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CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CCR2 antagonism in vivo has tractable pharmacodynamic effects that can be used to align target engagement with biologic effects on disease activity. (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 11, 2009 Category: Drugs & Pharmacology Authors: Yuanfan WangLong CuiWaldemar GonsiorekSoo-Hong MinGopinadhan AnilkumarStuart RosenblumJoseph KozlowskiDaniel LundellJay FineEthan Grant Source Type: journals

Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that functional IL-2R is produced by the ocular surface epithelia and that CD25 is proteolytic cleaved to its soluble form by MMP-9, which increases in desiccating stress. These findings provide new insight into IL-2 signaling in mucosal epithelia. (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 31, 2009 Category: Drugs & Pharmacology Authors: Cintia De PaivaKyung-Chul YoonSolherny PangelinanSapa PhamLarry PuthenparambilEliseu ChuangWilliam FarleyMichael SternDe-Quan LiStephen Pflugfelder Source Type: journals

Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The lung COX-2/PGE2/EP2 receptor pathway is upregulated in HDM-exposed mice, possibly as an effort to attenuate allergen-induced airway inflammation. Exogenous PGE2 downregulates its endogenous counterpart but maintains EP2 overexpression, a phenomenon that might be required for administered PGE2 to exert its protective effect. (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 30, 2009 Category: Drugs & Pharmacology Authors: Aida HerreriasRosa TorresMariona SerraAlberto MarcoLaura PujolsCesar PicadoFernando de Mora Source Type: journals

Protein kinase C promotes restoration of calcium homeostasis to platelet activating factor-stimulated human neutrophils by inhibition of phospholipase CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although generally considered to initiate and/or amplify intracellular signalling cascades which activate and sustain the pro-inflammatory activities of neutrophils and other cell types, the findings of the current study have identified a potentially important physiological, anti-inflammatory function for PKC, at least in neutrophils. (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 30, 2009 Category: Drugs & Pharmacology Authors: Gregory TintingerAnnette TheronHelen SteelRiana CockeranLynette PretoriusRonald Anderson Source Type: journals

Lactobacillus casei modulates the inflammation-coagulation interaction in a pneumococcal pneumonia experimental modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: L. casei proved effective to regulate coagulation activation and fibrinolysis inhibition during infection, leading to a decrease in fibrin deposits in lung. This protective effect of L. casei would be mediated by the induction of higher levels of IL-4 and IL-10 which could regulate the anti-inflammatory, procoagulant and antifibrinolytic effects of TNF-alpha, IL-1beta and IL-6. (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 15, 2009 Category: Drugs & Pharmacology Authors: Cecilia HaroJulio VillenaHortensia ZelayaSusana AlvarezGraciela Aguero Source Type: journals

Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data suggest that Hcy participates in inflammatory cytokines production by glomerular MC and that Hcy-induced MIP-2 mediates leukocyte adhesion to MC. (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 25, 2009 Category: Drugs & Pharmacology Authors: Suresh ShastryLeighton James Source Type: journals

Rho iso-alpha acids from hops inhibit the GSK-3/NF-kappaB pathway and reduce inflammatory markers associated with bone and cartilage degradationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: RIAA may have potential as an anti-inflammatory therapeutic. (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 26, 2009 Category: Drugs & Pharmacology Authors: Veera Reddy KondaAnuradha DesaiGary DarlandJeffrey BlandMatthew Tripp Source Type: journals

Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data suggest that IL-8 is a main adipocytokine producing insulin resistance via the inhibition of insulin-induced Akt phosphorylation in adipocytes. The attenuation of IL-8 action might be a target for prevention of diabetes and its complications. (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 26, 2009 Category: Drugs & Pharmacology Authors: Chikaaki KobashiSachie AsamizuManabu IshikiMinoru IwataIsao UsuiKatusuya YamazakiKazuyuki TobeMasashi KobayashiMasaharu Urakaze Source Type: journals

Modulation of expression and cellular distribution of p21 by macrophage migration inhibitory factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results demonstrate that in the absence of MIF p21 expression and nuclear distribution is reduced which is associated with a reduction in cell growth and increased apoptosis. MIF may therefore play a role in maintaining homeostatic control of p21. (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 23, 2009 Category: Drugs & Pharmacology Authors: Elliott TarantoJin XueEric MorandMichelle Leech Source Type: journals

