Integrated single-cell transcriptome and T cell receptor profiling reveals defects of T cell exhaustion in pulmonary tuberculosis
Tuberculosis-affected lungs with chronic inflammation harbor abundant immunosuppressive immune cells but the nature of such inflammation is unclear. Dysfunction in T cell exhaustion, while implicated in chronic inflammatory diseases, remains unexplored in tuberculosis. Given that immunotherapy targeting exhaustion checkpoints exacerbates tuberculosis, we speculate that T cell exhaustion is dysfunctional in tuberculosis. Using integrated single-cell RNA sequencing and T cell receptor profiling we reported defects in exhaustion responses within inflamed tuberculosis-affected lungs. (Source: Journal of Infection)
Source: Journal of Infection - April 18, 2024 Category: Infectious Diseases Authors: Zilu Wen, Lin Wang, Hui Ma, Leilei Li, Laiyi Wan, Lei Shi, Hongwei Li, Hui Chen, Wentao Hao, Shu Song, Qinghua Xue, Yutong Wei, Feng Li, Jianqing Xu, Shulin Zhang, Ka-Wing Wong, Yanzheng Song Tags: Bacteria and Bacterial Diseases Source Type: research
Performance of the Galactomannan Test for the Diagnosis of Invasive Pulmonary Aspergillosis using Non-invasive Proximal Airway Samples
To diagnose invasive pulmonary aspergillosis (IPA), galactomannan (GM) detection in serum or bronchoalveolar lavage fluid (BALF) is widely used. However, the utility of proximal airway GM test (from induced sputum or tracheal aspirate) has not been well elucidated. (Source: Journal of Infection)
Source: Journal of Infection - April 17, 2024 Category: Infectious Diseases Authors: June Young Chun, Sahng-Joon Jeong, Sinae Kim, Soyoung Choi, Jong Hyuk Lee, Hyun Sung Chung, Seungman Park, Hyewon Lee, Hyae Young Kim, Bin Hwangbo, Young Ju Choi Source Type: research
The Potential Value of a Quantitative PCR Assay for Assessing Respiratory Samples in Approaching a Laboratory Diagnosis of Pulmonary Mucormycosis
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - April 17, 2024 Category: Infectious Diseases Authors: Ya-Ping Chen, Cong-Tat Cia, Ya-Ting Hsu, Po-Lin Chen, Tsai-Yun Chen, Jen-Chieh Lee, Sin-Syue Li, Ming-I Hsieh, Hsuan-Chen Wang, Chi-Jung Wu Tags: Letter to the Editor Source Type: research
Distinct patterns of vital sign and inflammatory marker responses in adults with suspected bloodstream infection
To identify patterns in inflammatory marker and vital sign responses in adult with suspected bloodstream infection (BSI) and define expected trends in normal recovery. (Source: Journal of Infection)
Source: Journal of Infection - April 8, 2024 Category: Infectious Diseases Authors: Qingze Gu, Jia Wei, Chang Ho Yoon, Kevin Yuan, Nicola Jones, Andrew Brent, Martin Llewelyn, Tim EA Peto, Koen B Pouwels, David W Eyre, A Sarah Walker Source Type: research
Viruses associated with measles-like illnesses in Uganda
In this study, we investigated the causes of measles-like illnesses (MLI) in the Uganda national surveillance programme in order to inform diagnostic assay selection and vaccination strategies. (Source: Journal of Infection)
Source: Journal of Infection - April 6, 2024 Category: Infectious Diseases Authors: Prossy Namuwulya, Shirin Ashraf, Marc Niebel, Alfred Ssekagiri, Phionah Tushabe, Proscovia Kakooza, Lily Tong, Henry Bukenya, Hanna Jerome, Chris Davis, Molly Birungi, Irene Turyahabwe, Arnold Mugaga, James Peter Eliku, Aine Francis, Lucy Nakabazzi, Fred Source Type: research
Genomic evolution of human respiratory syncytial virus during a decade (2013-2023): bridging the path to monoclonal antibody surveillance
This study investigated the prevalence, genetic diversity, and evolution of human respiratory syncytial virus (HRSV) in Barcelona from 2013 to 2023. (Source: Journal of Infection)
Source: Journal of Infection - April 5, 2024 Category: Infectious Diseases Authors: Maria Pi ñana, Alejandra González-Sánchez, Cristina Andrés, Jorgina Vila, Anna Creus-Costa, Ignasi Prats-Méndez, Maria Arnedo-Muñoz, Narcís Saubi, Juliana Esperalba, Ariadna Rando, Patricia Nadal-Baron, Josep Quer, Juan José González-López, Pere Source Type: research
Change in Age profile of Respiratory Syncytial Virus disease over the course of annual epidemics: a multi-national study
We aimed to study whether the percentwise age distribution of RSV cases changes over time during annual epidemics. (Source: Journal of Infection)
Source: Journal of Infection - April 5, 2024 Category: Infectious Diseases Authors: Saverio Caini, Jean-Sebastien Casalegno, Ana Paula Rodrigues, Vernon Lee, Cheryl Cohen, Q Sue Huang, Alfredo Bruno Caicedo, Anne Teirlinck, Raquel Guiomar, Li Wei Ang, Jocelyn Moyes, Tim Wood, Dom énica de Mora, Mathieu Bangert, VRS study group in Lyon, Source Type: research
Transcriptomic crosstalk between viral and host factors drives aberrant homeostasis of T-cell proliferation and cell death in HIV-infected immunological non-responders
Immunological non-responders (INRs) among people living with HIV have inherently higher mortality and morbidity rates. The underlying immunological mechanisms whereby failure of immune reconstitution occurs in INRs require elucidation. (Source: Journal of Infection)
