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Predictors of a better outcome of pneumatic dilatation in patients with primary achalasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PD is a safe and effective treatment for achalasia, particularly in older patients who experience a better outcome than younger patients. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0145-4Authors Yuriko Tanaka, Nippon Medical School Division of Gastroenterology, Department of Medicine Sendagi 1-1-5, Bunkyo-ku Tokyo 113-8603 JapanKatsuhiko Iwakiri, Nippon Medical School Division of Gastroenterology, Department of Medicine Sendagi 1-1-5, Bunkyo-ku Tokyo 113-8603 JapanNoriyuki Kawami, Nippon Medical School Division of Gastroenterology, Departm...
Source: Journal of Gastroenterology - November 17, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human liversEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These findings indicated that LYVE-1 attenuation in sinusoidal endothelium was one of the manifestations of capillarization, and was associated with hepatic disease progression. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0152-5Authors Junko Arimoto, Osaka City University Graduate School of Medicine Department of Pathology 1-4-3, Asahimachi, Abeno-ku Osaka 545-8585 JapanYoshihiro Ikura, Osaka City University Graduate School of Medicine Department of Pathology 1-4-3, Asahimachi, Abeno-ku Osaka 545-8585 JapanTakehisa Suekane...
Source: Journal of Gastroenterology - November 11, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Gallstones increase the prevalence of Barrett’s esophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The presence of gallstones was independently associated with the presence of ESEM in the Japanese outpatient population, suggesting a causal association of distal esophageal bile exposure with the development of ESEM. Further studies are needed to confirm our findings in cases with histologically confirmed Barrett’s esophagus. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0153-4Authors Juntaro Matsuzaki, Keio University School of Medicine Division of Gastroenterology and Hepatology, Department of Internal Medicine 35 Shinanomachi Shinjuku-...
Source: Journal of Gastroenterology - November 11, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions shIGF-IR may have therapeutic utility in human digestive/gastrointestinal cancers, both alone and in combination with chemotherapy. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0151-6Authors Yu Wang, Sapporo Medical University First Department of Internal Medicine S-1, W-16, Chuo-ku Sapporo 060-8543 JapanYasushi Adachi, Sapporo Medical University First Department of Internal Medicine S-1, W-16, Chuo-ku Sapporo 060-8543 JapanArisa Imsumran, Sapporo Medical University First Department of Internal Medicine S-1, W-16, Chuo-ku Sapporo 060-8543 Jap...
Source: Journal of Gastroenterology - November 9, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Natural course of the remnant hepatic functional reserve as estimated by technetium-99m-galactosyl human serum albumin scintigraphy after a hepatectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Remnant hepatic functional reserve estimated by GSA scintigraphy revealed that a larger resected liver volume induced both more serious and continued remnant hepatic dysfunction in comparison to results shown by hematobiochemical tests, while the functional regeneration was also appreciably slower and more gradual in comparison to the volume regeneration. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0144-5Authors Yoshinori Shimizu, Showa University School of Medicine Division of Gastroenterological and General Surgery, Dep...
Source: Journal of Gastroenterology - November 6, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Clinical significance of alanine aminotransferase levels and the effect of ursodeoxycholic acid in hemodialysis patients with chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results indicate that HCV infection is a risk for thrombocytopenia which should be associated with hepatic fibrosis in HD patients. In addition, the clinical course of ALT levels predicts the progression of thrombocytopenia, and UDCA may effectively lower ALT levels in HD patients with HCV. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0149-0Authors Chika Nishida, Kagoshima University Graduate School of Medical and Dental Sciences Department of Digestive and Life-Style Related Disease, Health Research Course, Human an...
Source: Journal of Gastroenterology - November 4, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Age-related fat deposition in multifidus muscle could be a marker for nonalcoholic fatty liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The MM/F ratio was closely related to aging and visceral fat accumulation. The MM/F ratio was improved by weight reduction, indicating that fat accumulation in the multifidus muscle evaluated by computed tomography might be a therapeutic indicator of NAFLD. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0147-2Authors Yoichiro Kitajima, Saga Medical School Department of Internal Medicine 5-1-1 Nabeshima Saga 849-8501 JapanYuichiro Eguchi, Saga Medical School Department of Internal Medicine 5-1-1 Nabeshima Saga 849-8501 JapanE...
