Journal of Environmental Pathology, Toxicology and Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A Review on Protease Inhibitors of Herbal Origin to Combat Malignancy
J Environ Pathol Toxicol Oncol. 2024;43(3):1-11. doi: 10.1615/JEnvironPatholToxicolOncol.2024052872.ABSTRACTProtease is the enzyme accountable for the breakdown of proteins i.e., proteolysis. Proteases are reportedly involved in the events of growth, development, progression and metastasis of cancers. If any agent could inhibit/retard the protease enzyme, i.e., protease inhibitor, it would arrest the cancer; thus indicating the significance of exploring protease inhibitors for latest anti-malignant drug discovery. Higher plants are the rich sources of different protease inhibitors that are effective against several types o...
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Sanjib Bhattacharya Source Type: research

Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small-Cell Lung Cancer
This article discusses the molecular genetic landscape of NSCLC and the latest therapy developments, focusing on clinically relevant changes using several schematic and tabular representations.PMID:38608143 | DOI:10.1615/JEnvironPatholToxicolOncol.2024051317 (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Salik Abdullah Ratul Chakraborty Pratiksha Somnath Kumkar Biplab Debnath Asis Bala Source Type: research

Treatment Strategy for Breast Benign Intraductal Papilloma: A Meta-Analysis
This study aims to conduct a meta-analysis to determine the rate of upgrade from breast benign IDP and identify predictive factors associated with the conversion of benign IDP to high-risk lesions or carcinoma, which could guide healthcare practitioners in selecting the appropriate clinical treatment strategy. We conducted a comprehensive search across multiple databases (PubMed, Web Of Science, Cochrane Library, and Embase) for studies published between 2012 and 2023 that evaluated upgrade rates and predictive factors of breast benign IDP diagnosed via biopsy. In addition, we included studies that reported on the clinical...
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Congkun Lou Wenhsin Wang Binggang Zhou Source Type: research

Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma
In conclusion, our findings highlight the predictive role of IMRGs in prognosis and immune treatment of HCC, indicating that ADAMTS13, CRHBP, VIPR1, FCN3, and CLEC1B may serve as potential prognostic biomarkers for HCC.PMID:38608145 | DOI:10.1615/JEnvironPatholToxicolOncol.2024050167 (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Shijing Tang Hao Chen Source Type: research

RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting NLRP3 Ubiquitination in Liver Cancer
J Environ Pathol Toxicol Oncol. 2024;43(3):69-80. doi: 10.1615/JEnvironPatholToxicolOncol.2024053012.ABSTRACTThe present study explored that the effects and its possible mechanisms of ring finger protein 20 (RNF20) in Postoperative survival rate of liver cancer in clinical. All the serum samples were collected from our hospital. Quantitative polymerase chain reaction (PCR) and microarray analysis, and RNA pull down assay were used in this study. We found that the serum RNF20 mRNA expression level in patients with liver cancer were down-regulated. Postoperative survival rate of RNF20 high expression was higher than that of ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Deqin Liu Renyin Luo Qian Zhou Mei Li Source Type: research

Development of a Prognostic Model for Gastric Cancer Based on Apoptosis- and Hypoxia-Related Genes: Predictive Insights into Survival and Immune Landscape
This study attempted to delineate potential value of apoptosis and hypoxia-related genes (AHRGs) in prognosis of gastric cancer. Differential expression analysis was performed on GC transcriptomic data from TCGA. Apoptosis-related genes (ARGs) and hypoxia-related genes (HRGs) were obtained from MSigDB, followed by intersecting them with differentially expressed genes (DEGs) in GC. A prognostic model was constructed using univariate, LASSO, and multivariate regression analyses. The model was validated using a Gene Expression Omnibus dataset. DEGs between risk groups were subjected to enrichment analysis. A nomogram was plot...
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Jian Zhu Yao Ma Source Type: research

TFR1-Mediated Iron Metabolism Orchestrates Tumor Ferroptosis and Immunity in Non-Small Cell Lung Cancer
This study aimed to investigate the underlying molecular mechanisms of transferrin receptor (TFR1) in non-small cell lung cancer (NSCLC). Histological analysis was performed using hematoxylin-eosin (HE) staining. The number of CD8+ T cell were determined by flow cytometry and immunofluorescence assays. mRNA levels were analyzed by qRT-PCR. Protein expression was detected by western blot. Ferroptosis was detected by using propidium iodide (PI) staining. Xenograft experiment was applied for determining tumor growth. The results showed that interferon (IFN)-γ plus iron dextran (FeDx) induced iron overload and the ferroptosis...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Zunqiao Wang Xingkai Yao Keping Wang Bin Wang Source Type: research

Complex Genomic Rearrangement Patterns in Malignant Pleural Mesothelioma due to Environmental Asbestos Exposure
In this study, we aimed to characterize complex genomic rearrangement patterns and variations to better understand the genomics of MPM tumors. We comparatively scanned 3 MPM tumor genomes by Whole-Genome Sequencing and High-Resolution SNP array. We also used various computational algorithms to detect both CNAs and complex chromosomal rearrangements. Genomic data obtained from each bioinformatics tool are interpreted comparatively to better understand CNAs and cancer-related Nucleotide variations in MPM tumors. In patients 1 and 2, we found pathogenic nucleotide variants of BAP1, RB1, and TP53. These two MPM genomes exhibit...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Tun ç Tuncel G üntülü Ak Hasan Veysi G üneş Muzaffer Metinta ş Source Type: research

Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development
J Environ Pathol Toxicol Oncol. 2024;43(2):29-42. doi: 10.1615/JEnvironPatholToxicolOncol.2023046909.ABSTRACTWithaferin A (WA) is a natural steroidal lactone with promising pharmacological activities, but its poor solubility and bioavailability hinder its clinical application. The liposomal drug delivery system has attracted considerable attention to overcome the delivery limitations of pharmacological agents. The present study investigated the effect of WA-loaded pegylated nanoliposomes (LWA) on in vitro and in vivo B16F10 melanoma tumor models. In vitro results showed that LWA had significantly (P < 0.01) higher cytot...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Prathapan Abeesh Chandrasekharan Guruvayoorappan Source Type: research