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Vascular endothelial growth factor - prognostic factor in children with neuroblastoma: a retrospective analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: VEGF expression should be considered in a routine diagnostic workup of children with neuroblastoma, especially in those more than 18 months old and with advanced disease stage. High VEGF expression at the time of disease diagnosis is a bad risk prognostic factor, and can be used to characterize subsets of patients with an unfavourable outcome. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 6, 2009 Category: Cancer & Oncology Authors: Gordana JakovljevicSrdjana CulicJasminka StepanAleksandra BonevskiSven Seiwerth Source Type: journals

Octreotide treatment of patients with hepatocellular carcinoma - a retrospective single centre controlled studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Survival under octreotide treatment was not different compared to TACE or multimodal therapy and might be a therapeutic option for patients with HCC. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 3, 2009 Category: Cancer & Oncology Authors: Maximilian Schoniger-HekeleJoachim KettenbachMarkus Peck-RadosavljevicChristian Muller Source Type: journals

Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Leukemic MSCs can inhibit K562 cell expansion and modulate the cell cycle to a state of relative quiescence. This allows the K562 cells to endure adverse conditions such as serum starvation. The PI3K-Akt-Bad signaling pathway may be involved in this antiapoptotic process via phosphorylation of the Akt and Bad proteins. Blocking MSC-induced transduction of the PI3K-Akt-Bad pathway may be a potential strategy for a targeted therapy to combat leukemia. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 3, 2009 Category: Cancer & Oncology Authors: Zhaohui WeiNaiyao ChenHongxing GuoXueming WangFangyun XuQian RenShiHong LuBin LiuLei ZhangHui Zhao Source Type: journals

Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The findings indicate that polymorphisms of G241R are rare in Chinese population and that KK genotype of ICAM-1 K469E is significantly associated with well differentiation of CRC. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - October 12, 2009 Category: Cancer & Oncology Authors: Qing-lei WangBing-hui LiBin LiuYa-bin LiuYue-Ping LiuSui-Bing MiaoYi HanJin-Kun WenMei Han Source Type: journals

Alterations in integrin expression modulates invasion of pancreatic cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our results suggest that altered expression of integrins interacting with different extracellular matrixes may play a significant role in suppressing the aggressive invasive phenotype. Analysis of these clonal populations of MiaPaCa-2 provides a model for investigations into the invasive properties of pancreatic carcinoma. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - October 12, 2009 Category: Cancer & Oncology Authors: Naomi WalshMartin ClynesJohn CrownNorma O'Donovan Source Type: journals

Perfusion-CT monitoring of cryo-ablated renal cells tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Perfusion CT seems to be a feasible and promising technique in monitoring the effects of cryoablation therapy. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - October 9, 2009 Category: Cancer & Oncology Authors: Ettore SquillaciGuglielmo ManentiCarmelo CiccioFrancesca NuceraPierluigi BoveGiuseppe VespasianiLaura RussolilloGiovanni Simonetti Source Type: journals

Retraction: Substance P and beta-endorphin mediate electro-acupuncture induced analgesia in mouse cancer pain modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Retraction for Lee HJ, et al. Substance P and beta-endorphin mediate electro-acupuncture induced analgesia in mouse cancer pain model. J Exp Clin Cancer Res 2009, 28:102. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - October 8, 2009 Category: Cancer & Oncology Authors: Hyo-Jeong LeeJae-Ho LeeEun-Ok LeeHyo-Jung LeeKwan-Hyun KimSun-Hyung KimKeun-Sung LeeHee-Jae JungSung-Hoon Kim Source Type: journals

Urinary estrogen metabolites and prostate cancer: a case-control study and meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study and the pooled results provide evidence for a differential role of the estrogen hydroxylation pathway in Pca development and encourage further study. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - October 7, 2009 Category: Cancer & Oncology Authors: Maddalena BarbaLi YangHolger SchunemannFrancesca SperatiSara GrioniSaverio StrangesKim WesterlindGiovanni BlandinoMichele GallucciRossella LauriaLuca MalorniPaola Muti Source Type: journals