Gender-Based Reciprocal Expression of Transforming Growth Factor-Beta1 and the Inducible Nitric Oxide Synthase in a Rat Model of Cyclophosphamide-Induced CystitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of this study suggest that there exists an inverse relationship between the expression of TGF-beta1 and iNOS/NO2-/NO3- in CYP-inflamed bladder. The gender of the animal appears to magnify the differences in urine levels of TGF-beta1 and NO2-/NO3- in this inflammatory setting. These results support the hypothesis that TGF-beta1 can suppress iNOS expression associated with bladder inflammation and reduce systemic levels of NO2-/NO3-, and further suggest that this feature of TGF-beta1 can be harnessed for therapy and diagnosis of interstitial cystitis. (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 18, 2009 Category: Drugs & Pharmacology Authors: Pradeep TyagiVikas TyagiNaoki YoshimuraErich WitteemerDerek BarclayPatricia LoughranRuben ZamoraYoram Vodovotz Source Type: journals

CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: U83A diverts human chemokines from signalling, but not regulatory or scavenger, receptors facilitating their clearance, while occupying signalling receptors at the cell surface. This can enhance virus specific inflammation, facilitating dissemination to replication sensitive leukocytes while evading clearance; this has implications for linked neuro-inflammatory pathologies. (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 29, 2009 Category: Drugs & Pharmacology Authors: Julie CatusseDavid ClarkUrsula Gompels Source Type: journals

Is inflammation a consequence of extracellular hyperosmolarity?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study further suggests inflammation and hyperosmolarity are closely related phenomena if not synonymous. (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 22, 2009 Category: Drugs & Pharmacology Authors: Laurent SchwartzAdeline GuaisMohammad PooyaMohammad Abolhassani Source Type: journals

Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PIN1 reduced calpain activity and slowed the degradation of COX-2 in MAEC, an effect recapitulated by an inhibitor of calpain. Given the sensitivity of COX-2 and iNOS to calpain, PIN1 may normally limit induction of these and other calpain substrates by maintaining calpain activity in endothelial cells. (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 21, 2009 Category: Drugs & Pharmacology Authors: Tongzheng LiuRyan SchneiderVaibhav ShahYongcheng HuangRostislav LikhotvorikLakhu KeshvaraDale Hoyt Source Type: journals

Cadmium induces lung inflammation independent of lung cell proliferation: a molecular approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results prove that cadmium causes both inflammation and cell proliferation when applied in a low dose but proliferative changes occur independent of inflammation. (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 12, 2009 Category: Drugs & Pharmacology Authors: Subhadip KunduSuman SenguptaSoumya ChatterjeeSoham MitraArindam Bhattacharyya Source Type: journals

TNF-alpha and IL-10 downregulation and marked oxidative stress in Neuromyelitis OpticaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that there is a breakdown in immunoregulatory mechanisms and noteworthy pro-oxidant environment contributing to NMO pathogenesis. (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 2, 2009 Category: Drugs & Pharmacology Authors: Giselle Penton-RolMajel Cervantes-LlanosGregorio Martinez-SanchezJose A. Cabrera-GomezCarmen M. Valenzuela-SilvaOmar Ramirez-NunezMayte Casanova-OrtaMaria A. Robinson-AgramonteIleana Lopategui-CabezasPedro A. Lopez-Saura Source Type: journals

Role of TRPV3 in immune response to development of dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results confirm the contribution of the TRPV3Gly573Ser gene to the development of repeated hapten dermatitis, but not spontaneous dermatitis in NC/Nga mice. (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 25, 2009 Category: Drugs & Pharmacology Authors: Kinichi ImuraTakeshi YoshiokaTsutomu HirasawaTsuneaki Sakata Source Type: journals

Alterations in transcriptional responses associated with vascular agingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vascular aging is an independent risk factor for cardiovascular disease that can occur in the absence of other traditional risk factors. A hallmark of vascular aging is inflammation that ultimately leads to structural changes in the vessel wall including an increase in medial thickness and perivascular fibrosis. Several classes of transcription factors have been identified that participate in the regulation of cellular responses associated with vascular aging. Nuclear factor (NF)-kappaB is the prototypic example of a transcriptional activator in the setting of inflammation, being activated in response to multiple inflammat...
Source: Journal of Inflammation - May 21, 2009 Category: Drugs & Pharmacology Authors: Yumei ZhanLei YuanPeter Oettgen Source Type: journals

