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Clinical implication of alterations in serum Klotho levels in patients with type 2 diabetes mellitus and its associated complications
To investigate the clinical significance of serum α-Klotho and β-Klotho levels in patients with type 2 diabetes mellitus (T2DM) and its associated complications. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 12, 2018 Category: Endocrinology Authors: Lingling Zhang, Tianming Liu Source Type: research

The burden of uncontrolled A1C in type 1 diabetes: 30  years of insights from the DCCT/EDIC study
In the 1990s, the results of the Diabetes Control and Complication Trial (DCCT) set the standard for the management of type 1 diabetes.1 The trial unequivocally demonstrated that intensive diabetes therapy, based on multiple daily injections of insulin or insulin pump, frequent monitoring of blood glucose, and specific glucose targets, resulted in lower Hemoglobin A1C (A1C) and less microvascular complications than conventional therapy.1 After the trial closeout, patients were encouraged to adopt or to continue the intensive treatment regimen with their own healthcare providers, and their outcomes were followed up in the E...
Source: Journal of Diabetes and Its Complications - June 12, 2018 Category: Endocrinology Authors: Giampaolo Greco, David W. Lam Source Type: research

What are the Clinical, Quality-of-Life, and Cost Consequences of 30 Years of Excellent vs. Poor Glycemic Control in Type 1 Diabetes?
The Diabetes Control and Complications Trial (DCCT) demonstrated that intensive therapy for type 1 diabetes delayed the development of microvascular and neuropathic complications compared to conventional therapy. At the end of DCCT, all participants were trained in intensive therapy, care was transferred to community providers, and the difference in HbA1c between treatment groups narrowed and disappeared. Our objective was to describe the outcomes and the quality-of-life and costs associated with those outcomes in participants who maintained excellent vs. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 11, 2018 Category: Endocrinology Authors: William H. Herman, Barbara H. Braffett, Shihchen Kuo, Joyce M. Lee, Michael Brandle, Alan M. Jacobson, Lisa A. Prosser, John M. Lachin Source Type: research

The 30-Year Cost-Effectiveness of Alternative Strategies to Achieve Excellent Glycemic Control in Type 1 Diabetes: An Economic Simulation Informed by the Results of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC)
To simulate the cost-effectiveness of historical and modern treatment scenarios that achieve excellent vs. poor glycemic control in type 1 diabetes (T1DM). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 11, 2018 Category: Endocrinology Authors: William H. Herman, Barbara H. Braffett, Shihchen Kuo, Joyce M. Lee, Michael Brandle, Alan M. Jacobson, Lisa A. Prosser, John M. Lachin Source Type: research

High prevalence of systemic rheumatic diseases in women with type 1 diabetes
This study in 1212 adults with T1DM found an age-dependent enrichment of SRDs in women with T1DM: 9.2% prevalence in women overall and 14% in women over age 50. Clinicians taking care of older women with T1DM should monitor for these SRDs. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 7, 2018 Category: Endocrinology Authors: Yicheng K. Bao, Maamoun Salam, Deborah Parks, Janet B. McGill, Jing Hughes Source Type: research

Lower objectively measured physical activity is linked with perceived risk of hypoglycemia in type 1 diabetes
Compare physical activity (PA) levels in adults with and without type 1 diabetes and identify diabetes-specific barriers to PA. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 2, 2018 Category: Endocrinology Authors: Amena Keshawarz, Andrew R. Piropato, Talia L. Brown, Lindsey M. Duca, Rachel M. Sippl, R. Paul Wadwa, Janet K. Snell-Bergeon Source Type: research

Elevated N-acetyl- β-d-glucosaminidase, a urinary tubular damage marker, is a significant predictor of carotid artery atherosclerosis in type 1 diabetes, independent of albuminuria: A cross-sectional study
In this study, we evaluated the association between urinary N-acetyl- β-D-glucosaminidase (uNAG), an early renal tubular damage marker, and carotid artery atherosclerosis in patients with type 1 diabetes (T1D). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 1, 2018 Category: Endocrinology Authors: Minyoung Lee, Namki Hong, Yong-ho Lee, Eun Seok Kang, Bong Soo Cha, Byung-Wan Lee Source Type: research