Source: Journal of Gastroenterology - November 3, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Autofluorescence imaging videoendoscopy in the diagnosis of chronic atrophic fundal gastritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions AFI could diagnose the extent of CAFG as a green area in the gastric body, with higher reproducibility compared with white-light endoscopy. Therefore, AFI may be a useful adjunct to endoscopy to identify patients at high risk of developing gastric cancer. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0150-7Authors Takuya Inoue, Osaka Medical Center for Cancer and Cardiovascular Disease Department of Gastrointestinal Oncology 1-3-3 Nakamichi, Higashinari-ku Osaka 537-8511 JapanNoriya Uedo, Osaka Medical Center for Cancer and Cardiovascular Dis...
Source: Journal of Gastroenterology - October 29, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Efficacy of camostat mesilate against dyspepsia associated with non-alcoholic mild pancreatic diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Camostat mesilate may serve as a therapeutic agent for patients with dyspepsia associated with mild pancreatic disease, who do not habitually drink alcohol. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0148-1Authors Jin Kan Sai, Juntendo University Department of Gastroenterology 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 JapanMasafumi Suyama, Juntendo University Department of Gastroenterology 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 JapanYoshihiro Kubokawa, Juntendo University Department of Gastroenterology 2-1-1 Hongo, Bunkyo-ku T...
Source: Journal of Gastroenterology - October 29, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Regular surveillance with ultrasonography and contrast-enhanced imaging is useful for detecting early-stage HCC and increase chances for curative treatments in patients with HCV-related chronic liver disease. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0131-xAuthors Ikue Noda, Hiroshima Prefectural Hospital Department of Gastroenterology 1-5-54, Ujina-Kanda, Minami-ku Hiroshima 734-8530 JapanMikiya Kitamoto, Hiroshima Prefectural Hospital Department of Gastroenterology 1-5-54, Ujina-Kanda, Minami-ku Hiroshima 734-8530 Japa...
Source: Journal of Gastroenterology - October 29, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Methylation levels in gastric mucosae decreased to certain levels after HP eradication in profiles unique to individual markers. Involvement of chronic inflammation in methylation induction was suggested. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0142-7Authors Takeshi Nakajima, National Cancer Center Research Institute Carcinogenesis Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanShotaro Enomoto, National Cancer Center Research Institute Carcinogenesis Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanSatoshi Yamashita, National Can...
Source: Journal of Gastroenterology - October 10, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

A new approach to percutaneous transhepatic portal embolization using ethanolamine oleate iopamidolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion EOI is a safe embolic material that can be used to induce greater liver hypertrophy, in comparison to fibrin glue, in PTPE for liver tumors. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0143-6Authors Toru Beppu, Kumamoto University Department of Gastroenterological Surgery, Graduate School of Medical Sciences Honjo 1-1-1 Kumamoto 860-8556 JapanMasaaki Iwatsuki, Kumamoto University Department of Gastroenterological Surgery, Graduate School of Medical Sciences Honjo 1-1-1 Kumamoto 860-8556 JapanHirohisa Okabe, Kumamoto Univers...
Source: Journal of Gastroenterology - October 10, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Inflammatory bowel disease: review from the aspect of geneticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Regardless of how inflammatory bowel disease (IBD) is defined, the term “genetic susceptibility” is always included. Due to substantial progress in the characterization of susceptible genes that interact with environmental influences, a number of review articles offering the latest insights continue to be presented. To date, more than 30 novel IBD susceptible loci have been found, while several promising associations between IBD and gene variants have also been identified and replicated effectively. The present review highlights recent insights regarding linkage analysis and genome-wide associat...
Source: Journal of Gastroenterology - October 5, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

The intertwisted correlations among non-alcoholic fatty liver disease, atherosclerosis, and metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00535-009-0140-9Authors Haruhisa Nakao, Aichi Medical University Division of Gastroenterology, Department of Internal Medicine 21 Karimata Yazako Nagakute Aichi 480-1195 JapanMasashi Yoneda, Aichi Medical University Division of Gastroenterology, Department of Internal Medicine 21 Karimata Yazako Nagakute Aichi 480-1195 Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 3, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: the STEATO StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The results of the present study demonstrate that hepatic steatosis measured by echography is associated with carotid atherosclerosis in a large population mostly carrying cardiovascular or metabolic risk factors, independently of MS, cardiovascular diseases, diabetes mellitus and/or insulin resistance. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0125-8Authors Claudio Carallo, “Magna Græcia” University Metabolic Diseases Unit, Department of Clinical and Experimental Medicine “G. Salvatore” Viale Europa 88100 Cata...
