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HIV-1 neutralization by monoclonal antibody against conserved region 2 and patterns of epitope exposure on the surface of native virusesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study demonstrates the cross-clade neutralizing activity of a MAb directed against an epitope located in the C2 region of the HIV-1 env and highlights differences in the exposure of antigenic epitopes on the surface of various HIV-1 subtypes. The epitope for this newly identified neutralizing MAb made against a subtype CRF01_AE peptide is particularly exposed in subtype C viral isolates. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - October 11, 2009 Category: Allergy & Immunology Authors: Apichai SreepianJongruk PermmongkolWannee KantakamalakulSontana SiritantikornNattaya TanliengRuengpung Sutthent Source Type: journals

DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data presented in this study encourages a further investigation in the regulatory potential of the DNA-HSP65 construct. Our findings have important implications for the development of new immune therapy strategies to combat autoimmune diseases. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - September 14, 2009 Category: Allergy & Immunology Authors: Rubens Santos-JuniorAlexandrina SartoriDeison LimaPatricia SouzaArlete Coelho-CasteloVania BonatoCelio Silva Source Type: journals

Prospects for control of emerging infectious diseases with plasmid DNA vaccinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Experiments almost 20 years ago demonstrated that injections of a sequence of DNA encoding part of a pathogen could stimulate immunity. It was soon realized that "DNA vaccination" had numerous potential advantages over conventional vaccine approaches including inherent safety and a more rapid production time. These and other attributes make DNA vaccines ideal for development against emerging pathogens. Recent advances in optimizing various aspects of DNA vaccination have accelerated this approach from concept to reality in contemporary human trials. Although not yet licensed for human use, several DNA vaccines have now bee...
Source: Journal of Immune Based Therapies and Vaccines - September 6, 2009 Category: Allergy & Immunology Authors: Ronald Moss Source Type: journals

The first influenza pandemic in the new millennium: lessons learned hitherto for current control efforts and overall pandemic preparednessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Influenza viruses pose a permanent threat to human populations due to their ability to constantly adapt to impact immunologically susceptible individuals in the forms of epidemic and pandemics through antigenic drifts and antigenic shifts, respectively. Pandemic influenza preparedness is a critical step in responding to future influenza outbreaks. In this regard, responding to the current pandemic and preparing for future ones requires critical planning for the early phases where there is no availability of pandemic vaccine with rapid deployment of medical supplies for personal protection, antivirals, antibiotics and socia...
Source: Journal of Immune Based Therapies and Vaccines - August 6, 2009 Category: Allergy & Immunology Authors: Carlos Franco-ParedesPeter CarrascoJose Ignacio Santos-Preciado Source Type: journals

An alternative approach to combination vaccines: intradermal administration of isolated components for control of anthrax, botulism, plague and staphylococcal toxic shockEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results demonstrated that the physical separation of vaccines both in the syringe and at the site of administration did not adversely affect the biological activity of each component.The vaccination method we describe may be scalable to include a greater number of antigens, while avoiding the physical and chemical incompatibilities encountered by combining multiple vaccines together in one product. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - September 3, 2008 Category: Allergy & Immunology Authors: Garry L Morefield, Ralph F Tammariello, Bret K Purcell, Patricia L Worsham, Jennifer Chapman, Leonard A Smith, Jason B Alarcon, John A Mikszta and Robert G Ulrich Source Type: journals

CpG increases vaccine antigen-specific cell-mediated immunity when administered with hepatitis B vaccine in HIV infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In addition to enhancing humoral responses to vaccination, we describe for the first time that CPG 7909 enhances cellular immunity to vaccine antigen in a typically hyporesponsive population. This adjuvancy may be important in the development of an effective vaccine for which a cellular immune response is required for protection. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - August 12, 2008 Category: Allergy & Immunology Authors: Jonathan B Angel, Curtis L Cooper, Jennifer Clinch, Charlene D Young, Andreane Chenier, Karl G Parato, Michael Lautru, Heather Davis and Donald W Cameron Source Type: journals

Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The strong immune stimulatory effect of CpG on PBMC isolated from treatment-failed HCV patients suggests possible utility alone or in combination with current HCV antiviral treatment. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - June 9, 2008 Category: Allergy & Immunology Authors: Curtis L Cooper, Navneet K Ahluwalia, Susan M Efler, Jorg Vollmer, Arthur M Krieg and Heather L Davis Source Type: journals

Use of ultraviolet-light irradiated multiple myeloma cells as immunogens to generate tumor-specific cytolytic T lymphocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Since, HSP-associated peptides are known to mediate tumor rejection; these data suggest that immune-mediated eradication of MM cells could be elicited via a UV-induced HSP process. The finding that the addition of 17-allylamide-17-demethoxygeldanamycin (17AAG, an inhibitor of HSP 90-peptide interactions) resulted in decreased CTL-induced cytotoxicity supported this hypothesis. Our study, therefore, provides the framework for the development of anti-tumor CTL cellular vaccines for treating MM using UV-irradiated tumor cells as immunogens. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - April 28, 2008 Category: Allergy & Immunology Authors: Charles A Gullo, William YK Hwang, Chye K Poh, Melvin Au, Geraline Cow and Gerrard Teoh Source Type: journals

A new approach for the large-scale generation of mature dendritic cells from adherent PBMC using roller bottle technologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that the roller bottle technology can generate similar numbers of mDC from adherent PBMC as traditional static flask methods, but with having to use fewer culture vessels. Thus, this may be a more practical method to generate mDC in large-scale cutting down on the amount of laboratory manipulations, and can save both time and labor costs. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - March 6, 2008 Category: Allergy & Immunology Authors: Ryan E Campbell-Anson, Diane Kentor, Yi J Wang, Kathryn M Bushnell, Yufeng Li, Luis M Vence and Laszlo G Radvanyi Source Type: journals

An HIV/AIDS Prophylactic vaccine is possibleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One needs to think outside of the box, as one of us (Ronald B Luftig) learned from many years as a mathematician, and a biophysicist. In this short Review, the need to focus on producing high levels of neutralizing antibodies (NAbs) to incoming and conformationally altered virus after it has bound to CD4+ cells is essential. Increasing the number of gp120 molecules on the surface of L-2 particles, could allow for an enhanced number of NAbs. The attempt at increasing CD8+ T cell responses in recent vaccine trials has not worked perhaps because it may have allowed HIV to enter into remote sanctuaries. Our approach focuses on...
Source: Journal of Immune Based Therapies and Vaccines - December 19, 2007 Category: Allergy & Immunology Authors: Qiu Zhong and Ronald B Luftig Source Type: journals

Rapid generation of an anthrax immunotherapeutic from goats using a novel non-toxic muramyl dipeptide adjuvant.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The protection afforded by these GMP-grade caprine immunotherapeutics post-exposure in the pilot murine model suggests they could be used effectively to treat post-exposure, symptomatic human anthrax patients following a bioterrorism event. These results also indicate that recombinant PA83 coupled to NT-MDP is a potent inducer of neutralizing antibodies and suggest it would be a promising vaccine candidate for anthrax. The ease of production, ease of covalent attachment, and immunostimulatory activity of the NT-MDP indicate it would be a superior adjuvant to alum or other traditional adjuvants in vaccine formu...
Source: Journal of Immune Based Therapies and Vaccines - October 22, 2007 Category: Allergy & Immunology Authors: Cassandra D Kelly, Chris O'Loughlin, Frank B Gelder, Johnny W Peterson, Laurie E Sower and Nick M Cirino Source Type: journals

Age-related waning of in vitro Interferon-gamma levels against r32kDaBCG in BCG vaccinated childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims at ascertaining the need for a booster at a later age as indicated by in vitro release of IFN-g while evaluating Ag85A as an antigen. Methods: Ninety healthy children who were without any clinical evidence of the disease, 45 with a BCG-scar and the remaining 45 without scar and 25 with tuberculosis were included in the study. The incidence of TB was analyzed in 216 children attending a DOTS clinic during 1996-2005. CD3+, CD4+ and CD8+ cell counts were measured by Flow cytometry. r32kDaBCG (Ag85A-BCG) protein was used to stimulate T cells in in vitro T cell responses and interferon-g (IFN-g) cytokine levels ...
Source: Journal of Immune Based Therapies and Vaccines - June 7, 2007 Category: Allergy & Immunology Authors: Anuradha B, Santosh C M, Hari Sai Priya V, Suman Latha G, Murthy K.J R and Vijaya Lakshmi Valluri Source Type: journals

