A different picture on liver biopsy
A 32-year-old was referred to her local gastroenterologist for investigation of longstanding abnormal liver biochemistry. Her past medical history was of hepatic steatosis, pulmonary sarcoidosis and suspected ileal sarcoidosis. Sarcoidosis was in longstanding clinical remission. There was no relevant family history. She reported fatigue and myalgia. Her body mass index was 22, and physical examination was unremarkable. Labs showed a mildly elevated bilirubin, 35 μmol/L (normal range [NR] 3-20), mildly elevated ALT 51 U/L (NR 10-35) and total protein of 84 U/L (NR 60-80). (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Authors: Ashley Barnabas, Rosa Miquel Tags: What Is Your Diagnosis? Source Type: research
From the Editor ’s Desk...
Metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced non-alcoholic fatty liver disease (NAFLD). However, given that MASLD requires at least one cardiometabolic risk factor, questions were raised as to whether new evidence would need to be generated for MASLD. In this issue, Younossi and coworkers compared the clinical profile and outcomes of NAFLD to MASLD using a tertiary-care NAFLD database and NHANES-III. Ninety-nine percent of included patients met MASLD criteria while 95% met MASLD criteria on BMI only. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Authors: Patrizia Burra, Frank Tacke, Vlad Ratziu, Stefan Zeuzem, Bruno Sangro, Paolo Angeli Tags: From the Editor's Desk Source Type: research
JHEP at a glance (May 2024)
(Source: Journal of Hepatology)
Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Source Type: research
Editorial Board
(Source: Journal of Hepatology)
Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Source Type: research
Register now for the EASL Congress 2024, 5-8 June in Milan (Italy).
(Source: Journal of Hepatology)
Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Source Type: research
Let ’s unite Hepatology! Become an EASL member today and discover your benefits
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Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Source Type: research
Sign up to EASL Campus: your open-access eLearning Hub
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Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Source Type: research
Discover EASL Studio season 6!
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Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Source Type: research
Contents
(Source: Journal of Hepatology)
Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Source Type: research
Comparison of non-contrast abbreviated MRI and ultrasound as surveillance modalities for HCC
Ultrasonography (US) is recommended for HCC surveillance in high-risk patients, but has limited performance in detecting early-stage HCC. We aimed to compare the diagnostic performance of biannual US and annual non-contrast abbreviated magnetic resonance imaging (NC-AMRI) as HCC surveillance modalities in high-risk patients. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 16, 2024 Category: Gastroenterology Authors: Dong Hwan Kim, Jeong Hee Yoon, Moon Hyung Choi, Chang Hee Lee, Tae Wook Kang, Hyun A. Kim, Young-Mi Ku, Jeong Min Lee, Seong Hyun Kim, Kyung Ah Kim, Su Lim Lee, Joon-Il Choi Tags: Research Article Source Type: research
The pathophysiology of polycystic liver disease
Polycystic liver disease (PLD) is a rare genetic disorder characterized by ≥10 cysts within the liver parenchyma. PLD occurs independently as autosomal dominant polycystic liver disease (ADPLD) or as extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD). Although most patients with PLD are asymptomatic, a subset of patients will develop severe hepatomegaly affecting quality of life.1 (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 9, 2024 Category: Gastroenterology Authors: Ren ée Duijzer, Melissa M. Boerrigter, Tom J.G. Gevers, Joost P.H. Drenth Tags: Hepatology Snapshot Source Type: research
B cell characteristics define HCV reinfection outcome
In individuals highly exposed to hepatitis C virus (HCV), reinfection is common, suggesting that natural development of sterilising immunity is difficult. In those that are reinfected, some will develop a persistent infection, while a small proportion repeatedly clear the virus, suggesting natural protection is possible. The aim of this study was to characterise immune responses associated with rapid natural clearance of HCV reinfection. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 9, 2024 Category: Gastroenterology Authors: Alexander P. Underwood, Money Gupta, Bing-Ru Wu, Auda A. Eltahla, Irene Boo, Jing Jing Wang, David Agapiou, Arunasingam Abayasingam, Arnold Reynaldi, Elizabeth Keoshkerian, Yanran Zhao, Nicholas Brasher, Melanie R. Walker, Jens Bukh, Lisa Maher, Tom Gordo Tags: Research Article Source Type: research
EMC10 modulates hepatic ER stress and steatosis in an isoform specific manner
Endoplasmic reticulum (ER) membrane protein complex subunit 10 (EMC10) has been implicated in obesity. Here we investigated the roles of the two isoforms of EMC10, including a secreted isoform (scEMC10) and an ER membrane-bound isoform (mEMC10), in MASLD. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 7, 2024 Category: Gastroenterology Authors: Kuangyang Chen, Yahao Wang, Jia Yang, Nora Kl öting, Chuanfeng Liu, Jiarong Dai, Shuoshuo Jin, Lijiao Chen, Shan Liu, Yuzhao Liu, Yongzhuo Yu, Xiaoxia Liu, Qing Miao, Chong Wee Liew, Yangang Wang, Arne Dietrich, Matthias Blüher, Xuanchun Wang Tags: Research Article Source Type: research
Polyploidisation pleiotropically buffers ageing in hepatocytes
Polyploidy in hepatocytes has been proposed as a genetic mechanism to buffer against transcriptional dysregulation. Here, we aim to demonstrate the role of polyploidy in modulating gene regulatory networks in hepatocytes during ageing. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Kelvin Yin, Maren B üttner, Ioannis K. Deligiannis, Mateusz Strzelecki, Liwei Zhang, Carlos Talavera-López, Fabian Theis, Duncan T. Odom, Celia P. Martinez-Jimenez Tags: Research Article Source Type: research
Reply to: “Increase in HDV replication during steroid therapy – potential implications for testing and treatment strategies”
The case reported by Patmore et al.1 highlights the complexity of managing patients with chronic hepatitis D (CHD), particularly when the coexistence of liver damage co-factors may significantly impact the outcome of liver disease and jeopardize the patient’s treatment. Since 1983, a HDV-specific pattern of autoantibodies agai nst liver-kidney microsomal antigens has been described by indirect immunofluorescence in up to 13% of Italian patients with CHD.2 In the following years it was shown that, in addition to these autoantibodies targeting the uridine 5’-diphosphate-glucoronosyltransferases (UGT-1 family 1), severa...
Source: Journal of Hepatology - April 4, 2024 Category: Gastroenterology Authors: Gabriele Ricco, Maurizia R. Brunetto Tags: Letter to the Editor Source Type: research