Source: Journal of Gastroenterology - October 3, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Increased expression of miR-421 in human gastric carcinoma and its clinical associationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions miR-421 may involve in the early stage of stomach carcinogenesis and could be used as an efficient diagnostic biomarker. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0135-6Authors Zhen Jiang, Ningbo University School of Medicine Institute of Biochemistry and Molecular Biology Ningbo 315211 ChinaJunming Guo, Ningbo University School of Medicine Institute of Biochemistry and Molecular Biology Ningbo 315211 ChinaBingxiu Xiao, Ningbo University School of Medicine Institute of Biochemistry and Molecular Biology Ningbo 315211 ChinaYing Miao, Ningbo...
Source: Journal of Gastroenterology - October 3, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Microwave coagulation versus sclerotherapy after band ligation to prevent recurrence of high risk of bleeding esophageal varices in Child-Pugh’s A and B patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Application of MC to esophageal varices after band ligation is safe. The post-MC recurrence rate may be comparable to that observed following the combined treatment of EBL and EIS. The presence of gastric varices increases the risk of esophageal variceal recurrence. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0134-7Authors Leonardo Trevizan Monici, State University of Campinas (Unicamp) Gastroenterological Diagnosis and Research Center (Gastrocentro) Rua Carlos Chagas 420, Cidade Universitária Zeferino Vaz Campinas SP 13...
Source: Journal of Gastroenterology - October 3, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Identification and location of label retaining cells in mouse liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The LRC method together with our novel KAL method reported here may be used to identify and locate possible HSPCs. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0139-2Authors Fusheng Li, Zhejiang Sci-Tech University Institute of Biochemistry, College of Life Sciences 310018 Hangzhou People’s Republic of ChinaLeilei Lu, Tohoku University Department of Bimolecular Engineering Aoba-yama 6-6-11-608, Aoba-ku Sendai Miyagi 980-8579 JapanJingjing Lu, Changzhou Tenraid Biotech Company Room 303, Building A, No. 25 Mid Changjiang Rd ...
Source: Journal of Gastroenterology - October 3, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Prospective clinical trial: enteral nutrition during maintenance infliximab in Crohn’s diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The outcomes of this prospective study showed that concomitant EN during infliximab maintenance therapy does not significantly increase the maintenance rate of clinical remission in patients with CD. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0136-5Authors Takayuki Yamamoto, Yokkaichi Social Insurance Hospital Inflammatory Bowel Disease Center 10-8 Hazuyamacho Yokkaichi Mie 510-0016 JapanMaki Nakahigashi, Yokkaichi Social Insurance Hospital Inflammatory Bowel Disease Center 10-8 Hazuyamacho Yokkaichi Mie 510-0016 JapanSatoru Umegae, Yokkai...
Source: Journal of Gastroenterology - October 1, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Etiology of liver cirrhosis in Japan: a nationwide surveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The major etiology of liver cirrhosis in Japan remains HCV. Our survey revealed the prevalence of NASH-related LC in Japan and the frequency of HCC. Future changes in etiology must be considered in establishing preventive or educational strategies, as well as in developing new treatment strategies. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0128-5Authors Kojiro Michitaka, Ehime University Graduate School of Medicine Department of Gastroenterology and Metabology Shitsukawa Toon Ehime 791-0295 JapanShuhei Nishiguchi, Hyogo...
Source: Journal of Gastroenterology - September 29, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Steatosis and hepatic expression of genes regulating lipid metabolism in Japanese patients infected with hepatitis C virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These findings indicate that impaired degradation of lipid may contribute to the development of hepatitis C virus-related steatosis. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0133-8Authors Kohichiroh Yasui, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science 465 Kajii-cho, Kamigyo-ku Kyoto 602-8566 JapanYuichi Harano, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical ...
Source: Journal of Gastroenterology - September 29, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions REG4 is expressed in pancreatic cancer, and serum levels of REG4 offer a useful indicator for distinguishing between patients with pancreatic cancer and healthy subjects. Serum REG4 has potential for use as a screening serum marker for pancreatic cancers, including early-stage cancers. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0114-yAuthors Reiko Takayama, Aichi Cancer Center Hospital Department of Gastroenterology 1-1 Kanokoden, Chikusa-ku Nagoya Aichi 464-0021 JapanHidewaki Nakagawa, The University of Tokyo Laboratory...