A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Induction of HIV-1-specific cell-mediated responses is a major challenge in chronically HIV-1-infected patients even when combining immunisation with IL-2 therapy. An antigen-specific IL-4-associated suppressive response may play a role in attenuating HIV-specific responses. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - April 11, 2007 Category: Allergy & Immunology Authors: Gareth A D Hardy, Nesrina Imami, Mark R Nelson, Ann K Sullivan, Ron Moss, Marlen M I Aasa-Chapman, Brian Gazzard and Frances M Gotch Source Type: journals

IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: IMP321 as an adjuvant to HBsAg was well-tolerated and enhanced T cell response vaccine immunogenicity (i.e. induced both CD4 Th1 and CD8 Tc1 antigen-specific T cells). This latter property has allowed the development of IMP321 as an immunopotentiator for therapeutic vaccines. Trial Registration clinicaltrials.gov Identifier: NCT00354861 (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - March 29, 2007 Category: Allergy & Immunology Authors: Chrystelle Brignone, Caroline Grygar, Manon Marcu, Gaelle Perrin and Frederic Triebel Source Type: journals

Evaluation of a recombinant human gelatin as a substitute for a hydrolyzed porcine gelatin in a refrigerator-stable Oka/Merck live varicella vaccine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The recombinant human gelatin demonstrated similar ability to stabilize the live attenuated VZV (Oka/Merck) in an experimental, refrigerator-stable varicella vaccine when compared to the vaccine preparation formulated with hydrolyzed porcine gelatin used in currently marketed varicella vaccine. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - February 23, 2007 Category: Allergy & Immunology Authors: Vladimir Liska, Stacey A Bigert, Philip S Bennett, David Olsen, Robert Chang and Carl J Burke Source Type: journals

Evaluation of a recombinant human gelatin as a substitute for a hydrolyzed porcine gelatin in a refrigerator-stable Oka/Merck live varicella vaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The recombinant human gelatin demonstrated similar ability to stabilize the live attenuated VZV (Oka/Merck) in an experimental, refrigerator-stable varicella vaccine when compared to the vaccine preparation formulated with hydrolyzed porcine gelatin used in currently marketed varicella vaccine. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - February 23, 2007 Category: Allergy & Immunology Authors: Vladimir Liska, Stacey A Bigert, Philip S Bennett, David Olsen, Robert Chang and Carl J Burke Source Type: journals

Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - February 22, 2007 Category: Allergy & Immunology Authors: So-Yon Lim, Matt Meyer, Richard A Kjonaas and Swapan K. Ghosh Source Type: journals

Correction: Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is a correction article. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - February 22, 2007 Category: Allergy & Immunology Authors: So-Yon Lim, Matt Meyer, Richard A Kjonaas and Swapan K Ghosh Source Type: journals

Improved generation of anti-tumor immunity by antigen dose limitationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we sought to determine whether the balance between immunity and immunosuppression could be shifted towards a CD8 anti-CTCL response by lowering the ratio of apoptotic CTCL cells available for DC ingestion. CTCL cell apoptosis was produced by engagement of the TCR by anti-CD3 antibody affixed to magnetic beads. Results: The physical perturbation inherent in passage through a separation column induced monocytes to differentiate into DC, demonstrated by increased expression of class II and CD86 and decreased expression of the monocyte marker CD14. The immature DC internalized and processed apoptotic CTCL cells ...
Source: Journal of Immune Based Therapies and Vaccines - February 9, 2007 Category: Allergy & Immunology Authors: Joshua D Shofner, Juan G Vasquez, Carole L Berger and Richard L Edelson Source Type: journals