In vivo 99mTc-HYNIC-annexin V imaging of early tumor apoptosis in mice after single dose irradiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 99mTc-HYNIC-annexin V in vivo imaging is a feasible method to detect early radiation-induced apoptosis in different tumors, and might be predictive for radiation sensitivity. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - October 7, 2009 Category: Cancer & Oncology Authors: Ming-fang GuoYa-qing ZhaoRong TianLin LiLei-ming GuoFeng XuYong-mei LiuYong-bo HeSen BaiJin Wang Source Type: journals

Chromophobe renal cell cancer - review of the literature and potential methods of treating metastatic diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chromophobe renal cell carcinoma (ChRCC) is a subtype of renal cell carcinoma (RCC). ChRCC is diagnosed mainly in 6th decade of life. An incidence of ChRCC is similar in both men and woman. Eighty six percent of ChRCCs cases are diagnosed in stage 1 or 2. Prognosis of ChRCC is better than in other types of RCC. Five- and 10-year disease free survival (DFS) for ChRCC was 83.9% and 77.9%, respectively. Expression of immunohistological markers: cytokeratins (CK), vimentin, epithelial membrane antigen (EMA), CD10 could be potentially helpful in diagnosis of different subtypes of RCC. From all conventional RCC, CD 117 was detec...
Source: Journal of Experimental and Clinical Cancer Research - October 6, 2009 Category: Cancer & Oncology Authors: Rafal StecBartlomiej GralaMichal MaczewskiLubomir BodnarCezary Szczylik Source Type: journals

MMP7 expression regulated by endocrine therapy in ERbeta-positive colon cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings suggest that endocrine therapy is an efficient therapy for inhibiting ERbeta-positive colon cancer cell proliferation and migration via down-regulation of MMP7. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - September 28, 2009 Category: Cancer & Oncology Authors: Yu-Jing FangZhi-Zhong PanLi-Ren LiZhen-Hai LuLi-Yi ZhangDe-Sen Wan Source Type: journals

Generation of fusion protein EGFRvIII-HBcAg and its anti-tumor effect in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we prepared EGFRvIII-HBcAg fusion protein. After immunization with fusion protein, HBcAg or PBS, the titers of antibody in BALB/c mice immunized with fusion protein reached 2.75x105. Western blot analysis demonstrated that the fusion protein had specific antigenicity against anti-EGFRvIII antibody. Further observation showed fusion protein induced a high frequency of IFN-gamma-secreting lymphocytes. CD4+T cells rather than CD8+T cells were associated with the production of IFN-gamma. Using Renca-vIII(+) cell as specific stimulator, we observed remarkable cytotoxic activity in splenocytes from mice immunized ...
Source: Journal of Experimental and Clinical Cancer Research - September 28, 2009 Category: Cancer & Oncology Authors: Xiaoyi DuanDonggang HanMingxin ZhangJiansheng Wang Source Type: journals

The expression of PLK-1 in cervical carcinoma: a possible target for enhancing chemosensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that PLK-1 production in HeLa cells might be critical in determining whether cells survive or undergo apoptosis. Therefore, targeting PLK-1 might be a promising strategy for enhancing sensitivity to chemotherapeutic reagents in cervical carcinoma. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - September 22, 2009 Category: Cancer & Oncology Authors: Yuan ZhangYu LiuYuan-Xian YangJia-Hong XiaHong-Xiu ZhangHua-Bin LiChun-Zhao Yu Source Type: journals

Clinical research of Olanzapine for prevention of chemotherapy-induced nausea and vomitingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to mainly evaluate the activity and safety of olanzapine compared with 5-hydroxytryptamine3(5-HT3)receptor antagonists for prevention of chemotherapy-induced nausea and vomiting(CINV) in patients receiving highly or moderately emetogenic chemotherapy(HEC or MEC). The second goal was to evaluate the impact of olanzapine on quality of life(QoL) of cancer patients during the period of chemotherapy. Methods: 229 patients receiving highly or moderately emetogenic chemotherapy were randomly assigned to the test group [ olanzapine(O) 10mg p.o. plus azasetron(A) 10mg i.v. and dexamethasone(D) 10mg i.v. on d...
Source: Journal of Experimental and Clinical Cancer Research - September 22, 2009 Category: Cancer & Oncology Authors: Lijun TanJiangtao LiuXiuli LiuJie ChenZhijun YanHuifen YangDaxin Zhang Source Type: journals

Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings suggest the Sp1 transcription factor mediates ADAM17 expression under hypoxia, regulates glioma invasiveness, and thus, may be a target for anti-invasion therapies. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - September 21, 2009 Category: Cancer & Oncology Authors: Alexandra SzaladMark KatakowskiXuguang ZhengFeng JiangMichael Chopp Source Type: journals

Sexual dysfunction following surgery for rectal cancer - a clinical and neurophysiological studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients operated showed severe sexual dysfunction. The neurophysiological test may be a useful tool to investigate this complication. The neurological damage could be monitored to decide the rehabilitation strategy. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - September 16, 2009 Category: Cancer & Oncology Authors: Alberto PietrangeliPatrizia PuglieseMaria PerroneIsabella SperdutiMaurizio CosimelliBruno Jandolo Source Type: journals

Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The protease-free outgrowth of primary HBCEC offers a patient-specific approach to optimize an individually-designed cancer therapy. Moreover, HBCEC from long term breast tumor tissue cultures resemble tumor cell-like properties by an intact ECM formation and a stable cell surface protein expression providing a reproducible screening platform to identify new biomarkers and to test new therapeutics in individual tumor samples. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - September 13, 2009 Category: Cancer & Oncology Authors: Ralf HassCatharina Bertram Source Type: journals

Loss of imprinting of insulin-like growth factor 2 is associated with increased risk of lymph node metastasis and gastric corpus cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: IGF2 LOI is present in high frequency in Chinese gastric cancer patients, especially those with gastric corpus cancer. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - September 8, 2009 Category: Cancer & Oncology Authors: Yang LuPing LuZhi ZhuHuimian XuXike Zhu Source Type: journals

Mining novel biomarkers for prognosis of gastric cancer with serum proteomicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present here the attempt of mining novel biomarkers for GC prognosis by using serum proteomics. Methods: Sera from 43 GC patients and 41 controls with gastritis as Group 1 and 11 GC patients as Group 2 was successively detected by Surface Enhanced Laser Desorption/ionization Time of Flight Mass Spectrometry (SELDI-TOF-MS) with Q10 chip. Peaks were acquired by Ciphergen ProteinChip Software 3.2.0 and analyzed by Zhejiang University-ProteinChip Data Analysis System (ZJU-PDAS). CEA level were evaluated by chemiluminescence immunoassay. Results: After median follow-up periods of 33 months, Group 1 with 4 GC patients lost wa...
Source: Journal of Experimental and Clinical Cancer Research - September 8, 2009 Category: Cancer & Oncology Authors: Fu-Ming QiuJie-Kai YuYi-Ding ChenQi-Feng JinMei-Hua SuiJian Huang Source Type: journals

Effect of genistein on vasculogenic mimicry formation by human uveal melanoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Genistein inhibits VM formation of uveal melanoma cells in vivo and in vitro. One possible underlying molecular mechanism by which Genistein could inhibit VM formation of uveal melanoma is related to down-regulation of VE-cadherin. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - September 6, 2009 Category: Cancer & Oncology Authors: Rihong CongQingmin SunLi YangHaijuan GuYing ZengBin Wang Source Type: journals

The drug-resistance to gefitinib in PTEN low expression cancer cells is reversed by irradiation in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggested that PTEN gene is an important regulator on TKI inhibition, and the resistance to tyrosine kinase inhibitors might be reversed by irradiation in PTEN low expression cancer cells. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 31, 2009 Category: Cancer & Oncology Authors: Hongqing ZhuangJun WangZhiyong YuanLujun ZhaoPing WangChangli Wang Source Type: journals