Source: Journal of Gastroenterology - September 29, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Ultrasound-guided percutaneous drainage may decrease the mortality of severe acute pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Patients with SAP and a CTSI ≤ 8.0 could be treated with conservative therapy, while patients with a CTSI > 8.0 should be treated with surgery or PCD therapy if the life-threatening complications of extensive fluid collection or necrosis are a factor. However, PCD therapy used in a timely manner for drainage may decrease mortality in patients with SAP, decrease inflammatory mediator release, and avoid incidence of severe sepsis or acute respiratory distress syndrome (ARDS) and emergency surgery. Content Type Journal ArticleCategory Original Article—Liver, Pancreas...
Source: Journal of Gastroenterology - September 29, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Retrospective analysis on the management of anticoagulants and antiplatelet agents for scheduled endoscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We revealed the low permeation of the guideline to prescribing doctors. Cessation before endoscopy to avoid bleeding complications can be dispensable. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0127-6Authors Satoshi Ono, University of Tokyo Department of Gastroenterology, Graduate School of Medicine 7-3-1 Hongo Bunkyo Tokyo JapanMitsuhiro Fujishiro, University of Tokyo Department of Gastroenterology, Graduate School of Medicine 7-3-1 Hongo Bunkyo Tokyo JapanKousuke Hirano, University of Tokyo Department of Gastroenterology, Graduate School ...
Source: Journal of Gastroenterology - September 18, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Long-term outcome of endoscopic and/or percutaneous transhepatic therapy in patients with biliary stricture after orthotopic liver transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Endoscopic as well as percutaneous transhepatic approaches in combination or as monotherapy are effective in the management of anastomotic and non-anastomotic strictures after liver transplantation. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0123-xAuthors Andreas Weber, Technical University of Munich Department of Gastroenterology and Hepatology Munich GermanyChristian Prinz, Technical University of Munich Department of Gastroenterology and Hepatology Munich GermanyCarlos Gerngroß, Technical University of Munich Departme...
Source: Journal of Gastroenterology - September 18, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study indicated risk factors for serious complications of ESD. Large resected tumor size was a risk factor for post-operative bleeding, while long operation time was a risk factor for perforation. Information regarding operation risk factors should be useful for planning strategies for ESD. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0137-4Authors Kotaro Mannen, Saga Medical School Department of Internal Medicine and Gastrointestinal Endoscopy 5-1-1 Nabeshima Saga 849-8501 JapanSeiji Tsunada, Saga Medical School Department of Internal...
Source: Journal of Gastroenterology - September 17, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The results of this study suggest that the replication of HCV replicon utilizes machinery involving cellular autophagic proteolysis. The therapy targeted to autophagic proteolysis by using chloroquine may provide a new therapeutic option against chronic hepatitis C. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0132-9Authors Tomokazu Mizui, Juntendo University, School of Medicine Department of Gastroenterology Hongo 2-1-1, Bunkyo-ku Tokyo 113-8421 JapanShunhei Yamashina, Juntendo University, School of Medicine Department of ...
Source: Journal of Gastroenterology - September 17, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Immunoglobin G4-related sclerosing cholangitis (IgG4-SC) is recognized as one of the systemic sclerosing diseases characterized by abundant IgG4-positive plasma cells with effective steroid therapy. On the other hand, primary sclerosing cholangitis (PSC), recognized as a sclerosing cholangitis of unknown origin without steroid efficacy, has been often clinically confused with IgG4-SC. To date, the prognosis of IgG4-SC is unclear, while the prognosis of PSC is well known to be poor. Therefore, it is clinically very important to be able to distinguish IgG4-SC from PSC. However, at the present time it ...
Source: Journal of Gastroenterology - September 17, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Viral factors influencing the response to the combination therapy of peginterferon plus ribavirin in chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hepatitis C virus (HCV) is a single-stranded RNA virus known for its high genetic variability owing to the lack of a proofreading mechanism of its RNA dependent RNA polymerase. Until now, numerous studies have been undertaken to clarify the correlation between pretreatment HCV genetic variability and the therapeutic response. Even with the recent combination therapy of peginterferon plus ribavirin for chronic hepatitis C, viral response is variable, and only half of treated patients could clear the virus [sustained viral response (SVR)]. In this review, the contribution of viral genetic variability ...