The effect of CpG-ODN on antigen presenting cells of the foalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CpG-ODN treatment did not induce specific maturation and cytokine expression in foal macrophages and DCs. Nevertheless, adult horse DCs, but not macrophages, increased their expression of IL-12 and IFNa; cytokines upon CpG-ODN stimulation. Importantly, foals presented an age-dependent limitation in the expression of MHC class II in macrophages and DCs, independent of treatment. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - January 25, 2007 Category: Allergy & Immunology Authors: M. Julia B.F. Flaminio, Alexandre S. Borges, Daryl V. Nydam, David W. Horohov, Rolf Hecker and Mary Beth Matychak Source Type: journals

Longitudinal changes in HIV-specific IFN-gamma secretion in subjects who received RemuneTM vaccination prior to treatment interruptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study explored whether HAART intensification with RemuneTM vaccination before TI can boost HIV-1-specific immunity, leading to improved control of viremia off HAART. Methods: Ten chronically HIV-infected adults were enrolled in this proof of concept study. After a 6-month HAART intensification phase with didanosine, hydroxyurea, granulocyte-macrophage colony-stimulating factor, (GM-CSF), and a first dose of RemuneTM (HIV-1 Immunogen), HAART was discontinued. Patients continued to receive RemuneTM every 3 months until the end of study. HAART was restarted if viral load did not fall below 50,000 copies/ml of plasma wi...
Source: Journal of Immune Based Therapies and Vaccines - November 28, 2006 Category: Allergy & Immunology Authors: Kenneth H Huang, Marie-Pierre Boisvert, Famane Chung, Maude Loignon, Don Zarowny, Lise Cyr, Emil Toma and Nicole F Bernard Source Type: journals

Longitudinal changes in HIV-specific IFN-γ secretion in subjects who received Remune™ vaccination prior to treatment interruptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study explored whether HAART intensification with Remune™ vaccination before TI can boost HIV-1-specific immunity, leading to improved control of viremia off HAART. Methods: Ten chronically HIV-infected adults were enrolled in this proof of concept study. After a 6-month HAART intensification phase with didanosine, hydroxyurea, granulocyte-macrophage colony-stimulating factor, (GM-CSF), and a first dose of Remune™ (HIV-1 Immunogen), HAART was discontinued. Patients continued to receive Remune™ every 3 months until the end of study. HAART was restarted if viral load did not fall below 50,000 copies/ml of plasma w...
Source: Journal of Immune Based Therapies and Vaccines - November 28, 2006 Category: Allergy & Immunology Authors: Kenneth H Huang, Marie-Pierre Boisvert, Famane Chung, Maude Loignon, Don Zarowny, Lise Cyr, Emil Toma and Nicole F Bernard Source Type: journals

Phytol-based novel adjuvants in vaccine formulation: 2. assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results show that vaccine formulations containing phytol and PHIS-01 as adjuvants confer a robust and protective immunity against both Gram-negative and Gram-positive bacteria without inducing adverse inflammatory cytokine due to IL-6. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - October 23, 2006 Category: Allergy & Immunology Authors: So-Yon Lim, Adam Bauermeister, Richard A. Kjonaas and Swapan K Ghosh Source Type: journals

Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study demonstrates the immune response to oral immunisation with M. bovis BCG Moreau RDJ in humans. All subjects, including those who did not respond to the skin test at study commencement, were capable of mounting humoral and cellular immune responses to the antigens tested. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - September 6, 2006 Category: Allergy & Immunology Authors: Renata Monteiro-Maia, Maria B Ortigao-de-Sampaio, Rosa T Pinho and Luiz R R Castello-Branco Source Type: journals

Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All subjects, including those who did not respond to the skin test at study commencement, were capable of mounting humoral and cellular immune response to the antigens tested. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - September 6, 2006 Category: Allergy & Immunology Authors: Renata Monteiro-Maia, Maria B Ortigão-de-Sampaio, Rosa T Pinho and Luiz RR Castello-Branco Source Type: journals