Inhibition of NFkappaB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cystic Fibrosis (CF) is one of the most common autosomal genetic disorders in humans. This disease is caused by mutations within a single gene, coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The phenotypic hallmark of CF is chronic lung infection and associated inflammation from opportunistic microbes such as Pseudomonas aeruginosa (PA), Haemophilus influenzae, and Staphylococcus aureus. This eventually leads to deterioration of lung function and death in most CF patients. Unfortunately, there is no approved therapy for correcting the genetic defect causal to the disease. Hence, controll...
Source: Journal of Inflammation - May 13, 2009 Category: Drugs & Pharmacology Authors: Rangan Maitra, Melissa A Porter, Shan Huang and Brian P Gilmour Source Type: journals

Inhibition of zymosan-induced kidney dysfunction by tyrphostin AG-490Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Tyrphostin AG-490 reduced the magnitude of the initial inflammatory response in zymosan-induced shock and prevented the development of severe kidney dysfunction. Our data suggest that the drug might be used as a therapeutic approach in cases where shock is combined with acute renal injury. (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 5, 2009 Category: Drugs & Pharmacology Authors: Petya Dimitrova, Valeriya Gyurkovska, Irina Shalova, Luciano Saso and Nina Ivanovska Source Type: journals

Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: TLR4 may be involved in the pathogenesis of lung emphysema and oxidative stress and seems to be a crucial contributor in lung inflammation (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 1, 2009 Category: Drugs & Pharmacology Authors: Hadi Sarir, Esmaeil Mortaz, Khalil Karimi, Aletta D Kraneveld, Irfan Rahman, Eric Caldenhoven, Frans Nijkampa and Gert Folkerts Source Type: journals

Enhanced release of IgE-dependent early phase mediators from nasal polyp tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This human nasal challenge model mimics the allergic early phase reaction. The release of histamine, cys-leukotrienes and PGD2 was significantly higher in nasal polyps versus inferior turbinates, however, this observation could not be explained by differences in mast cell or FcepsilonRI+ cell numbers. (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 20, 2009 Category: Drugs & Pharmacology Authors: Joke Patou, Gabriele Holtappels, Karen Affleck, Philippe Gevaert, Claudina Perez-Novo, Paul Van Cauwenberge and Claus Bachert Source Type: journals

Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interleukin-6 is a multifunctional cytokine that is critical for T/B-cell differentiation and maturation, immunoglobulin secretion, acute-phase protein production, and macrophage/monocyte functions. Extensive research into the biology of IL-6 has implicated IL-6 in the pathophysiology and pathogenesis of RA. An anti-murine IL-6 mAb that neutralizes mouse IL-6 activities was tested in animal model of collagen-induced arthritis. Prophylactic treatment with anti-IL-6 mAb significantly reduced the incidence and severity of arthritis compared to control mAb treated mice. The mitogenic response of B and T cells isolated from the...
Source: Journal of Inflammation - April 15, 2009 Category: Drugs & Pharmacology Authors: Bailin Liang, Zheng Song, Bin Wu, Debra Gardner, David Shealy, Xiao-Yu Song and Paul H. Wooley Source Type: journals

Inflammatory markers in a 2-year soy intervention among premenopausal womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: During this 2-year intervention, soy foods did not modify serum levels of CRP, IL-6, leptin, and adiponectin in premenopausal women although leptin levels remained stable among women in the intervention group who were obese or of Asian ancestry. Further studies with diverse markers of inflammation are necessary to clarify the specific effect of soy on immune responses. (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 7, 2009 Category: Drugs & Pharmacology Authors: Gertraud Maskarinec, Jana S Sofias, Adrian A Franke and Robert V Cooney Source Type: journals

Stimulation with Peptidoglycan Induces Interleukin 6 and TLR2 Expression and a Concomitant Downregulation of Expression of Adiponectin Receptors 1 and 2 in 3T3-L1 AdipocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammation is a major component of obesity and diabetes. Toll-like receptors (TLRs) play critical roles in the regulation of inflammation in adipocytes in response to pathogen associated molecular patterns (PAMPs), fatty acids, and extracellular matrix proteins. Although immune cells are primarily responsible for recognition and clearance of pathogens, current evidence indicates that adipocytes are also closely involved in the regulation of innate immunity and inflammation. Whereas it has been demonstrated that adipocytes respond to TLR4 stimulation with lipopolysacccharide, very little is known about their response to t...
Source: Journal of Inflammation - April 6, 2009 Category: Drugs & Pharmacology Authors: Kolapo M Ajuwon, William Banz and Todd A Winters Source Type: journals

