Journal of Integrative NeuroscienceThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4

The neuroscience of vision-based grasping: a functional review for computational modeling and bio-inspired robotics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The topic of vision-based grasping is being widely studied in humans and in other primates using various techniques and with different goals. The fundamental related findings are reviewed in this paper, with the aim of providing researchers from different fields, including intelligent robotics and neural computation, a comprehensive but accessible view on the subject. A detailed description of the principal sensorimotor processes and the brain areas involved is provided following a functional perspective, in order to make this survey especially useful for computational modeling and bio-inspired robotic applications. ...
Source: Journal of Integrative Neuroscience - June 1, 2009 Category: Neuroscience Authors: Chinellato E, Del Pobil AP Tags: J Integr Neurosci Source Type: journals

Probability distributions of markovian sodium channel States during propagating axonal impulses with or without recovery supernormality.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study addressed a macroscopic neurophysiological phenomenon - supernormality during the recovery phase of propagating axonal impulses - in explicit chemical terms. Excitation was reconstructed numerically using the kinetic scheme of multiple-state probabilistic transitions within a population of voltage-dependent sodium channels (NaCh) derived by Vandenberg and Bezanilla ("PC" scheme). Each NaCh transition was characterized as a reversible Markov process with voltage-dependent rate constants associated with each respective directional transition. While recovery reconstructed with the Hodgkin-Huxley formalism included ...
Source: Journal of Integrative Neuroscience - June 1, 2009 Category: Neuroscience Authors: Goldfinger MD Tags: J Integr Neurosci Source Type: journals

AN fMRI EXAMINATION OF VISUAL INTEGRATION IN SCHIZOPHRENIA.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study used functional Magnetic Resonance Imaging (fMRI) to examine the relative involvement of visual cortex areas (involved in form perception) and parietal and frontal regions (involved in attention), in the visual integration impairment in schizophrenia. Fourteen patients with schizophrenia and 14 healthy controls were compared on behavioral performance and data acquired via fMRI while completing a contour integration task that had previously been used to identify a visual integration deficit in schizophrenia. The schizophrenia patients demonstrated poorer visual integration than controls. Analyses of peak signal c...
Source: Journal of Integrative Neuroscience - June 1, 2009 Category: Neuroscience Authors: Silverstein SM, Berten S, Essex B, Kovács I, Susmaras T, Little DM Tags: J Integr Neurosci Source Type: journals

Overt and covert visual search in primates: reaction times and gaze shift strategies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to investigate the search performance and strategies of nonhuman primates, two macaque monkeys were trained to search for a target template among differently oriented distractors in both free-gaze and fixed-gaze viewing conditions (overt and covert search). In free-gaze search, reaction times (RT) and eye movements revealed the theoretically predicted characteristics of exhaustive and self-terminating serial search, with certain exceptions that are also observed in humans. RT was linearly related to the number of fixations but not necessarily to the number of items on display. Animals scanned the scenes in a n...
Source: Journal of Integrative Neuroscience - June 1, 2009 Category: Neuroscience Authors: Nothdurft HC, Pigarev IN, Kastner S Tags: J Integr Neurosci Source Type: journals

Tolerance to oxygen nutrient deprivation in the hippocampal slices of the naked mole rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to determine whether evidence of tolerance to oxygen nutrient deprivation exists in the chronic cultures of the naked mole rats hippocampal slices. We used oxygen nutrient deprivation (OND), an in vitro model of hypoxia tolerance, to determine neuronal survival in the hippocampal slices of mole rats and rats (Rattus sp.). Our results indicate that hippocampal slices of mole rats kept in hypoxic condition consistently tolerate OND right from the onset time of 5 hrs and the tolerance to OND is maintained for 24 hrs, suggesting that there is evidence of tolerance to OND in hippocampal slices of...
Source: Journal of Integrative Neuroscience - June 1, 2009 Category: Neuroscience Authors: Nathaniel TI, Saras A, Umesiri FE, Olajuyigbe F Tags: J Integr Neurosci Source Type: journals

A classification method of different motor imagery tasks based on fractal features for brain-machine interface.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to classify spontaneous electroencephalogram (EEG) signal on the basis of fractal concepts. Four motor imagery tasks (left hand movement, right hand movement, feet movement, and tongue movement) were investigated for each EEG recording session. Ten subjects volunteered to participate in this study. As we known, fractal geometry is a mathematical tool for dealing with complex systems like EEG signal. Therefore, we used the fractal dimension (FD) as feature for the application of brain-machine interface (BMI). Effective algorithm, namely, detrended fluctuation analysis (DFA) has been selected t...
Source: Journal of Integrative Neuroscience - March 1, 2009 Category: Neuroscience Authors: Phothisonothai M, Nakagawa M Tags: J Integr Neurosci Source Type: journals