Levamizole enhances immune responsiveness to intra-dermal and intra-muscular hepatitis B vaccination in chronic hemodialysis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Hemodialysis patient are at high risk for hepatitis B virus (HBV) infection. Although preventive vaccination is done routinely, the response to vaccination is low in this patient population. The aim of this study was to evaluate the effect of Levamizol, an enhancer of the immune responsiveness, on different routs of vaccination, i.e., intradermal (ID) versus intramuscular (IM), in stable chronic hemodialysis patients. Material and method: Forty four chronic heamodialyses patient were divided into four equal groups. The first group was received 40 ug HB vaccine intramuscularly. The second group was received ...
Source: Journal of Immune Based Therapies and Vaccines - May 30, 2006 Category: Allergy & Immunology Authors: Hassan Argani and Ebrahim Akhtari Source Type: journals

Levamizol enhances immune responsiveness of intradermal and intramuscular hepatitis B vaccination in hemodialysis patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Hemodialysis patient are at high risk for hepatitis B virus (HBV) infection. Although preventive vaccination is done routinely, the response to vaccination is low in this patient population. The aim of this study was to evaluate the effect of Levamizol, an enhancer of the immune responsiveness, on different routs of vaccination, i.e., intradermal (ID) versus intramuscular (IM), in stable chronic hemodialysis patients. Material and method: Forty four chronic heamodialyses patient were divided into four equal groups. The first group was received 40 ug HB vaccine intramuscularly. The second group was received ...
Source: Journal of Immune Based Therapies and Vaccines - May 30, 2006 Category: Allergy & Immunology Authors: Hassan Argani and Ebrahim Akhtari Source Type: journals

A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The heat shock protein, Hsp70, has been shown to play an important role in tumour immunity. Vaccination with Hsp70-peptide complexes (Hsp70-PCs), isolated from autologous tumour cells, can induce protective immune responses. We have developed a novel method to identify synthetic mimic peptides of Hsp70-PCs and to test their ability to activate T-cells. Peptides (referred to as "recognisers") that bind to Hsp70-PCs from the human breast carcinoma cell line, MDA-MB-231, were identified by bio-panning a random peptide M13 phage display library. Synthetic recogniser peptides were subsequently used as bait in a reverse bio-pann...
Source: Journal of Immune Based Therapies and Vaccines - April 8, 2006 Category: Allergy & Immunology Authors: Blanca Arnaiz, Laura Madrigal-Estebas, Stephen Todryk, Tharappel C James, Derek D Doherty and Ursula Bond Source Type: journals

Cellular metabolism as a basis for immune privilegeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We hypothesize that the energy strategy of a cell is a key factor for determining how, or if, the immune system interacts with that cell. Cells have a limited number of metabolic states, in part, depending on the type of fuels the cell consumes. Cellular fuels include glucose (carbohydrates), lipids (fats), and proteins. We propose that the cell's ability to switch to, and efficiently use, fat for fuel confers immune privilege. Additionally, because uncoupling proteins are involved in the fat burning process and reportedly in protection from free radicals, we hypothesize that uncoupling proteins play an important role in i...
Source: Journal of Immune Based Therapies and Vaccines - March 17, 2006 Category: Allergy & Immunology Authors: M Karen Newell, Elizabeth Villalobos-Menuey, Susan C Schweitzer, Mary-Ellen Harper and Robert E Camley Source Type: journals

Mycobacterial immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy is associated with deregulated specific T-cell responses: Beneficial effect of IL-2 and GM-CSF immunotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data suggest that mycobacterial IRIS is associated with inadequate immune reconstitution rather than vigorous specific T-cell responses, and concomitant administration of IL-2 and GM-CSF immunotherapy with effective ART may correct/augment T-cell immunity in such setting resulting in clinical benefit. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - September 25, 2005 Category: Allergy & Immunology Authors: A Pires, M Nelson, AL Pozniak, M Fisher, B Gazzard, F Gotch and N Imami Source Type: journals