Association between physical activity and abnormal glucose metabolism —A population-based cross-sectional study in China
The association between physical activity (PA) level and abnormal glucose metabolism (AGM) remains unclear. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 1, 2018 Category: Endocrinology Authors: Hu Ping, Li Yufeng, Zhou Xianghai, Zhang Xiuying, Zhang Fang, Ji Linong Source Type: research

The effect of dulaglutide on body composition in type 2 diabetes mellitus patients on hemodialysis
To evaluate the effect of dulaglutide on body composition in type 2 diabetes mellitus (T2DM) patients undergoing hemodialysis (HD). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 1, 2018 Category: Endocrinology Authors: Takahiro Yajima, Kumiko Yajima, Hiroshi Takahashi, Keigo Yasuda Source Type: research

Three-year renal function trajectory and its association with adverse renal event in patients with type 2 diabetes
The study evaluated associations between 3-year eGFR trajectory patterns and adverse renal event in diabetic patients. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 31, 2018 Category: Endocrinology Authors: Tsai-Chung Li, Tzu-Yun Yu, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Jen-Huai Chiang, Cheng-Chieh Lin Source Type: research

Relationships between cerebral structure and cognitive function in African Americans with type 2 diabetes
Relationships between cognitive function and brain structure remain poorly defined in African Americans with type 2 diabetes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 29, 2018 Category: Endocrinology Authors: Timothy M. Hughes, Kaycee M. Sink, Jeff D. Williamson, Christina E. Hugenschmidt, Benjamin C. Wagner, Christopher T. Whitlow, Jianzhao Xu, S. Carrie Smith, Lenore J. Launer, Joshua I. Barzilay, Faramarz Ismail-Beigi, R. Nick Bryan, Fang-Chi Hsu, Donald W. Source Type: research

Role of plasma glucose level on myocardial perfusion in st-segment elevation myocardial infarction patients
Hyperglycemia is frequent in patients with ST elevation myocardial infarction (STEMI) and was found to be associated with adverse outcome. Aim of our study was to evaluate the correlation between admission plasma glucose level (PGL) and coronary arteries flow velocity and to investigate if this relationship satisfies a predefined mathematical model. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 25, 2018 Category: Endocrinology Authors: Pepe Martino, Zanna Domenico, Cafaro Alessandro, Marchese Alfredo, Addabbo Francesco, Navarese Eliano Pio, Napodano Massimo, Cecere Annagrazia, Resta Fabrizio, Paradies Valeria, Bortone Alessandro Santo, Favale Stefano Source Type: research

FGF21 protects human umbilical vein endothelial cells against high glucose-induced apoptosis via PI3K/Akt/Fox3a signaling pathway
In this study, we aimed to investigate the protective capacity of FGF21 in human umbilical vein endothelial cells (HUVECs) against high glucose (HG)-induced apoptosis via phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt)/FoxO3a pathway. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 25, 2018 Category: Endocrinology Authors: Dongmin Guo, Lele Xiao, Huijun Hu, Mihua Liu, Lu Yang, Xiaolong Lin Source Type: research

Prevalence of arterial stiffness in adolescents with type 2 diabetes in the TODAY cohort: Relationships to glycemic control and other risk factors
We aimed to determine the prevalence of arterial stiffness in young adults with youth-onset type 2 diabetes who previously participated in the TODAY clinical trial and whether arterial stiffness is influenced by their prior diabetes treatment assignment or glycemic control. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 25, 2018 Category: Endocrinology Authors: Amy S. Shah, Laure El Ghormli, Samuel S. Gidding, Fida Bacha, Kristen J. Nadeau, Lorraine E. Levitt Katz, Jeanie B. Tryggestad, Natasha Leibel, Daniel E. Hale, Elaine M. Urbina Source Type: research

Exploratory Lipidomics in Patients with Nascent Metabolic Syndrome
Metabolic Syndrome (MetS) is a a cardio-metabolic cluster that confers an increased risk of developing both diabetes and atherosclerotic cardiovascular disease (ASCVD). The mechanisms governing the increased ASCVD risk remains to be elucidated. Moreover, lipidomics poses as an exciting new tool that has potential to shed more light on the pathogenesis of MetS . (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 25, 2018 Category: Endocrinology Authors: Neeraj Ramakrishanan, Travis Denna, Sridevi Devaraj, Beverley Adams-Huet, Ishwarlal Jialal Source Type: research