Receptive field sizes of direction-selective units in the fish tectum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Responses of direction-selective (DS) ganglion cells (GCs) were recorded extracellularly from their axon terminals in the superficial layer of tectum opticum (TO) of immobilized cyprinid fish Carassius gibelio (Bloch, 1782). Excitatory receptive field (ERF) sizes of six types of DS GCs (ON and OFF cells, each of three distinct preferred directions) were evaluated on the basis of four different methods. In Method 1, the ERF width was calculated as a product of duration of spike train, generated in response to contrast edge moving across the ERF in preferred direction, and the velocity of the stimulus movement. The durat...
Source: Journal of Integrative Neuroscience - March 1, 2009 Category: Neuroscience Authors: Damjanović I, Maximova E, Maximov V Tags: J Integr Neurosci Source Type: journals

A hierarchical modeling approach of hippocampus local circuit.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The modeling and simulation of a realistic nervous tissue are difficult because of the number of implied cell types (neuronal and glial), the topology of the networks, and the various heterogeneous molecular mechanisms. The MTIP (Mathematical Theory of Integrative Physiology) is used as a new modeling approach based on a representation in terms of functional interactions and a formalism (S-Propagator) related to n-level field theory. This work presents the passage from a theoretical description of the biological system to a computing implementation in the general case. The specific case of the hippocampus is presented,...
Source: Journal of Integrative Neuroscience - March 1, 2009 Category: Neuroscience Authors: Bennani O, Chauvet G, Chauvet P, Dupont JM, Jouen F Tags: J Integr Neurosci Source Type: journals

Morpholess neurons compromise the development of cortical connectivity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is currently accepted that cortical maps are dynamic constructions that are altered in response to external input. Experience-dependent structural changes in cortical microcircuits lead to changes of activity, i.e., changes in information encoded. Specific patterns of external stimulation can lead to creation of new synaptic connections between neurons. The calcium influxes controlled by neuronal activity regulate the processes of neurotrophic factors released by neurons, growth cones movement and synapse differentiation in developing neural systems. We propose a model for description and investigation of the activi...
Source: Journal of Integrative Neuroscience - March 1, 2009 Category: Neuroscience Authors: Gafarov F, Khusnutdinov N, Galimyanov F Tags: J Integr Neurosci Source Type: journals

Social training of autistic children with interactive intelligent agents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ability of autistic children to learn by applying logical rules has been used widely in behavioral therapies for social training. We propose to teach social skills to autistic children through games that simultaneously stimulate social behavior and include recognition of elements of social interaction. For this purpose we created a multi-agent platform of interactive blocks, and we created appropriate games that require shared activities leading to a common goal. The games included perceiving and understanding elements of social behavior that non-autistic children can recognize. We argue that the importance of elem...
Source: Journal of Integrative Neuroscience - March 1, 2009 Category: Neuroscience Authors: Barakova E, Gillessen J, Feijs L Tags: J Integr Neurosci Source Type: journals

Multi-channel magnetoencephalogram on Alzheimer disease patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Magnetoencephalogram (MEG) recordings of 8 patients with advanced Alzheimer Disease (AD) and 9 normal individuals were obtained with a 122-channel whole head biomagnetometer SQUID (Superconductive Quantum Interference Device) to record the minute magnetic fields generated by the brain. The obtained MEG signals were analyzed using linear signal analysis techniques such as Fourier Transform in order to get the frequency distribution of MEG values. The obtained frequencies from all MEG sensors located outside the scalp of each subject were stored for evaluation. From this evaluation it was concluded that in patients with ...
Source: Journal of Integrative Neuroscience - March 1, 2009 Category: Neuroscience Authors: Abatzoglou I, Anninos P, Tsalafoutas I, Koukourakis M Tags: J Integr Neurosci Source Type: journals