Psoriatic arthritis: Pathogenesis and novel immunomodulatory approaches to treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis and psoriasis. PsA runs a variable course, from mild synovitis to severe, progressive, erosive arthropathy. The pathogenesis of PsA involves alteration in the components of the immune response, although the exact cause of PsA is unknown. A number of patients with severe peripheral arthritis fail to respond to standard conventional therapy. Advances in biotechnology and in our understanding of the immunopathogenesis of PsA have led to great interest and progress in regards to biologic treatments for PsA. Notable suc...
Source: Journal of Immune Based Therapies and Vaccines - September 2, 2005 Category: Allergy & Immunology Authors: Sarah Cassell and Arthur Kavanaugh Source Type: journals

The significance of glucose, insulin and potassium for immunology and oncology: a new model of immunityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude that TGIK has anti-tumor activity when administered intratumorally, probably by stimulating lymphocytes to attack tumors. This is similar to the effect of GIK on reducing sepsis in critical care patients. We suggest that when GIK is administered exogenously, it restores immune competence to the critically ill or cancer patient and causes destruction of pathogens or tumors, while endogenous resources are devoted to repair. This implies that hormonal therapy may be useful in treating various other pathologies involving immune suppression, as well as malignancies. We also propose research that could br...
Source: Journal of Immune Based Therapies and Vaccines - August 19, 2005 Category: Allergy & Immunology Authors: Albert F Hill, William J Polvino and Darcy B Wilson Source Type: journals

Rapid construction of a dendritic cell vaccine through physical perturbation and apoptotic malignant T cell loadingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a simple one-step procedure where maturing DC containing apoptotic malignant T cells can be prepared rapidly for potential use in vaccine immunotherapy. Ready access to both the DC and apoptotic cells provided by this system will allow extension to other malignancies through the addition of a variety of apoptotic tumor cells and maturation stimuli. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - July 19, 2005 Category: Allergy & Immunology Authors: Maria Salskov-Iversen, Carole L Berger and Richard L Edelson Source Type: journals

Granulocyte-macrophage colony-stimulating factor as an immune-based therapy in HIV infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The HIV/AIDS epidemic continues to spread despite more than 20 years of significant research and major advances in its treatment. The introduction of highly active antiretroviral therapy in recent years has significantly improved disease treatment with a dramatic impact in HIV/AIDS associated morbidity and mortality in countries which have access to this therapy. Despite these advances, such therapies are imperfect and other therapeutic modalities, including immune-based therapies, are being actively sought. Potential benefits of immune-based therapies include: 1) the improvement of HIV-specific immunity to enhance control...
Source: Journal of Immune Based Therapies and Vaccines - May 18, 2005 Category: Allergy & Immunology Authors: Pierre Antoine Brown and Jonathan B Angel Source Type: journals

Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results show that the HPV 6, 11, 16 and 18 L1-VLP vaccine formulated with Merck aluminum adjuvant elicits a robust and durable immune response and holds promise as a vaccine for preventing cervical cancer. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - April 20, 2005 Category: Allergy & Immunology Authors: Wanda Ruiz, William L McClements, Kathrin U Jansen and Mark T Esser Source Type: journals

BCG vaccination at three different age groups: response and effectivenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data suggest that the lyophilized BCG vaccine used for BCG programs at different age groups is equally effective and may confer satisfactory protection against tuberculosis in puberty. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - April 1, 2005 Category: Allergy & Immunology Authors: George Briassoulis, Irene Karabatsou, Vasilis Gogoglou and Athina Tsorva Source Type: journals

Antigenized antibodies expressing Vβ8.2 TCR peptides immunize against rat experimental allergic encephalomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results indicate that antigenized antibodies expressing conformationally-constrained TCR peptides are a simple means to induce humoral anti-idiotypic immunity against the TCR and to vaccinate against EAE. The study also suggests the possibility to target idiotypic determinants of TCR borne on pathogenetic T cells to vaccinate against disease. (Source: Journal of Immune Based Therapies and Vaccines)
Source: Journal of Immune Based Therapies and Vaccines - November 12, 2004 Category: Allergy & Immunology Authors: Cristina Musselli, Svetlana Daverio-Zanetti and Maurizio Zanetti Source Type: journals