Post heat shock tolerance: a neuroimmunological anti-inflammatory phenomenonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalgesic/allodynic area of burned skin to local hyperthermia (45°C, 30 seconds), which is a non-painful stimulus for normal skin, results in a painful sensation transmitted by nociceptors. This hyperthermia is too mild to induce any tissue injury, but it does result in pain due to burn-induced hyperalgesia/allodyn...
Source: Journal of Inflammation - March 27, 2009 Category: Drugs & Pharmacology Authors: Shahram Shahabi, Zuhair M Hassan and Nima Hosseini Jazani Source Type: journals

Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Increases in spleen size and CRP levels represent a reliable tool in diagnosing insulin resistance. (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 16, 2009 Category: Drugs & Pharmacology Authors: Giovanni Tarantino, Patrizia Colicchio, Paolo Conca, Carmine Finelli, Dario MATTEO NICOLA Di Minno, Marianna Tarantino, Domenico Capone and Fabrizio Pasanisi Source Type: journals

Antiinflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the islands of Providencia and San Andres (SW Caribbean)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: All results presented contribute to demonstrate that the compounds isolated in this work from P. elisabethae are promising molecules with an interesting anti-inflammatory activity profile. Additionally, the results obtained could provide preliminary insights towards their structure-activity relationship. (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 10, 2009 Category: Drugs & Pharmacology Authors: Hebelin Correa, Alba L Valenzuela, Luis F Ospina and Carmenza Duque Source Type: journals

Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These novel pharmacological actions of POMx provide new suggestion that POMx or POMx-derived compounds may be of therapeutic use for the treatment of inflammatory diseases by suppressing mast cells/basophils activation. (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 8, 2009 Category: Drugs & Pharmacology Authors: Zafar Rasheed, Nahid Akhtar, Arivarasu N Anbazhagan, Sangeetha Ramamurthy, Meenakshi Shukla and Tariq M Haqqi Source Type: journals

Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI- induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-kappaB in human KU812 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These novel pharmacological actions of POMx provide new suggestion that POMx or POMx-derived compounds may be of therapeutic value for the treatment of inflammatory diseases by suppressing mast cells/basophils activation. (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 8, 2009 Category: Drugs & Pharmacology Authors: Zafar Rasheed, Nahid Akhtar, Ariavarasu N Anbazhagan, Sangeetha Ramamurthy, Meenakshi Shukla and Tariq M Haqqi Source Type: journals

Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: TMP inhibited the LPS-induced production of lipid mediators and several key inflammatory cytokines and chemokines, both in vitro and in vivo, raising the possibility that TMP might be useful as a treatment for a variety of inflammatory disorders. (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 8, 2009 Category: Drugs & Pharmacology Authors: D. Eads, R. L. Hansen, B. O Oyegunwa, C. E. Cecil, C. A. Culver, F. Scholle, I.t. D. Petty and S. M. Laster Source Type: journals

Possible contribution of endogenous carbon monoxide to the development of allergic rhinitis in guinea pigsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The mechanisms responsible for the development of allergic rhinitis(AR) are not fully understood. The present study was designed to explore the possible roles of carbon monoxide(CO) on the pathogenesis of AR. Methods: AR guinea pig model was established by nasal ovalbumin sensitization. Twenty-four AR guinea pigs were divided into four groups, 6 in each: Saline control group, AR sensitized group, Hemin treated group, and Zinc protoporphyrin (ZnPP) treated group. The frequency of sneezing and nose rubbing was recorded. Leukocyte infiltration in nasal lavage fluid, serum IgE level and plasma CO were measured. Exp...
Source: Journal of Inflammation - December 5, 2008 Category: Drugs & Pharmacology Authors: Yu Shaoqing, Zhang Ruxin, Chen Yinjian, Chen Jianqiu, Zhu Chunsheng, Tng Jiangfeng and Li Genghong Source Type: journals

Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: p-Benzosemiquinone appears to be a major causative factor of cigarette smoke-induced oxidative protein damage that leads to apoptosis and lung injury. The pathophysiological events are prevented by a moderately large dose of vitamin C. (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 11, 2008 Category: Drugs & Pharmacology Authors: Shuvojit Banerjee, Ranajoy Chattopadhyay, Arunava Ghosh, Hemanta Koley, Koustubh Panda, Siddhartha Roy, Dhrubajyoti Chattopadhyay and Indu B Chatterjee Source Type: journals

Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic propertiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results may explain the efficacy of lysoPC therapy during periods of elevated inflammatory activity and further highlight the utility uncompetitive enzyme inhibitors. In this case, the inhibitor is a product of the enzyme reaction, and therefore represents an example of activity-driven feedback inhibition. (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 22, 2008 Category: Drugs & Pharmacology Authors: Timothy J Cunningham, Lihua Yao and Angel Lucena Source Type: journals

Augmentation of Pulmonary Epithelial Cell IL-8 Expression and Permeability by Pre-B-cell Colony Enhancing FactorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that PBEF may play a vital role in basal and TNFalpha-mediated pulmonary inflammation and pulmonary epithelial barrier dysfunction via its regulation of other inflammatory cytokines such as IL-8, which could in part explain the role of PBEF in the susceptibility and pathogenesis of ALI. These results lend further support to the potential of PBEF to serve as a diagnostic and therapeutic target to ALI. Methods: Human pulmonary alveolar epithelial cells (cell line and primary cells) were transfected with human PBEF cDNA or PBEF siRNA and then cultured in the presence or absence of TNF. PBEF...
Source: Journal of Inflammation - September 22, 2008 Category: Drugs & Pharmacology Authors: Hailong Li, Peng Liu, Javier Cepeda, Deyu Fang, Blaine Easley, Brett Simon, Li Q Zhang and Shui Q Ye Source Type: journals

15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest that 15d-PGJ2 inhibits inflammation at multiple steps and thus is a potential therapeutic target for various inflammatory diseases. (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 8, 2008 Category: Drugs & Pharmacology Authors: Ratna Prasad, Shailendra Giri, Avtar K Singh and Inderjit Singh Source Type: journals

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Here we show that furoxan-aspirin, B8, significantly reduces TNFα release from both monocytes and macrophages and suggest that inhibition of NF-κB activation is a likely mechanism for the effect. This anti-inflammatory action highlights a further therapeutic potential of drugs of this class. (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 31, 2008 Category: Drugs & Pharmacology Authors: Catriona M Turnbull, Paolo Marcarino, Tara A Sheldrake, Loretta Lazzarato, Clara Cena, Roberta Fruttero, Alberto Gasco, Sarah Fox, Ian L Megson and Adriano G Rossi Source Type: journals

Anti-inflammatory effects of ciprofloxacin in S. aureus Newman induced nasal inflammation in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Ciprofloxacin exerts anti-inflammatory effects in S. aureus Newman driven nasal inflammation. Inhibitory effects were comparable to those of prednisolone and clarithromycin. (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 29, 2008 Category: Drugs & Pharmacology Authors: F. Sachse, C. v. Eiff, K. Becker and C. Rudack Source Type: journals

Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Circulating 25 hydroxyvitamin D (25 (OH)D), an accurate measure of vitamin D status, is markedly greater in individuals with increased exposure to ultraviolet B (UVB) light via sunlight or the use of artificial UV light. Aside from the known relationship between vitamin D and bone, vitamin D has also been implicated in immune function and inflammation. Furthermore, a mass of evidence is accumulating that vitamin D deficiency could lead to immune malfunction. Our overall objective was to study the relationship between vitamin D status (as determined by serum 25(OH) D concentrations) and inflammatory markers in h...
Source: Journal of Inflammation - July 24, 2008 Category: Drugs & Pharmacology Authors: Catherine A Peterson and Mary E Heffernan Source Type: journals

Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several recent studies have documented that supplementation with pomegranate fruit extract inhibits inflammatory symptoms in vivo. However, the molecular basis of the observed effects has not been fully revealed. Although previous studies have documented the inhibition of nitric oxide and cyclooxygenase (COX) activity in vitro by plant and fruit extracts added directly into the culture medium but whether concentrations of bioactive compounds sufficient enough to exert such inhibitory effects in vivo can be achieved through oral consumption has not been reported. In the present study we determined the effect of rabbit plasm...
Source: Journal of Inflammation - June 13, 2008 Category: Drugs & Pharmacology Authors: Meenakshi Shukla, Kalpana Gupta, Zafar Rasheed, Khursheed A Khan and Tariq M Haqqi Source Type: journals

IFN-gamma regulation of ICAM-1 receptors in bronchial epithelial cells: soluble ICAM--1 release inhibits human rhinovirus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings support the hypothesis that in epithelial cells conditioned to IFN- and subsequently exposed to HRV-14 infection, differential modulation in the ratio of ICAM-1 receptors prevails in favour of an anti-viral milieu, appearing to limit further target cell viral attachment and propagation. (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 5, 2008 Category: Drugs & Pharmacology Authors: Suzanne C Whiteman and Monica A Spiteri Source Type: journals

Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcriptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These studies demonstrate that short-term treatment with a transcriptional inhibitor of TNF production can decrease systemic and local colonic levels of TNF but may not decrease the histologic severity of colitis. Longer term studies using colitis models that are more dependent on TNF elevation should be performed to more accurately assess the potential of LMP-420 for therapy of inflammatory bowel disease. (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 10, 2008 Category: Drugs & Pharmacology Authors: Laura P Hale and George Cianciolo Source Type: journals

Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that FTI may be applied as an effective inhibitor for RET/PTC3-oncogene induced pro-inflammatory mediators. (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 27, 2008 Category: Drugs & Pharmacology Authors: Katharine C DeGeorge, Brent R DeGeorge, James S Testa and Jay L Rothstein Source Type: journals

Does CD4+CD25+FoxP3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HIV-specific T-lymphocyte responses that underlie IRIS are incomplete and largely remain hypothetical. Of the several mechanisms presented by the host to control host immunological damage, Treg cells are believed to play a critical role. Using the available experimental evidence, it is proposed that enormous synthesis of conventional FoxP3A Th cells (responsive) often renders subjects inherently vulnerable to IRIS, whereas that of natural FoxP3+ Treg cell synthesis predominate among subjects that may not progress to IRIS. We also propose that IRIS non-developers generate precursor T-cells with a high avidity to generate CD...
Source: Journal of Inflammation - February 18, 2008 Category: Drugs & Pharmacology Authors: Esaki Muthu Shankar, Ramachandran Vignesh, Vijayakumar Velu, Kailapuri G Murugavel, Ramalingam Sekar, Pachamuthu Balakrishnan, Charmaine AC Lloyd, Shanmugam Saravanan, Suniti Solomon and Nagalingeswaran Kumarasamy Source Type: journals

Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: PCE inhibits development of edema and neutrophil infiltration in the TPA-treated mouse ear model of topical inflammation. (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 8, 2008 Category: Drugs & Pharmacology Authors: Eve E. Bralley, Phillip Greenspan, James L. Hargrove, Louise Wicker and Diane K. Hartle Source Type: journals

Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: 1H MRS is a sensitive tool to detect early colonic inflammation in an animal model of IBD. (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 26, 2007 Category: Drugs & Pharmacology Authors: Sonal Varma, Ranjana Bird, Michael Eskin, Brion Dolenko, Jayadev Raju and Tedros Bezabeh Source Type: journals

Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol dietEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: HCD increased the sensitivity of mice to LPS without affecting its plasma level. Although increased serum amyloid A and CD14 in the circulation may inhibit LPS actions, their overexpression, along with hepatic toll-like receptor-4 or other factors, may contribute to the heightened sensitivity to LPS. (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 12, 2007 Category: Drugs & Pharmacology Authors: Hong Huang, Tongzheng Liu, Jane L Rose, Rachel L Stevens and Dale G Hoyt Source Type: journals

Alveolar macrophages lack CCR2 expression and do not migrate to CCL2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data support the specificity of CCL2 to selectively drive monocyte, but not alveolar macrophage recruitment to the lung and CCR5 as the primary macrophage receptor for CCL3. (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 22, 2007 Category: Drugs & Pharmacology Authors: Judy M Opalek, Naeem A Ali, Jennifer M Lobb, Melissa G Hunter and Clay B Marsh Source Type: journals

Host predisposition by endogenous Transforming Growth Factor-beta1 overexpression promotes pulmonary fibrosis following bleomycin injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This data emphasises the importance of a host predisposition in the form of endogenous TGFbeta1, in the development of pulmonary fibrosis in response to an exogenous injury. (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 20, 2007 Category: Drugs & Pharmacology Authors: Yussef Haider, Andrea P Malizia, Dominic T Keating, Mary Birch, Annette Tomlinson, Gail Martin, Mark WJ Ferguson, Peter P Doran and Jim J Egan Source Type: journals

Soy isoflavones avert chronic inflammation-induced bone loss and vascular diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest IF may attenuate the negative effects of chronic inflammation on bone and cardiovascular health. Additional research is warranted to examine the anti-inflammatory properties of the soy isoflavones and the mechanisms underlying their prevention of chronic inflammation-induced bone loss. (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 7, 2007 Category: Drugs & Pharmacology Authors: Elizabeth A Droke, Kelly A Hager, Megan R Lerner, Stan A Lightfoot, Barbara J Stoecker, Daniel J Brackett and Brenda J Smith Source Type: journals