The dependence of behavioral auditory thresholds on the delay of echo-like signals in noctuid moths (lepidoptera, noctuidae).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The auditory system of noctuoid moths capable to respond to ultrasounds has long been a model for anti-predator studies in neuroethology. Many moths avoid hunting bats by listening for their echolocation calls and taking evasive manoeuvres to escape predation. Besides these flight defences, certain tiger moths (Arctiidae) emit high-frequency clicks to jam the echolocator of an attacking bat. Another suggested function for ultrasonic audition in moths along with their capability to emit loud ultrasonic clicks was pulse echolocation. However, it seemed difficult to arrange sufficient temporal resolution in a simple inver...
Source: Journal of Integrative Neuroscience - March 1, 2009 Category: Neuroscience Authors: Lapshin DN, Vorontsov DD Tags: J Integr Neurosci Source Type: journals

The self and its awareness: genesis of psychoses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Agnosias demonstrate the broadest spectrum of pathology of consciousness in neurology and psychiatry. Agnosias wipe off the definite functions from the brain's activity precisely and completely, allowing the consciousness to be investigated in itself. Thorough investigations of confabulatory manifestations disclose the rationale for the development of pathological functions and point out that there is a remedial (reconstructive) sense behind the senselessness of a mental state. Pathology seems to be accompanied by involuntary reparation on the part of the brain. Investigations of the conscious activity in agnosias show...
Source: Journal of Integrative Neuroscience - December 1, 2008 Category: Neuroscience Authors: Mazur L Tags: J Integr Neurosci Source Type: journals

Neural mechanisms of erp change: combining insights from electrophysiology and mathematical modeling.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using a standardized database of EEG data, recorded during the habituation and oddball paradigms, changes in the auditory event-related potential (ERP) are demonstrated on the time scale of seconds and minutes. Based on previous research and a mathematical model of neural activity, neural mechanisms that could account for these changes are proposed. When the stimulus tones are not relevant to a task, N100 magnitude decreases substantially for the first repetition of a stimulus pattern and increases in response to a variant tone. It is argued these short-term changes are consistent with the hypothesis that there is a re...
Source: Journal of Integrative Neuroscience - December 1, 2008 Category: Neuroscience Authors: Clearwater JM, Kerr CC, Rennie CJ, Robinson PA Tags: J Integr Neurosci Source Type: journals

Neural mechanisms of auditory discrimination of long-duration tonal patterns: a neural modeling and FMRI study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Language perception comprises mechanisms of perception and discrimination of auditory stimuli. An important component of auditory perception and discrimination concerns auditory objects. Many interesting auditory objects in our environment are of relatively long duration; however, the temporal window of integration of auditory cortex neurons processing these objects is very limited. Thus, it is necessary to make active use of short-term memory in order to construct and temporarily store long-duration objects. We sought to understand the mechanisms by which the brain manipulates long-duration tonal patterns, temporarily...
Source: Journal of Integrative Neuroscience - December 1, 2008 Category: Neuroscience Authors: Ulloa A, Husain FT, Kemeny S, Xu J, Braun AR, Horwitz B Tags: J Integr Neurosci Source Type: journals

A model of the cerebellar sensory - motor control applied to fast human forearm movements.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To address the problem of how the cerebellum processes the premotor orders that control fast movements of the forearm, a model of the cerebellar control is proposed: a cybernetic circuit composed of a model of the cerebellar premotor pathways driving a biomechanical model of the human forearm. Experiments consist of recording electromyographic (EMG) activities and cinematic variables of the human forearm during fast, single joint, point-to-point movements performed in horizontal and vertical directions with and without mass. The biomechanical model of the forearm is first validated by comparing actual movements and mov...
Source: Journal of Integrative Neuroscience - December 1, 2008 Category: Neuroscience Authors: Eskiizmirliler S, Papaxanthis C, Pozzo T, Darlot C Tags: J Integr Neurosci Source Type: journals

Meg evaluation of epileptic activity in the time and frequency domain.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the localization of current sources in the time and frequency domain from spontaneous MEG data recorded from nine epileptic patients (six females; three males) randomly selected, who had a mean age of 41 years old (range of 17-78 years old), with different types of epilepsy. The MEG data were recorded in a magnetically shielded room with a whole-head 122 channel biomagnetometer. For each MEG spike, we calculated the single Equivalent Current Dipole (ECD) sources at the initial spike peaks with a spherical model. MRI and EEG findings were available in patients' records. Prominent low frequencies can be s...
Source: Journal of Integrative Neuroscience - December 1, 2008 Category: Neuroscience Authors: Kotini A, Mavraki E, Anninos P, Piperidou H, Prassopoulos P Tags: J Integr Neurosci Source Type: journals

