CACNA2D1 regulates the progression and influences the microenvironment of colon cancer
ConclusionsCACNA2D1 plays an important role in the progression and the microenvironment of CC by regulating fibroblasts and may act as a biomarker for disease progression and a therapeutic target for CC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 27, 2024 Category: Gastroenterology Source Type: research

Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults.
ConclusionsBTR varies by sex and age even among healthy adults, and decreasing process and timing of BTR during disease progression is different among CLD etiologies. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 26, 2024 Category: Gastroenterology Source Type: research

A revolutionary oral HBV treatment candidate as innovative therapeutic approach warranting clinical trials
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 25, 2024 Category: Gastroenterology Source Type: research

Severe induction of aberrant DNA methylation by nodular gastritis in adults
ConclusionsSevere aberrant methylation, involving multiple tumor-suppressor genes, was induced in the gastric antrum and body of patients with NG, in accordance with their high gastric cancer risk. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 19, 2024 Category: Gastroenterology Source Type: research

Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
ConclusionsOST is an effective and safe low-volume agent for colonoscopy, with better tolerance than 2 L-PEG/Asc, in older individuals aged  ≥ 70 years. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 16, 2024 Category: Gastroenterology Source Type: research

Change in systemic steroid use and surgery rate in patients with inflammatory bowel disease: a Japanese real-world database analysis
ConclusionsSince biologics became available, corticosteroid use appears to have decreased, with more appropriate use. Furthermore, use of biologics may reduce surgery rates, particularly in patients with CD. UMIN Clinical Trials Registry; UMIN000035384. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 16, 2024 Category: Gastroenterology Source Type: research

Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
ConclusionsOST is an effective and safe low-volume agent for colonoscopy, with better tolerance than 2 L-PEG/Asc, in older individuals aged  ≥ 70 years. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 16, 2024 Category: Gastroenterology Source Type: research

Change in systemic steroid use and surgery rate in patients with inflammatory bowel disease: a Japanese real-world database analysis
ConclusionsSince biologics became available, corticosteroid use appears to have decreased, with more appropriate use. Furthermore, use of biologics may reduce surgery rates, particularly in patients with CD. UMIN Clinical Trials Registry; UMIN000035384. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 16, 2024 Category: Gastroenterology Source Type: research

The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia
ConclusionsIn LES of patients with achalasia, hypophosphorylation of LC20, a possible cause of impaired contractility, was associated with CPI-17 downregulation and an increased Th17-related immune response. The esophageal intraluminal environment, represented by the esophageal microbiota, could be associated with the development and exacerbation of achalasia. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 12, 2024 Category: Gastroenterology Source Type: research

Prevalence of colonoscopy in Japan using a large-scale health claims data compared to esophagogastroduodenoscopy
ConclusionsUsing large-scale data, we determined the status of CS and EGD in Japan. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 11, 2024 Category: Gastroenterology Source Type: research

Characterization of tumor microbiome and associations with prognosis in intrahepatic cholangiocarcinoma
ConclusionIn conclusion, our study characterized the tumor microbiome and revealed its role in predicting prognosis in ICC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 10, 2024 Category: Gastroenterology Source Type: research