Source: Journal of Gastroenterology - September 15, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The EC system is markedly up-regulated in the livers of patients with PBC and it may exert a role regulating adaptive mechanisms in cholestasis. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0122-yAuthors Annarosa Floreani, University of Padua Department of Surgical and Gastroenterological Sciences Via Giustiniani, 2 35128 Padua ItalyRoberta Lazzari, University of Padua Department of Surgical and Gastroenterological Sciences Via Giustiniani, 2 35128 Padua ItalyVeronica Macchi, University of Padua Department of Human Anatomy ...
Source: Journal of Gastroenterology - September 15, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Pharmacogenomics in chemotherapy for GI tract cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The study of pharmacogenomics (PGx) has recently been intensively applied to gastrointestinal tract cancer. It has become clear that there are genetic differences in the activities of enzymes that influence the kinetics of chemotherapeutic agents. Moreover, genetic differences related to cellular sensitivity to anti-cancer agents have also been elucidated. In GI-tract cancer chemotherapy, 5-FU, gemcitabine, taxanes (docetaxel and paclitaxel), platinum (cisplatin and oxaliplatin) and irinotecan are often used, and molecular targeting therapy has also been developed. The respective PGx markers to such...
Source: Journal of Gastroenterology - September 3, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

A pilot trial of body weight reduction for nonalcoholic fatty liver disease with a home-based lifestyle modification intervention delivered in collaboration with interdisciplinary medical staffEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The reduction in body weight achieved by NAFLD patients during the 6-month intervention was associated with improved fat deposition and liver function. This intervention offers a practical approach for treating a large number of NAFLD patients with lifestyle modification therapy. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0115-xAuthors Noriko Oza, Saga Medical School Department of Internal Medicine 5-1-1 Nabeshima Saga 849-8501 JapanYuichiro Eguchi, Saga Medical School Department of Internal Medicine 5-1-1 Nabeshima Saga...
Source: Journal of Gastroenterology - September 3, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive JapaneseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our study results revealed that the RUNX3 intronic T/A polymorphism (rs760805) might modulate the risk of gastric atrophy among H. pylori seropositive subjects, and the RUNX3 T/A polymorphism at exon 1 (rs6672420) had little influence on the risks of H. pylori infection, gastric atrophy or gastric cancer in Japanese people. Further investigation is required to verify our findings. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0118-7Authors Asahi Hishida, Nagoya University Graduate School of Medicine Department of Preventive Medicine/Biostatist...
Source: Journal of Gastroenterology - September 3, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Diagnosis of endoscopic Barrett’s esophagus by transnasal flexible spectral imaging color enhancementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The transnasal FICE system enables clear visualization of palisade vessels and provides better contrasting images of the demarcation between the BE mucosa and the gastric mucosa, and thus contributes to easier diagnosis of endoscopic BE. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0121-zAuthors Hiroyuki Osawa, Jichi Medical University Division of Gastroenterology, Department of Internal Medicine 3311-1 Yakushiji, Shimotsuke Tochigi 329-0498 JapanHironori Yamamoto, Jichi Medical University Division of Gastroenterology, Department of Internal...
Source: Journal of Gastroenterology - August 28, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Eradication of gastric cancer and more efficient gastric cancer surveillance in Japan: two peas in a podEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We provide a historical review and update on current thinking regarding the possibility of elimination of gastric cancer from Japan. Because Helicobacter pylori infection is the cause gastric cancer, its elimination forms the cornerstone of eradication of gastric cancer. However, simply eradicating H. pylori from the entire population will not immediately solve the problem because many patients with H. pylori infections have already developed the precursor lesion, atrophic gastritis. Cure of H. pylori in these high risk patients will only reduce the risk of subsequent cancer. In contrast, treatment of...
Source: Journal of Gastroenterology - August 28, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Interleukin 10 inhibits interferon γ- and tumor necrosis factor α-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions IL-10 may be a possible down-regulator of the Nox1-based oxidase in the colon, suggesting a potential role of reactive oxygen species (ROS) derived from Nox1-based oxidase in inflammation of the colon. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0119-6Authors Mai Kamizato, The University of Tokushima Graduate School Department of Stress Science, Institute of Health Biosciences 3-18-15 Kuramoto-cho Tokushima 770-8503 JapanKensei Nishida, The University of Tokushima Graduate School Department of Stress Science, Institute of Health Biosciences...