Breast cancer humoral immune response: involvement of Lewis y through the detection of circulating immune complexes and association with Mucin 1 (MUC1)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: In cancer patients, MUC1 glycoprotein may carry Lewis y which could be involved in immune response. Purposes: 1- to evaluate the presence of Lewis y and MUC1 in circulating immune complexes (Lewis y/CIC and MUC1/CIC, respectively) and their correlation; 2- to analyze the possible presence of Lewis y in carbohydrate chains of tumoral MUC1 glycoprotein and 3- to correlate serum and tissue parameters considered. Methods: Pretreatment serum and tissue breast samples from 76 adenocarcinoma, 34 benign and 36 normal specimens were analyzed. Anti-MUC1 and Anti-Lewis y MAbs were employed. To detect Lewis y/CIC and MUC1/...
Source: Journal of Experimental and Clinical Cancer Research - August 27, 2009 Category: Cancer & Oncology Authors: Marina Isla LarrainSandra DemichelisMarina CrespoEzequiel LacunzaAlberto BarberaAldo CretonFrancisco TerrierAmada Segal-EirasMaria Croce Source Type: journals

Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings elucidate that there are common features between CHB-developed HCC and LC-developed HCC. The identified proteins are valuable for studying the hepatocarcinogenesis, and may be potential diagnostic markers or therapeutic targets for HBV-related HCC. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 27, 2009 Category: Cancer & Oncology Authors: Ning LiYunzhu LongXuegong FanHongbo LiuCui LiLizhang ChenZhiming Wang Source Type: journals

Serum human chorionic gonadotropin is associated with angiogenesis in germ cell testicular tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Germ cell testicular tumors have a survival rate that diminishes with high tumor marker levels, such as human chorionic gonadotropin (hCG). hCG may regulate vascular neoformation through vascular endothelial growth factor (VEGF). Our purpose was to determine the relationship between hCG serum levels, angiogenesis, and VEGF expression in germ cell testicular tumors. Methods: We conducted a retrospective study of 101 patients. Serum levels of hCG, alpha-fetoprotein (AFP), and lactate dehydrogenase were measured prior to surgery. Vascular density (VD) and VEGF tissue expression were determined by immunohistochemis...
Source: Journal of Experimental and Clinical Cancer Research - August 26, 2009 Category: Cancer & Oncology Authors: Oscar ArrietaRosa Michel OrtegaJulian Angeles-SanchezCynthia Villarreal-GarzaAlejandro Aviles-SalasJose Chanona-VilchisElena Arechaga-OcampoArturo Luevano-GonzalezMiguel JimenezJose Aguilar Source Type: journals

Oxaliplatin-dacarbazine combination chemotherapy for the treatment of advanced soft tissue sarcoma of the limbsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to explore the feasibility, safety, and outcomes of pre-operative oxaliplatin-dacarbazine combination therapy for the treatment of advanced soft tissue sarcoma (STS) of the limb.Patients and Methods: Between November 2005 and November 2008, 31 patients with advanced limb STS classified with stage IV STS were randomly assigned into experimental or control groups, and both were given 2 cycles of chemotherapy before undergoing surgery. The regimen for the experimental group was oxaliplatin (120 mg/m2, d1) in combination with dacarbazine (175 mg/m2, d1-3), while that for the control group was a standard...
Source: Journal of Experimental and Clinical Cancer Research - August 25, 2009 Category: Cancer & Oncology Authors: Xiang-Yun ZongYang YuHong-Jian Yang Source Type: journals

Does vimentin help to delineate the so-called 'basal type breast cancer'?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Vimentin is one of the cytoplasmic intermediate filament proteins which are the major component of the cytoskeleton. In our study we checked the usefulness of vimentin expression in identifying cases of breast cancer with poorer prognosis, by adding vimentin to the immunopanel consisting of basal type cytokeratins, estrogen, progesterone, and HER2 receptors. Methods: 179 tissue specimens of invasive operable ductal breast cancer were assessed by the use of immunohistochemistry. The median follow-up period for censored cases was 90 months. Results: 38 cases (21.2%) were identified as being vimentin-positive. Vim...
Source: Journal of Experimental and Clinical Cancer Research - August 19, 2009 Category: Cancer & Oncology Authors: Renata KusinskaRadzislaw KordekElzbieta PluciennikAndrzej BednarekJanusz PiekarskiPiotr Potemski Source Type: journals