Source: Journal of Infection - April 3, 2024 Category: Infectious Diseases Authors: Shengquan Tang, Yanqiu Lu, Feng Sun, Yuanyuan Qin, Vijay Harypursat, Renni Deng, Gong Zhang, Yaokai Chen, Tong Wang Source Type: research
Parasitological and clinical effects of malaria chemoprevention with sulfadoxine-pyrimethamine in pregnant women from southern Mozambique
The effectiveness of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) is threatened by increasing SP resistance in Africa. We assessed the level of SP-resistance markers, and the clinical and parasitological effectiveness of IPTp-SP in southern Mozambique. (Source: Journal of Infection)
Source: Journal of Infection - April 2, 2024 Category: Infectious Diseases Authors: Gl ória Matambisso, Nanna Brokhattingen, Sónia Maculuve, Pau Cístero, Henriques Mbeve, Anna Escoda, Gizela Bambo, Boaventura Cuna, Cardoso Melembe, Nelo Ndimande, Kevin K.A. Tetteh, Chris Drakeley, Benoit Gamain, Chetan Chitnis, Virander Chauhan, Llore Source Type: research
An early and trustable indicator suggestive of non-tuberculosis mycobacteria isolation in a high Tuberculosis burden setting
Distinguishing between non-tuberculous mycobacterial (NTM) lung infections and pulmonary tuberculosis becomes challenging due to their similar clinical manifestations and radiological images. Consequently, instances of delayed diagnosis or misdiagnosis are highly frequent. A feasible and reliable indicator of the existence of NTM in the early stages of the disease would help to solve this dilemma. (Source: Journal of Infection)
Source: Journal of Infection - April 2, 2024 Category: Infectious Diseases Authors: Qian Liang, Xiaoyi Jiang, Junnan Jia, Liping Zhao, Yunxu Li, Fen Wang, Lingling Dong, Yi Xue, Guanglu Jiang, Hairong Huang Source Type: research
“Risk of death in Klebsiella pneumoniae bloodstream infections is associated with specific phylogenetic lineages.”
Klebsiella pneumoniae species complex (KpSC) bloodstream infections (BSIs) are associated with considerable morbidity and mortality, particularly in elderly and multimorbid patients. Multidrug resistant (MDR) strains have been associated with poorer outcome. However, the clinical impact of KpSC phylogenetic lineages on BSI outcome is unclear. (Source: Journal of Infection)
Source: Journal of Infection - April 1, 2024 Category: Infectious Diseases Authors: Aasmund Fostervold, Niclas RAFFELSBERGER, Marit A.K. Hetland, Ragna Bakksj ø, Eva Bernhoff, Ørjan SAMUELSEN, Arnfinn Sundsfjord, Jan E. AFSET, Christopher F. BERNTSEN, Roar BÆVRE-JENSEN, Marit H. EBBESEN, Karianne W. GAMMELSRUD, Anja D. GULENG, Nina HA Source Type: research
Role of SARS-CoV-2 mutations in the evolution of the COVID-19 pandemic
The SARS-CoV-2 pandemic and large-scale genomic surveillance provided an exceptional opportunity to analyze mutations that appeared over three years in viral genomes. Here we studied mutations and their epidemic consequences for SARS-CoV-2 genomes from our center. (Source: Journal of Infection)
Source: Journal of Infection - March 31, 2024 Category: Infectious Diseases Authors: Philippe Colson, Herv é Chaudet, Jérémy Delerce, Pierre Pontarotti, Anthony Levasseur, Jacques Fantini, Bernard La Scola, Christian Devaux, Didier Raoult Source Type: research
Relapsing epidemic typhus (Brill-Zinsser disease) in China
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - March 30, 2024 Category: Infectious Diseases Authors: Miao Lu, Shizhe Chen, Huafeng Li, Wen Wang, Kun Li Tags: Letter to the Editor Source Type: research
Utility of an in-house real-time PCR in whole blood samples as a minimally invasive method for early and accurate diagnosis of invasive mould infections.
Invasive mould infections (IMIs) are a leading cause of death in patients with compromised immune systems. Proven invasive mould infection requires detection of a fungus by histopathological analysis of a biopsied specimen, sterile culture, or fungal DNA amplification by PCR in tissue. However, the clinical performance of a PCR assay on blood samples taken from patients suspected of invasive mould disease has not been fully evaluated, particularly for the differential diagnosis of invasive aspergillosis (IA) and invasive Mucormycosis (IM). (Source: Journal of Infection)
Source: Journal of Infection - March 27, 2024 Category: Infectious Diseases Authors: Mragnayani Pandey, Immaculata Xess, Janya Sachdev, Neha Sharad, Sonakshi Gupta, Gagandeep Singh, Renu Kumari Yadav, Bhaskar Rana, Stephen Raj, M Nizam Ahmad, Neha Nityadarshini, Upendra Baitha, Manish Soneja, Shalimar, Bindu Prakash, Kapil Sikka, Purva M Source Type: research
Paediatric meningitis in the conjugate vaccine era and a novel clinical decision model to predict bacterial aetiology
The aims of this study were to assess aetiology and clinical characteristics in childhood meningitis, and develop clinical decision rules to distinguish bacterial meningitis from other similar clinical syndromes. (Source: Journal of Infection)
Source: Journal of Infection - March 26, 2024 Category: Infectious Diseases Authors: Martin NG, Defres S, Willis L, Beckley R, Hardwick H, Coxon A, Kadambari S, Yu L-M, Liu X, Galal U, Conlin K, Griffiths MJ, Kneen R, Nadel S, Heath PT, Kelly DF, Solomon T, Sadarangani M, Pollard AJ, on behalf of the UK-ChiMES and ENCEPH-UK study groups Source Type: research
