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P38 mitogen activated protein kinase expression and regulation by interleukin-4 in human B cell non-Hodgkin lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, there is constitutive expression and activation of p38 MAPK in a large number of B-lymphoma-derived cell lines and primary lymphoma tissues, supportive of its role in lymphomagenesis. The differential IL-4 regulation of p38 MAPK expression in cell lines derived from DLBCL may relate to the cellular origin of these neoplasms. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12308-009-0049-5Authors Hu Ding, University of Utah Health Sciences Center Salt Lake City UT USAAli M. Gabali, University of Michigan Department of Pathology 4061 BSRB, 109 Zina Pitcher Place Ann Arbor MI 48109 USAS...
Source: Journal of Hematopathology - October 21, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Changed concepts and definitions of myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in the updated 2008 WHO classificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The purpose of this overview is to discuss the changes in the 2008 WHO classification of myeloid neoplasms, with exclusion of acute myeloid leukaemia. Specific mutations or rearrangements leading to constitutive activation of growth factor receptors or cytoplasmic tyrosine kinases are now recognised as recurrent genetic events characterising the group of myeloproliferative neoplasms (MPN). A newly introduced subgroup consists of patients with persistent eosinophilia and myeloid or lymphoid proliferations harbouring specific genetic changes involving platelet-derived growth factor receptors alpha and...
Source: Journal of Hematopathology - September 28, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Journal of Hematopathology listed in PubMed!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12308-009-0047-7Authors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - September 28, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Recent advances in bone marrow biopsy pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The second quarter of 2009 saw steady advances in bone marrow biopsy (BMB) pathology. The following publications are a personal selection of the highlights. Quality issues in diagnostic immunohistochemistry for BMB have largely been ignored in external quality assurance programmes, and this issue is highlighted. In other areas, publications reflecting advances in flow cytometry and aspirate morphology are discussed where translation to the BMB is possible. Classifications undergo constant change, and several publications address the redefinition of the cut off points between malignancy, benign, and ...
Source: Journal of Hematopathology - September 28, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

New developments in the pathology of malignant lymphoma: a review of the literature published from January to August 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Review of the LiteratureDOI 10.1007/s12308-009-0046-8Authors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - September 28, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

A cytomorphological and immunohistochemical profile of aggressive B-cell lymphoma: high clinical impact of a cumulative immunohistochemical outcome predictor scoreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We analyzed morphological and immunohistochemical features in 174 aggressive B-cell lymphomas of nodal and extranodal origin. Morphological features included presence or absence of a follicular component and cytologic criteria according to the Kiel classification, whereas immunohistochemical studies included expression of CD10, BCL-2, BCL-6, IRF4/MUM1, HLA-DR, p53, Ki-67 and the assessment of plasmacytoid differentiation. Patients were treated with a CHOP-like regimen. While the presence or absence of either CD10, BCL-6 and IRF4/MUM1 reactivity or plasmacytoid differentiation did not identify partic...
Source: Journal of Hematopathology - September 3, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Rare lymphoid malignancies of the breast: a report of two cases illustrating potential diagnostic pitfallsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe two cases of lymphoid malignancies predominantly involving the breast, both presenting diagnostic dilemmas. The first case, ALK-negative anaplastic large-cell lymphoma involving a seroma associated with a breast implant, is an emerging clinicopathologic entity. Anaplastic large-cell lymphoma has been identified in association with breast implants and seroma formation relatively recently. The second case, hairy cell leukemia involving the breast and ipsilateral axillary sentinel lymph node, is, to our knowledge, the first reported case of hairy cell leukemia involving the breast at the time of diagnosis. Wh...
Source: Journal of Hematopathology - August 20, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

The 2008 WHO-classification: small and big changes!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12308-009-0042-zAuthors J. H. van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - July 30, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Carcinoma and multiple lymphomas in one patient: establishing the diagnoses and analyzing risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a patient who showed the sequential occurrence of four different lymphoid neoplasms together with a squamous cell carcinoma of the lung. A 62-year-old man with adenopathy was admitted to the hospital, and lymph node biopsy was positive for low-grade follicular lymphoma. He achieved a partial remission with chemotherapy. Two years later, a PET-CT scan showed a left hilar mass in the lung; biopsy showed a squamous cell carcinoma. Simultaneously, he was diagnosed with diffuse large B cell lymphoma in a neck lymph node; after chemo- and radiotherapy, he achieved a complete response. A restaging PET-C...
Source: Journal of Hematopathology - July 30, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Commentary on the WHO 2008 classification of neoplasms arising from histiocytic and other accessory cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CommentDOI 10.1007/s12308-009-0035-yAuthors Megan S. Lim, University of Michigan Medical School Department of Pathology M5242D, Med Sci I, 1301 Catherine Road Ann Arbor MI 48109 USA Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - July 30, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

UK-based real-time lymphoproliferative disorder diagnostic service to improve the management of patients in GhanaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study confirmed findings from wealthy countries that a specialised haematopathology service can improve LPD diagnosis. This model of Ghana–UK collaboration provides a platform on which to build local capacity to operate an international quality diagnostic service for LPDs. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12308-009-0032-1Authors Elizabeth Parkins, Royal Cornwall Hospital Trust Truro TR1 3LJ UKRoger G. Owen, St James’s Institute of Oncology HMDS Laboratory Beckett Street Leeds LS9 7TF UKGeorge Bedu-Addo, Kwame Nkrumah University of Science and Technology Komfo Anokye Teachin...
Source: Journal of Hematopathology - July 9, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A case of primary myelofibrosis involving lymph node and with a novel cytogenetic abnormality [del (18) (p11.2-3)] is reported. The abnormalities are identical among specimens from the lymph node, peripheral blood, and bone marrow that were analyzed years apart. Additionally, we show that the infiltrate by dysplastic megakaryocytes in the lymph node morphologically mimics a metastatic mesenchymal neoplasm, even when the clinical history myelofibrosis was known. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12308-009-0040-1Authors Youjun Hu, Stony Brook University Hospital Departme...
Source: Journal of Hematopathology - June 30, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Commentary on the 2008 WHO classification of mature T- and NK-cell neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In 2008, the World Health Organization (WHO) published a revised and updated edition of the classification of tumors of the hematopoietic and lymphoid tissues. The aims of the fourth edition of the WHO classification was to incorporate new scientific and clinical information in order to refine diagnostic criteria for previously described neoplasms and to introduce newly recognized disease entities. The recognition that T-cell lymphomas are related to the innate and adaptive immune system, as well as enhanced understanding of other T-cell subsets, such as the regulatory T-cell and follicular helper T...
Source: Journal of Hematopathology - June 29, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Commentary on the WHO classification of tumors of lymphoid tissues (2008): “Gray zone” lymphomas overlapping with Burkitt lymphoma or classical Hodgkin lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The 2008 WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues has introduced two new categories of high-grade B-cell lymphomas: entities in which features of diffuse large B-cell lymphoma (DLBCL) overlap with Burkitt lymphoma (DLBCL/BL) or classical Hodgkin lymphoma (DLBCL/HL). The DLBCL/BL category encompasses cases that resemble Burkitt lymphoma morphologically, but have one or more immunophenotypic or molecular genetic deviations that would exclude it from the BL category; conversely, some cases have immunophenotypic and/or genetic features of BL, but display cytologic variability ...
Source: Journal of Hematopathology - June 29, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Commentary on the WHO classification of tumors of lymphoid tissues (2008): indolent B cell lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The 4th edition of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues introduces many new items to the classification scheme of the so-called indolent B cell lymphomas. New proposed entities, such as splenic B cell lymphoma/leukemia, unclassifiable, splenic diffuse red pulp small B cell lymphoma, hairy cell leukemia variant, pediatric follicular lymphoma, and pediatric marginal zone lymphoma have been coined, and some definitions of established diseases, such as chronic lymphocytic leukemia or Waldenström’s macroglobulinemia have been revised. One aspect o...
Source: Journal of Hematopathology - June 25, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Commentary on the WHO classification of tumors of lymphoid tissues (2008): aggressive B-cell lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In the novel WHO classification 2008, the classification of aggressive B-cell lymphoma has been revised for several categories with the aim to define “clean” entities. Within large B-cell lymphoma, a few distinct clinico-pathological entities have been recognized with more clinically defined entities than pathologically defined ones. The majority of known morphological variations were not considered to merit more than classification as a variant of DLBCL, not otherwise specified. Specifically, a biological subgrouping of DLBCL on the basis of molecular (activated B-cell versus germinal center B-...
Source: Journal of Hematopathology - June 17, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Ki-67 as a prognostic marker in mantle cell lymphoma—consensus guidelines of the pathology panel of the European MCL NetworkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Mantle cell lymphoma (MCL) has a heterogeneous clinical course and is mainly an aggressive B cell non-Hodgkin lymphoma; however, there are some indolent cases The Ki-67 index, defined by the percentage of Ki-67-positive lymphoma cells on histopathological slides, has been shown to be a very powerful prognostic biomarker. The pathology panel of the European MCL Network evaluated methods to assess the Ki-67 index including stringent counting, digital image analysis, and estimation by eyeballing. Counting of 2 × 500 lymphoma cells is the gold standard to assess the Ki-67 index since this value has...
Source: Journal of Hematopathology - June 17, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Recent advances in bone marrow biopsy pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12308-009-0033-0Authors Jon van der Walt, St. Thomas’ Hospital Department of Histopathology Westminster Bridge Road London SE1 7EH UK Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 14, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Transdifferentiation of B cell lymphoma of germinal center cell origin to histiocytic sarcoma has recently been described but is a rare occurrence. The cause for loss of B cell differentiation in these lymphomas is unknown. We investigated whether somatic hypermutation of the PAX-5 gene, a transcription factor that is important for maintaining B cell identity and is frequently mutated in B cell lymphomas of germinal center cell origin, might be a cause for loss of PAX-5 expression and thus B cell phenotype. However, no somatic hypermutation of the PAX-5 gene was detected in the two cases we studied....
Source: Journal of Hematopathology - May 9, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Epstein–Barr virus-associated inflammatory pseudotumor of the spleen: report of two cases and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two rare examples of Epstein–Barr virus (EBV)-associated inflammatory pseudotumor of the spleen. One patient presented with night sweats, abdominal pain, and weight loss and was found to have a splenic mass on CT scan suspected of lymphoma. The splenic mass in second patient was found incidentally at the time of work up for kidney stones. The pathologic examination of these splenectomy specimens showed similar histologic features. However, the spindle cells were composed of EBV-infected follicular dendritic cells in one case whereas the second case lacked significant follicular dendritic cell proliferation ...
Source: Journal of Hematopathology - March 31, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

T cell lymphoproliferative disorders associated with anti-tumor necrosis factor alpha antibody therapy for ulcerative colitis: literature summaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the histologic, immunophenotypic, and molecular features of a T cell lymphoproliferative disorder involving the axillary lymph node of a 33-year-old male following infliximab treatment for ulcerative colitis. These EBV-negative lymphomas suggest that lymphoproliferative disorders following infliximab treatment for inflammatory bowel disease may involve EBV-independent immune dysregulation. The spectrum of lymphoproliferative disorders associated with infliximab and the potential mechanisms by which they occur are discussed. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12308-009-0029-9Autho...
Source: Journal of Hematopathology - March 18, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

The second year of the Journal of Hematopathology has startedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12308-009-0026-zAuthors J. H. van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 Journal Volume Volume 2 Journal Issue Volume 2, Number 1 / March, 2009 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - March 7, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

The second year of the Journal of Hematopathology has startedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12308-009-0026-zAuthors J. H. van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - March 7, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

New developments in the pathology of malignant lymphoma: a review of the literature published from August to December 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Review of the LiteratureDOI 10.1007/s12308-009-0027-yAuthors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P. O. Box 91016500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - March 5, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Primary mediastinal large B-cell lymphoma in HIV: report of two casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here two cases of PMLBCL arising in AIDS patients. In both cases, PMLBCL presented in a setting of low CD4 T-cell count as rapidly enlarging mediastinal mass. The morphologic and immunophenotypic findings are characteristic of PMLBCL. One of the two patients, a 25-year-old woman who had localized disease and evidence of Epstein–Barr virus in lymphoma cells, did not respond to chemotherapy and died of disease progression 5 months after diagnosis. The second patient, a 38-year-old male with disseminated disease, responded to therapy and is disease-free after 9 months of follow-up. Content Type J...
Source: Journal of Hematopathology - February 28, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Apoptosis of t(14;18)-positive lymphoma cells by a Bcl-2 interacting small moleculeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we sought to determine the in vitro efficacy of HA14–1 as a therapeutic agent for non-Hodgkin lymphomas expressing Bcl-2. Assessment of cell viability demonstrated that HA14–1 induced a dose- (IC50 = 10 μM) and time-dependent growth inhibition of a cell line (SudHL-4) derived from a t(14;18)-positive, Bcl-2-positive, non-Hodgkin lymphoma. HA14–1 effectively induced apoptosis via a caspase 3-mediated pathway but did not affect either the p38 MAPK or p44/42 MAPK pathways. Western blot analyses of Bcl-2 family proteins and other cell cycle-associated proteins were performed to determine the...
Source: Journal of Hematopathology - February 28, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Highlights of 2008 in bone marrow biopsy pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s12308-009-0025-0Authors Jon van der Walt, St Thomas’ Hospital Department of Histopathology Westminster Bridge Road London SE1 7EH UK Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 24, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

PCR clonality detection in Hodgkin lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract B-cell clonality detection in whole tissue is considered indicative of B-cell non-Hodgkin lymphoma (NHL). We tested frozen tissue of 24 classical Hodgkin lymphomas (cHL) with a varying tumor cell load with the multiplex polymerase chain reaction (PCR) primer sets for IGH and IGK gene rearrangement (BIOMED-2). A clonal population was found in 13 cases with the IGH FR1 and/or FR2/FR3 PCRs. Using the IGK-VJ and IGK-DE PCRs, an additional six cases had a dominant clonal cell population, resulting in a detection rate of 79% in frozen tissue. Of 12 cases, also the formalin-fixed and paraffin-embedded (FFPE...
Source: Journal of Hematopathology - February 20, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Prognostic impact of C-REL expression in diffuse large B-cell lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Diffuse large B-cell lymphoma (DLBCL) with a germinal center B-cell (GCB) phenotype is believed to confer a better prognosis than DLBCL with an activated B-cell (ABC) phenotype. Previous studies have suggested that nuclear factor-κB (NF-κB) activation plays an important role in the ABC subtype of DLBCL, whereas c-REL amplification is associated with the GCB subtype. Using immunohistochemical techniques, we examined 68 newly diagnosed de novo DLBCL cases (median follow-up 44 months, range 1 to 142 months) for the expression of c-REL, BCL-6, CD10, and MUM1/IRF4. Forty-four (65%) cases demo...
Source: Journal of Hematopathology - February 13, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Systemic mastocytosis associated with t(8;21)(q22;q22) acute myeloid leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the clinicopathologic features of SM associated with t(8;21)(q22;q22) AML in ten patients (six from our institutions and four from published literature) with t(8;21) AML and SM. In the majority of these cases, a definitive diagnosis of SM was made after chemotherapy, when the mast cell infiltrates were prominent. Deletion 9q was an additional cytogenetic abnormality in four cases. Four of the ten patients failed to achieve remission after standard chemotherapy and seven of the ten patients have died of AML. In the two patients who achieved durable remission after allogeneic hematopoietic stem cell transpla...
Source: Journal of Hematopathology - February 11, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Efficient shRNA delivery into B and T lymphoma cells using lentiviral vector-mediated transferEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we devised a rapid and efficient way to screen suitable siRNA sequences and subsequently employ them for specific gene knockdown in usually hard-to-transfect lymphoid cell lines, using a self-inactivating lentiviral vector. Two proteins with different half-lives were chosen, cyclin D1 and STAT3. A specific lacZ reporter fusion assay was used to identify highly effective siRNA sequences. Only siRNA molecules with more than 85% of knockdown efficiency were selected for the generation of lentiviral transfer vectors. Transduction rates of 75–99% were achieved in the lymphoma cell lines Granta 519 (mantle ...
Source: Journal of Hematopathology - November 19, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Analysis of Aurora kinase A expression in CD34+ blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Aurora kinase A, also known as aurora A, is a serine/threonine kinase that plays critical roles in mitosis entry, chromosome alignment, segregation, and cytokinesis. Overexpression of aurora A has been observed in many solid tumors and some hematopoietic neoplasms, but little is known about its expression in myeloid diseases. Because cytogenetic abnormalities play an essential role in the pathogenesis of myeloid malignancies, we hypothesized that aurora A deregulation may be involved in myelodysplastic syndromes and acute myeloid leukemia and contribute to the chromosomal instability observed in the...
Source: Journal of Hematopathology - November 4, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Lymphomas originating from the lymphatic system comprise about 30 entities classified according to the World Health Organization (WHO). The histopathological diagnosis is generally considered difficult and prone to mistakes. Since non-random chromosomal translocations are specifically involved in different lymphoma entities, their detection will be increasingly important. Hence, a split-signal fluorescence in situ hybridisation (FISH) procedure would be helpful in discriminating the most difficult classifications. The Euro-FISH programme, a concerted action of nine European laboratories, has validat...
Source: Journal of Hematopathology - September 5, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Bone Marrow Symposium 21 September 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory AbstractsDOI 10.1007/s12308-008-0011-y Journal Journal of HematopathologyPrint ISSN 1865-5785 Journal Volume Volume 1 Journal Issue Volume 1, Number 2 / September, 2008 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - September 5, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

The implication of identifying JAK2V617F in myeloproliferative neoplasms and myelodysplastic syndromes with bone marrow fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) occasionally demonstrate overlapping morphological features including hypercellularity, mild/nonspecific dysplastic changes and variable bone marrow fibrosis. Thus, when the associated bone marrow fibrosis results in a suboptimal specimen for morphological evaluation, the descriptive diagnosis “fibrotic marrow with features indeterminate for MDS versus MPN” is often applied. The JAK2 V617F mutation was recently shown to be frequently identified in MPN, but it is rarely present in other myeloid disorders. However, the ...
Source: Journal of Hematopathology - August 27, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

The implication of identifying JAK2 V617F in myeloproliferative neoplasms and myelodysplastic syndromes with bone marrow fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) occasionally demonstrate overlapping morphological features including hypercellularity, mild/nonspecific dysplastic changes and variable bone marrow fibrosis. Thus, when the associated bone marrow fibrosis results in a suboptimal specimen for morphological evaluation, the descriptive diagnosis “fibrotic marrow with features indeterminate for MDS versus MPN” is often applied. The JAK2 V617F mutation was recently shown to be frequently identified in MPN, but it is rarely present in other myeloid disorders. However, the ...
Source: Journal of Hematopathology - August 27, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

New developments in the pathology of malignant lymphoma: a review of the literature published from May to July 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Review of the LiteratureDOI 10.1007/s12308-008-0012-xAuthors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - August 27, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

The γδ variant of T cell large granular lymphocyte leukemia is very similar to the common αβ type: report of two casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The vast majority of cases of T cell large granular lymphocyte (T-LGL) leukemia have a CD3+, CD4−, CD8+ phenotype and express the αβ T cell receptor. Whether the rare γδ variant should be included in the same diagnostic category is currently unclear. Two well-characterized cases of γδ T-LGL leukemia were identified by our laboratory in 2007. These two cases and other reports of γδ T-LGL leukemia were compared with the common αβ variant. Other than more often being negative for both CD4 and CD8 (in about 35% to 40% of cases), the γδ variant of T-LGL leukemia is similar to the common α�...
Source: Journal of Hematopathology - August 24, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Pitfalls in TCR gene clonality testing: teaching casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Clonality testing in T-lymphoproliferations has technically become relatively easy to perform in routine laboratories using standardized multiplex polymerase chain reaction protocols for T-cell receptor (TCR) gene analysis as developed by the BIOMED-2 Concerted Action BMH4-CT98-3936. Expertise with clonality diagnostics and knowledge about the biology of TCR gene recombination are essential for correct interpretation of TCR clonality data. Several immunobiological and technical pitfalls that should be taken into account to avoid misinterpretation of data are addressed in this report. Furthermore, we...
Source: Journal of Hematopathology - August 22, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Well-differentiated (Marschalko-type) plasmacytoma resembling thyroid follicular structuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12308-008-0015-7Authors César O. Lara-Torres, The American British Cowdray Medical Center Department of Pathology Mexico City MexicoCarlos Ortiz-Hidalgo, The American British Cowdray Medical Center Department of Pathology Mexico City Mexico Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - August 22, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Welcome to the first printed issue of the Journal of HematopathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12308-008-0018-4Authors J. Han van Krieken, Radboud University Department of Pathology, Nijmegen Medical Centre P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - August 19, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

New developments in the pathology of malignant lymphoma: a review of the literature published from January to April 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Review of the LiteratureDOI 10.1007/s12308-008-0010-zAuthors J. Han J. M. van Krieken, Radboud University Department of Pathology, Nijmegen Medical Centre P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - July 22, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

The Journal of Hematopathology : a new adventure!?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12308-008-0009-5Authors J. Han J. M. van Krieken, Radboud University Nijmegen, Medical Centre Department of Pathology Postbus 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - July 18, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Genomic deletion and promoter methylation status of Hypermethylated in Cancer 1 ( HIC1 ) in mantle cell lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Mantle cell lymphomas (MCL), characterized by the t(11;14)(q13;q32), frequently carry secondary genetic alterations such as deletions in chromosome 17p involving the TP53 locus. Given that the association between TP53-deletions and concurrent mutations of the remaining allele is weak and based on our recent report that the Hypermethylated in Cancer 1 (HIC1) gene, that is located telomeric to the TP53 gene, may be targeted by deletions in 17p in diffuse large B-cell lymphoma (DLBCL), we investigated whether HIC1 inactivations might also occur in MCL. Monoallelic deletions of the TP53 locus were detected...
Source: Journal of Hematopathology - July 5, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Primary central nervous system lymphoma (PCNSL) is an extranodal non-Hodgkin lymphoma involving brain, intraocular structures and spinal cord, without evidence of systemic disease. The majority of PCNSLs are diffuse large B-cell type. We encountered a rare case of primary dural marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) with extension into the brain in a 59-year-old man. A magnetic resonance imaging scan showed a 22-mm tumor located in the left posterior temporal lobe extending from the dura. Histopathology revealed a lymphoplasmacytic infiltration of the dura and the brain p...
Source: Journal of Hematopathology - June 19, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Primary mediastinal B-cell lymphoma: detection of BCL2 gene rearrangements by PCR analysis and FISHEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Primary mediastinal large B-cell lymphoma (PMBCL) has a characteristic clinical presentation, morphology, and immunophenotype, representing a clinically favorable subgroup of diffuse large B-cell lymphoma (DLBCL). By gene expression profiling (GEP), PMBCL shares features with classical Hodgkin lymphoma (cHL). Of further interest, BCL6 gene mutations and BCL6 and/or MUM1 expression in a number of PMBCLs have supported an activated B-cell (ABC) origin. Several studies, including GEP, have failed to detect BCL2 gene rearrangements (GRs) in PMBCL. An index case of t(14; 18)+ PMBCL prompted our study of t...
Source: Journal of Hematopathology - June 19, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Primary gastric T cell lymphoma mimicking marginal zone B cell lymphoma of mucosa-associated lymphoid tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Primary gastric T cell lymphoma is rare and mostly of large cell type. In this paper, we present a case of gastric T cell lymphoma morphologically similar to the gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT). Morphologically, the cells are small with abundant clear cytoplasm. Lymphoepithelial lesions are readily identified with diffuse destruction of gastric glands. Immunohistochemically, the neoplastic cells are CD3+/CD4+/CD8−/Granzyme B−. Molecular studies revealed monoclonal T cell receptor γ gene rearrangement. Clinically, the patient responded initially ...
Source: Journal of Hematopathology - May 20, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occurred at a different frequency compared to healthy individuals. Therefore, SNPs in these genes are not asso...
Source: Journal of Hematopathology - April 25, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Differential diagnostic challenge of chronic neutrophilic leukemia in a patient with prolonged leukocytosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Our interesting case deals with the clinical and morphological aspects of a chronic neutrophilic leukemia and the critical evaluation of differential diagnosis of leukemoid reaction in bone marrow biopsies. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12308-008-0004-xAuthors Daniel Neureiter, Paracelsus Private Medical University Institute of Pathology Salzburger Landeskliniken Salzburg AustriaRalf Kemmerling, Paracelsus Private Medical University Institute of Pathology Salzburger Landeskliniken Salzburg AustriaMatthias Ocker, Paracelsus Private Medical University Institute of Path...
Source: Journal of Hematopathology - April 19, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

HIV-1 Tat mimetic of VEGF correlates with increased microvessels density in AIDS-related diffuse large B-cell and Burkitt lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Angiogenic switch marks the beginning of tumor’s strategy to acquire independent blood supply. In some subtypes of non-Hodgkin’s lymphomas, higher local vascular endothelial growth factor (VEGF) expression correlates with increased microvessel density. However, this local VEGF expression is higher only in tumors with elevated expression of the receptors of the growth factor, suggesting an autocrine growth-promoting feedback loop. Several studies have indicated that VEGF receptors are also targeted by Tat protein from the HIV-1-infected cells. Given the similarity of the basic region of Tat to th...
Source: Journal of Hematopathology - April 16, 2008 Category: Pathology Tags: Journal of Hematopathology Source Type: journals