Modeling of alpha/beta for late rectal toxicity from a randomized phase II study: conventional versus hypofractionated scheme for localized prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The ≥ G2 late toxicities in both arms were comparable, indicating the feasibility of hypofractionated regimes in prostate cancer. An α/β ratio for late rectal toxicity very close to 3 Gy was found. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 18, 2009 Category: Cancer & Oncology Authors: Simona MarziBiancamaria SaracinoMaria PetrongariStefano ArcangeliSara GomelliniGiorgio ArcangeliMarcello BenassiValeria Landoni Source Type: journals

Impact of relative dose intensity (RDI) in CHOP combined with rituximab (R-CHOP) on survival in diffuse large B-cell lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that in DLBL patients, mortality was affected by RDI of R-CHOP as the initial treatment, and the retention of a high RDI could therefore be crucial. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 18, 2009 Category: Cancer & Oncology Authors: Yoshiki TeradaHirohisa NakamaeRan AimotoHiroshi KanasimaErina SakamotoMizuki AimotoEri InoueHideo KohTakahiko NakaneYasunobu TakeokaMasahiko OhsawaKi-Ryang KohTakahisa YamaneYoshitaka NakaoKensuke OhtaAtsuko MugitaniHirofumi TeshimaMasayuki Hino Source Type: journals

Modeling of alfa beta ratio for late rectal toxicity from a randomized phase II study: conventional versus hypofractionated scheme for localized prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The >= G2 late toxicities in both arms were comparable, indicating the feasibility of hypofractionated regimes in prostate cancer. An alfa beta ratio for late rectal toxicity very close to 3 Gy was found. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 18, 2009 Category: Cancer & Oncology Authors: Simona MarziBiancamaria SaracinoMaria PetrongariStefano ArcangeliSara GomelliniGiorgio ArcangeliMarcello BenassiValeria Landoni Source Type: journals

Association of cetuximab with adverse pulmonary events in cancer patients: a comprehensive reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Development of anti-cancer targeted therapies from biologics is increasingly being utilized. Cetuximab, a chimeric monoclonal antibody, is one such anti-cancer targeted therapeutic that has shown efficacy in quelling the rate of patient decline in colorectal, head/neck, and non-small cell lung cancer. However, due to the relatively recent addition of biologic compounds to the therapeutic arsenal, information related to adverse reactions is less well known than those seen in traditional chemotherapeutics. ...
Source: Journal of Experimental and Clinical Cancer Research - August 13, 2009 Category: Cancer & Oncology Authors: Jeffrey HoagAimel AziziTimothy DohertyJason LuRudolph WillisMark Lund Source Type: journals

Association of cetuximab with adverse pulmonary events in lung cancer patients: a comprehensive reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Cetuximab, a chimeric monoclonal antibody, is one such biologic that has shown efficacy in quelling the rate of patient decline in colorectal, head/neck, and non-small cell lung cancer. However, due to the relatively recent addition of these biologic compounds to the therapeutic arsenal, information related to adverse reactions are less well known than those seen in traditional chemotherapeutics. Dermatologic reactions have been demonstrated as the most frequent side effect cited during cetuximab therapy ...
Source: Journal of Experimental and Clinical Cancer Research - August 13, 2009 Category: Cancer & Oncology Authors: Jeffrey HoagAimel AziziTimothy DohertyJason LuRudolph WillisMark Lund Source Type: journals

Adjuvant electrochemotherapy in veterinary patients: a model for the planning of future therapies in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperative, intraoperative, or postoperative. In selected patients adjuvant brachytherapy can be adopted. The goal of these associations is to achieve tumor control while maximally preserving the normal tissues from side effects. Unfortunately, the occurrence of local and distant complications is still elevated. Electrochemotherapy is a novel technique that combines the administration of anticancer agents to the application of...
Source: Journal of Experimental and Clinical Cancer Research - August 13, 2009 Category: Cancer & Oncology Authors: Enrico SpugniniGennaro CitroAlfonso Baldi Source Type: journals