Source: Journal of Gastroenterology - August 28, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Clinical impact of radiotherapy for locally advanced pancreatic cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Gemcitabine chemotherapy showed similar survival benefit compared to 5-fluorouracil- and gemcitabine-based chemoradiotherapy. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0116-9Authors Akira Sawaki, Aichi Cancer Center Hospital Department of Gastroenterology 1-1 Kanokoden Chikusa-ku Nagoya Aichi 464-8681 JapanNoriyuki Hoki, Bell Land General Hospital Department of Gastroenterology Sakai JapanSatoko Ito, Shimane University School of Medicine Department of Gastroenterology Izumo JapanKazuya Matsumoto, Aichi Cancer Center Hospi...
Source: Journal of Gastroenterology - August 24, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The results suggest that plasma acyl-ghrelin concentration decreases in accordance with the extent of atrophic change in gastric mucosa irrespective of Hp infection, indicating that the low plasma acyl-ghrelin level of subjects with Hp infection is mainly caused by the progress of atrophic changes in gastric mucosa. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0120-0Authors Junichi Kawashima, Saitama Medical University Department of Gastroenterology and Hepatology, Saitama Medical Center 1981 Kamoda Tsujido-Machi Kawagoe Saitama 350-8550 Ja...
Source: Journal of Gastroenterology - August 21, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Taken together, CHM-1 acted against colorectal adenocarcinoma cells in vitro via G2/M arrest and apoptosis, and CHM-1-P inhibited tumor growth in vivo. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0111-1Authors Li-Chen Chou, China Medical University Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy No 91, Hsueh-Shih Road Taichung 404 TaiwanJai-Sing Yang, China Medical University Department of Pharmacology, School of Medicine, College of Medicine Taichung 404 TaiwanLi-Jiau Huang, China Medical University Graduate Institute o...
Source: Journal of Gastroenterology - August 18, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion ES may promote GAR in humans through nNOS-related NO; therefore, it may be useful for patients with FD. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0113-zAuthors Yoshiaki Matsumoto, Hiroshima University Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences 1-2-3 Kasumi, Minami-ku Hiroshima 734-8551 JapanMasanori Ito, Hiroshima University Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences 1-2-3 Kasumi, Minami-ku Hiroshima 734-8551 JapanMasataka Tsuge, Hiroshima University Departm...
Source: Journal of Gastroenterology - August 14, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study indicates HCC might arise frequently from non-cirrhotic NASH. While further studies are needed to confirm this observation, both cirrhotic and non-cirrhotic NASH warrant regular screening for HCC. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0112-0Authors Natsuko Kawada, Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Gastrointestinal Oncology 1-3-3 Nakamichi, Higashinari-ku Osaka 537-8511 JapanKazuho Imanaka, Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Gastr...
Source: Journal of Gastroenterology - August 11, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Sonic hedgehog relates to colorectal carcinogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This result indicates that Shh-related carcinogenesis and Shh expression may be a trigger for the adenoma-carcinoma sequence. This study suggests a potential therapeutic target of hedgehog blockade in carcinogenesis. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0110-2Authors Kozo Yoshikawa, The University of Tokushima Graduate School Department of Surgery, Institute of Health Biosciences 3-18-15 Kuramoto Tokushima Tokushima 770-8503 JapanMitsuo Shimada, The University of Tokushima Graduate School Department of Surgery, Institute of Health Bio...
Source: Journal of Gastroenterology - August 7, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Transcatheter arterial infusion chemotherapy with cisplatin–lipiodol suspension in patients with hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions TAI with cisplatin suspended in lipiodol exhibited favorable tumor efficacy and survival in patients with hepatocellular carcinoma. The prognostic factors identified and the index proposed based on these factors may be useful for predicting life expectancy, determining treatment strategies, and designing future clinical trials. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0109-8Authors Masafumi Ikeda, Kumamoto University Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences 1-1-1, Honjo Kumamot...
Source: Journal of Gastroenterology - August 4, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Endoscopic transpapillary intraductal ultrasonography and biopsy in the diagnosis of IgG4-related sclerosing cholangitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The IDUS findings were useful for distinction of IgG4-SC from cholangiocarcinoma. Transpapillary biopsy was not useful for direct diagnosis of IgG4-SC even after IgG4 immunostaining, but it did allow distinction of IgG4-SC from cholangiocarcinoma in some cases. IDUS and transpapillary biopsy after endoscopic retrograde cholangiopancreatography can provide further information for precise diagnosis of IgG4-SC. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0108-9Authors Itaru Naitoh, Nagoya City University Graduate School of ...
