, 2008 Category: Endocrinology Authors: Anjuman Gul, Muhammad Ataur Rahman, Asmat Salim, Shabana U. Simjee Tags: Original Articles Source Type: journals

Changes in the diabetic retinopathy epidemiology after 14 years in a population of Type 1 and 2 diabetic patients after the new diabetes mellitus diagnosis criteria and a more strict control of the patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We may observe a decrease in the prevalence of DR, overt nephropathy, and blindness in Type 1 and 2 patients and a decrease in the prevalence of microalbuminuria only in Type 2 patients. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 24, 2008 Category: Endocrinology Authors: Pedro Romero-Aroca, Juan Fernández-Balart, Marc Baget-Bernaldiz, Inmaculada Martinez-Salcedo, Isabel Méndez-Marín, Mercè Salvat-Serra, Jose Antonio Buil-Calvo Tags: Original Articles Source Type: journals

Recovery from stroke in patients with diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and Aim: Diabetes mellitus (DM) is recognized as an important risk factor for stroke and might theoretically influence post-stroke level of disability, increasing the extension of the cerebral injured area. However, results of the few researches aimed at studying this influence are contradictory; moreover, the effect of DM on motor recovery has not been extensively studied. The aim of this study was to investigate the effect of DM on both functional and motor recovery.Methods: A total of 395 acute patients with first stroke were selected in a rehabilitation department and divided into two groups on the...
Source: Journal of Diabetes and Its Complications - April 16, 2008 Category: Endocrinology Authors: Luca Nannetti, Matteo Paci, Marco Baccini, Lucio A Rinaldi, Piero G Taiti Tags: Original Articles Source Type: journals

Comparison of dilated fundus examinations with seven-field stereo fundus photographs in the Veterans Affairs Diabetes TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a comparison of fundus photographs and ophthalmologic examination at baseline, permitting an evaluation of multiple settings similar to common clinical practice.Research Design and Methods: A 340-patient subset had both local dilated fundus examinations and centrally read seven-field stereo fundus photographs completed within 60 days of each other (median 28 days). Local examiners were unaware of the stereo photographs.Results: Overall, agreement within one step was 76% and exact agreement between ophthalmoscopy and central gradings of fundus photographs on a five-step retinopathy severity scale was 43% (weighted...
Source: Journal of Diabetes and Its Complications - April 13, 2008 Category: Endocrinology Authors: Nicholas Emanuele, Ronald Klein, Thomas Moritz, Matthew D. Davis, Kathleen Glander, Robert Anderson, Domenic Reda, William Duckworth, Carlos Abraira, for the VADT Study Group Tags: Original Articles Source Type: journals