Polymorphisms of TP53 codon 72 with breast carcinoma risk: evidence from 12226 cases and 10782 controlsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Collectively, the results of the present study suggest that TP53 codon 72 polymorphisms might not be a low-penetrant risk factor for developing breast carcinoma. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 13, 2009 Category: Cancer & Oncology Authors: Wenlei ZhuoYunsong ZhangZhaolan XiangLei CaiZhengtang Chen Source Type: journals

Traditional Chinese medicines in the treatment of hepatocellular cancers: a systematic review and meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined survival rates and pooled 15 studies reporting on 6 month outcomes (RR 1.10, 95% CI, 1.04-1.15, P= (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 11, 2009 Category: Cancer & Oncology Authors: Ping WuJean-Jacques DugouaOghenowede EyawoEdward Mills Source Type: journals

Subcellular localization of APMCF1 and its biological significance of expression pattern in normal and malignant human tissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results revealed a cytoplastic expression pattern of APMCF1 and up-regulated in tumour tissues suggesting APMCF1 may have potential relationship with oncogenesis. The data presented should serve as a useful reference for further studies of APMCF1 functions in tumorigenesis and might provide a potential anti-tumor target. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 8, 2009 Category: Cancer & Oncology Authors: Yaqing ZhangQinlong LiFeng ZhuJihong CuiKainan LiQing LiRuian WangWenyong WangWeihua WangWei Yan Source Type: journals

Arsenic trioxide exerts synergistic effects with cisplatin on non-small cell lung cancer cells via apoptosis inductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions As2O3 exerted synergistic effects with DDP on NSCLC cells, and the synergistic effects were partly due to the induction of caspase-independent apoptosis. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 7, 2009 Category: Cancer & Oncology Authors: Hecheng LiXiaoli ZhuYawei ZhangJiaqing XiangHaiquan Chen Source Type: journals

Multicenter safety study of mFOLFOX6 for unresectable advanced/recurrent colorectal cancer in elderly patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: mFOLFOX6 therapy was well-tolerated and effective in both non-elderly and elderly patients. However, discontinuation of treatment was sometimes necessary due to peripheral neuropathy, which is dose-limiting toxicity of this therapy. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 6, 2009 Category: Cancer & Oncology Authors: Shinichi SugimotoKuniyuki KatanoAkiyoshi KanazawaHiroshi YoshimuraAkihiko KidaniHiroshi TakedaMasato MakinoNobuhiro OzakiTsuneo TanakaMasahide Ikeguchi Source Type: journals

CDX2 hox gene product in a rat model of esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: De novo expression of Cdx2 is an early event in the spectrum of the lesions induced by experimental gastro-esophageal reflux and should be considered as a key step in the morphogenesis of esophageal adenocarcinoma. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 6, 2009 Category: Cancer & Oncology Authors: Giuseppe IngravalloLuigi Dall'OlmoDaniela SegatMatteo FassanClaudia MescoliEmanuela DazzoCarlo CastoroLorenzo PolimenoChristian RizzettoMaurizio David BaroniGiovanni ZaninottoErmanno AnconaMassimo Rugge Source Type: journals

Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this study, we provide the global gene expression profiles during the development and progression of liver cancer in rats. The data obtained from the gene expression profiles will allow us to acquire insights into the molecular mechanisms of hepatocarcinogenesis and identify specific genes (or gene products) that can be used for early molecular diagnosis, risk analysis, prognosis prediction, and development of new therapies. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 28, 2009 Category: Cancer & Oncology Authors: Yue-Fang LiuBin-Shan ZhaHui-Lin ZhangXiao-Jing ZhuYu-Hua LiJin ZhuXiao-Hong GuanZhen-Qing FengJian-Ping Zhang Source Type: journals

Mutation analysis of Rad18 in human cancer cell lines and NSCLC tissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Though the frequency of SNP was tended to be higher in NSCLC patients than healthy volunteers (57.7%), as the difference was not significant, we have concluded that there is no relation between Rad18 SNP and lung cancer development. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 24, 2009 Category: Cancer & Oncology Authors: Tadahiko NakamuraShinji IshikawaYoshikatsu KogaYouhei NagaiYu ImamuraKouei IkedaTakeshi MoriHiroaki NomoriHideo Baba Source Type: journals