Source: Journal of Gastroenterology - July 27, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

A prospective randomized controlled multicenter trial of duodenoscopes with 5° and 15° backward-oblique angle using wire-guided cannulation: effects on selective cannulation of the common bile duct in endoscopic retrograde cholangiopancreatographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions With 15° BOAD, bile duct cannulation was favorable without papillotome bow-up. With 5° BOAD, the success rate of WGC may be improved by adjusting the angle based on papillotome bow-up. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0107-xAuthors Hiroshi Kawakami, Hokkaido University Graduate School of Medicine Department of Gastroenterology Kita 15, Nishi 7, Kita-ku Sapporo 060-8638 JapanHiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital Sapporo JapanTsuyoshi Hayashi, Sapporo Medical University School o...
Source: Journal of Gastroenterology - July 27, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Cardiac tamponade originating from gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the editorDOI 10.1007/s00535-009-0105-zAuthors Kazuya Hattori, University of Tsukuba Departments of Internal Medicine and Surgery, Mito Medical Center, Mito Kyodo General Hospital Mito Ibaraki 310-0015 JapanTadashi Kondo, University of Tsukuba Departments of Internal Medicine and Surgery, Mito Medical Center, Mito Kyodo General Hospital Mito Ibaraki 310-0015 JapanMasayoshi Yamamoto, University of Tsukuba Departments of Internal Medicine and Surgery, Mito Medical Center, Mito Kyodo General Hospital Mito Ibaraki 310-0015 JapanMuneaki Watanabe, University of Tsukuba Departmen...
Source: Journal of Gastroenterology - July 25, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Decreased production of immunoglobulin M and A in autoimmune pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The ratios of IgG to IgM and IgG to IgA may serve as novel diagnostic markers to differentiate AIP from other hepato-pancreatic diseases. Furthermore, low concentrations of IgM and IgA may be involved in the pathogenesis of AIP. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0106-yAuthors Masashi Taguchi, University of Occupational and Environmental Health, Japan School of Medicine Third Department of Internal Medicine 1-1 Iseigaoka, Yahatanishi-ku Kitakyushu 807-8555 JapanYasuyuki Kihara, University of Occupational and Envir...
Source: Journal of Gastroenterology - July 24, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Coping strategy when patients with quiescent Crohn’s disease recognize that their conditions are worseningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The major coping strategy was “change contents of meals,” and the minor coping strategy was “see a doctor immediately.” The subjects with unstable disease state adopted the coping strategy of “take (add to) elemental diet.” The coping strategies for worsening conditions vary according to patients’ backgrounds. The coping type should be taken into account when treating CD patients. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0104-0Authors Makoto Tanaka, The University of Tokyo Department of Adult Nursing/Palliative Care Nursin...
Source: Journal of Gastroenterology - July 15, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Comparison between emergency and elective endoscopic sphincterotomy in patients with acute cholangitis due to choledocholithiasis: is emergency endoscopic sphincterotomy safe?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Combination therapy comprising EBD plus EST as the initial treatment for patients with moderate acute cholangitis due to choledocholithiasis was safe and did not prolong the period of hospitalization. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0100-4Authors Toshiharu Ueki, Fukuoka University Department of Gastroenterology, Chikushi Hospital 1-1-1 Zokumyoin Chikushino Fukuoka 818-8502 JapanKeisuke Otani, Fukuoka University Department of Gastroenterology, Chikushi Hospital 1-1-1 Zokumyoin Chikushino Fukuoka 818-8502 JapanNa...
Source: Journal of Gastroenterology - July 14, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Appearance of epithelial and stromal genomic instability in background colorectal mucosa of sporadic colorectal cancer patients: relation to age and genderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Genomic instability of both MSI and LOH in noncancerous colonic mucosa, and more particularly epithelial and stromal LOH, appears relatively early in adults, suggesting age-related changes which increase the risk of cancer development, particularly in males. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0103-1Authors Harue Umeto, Kitasato University Postgraduate School of Medical Sciences Department of Cellular and Histo-pathology Sagamihara JapanTsutomu Yoshida, Kitasato University Postgraduate School of Medical Sciences Department of Cellu...
Source: Journal of Gastroenterology - July 10, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals