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Subject IndexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Author IndexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Volume ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

AnnouncementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Goodbye from Milan!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As the 5-year term of the editorial team in Milan draws to an end, I would like to take the opportunity to briefly illustrate what we perceive as being the achievements of our tenure together with some of the inevitable unmet goals, and above all to acknowledge the merits of all the persons who successfully contributed to keeping and eventually raising the standard of the Journal. (Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Authors: Massimo Colombo Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Many Ways One AimEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

The International Liver Congress 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Season’s Greetings and Best Wishes for 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - October 13, 2009 Category: Gastroenterology Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - October 13, 2009 Category: Gastroenterology Source Type: journals

Signaling in the LiverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - October 13, 2009 Category: Gastroenterology Source Type: journals

Many Ways One AimEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - October 13, 2009 Category: Gastroenterology Source Type: journals

The International Liver Congress 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - October 13, 2009 Category: Gastroenterology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - October 13, 2009 Category: Gastroenterology Source Type: journals

Europe’s hepatitis challenge: Defusing the “viral time bomb”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since its foundation in 2005, the European Liver Patients’ Association (ELPA) – a not-for-profit-organisation with 21 members across Europe – has been at the forefront of raising awareness of liver diseases, in particular hepatitis, throughout the EU. In line with the main challenge for hepatitis carriers, which is to “become a patient”, ELPA calls for targeted screening of risk groups in order to facilitate early diagnosis and, if appropriate, treatment. To this end, ELPA and its members have embarked on a multi-level lobbying campaign, involving EU and national policymakers, liver specialist associations and pu...
Source: Journal of Hepatology - October 8, 2009 Category: Gastroenterology Authors: Nadine Y. Piorkowsky Tags: Special Article Source Type: journals

Antiviral therapy for chronic hepatitis B: Challenges in Hong KongEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with great interest the review article by Prof. Liaw published in a recent issue of this journal . The article highlighted the reality and difficulties many patients and clinicians in Asian countries are now facing in the treatment of chronic hepatitis B. Although the more recent antiviral agents (entecavir and tenofovir) have strong antiviral potency and very low risk of drug resistance, these drugs may not be available to all patients in need. This is due to the restricted reimbursement criteria in place in different countries as well as the low income of the population in some areas. (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 7, 2009 Category: Gastroenterology Authors: Henry Lik-Yuen Chan Tags: Letters to the Editor Source Type: journals

Some oral antivirals are more cost-effective than others for the treatment of chronic hepatitis BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In their letter referring to our study “Modeling the cost-effectiveness of different oral antiviral therapies in patients with chronic hepatitis B”, Mantovani and de Portu claim that the presentation of our results is inappropriate. We beg to disagree. (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 7, 2009 Category: Gastroenterology Authors: Miguel A. Casado, Max Brosa, Maria Buti Tags: Letters to the Editor Source Type: journals

Oral antiviral therapies are cost-effective vs. no treatment but indirect comparisons should be avoidedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In their recent paper Buti and colleagues claim to have performed a “cost-effectiveness analysis of different oral antiviral therapies in patients with chronic hepatitis B”, but they did so presenting credible results in an inappropriate and potentially misleading manner. (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 7, 2009 Category: Gastroenterology Authors: Lorenzo G. Mantovani, Simona de Portu Tags: Letters to the Editor Source Type: journals

Ursodeoxycholic acid in primary biliary cirrhosis: ReplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We thank Dr. Tsochatzis et al. for their comments. In the EASL Clinical Practice Guidelines (CPG), we discussed in detail relevant data available to provide a balanced discussion of the pro’s and con’s of ursodeoxycholic acid (UDCA) treatment in primary biliary cirrhosis (PBC) . Tsochatzis et al. address the difficulty of finding a long-term benefit of medical treatment particularly in patients in the early stages of a slowly progressive disease which usually has a course of up to two decades . We agree with the authors that additional data on the use of UDCA in asymptomatic, early-stage PBC would be most welcome to fu...
Source: Journal of Hepatology - October 7, 2009 Category: Gastroenterology Authors: Ulrich Beuers, Michael Trauner Tags: Letters to the Editor Source Type: journals

Ursodeoxycholic acid and primary biliary cirrhosis: EASL and AASLD guidelinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the recent EASL Clinical Practice Guidelines on management of cholestatic liver disease . We would like to congratulate the authors on the correct grading of evidence for the use of ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) but at the same time we would like to challenge them about the interpretation of data. (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 7, 2009 Category: Gastroenterology Authors: Emmanuel A. Tsochatzis, Kurinchi S. Gurusamy, Christian Gluud, Andrew K. Burroughs Tags: Letters to the Editor Source Type: journals

A novel model of CCl4-induced cirrhosis with ascites in the mouseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The use of short cycles of CCl4 inhalation represents a novel, safe, and effective method to induce decompensated cirrhosis in mice. Intraperitoneal CCl4 leads instead to abdominal adhesions precluding a correct evaluation of ascites, while subcutaneous CCl4 causes an unwanted systemic inflammatory response. (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 7, 2009 Category: Gastroenterology Authors: Marco Domenicali, Paolo Caraceni, Ferdinando Giannone, Maurizio Baldassarre, Giovanna Lucchetti, Carmelo Quarta, Corrado Patti, Lucia Catani, Cristina Nanni, Roberto M. Lemoli, Mauro Bernardi Tags: Cirrhosis and its Complications Source Type: journals

Early prediction of encephalopathy in hospitalized patients with severe acute liver disease: The narrow window of opportunity for transplant-free survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transplant-free survival, clearly the most suitable outcome for any patient hospitalized (inpatient) with a life-threatening acute liver disease (ALD), is unfortunately uncommon among inpatients with acute liver failure (ALF) not due to poisoning (paracetamol, mushroom poisoning) (non-P) (non-P ALF). Despite some recent improvements, transplant-free survival rates of these patients, who were often in a good condition before the onset of the causal ALD, remain low: 21% to 39% in those with grade 3–4 hepatic encephalopathy (HE), and 28% to 67% in those with grade 1–2 HE at admission to the liver unit. Even when IV N-acet...
Source: Journal of Hepatology - October 7, 2009 Category: Gastroenterology Authors: Jacques Bernuau, François Durand Tags: Editorials Source Type: journals

Pegylated interferon α2b versus pegylated interferon α2a for chronic hepatitis C: The unreached goal of superiorityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In patients infected with HCV genotype 1, the rates of sustained virologic response and tolerability did not differ significantly between the two available peginterferon–ribavirin regimens or between the two doses of peginterferon alfa-2b. (ClinicalTrials. gov number, NCT00081770.)[Abstract reproduced by permission of N Engl J Med 2009;361:580–593] (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 5, 2009 Category: Gastroenterology Authors: Maria Grazia Rumi Tags: Journal Club Source Type: journals

Vinyl chloride and the liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on which this conclusion is based is incomplete. There is inadequate ascertainment of unequivocal diagnoses. In the largest studies lack of data meant that confounding diseases such as viral hepatitis or alcoholic liver disease could not be assessed. At best, the increase in risk is minimal, based on more than 22,000 exposed workers and more than 640,000 person years of observation.Howeve...
Source: Journal of Hepatology - October 1, 2009 Category: Gastroenterology Authors: Morris Sherman Tags: Review Source Type: journals

Transarterial chemotherapy alone versus transarterial chemoembolization for hepatocellular carcinoma: A randomized phase III trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of this study suggest that treatment intensification by adding embolization did not increase survival over TAI with zinostatin stimalamer alone in patients with HCC. (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 1, 2009 Category: Gastroenterology Authors: Takuji Okusaka, Hiroshi Kasugai, Yasukazu Shioyama, Katsuaki Tanaka, Masatoshi Kudo, Hiromitsu Saisho, Yukio Osaki, Michio Sata, Shigetoshi Fujiyama, Takashi Kumada, Keiko Sato, Seiichiro Yamamoto, Shiro Hinotsu, Tosiya Sato Tags: Liver Failure, Growth and Cancer Source Type: journals

Early prediction of short-term development of hepatic encephalopathy in patients with acute liver disease unrelated to paracetamol. A prospective study in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In Japanese patients with symptomatic non-P ALD, our model, which includes four of the five items used in the King’s College Hospital criteria, represents an acceptable, effective model to allow early detection of the risk of short-term development of HE. Using this model in other populations requires further validation specific to each of them. (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 1, 2009 Category: Gastroenterology Authors: Yasuhiro Takikawa, Ryujin Endo, Kazuyuki Suzuki, Hirohito Tsubouchi, on behalf of the Fulminant Hepatitis Study Group of Japan Tags: Liver Failure, Growth and Cancer Source Type: journals

Transarterial therapies in HCC: Does embolization increase survival?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Treatment of hepatocellular carcinoma (HCC) is an area of active research that has witnessed unprecedented change in recent years with the emergence of transarterial chemoembolization (TACE) and sorafenib as palliative standard of care, new potentially curative treatments such as radiofrequency, and the consolidation of an evidence-based approach to evaluate all potential treatment options . The implementation of screening through biannual abdominal ultrasound has led to increased diagnosis of HCC at early stages in more than 50% of correctly screened patients. However, despite the correct implementation of surveillance pr...
Source: Journal of Hepatology - September 30, 2009 Category: Gastroenterology Authors: Alejandro Forner, Jean-Claude Trinchet Tags: Editorials Source Type: journals

Corrigendum to “Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis” [J Hepatol 50 (2009) 1174–1183]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the above article we omitted to include supporting grants that significantly contributed to the study. The corrected “Acknowledgement” reads as follows: This work was supported by grants from the Natural Science Foundation of Beijing (No. 7072008), the Basic Science and Technology Research Program Foundation of Ministry of Education (No.106003, No.208001), the Basic Science and Technology Research Program Foundation of Ministry of Personnel, the Science and Technology Grant from Education Department of Beijing (No.KM200710025001), and the National Basic Research Program (No. 2008CB517401)” to Liying Li. It was al...
Source: Journal of Hepatology - September 28, 2009 Category: Gastroenterology Authors: Changyong Li, Yaxian Kong, Hong Wang, Shuling Wang, Hao Yu, Xin Liu, Lin Yang, Xiangming Jiang, Lingsong Li, Liying Li Tags: Corrigendum Source Type: journals

Combined approach for non-invasive measurement of liver pathology by MREmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We welcome the response from Guiu et al. regarding our recently published study . We fully agree that for MR methods to become a clinical tool, standardization of the techniques is required. Our results were obtained at 1.5T, which remains the predominant clinical MRI system. The authors fully recognise that there will be benefits in using 3T, but the aim of this paper was to present results that are relevant to the broader clinical community. (Source: Journal of Hepatology)
Source: Journal of Hepatology - September 23, 2009 Category: Gastroenterology Authors: Gary J. Cowin, Julie R. Jonsson, Stuart McPherson, Andrew D. Clouston, Mark Benson, Elizabeth E. Powell, Graham J. Galloway Tags: Letters to the Editor Source Type: journals

Magnetic resonance imaging and spectroscopy for quantification of hepatic steatosis: Urgent need for standardization!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with great interest the study by McPherson and colleagues that evaluated the accuracy of magnetic resonance spectroscopy (MRS) and imaging (MRI) for grading the severity of hepatic steatosis. In their study, the authors concluded that, using histology as a reference standard, MRS and MRI gave an accurate evaluation of the severity of steatosis, provided that the stage of fibrosis was considered. Our concerns regarding this study and its conclusion are outlined as follows. (Source: Journal of Hepatology)
Source: Journal of Hepatology - September 23, 2009 Category: Gastroenterology Authors: Boris Guiu, Romaric Loffroy, Patrick Hillon, Jean-Michel Petit Tags: Letters to the Editor Source Type: journals

Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: No interference between the two hepatitis viruses exists in the liver in the absence of hepatitis. The mechanisms of IFN resistance of the two viruses target different areas of the IFN system. (Source: Journal of Hepatology)
Source: Journal of Hepatology - September 23, 2009 Category: Gastroenterology Authors: Nobuhiko Hiraga, Michio Imamura, Tsuyoshi Hatakeyama, Shosuke Kitamura, Fukiko Mitsui, Shinji Tanaka, Masataka Tsuge, Shoichi Takahashi, Hiromi Abe, Toshiro Maekawa, Hidenori Ochi, Chise Tateno, Katsutoshi Yoshizato, Takaji Wakita, Kazuaki Chayama Tags: Molecular and Cell Biology Source Type: journals

Validity of real time ultrasound in the diagnosis of hepatic steatosis: A prospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Real time ultrasound using a combination of sonographic findings has a high specificity but underestimates the prevalence of hepatic steatosis when there is (Source: Journal of Hepatology)
Source: Journal of Hepatology - September 22, 2009 Category: Gastroenterology Authors: Srinivasan Dasarathy, Jaividhya Dasarathy, Amer Khiyami, Rajesh Joseph, Rocio Lopez, Arthur J. McCullough Tags: Genetic and Metabolic Liver Disease Source Type: journals

AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - September 14, 2009 Category: Gastroenterology Tags: Journal Club Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - September 14, 2009 Category: Gastroenterology Source Type: journals

The International Liver Congress 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - September 14, 2009 Category: Gastroenterology Source Type: journals

EASL Clinical School of HepatologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - September 14, 2009 Category: Gastroenterology Source Type: journals

Many Ways One AimEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - September 14, 2009 Category: Gastroenterology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Hepatology)
Source: Journal of Hepatology - September 14, 2009 Category: Gastroenterology Source Type: journals

The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data support the relevance of EGFR-mediated signalling in the modulation of cytokine-activated pathways. We have identified AR as a key regulator of hepatic APP gene expression during inflammation and liver regeneration. (Source: Journal of Hepatology)
Source: Journal of Hepatology - September 14, 2009 Category: Gastroenterology Authors: Ana Pardo-Saganta, Maria Ujue Latasa, Josefa Castillo, Laura Alvarez-Asiain, María J. Perugorría, Pablo Sarobe, Carlos M. Rodriguez-Ortigosa, Jesús Prieto, Carmen Berasain, Mónica Santamaría, Matías A. Avila Tags: Liver Failure, Growth and Cancer Source Type: journals

Preservation of immune function and anti-hepatitis C virus (HCV) immune responses after liver transplantation in HIV–HCV coinfected patients (ANRS-HC08 “THEVIC” trial)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background/Aims: Liver transplantation (LT) in immune-suppressed human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfected patients is feasible but raises questions regarding the severity of HCV recurrence on the liver graft and preservation of immune function. We investigated whether LT is deleterious to the immune system.Methods: Fourteen HIV–HCV coinfected patients (HIV viral load [VL] (Source: Journal of Hepatology)
Source: Journal of Hepatology - September 14, 2009 Category: Gastroenterology Authors: Assia Samri, Anne-Marie Roque-Afonso, Ondrej Beran, Mariagrazia Tateo, Elina Teicher, Cyrille Feray, Mylène Sebagh, Catherine Guettier, Elisabeth Dussaix, Daniel Vittecoq, Didier Samuel, Brigitte Autran, Jean-Charles Duclos-Vallée Tags: Transplantation Source Type: journals

The long and winding road leading to the identification of the hepatitis C virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review describes work conducted largely in my laboratory at the Chiron Corporation between 1982 and 1989 that led to the identification of the hepatitis C virus (HCV). Key colleagues included Dr. Qui-Lim Choo in my laboratory and Dr. George Kuo also of Chiron as well as my collaborator Dr. Daniel Bradley at the CDC who provided many biological samples from the NANBH chimpanzee model. Numerous molecular approaches were explored including the screening of tens of millions of bacterial cDNA clones derived from these materials. While this early genomics approach resulted in the identification of many host gene activities ...
Source: Journal of Hepatology - September 9, 2009 Category: Gastroenterology Authors: Michael Houghton Tags: Review Source Type: journals

Risk of recurrence in hepatitis B-related hepatocellular carcinoma: Impact of viral load in late recurrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatocellular carcinoma (HCC) is a highly prevalent and lethal cancer type being the third leading cause of cancer-related death worldwide . More than 80% of cases occur in developing countries particularly in Eastern Asia and sub-Saharan Africa mainly due to chronic infection with hepatitis B virus (HBV) . Hence, HBV is the most common cause of HCC in the world. Although population-based universal infant vaccination is shown to be effective in preventing new neonatal HBV infection and related HCC , there are still over 350 million individuals with chronic infection, and the prevalence reaches 10–20% of the population i...
Source: Journal of Hepatology - September 1, 2009 Category: Gastroenterology Authors: Yujin Hoshida Tags: Editorials Source Type: journals

Soft drink consumption is associated with fatty liver disease independent of metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background/Aims: The independent role of soft drink consumption in non-alcoholic fatty liver disease (NAFLD) patients remains unclear. We aimed to assess the association between consumption of soft drinks and fatty liver in patients with or without metabolic syndrome.Methods: We recruited 31 patients (age: 43±12years) with NAFLD and risk factors for metabolic syndrome, 29 patients with NAFLD and without risk factors for metabolic syndrome, and 30 gender- and age-matched individuals without NAFLD. The degree of fatty infiltration was measured by ultrasound. Data on physical activity and intake of food and soft drinks were ...
Source: Journal of Hepatology - August 20, 2009 Category: Gastroenterology Authors: Ali Abid, Ola Taha, William Nseir, Raymond Farah, Maria Grosovski, Nimer Assy Tags: Genetic and Metabolic Liver Disease Source Type: journals

Redundant roles for cJun-N-terminal kinase 1 and 2 in interleukin-1β-mediated reduction and modification of murine hepatic nuclear retinoid X receptor αEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Functional redundancy exists for JNK1 and JNK2 in IL-1β-mediated alterations of hepatic nuclear RXRα levels, stressing the importance of this pathway in mediating the hepatic response to inflammation. (Source: Journal of Hepatology)
Source: Journal of Hepatology - August 19, 2009 Category: Gastroenterology Authors: Astrid Kosters, Damara D. White, Hongdan Sun, Sundararajah Thevananther, Saul J. Karpen Tags: Molecular and Cell Biology Source Type: journals

HCV genotype 3: An independent predictor of fibrosis progression in chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The multi-centre study, by Bochud et al. , demonstrating an association between hepatitis C virus (HCV) genotype 3 and rapid progression of liver fibrosis in chronically infected patients, amplifies the potential clinical meaning of HCV genotypes, originally identified as predictors of interferon therapy outcome. The report from Switzerland corroborates the increasing evidence that the natural history of hepatitis C may be also influenced by the genotype of HCV in addition to host and environmental co-factors of morbidities. The road to HCV genotype being a modifier of the course of HCV infection was opened a long time ago...
Source: Journal of Hepatology - August 18, 2009 Category: Gastroenterology Authors: Stella De Nicola, Alessio Aghemo, Maria Grazia Rumi, Massimo Colombo Tags: Letters to the Editor Source Type: journals

Hepatitis C after simultaneous liver–kidney transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The introduction of the MELD score for organ allocation in liver transplantation led to an increased emphasis on renal impairment and to a proliferation of simultaneous liver–kidney transplantation (SLK). While the discussion on criteria is ongoing, information on the natural history and management of recurrent hepatitis C in this situation is lacking and consists mostly of small retrospective reports based on the experience of single centers. (Source: Journal of Hepatology)
Source: Journal of Hepatology - August 17, 2009 Category: Gastroenterology Authors: Andreas Cerny Tags: Editorials Source Type: journals

Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background/Aims: Liver pathology induced by chemotherapy (steatosis or vascular injury) is known to increase the liver’s sensitivity to ischemia/ reperfusion (I/R) injury, thereby increasing morbidity and mortality after liver resection. Our aim was to assess whether ischemic preconditioning (IP) reduces I/R injury to livers with chemotherapy-induced pathology.Methods: We analyzed a series of livers from patients treated with chemotherapy for colorectal cancer who underwent IP (n=30) or not (n=31) before hepatectomy. All but one of the livers exhibited chemotherapy-induced steatosis and/ or peliosis before the I/R insult...
Source: Journal of Hepatology - August 13, 2009 Category: Gastroenterology Authors: Marie-Charlotte Domart, Davide Degli Esposti, Mylène Sebagh, Natalia Olaya, Francis Harper, Gérard Pierron, Brigitte Franc, Kenneth K. Tanabe, Brigitte Debuire, Daniel Azoulay, Catherine Brenner, Antoinette Lemoine Tags: Liver Failure, Growth and Cancer Source Type: journals

Nonstructural 5A protein activates β-catenin signaling cascades: Implication of hepatitis C virus-induced liver pathogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NS5A activates β-catenin signaling cascades through increasing the stability of β-catenin. This modulation is accomplished by the protein interplay between viral and cellular signaling transducer. These data suggest that NS5A protein may directly be involved in Wnt/β-catenin-mediated liver pathogenesis. (Source: Journal of Hepatology)
Source: Journal of Hepatology - August 11, 2009 Category: Gastroenterology Authors: Chul-Yong Park, Soo-Ho Choi, Sang-Min Kang, Ju-Il Kang, Byung-Yoon Ahn, Hoguen Kim, Guhung Jung, Kang-Yell Choi, Soon B. Hwang Tags: Viral Hepatitis Source Type: journals