Risedronate inhibits human osteosarcoma cell invasionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Given that MMP-2 and MMP-9 are instrumental in tumor cell invasion, our results suggest the risedronate could reduce osteosarcoma cell invasion. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 21, 2009 Category: Cancer & Oncology Authors: Zeng Feng XinYang Kyung KimSung Taek Jung Source Type: journals

Statistically significant association of the single nucleotide polymorphism (SNP) rs13181 (ERCC2) with predisposition to Squamous Cell Carcinomas of the Head and Neck (SCCHN) and Breast cancer in the north Indian populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of this case-control study indicate that the polymorphism rs13181 might be a risk factor for predisposition towards SCCHN and Breast cancer among north Indian subpopulations. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 17, 2009 Category: Cancer & Oncology Authors: Amit Kumar MitraNeetu SinghVivek Kumar GargRashmi ChaturvediMandira SharmaSrikanta Kumar Rath Source Type: journals

Lung cancer gene expression database analysis incorporating prior knowledge with support vector machine-based classification methodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The method that incorporates prior knowledge into discriminant analysis could effectively improve the capacity and reduce the impact of noise. This idea may have good future not only in practice but also in methodology. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 17, 2009 Category: Cancer & Oncology Authors: Peng GuanDesheng HuangMiao HeBaosen Zhou Source Type: journals

Retraction: siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Retraction (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 15, 2009 Category: Cancer & Oncology Authors: Huang HaoYu NancaiFu LeiWei XiongSu WenHuang GuofuWu YanxiaHuang HanjuLiu QianXiao Hong Source Type: journals

Substance P and beta endorphin mediate electro-acupuncture induced analgesia in mouse cancer pEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The findings of this study suggest that a S-180 cancer pain model is useful as a consistent and short time animal model. It also indicated that EA treatment could be used as an alternative therapeutic method for cancer pain due to a consequent decrease in substance P and increase in beta-endorphin levels. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 15, 2009 Category: Cancer & Oncology Authors: Hyo-Jeong LeeJae-Ho LeeEun-Ok LeeHyo-Jung LeeKwan-Hyun KimKeun-Sung LeeHee-Jae JungSun Hyung KimSung-Hoon Kim Source Type: journals

The calcimimetic R-568 induces apoptotic cell death in prostate cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Taken together, our data demonstrated that calcimimetic R-568 triggers an intrinsic mitochondria-related apoptotic pathway, which is modulated by Bcl-xL protein. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 13, 2009 Category: Cancer & Oncology Authors: Huaifu LiGuofeng RuanZhijun LiZiwei LiuXiaoqing ZhengHao ZhengGuangming ChengBenyi LiMing Zhan Source Type: journals

Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study suggests that intentional inhibition of ABCB1 and ABCG2 function at the blood-brain barrier is unlikely to significantly improve clinical outcome of imatinib with currently used dosing regimens. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 9, 2009 Category: Cancer & Oncology Authors: Erin GardnerNicola SmithWilliam FiggAlex Sparreboom Source Type: journals

The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: VEGF-C/D and Flt-4 may play an important role in the process of lymphatic metastasis of early-stage invasive cervical carcinoma through paracrine and autocrine mechanisms. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 8, 2009 Category: Cancer & Oncology Authors: Hao YuShiqian ZhangRenhua ZhangLinlin Zhang Source Type: journals

The effect of HER2 expression on cisplatin-based chemotherapy in advanced non- small cell lung cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Non-small cell lung cancer patients with high expression of HER2 exhibited resistance to cisplatin-based chemotherapies that are the standard treatment for this disease. Our results indicate that HER2 status may be a predictive and prognostic factor for cisplatin- based therapy response and disease survival. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - July 2, 2009 Category: Cancer & Oncology Authors: Zuleyha CalikusuYesim YildirimZafer AkcaliHakan SakalliNebil BalIlker UnalOzgur Ozyilkan Source Type: journals