Interaction of brain and intracardiac levels of rhythmogenesis hierarchical system at heart rhythm formation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A single-stage bilateral conduction blockade of the vagus nerves (functional denervation) by constant anodal current was carried out in 13 dogs which are under anesthesia and 3-5 days after operation in chronic experiments. In anesthetized animals, "functional denervation" led to acceleration of the heart rhythm from 102.4 +/- 3.2 bmp to 123.8 +/- 4.4 bmp. In chronic dogs "functional denervation" led to transient stoppage of the heart - a preautomatic pause with duration of 2.7 +/- 0.2 sec. The heartbeats recommenced with the frequency of 89.0 +/- 3.4 bmp versus an initial rhythm of 118 +/- 1.5 bpm, i.e., a rhythm dece...
Source: Journal of Integrative Neuroscience - December 1, 2008 Category: Neuroscience Authors: Pokrovskii VM, Abushkevich VG, Gurbich DV, Klykova MS, Nechepurenko AA Tags: J Integr Neurosci Source Type: journals

A model of the cerebellar sensory--motor control applied to fast human forearm movements.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To address the problem of how the cerebellum processes the premotor orders that control fast movements of the forearm, a model of the cerebellar control is proposed: a cybernetic circuit composed of a model of the cerebellar premotor pathways driving a biomechanical model of the human forearm. Experiments consist of recording electromyographic (EMG) activities and cinematic variables of the human forearm during fast, single joint, point-to-point movements performed in horizontal and vertical directions with and without mass. The biomechanical model of the forearm is first validated by comparing actual movements and mov...
Source: Journal of Integrative Neuroscience - December 1, 2008 Category: Neuroscience Authors: Eskiizmirliler S, Papaxanthis C, Pozzo T, Darlot C Tags: J Integr Neurosci Source Type: journals

Developing an integrated brain, behavior and biological response profile in posttraumatic stress disorder (ptsd).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present study sought to determine a profile of integrated behavioral, brain and autonomic alterations in PTSD. Previous findings suggest that PTSD is associated with changes across electrophysiological (EEG and ERP), autonomic and cognitive/behavioral measures. In particular, PTSD has been associated with reduced cognitive performance, altered cortical arousal (measured by EEG), diminished late ERP component to oddball task targets (reduced P3 amplitude) and increased autonomic arousal relative to healthy controls. The present study examined measures of cognitive function, auditory oddball ERP components, autonomic...
Source: Journal of Integrative Neuroscience - September 1, 2008 Category: Neuroscience Authors: Falconer EM, Felmingham KL, Allen A, Clark CR, McFarlane AC, Williams LM, Bryant RA Tags: J Integr Neurosci Source Type: journals

EEG phenotypes predict treatment outcome to stimulants in children with ADHD.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates that the EEG phenotypes as described by Johnstone, Gunkelman & Lunt are identifiable EEG patterns with good inter-rater reliability. Furthermore, it was also demonstrated that these EEG phenotypes occurred in both ADHD subjects as well as healthy control subjects. The Frontal Slow and Slowed Alpha Peak Frequency and the Low Voltage EEG phenotype discriminated ADHD subjects best from controls (however the difference was not significant). The Frontal Slow group responded to a stimulant with a clinically relevant decreased number of false negative errors on the CPT. The Frontal Slow and Slowed Alph...
Source: Journal of Integrative Neuroscience - September 1, 2008 Category: Neuroscience Authors: Arns M, Gunkelman J, Breteler M, Spronk D Tags: J Integr Neurosci Source Type: journals

The effects of a poor night sleep on mood, cognitive, autonomic and electrophysiological measures.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examines the less understood, finer grained effects of a single bad night's sleep on mood, cognitive, autonomic and electrophysiological functions. We assessed 338 individuals who had no symptoms of a clinical sleep disorder. Of these, 226 individuals had six or more hours sleep and 112 individuals had less than six hours sleep prior to an assessment of mood, cognition, autonomic and electrophysiological functioning. Individuals in the relatively "bad night" sleep group had higher depression, anxiety, and stress scores and reported significantly poorer overall wellbeing. They made more errors on simple cognitive...
Source: Journal of Integrative Neuroscience - September 1, 2008 Category: Neuroscience Authors: Barnett KJ Tags: J Integr Neurosci Source Type: journals

The integrate model of emotion, thinking and self regulation: an application to the "paradox of aging".Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was undertaken using the INTEGRATE Model of brain organization, which is based on a temporal continuum of emotion, thinking and self regulation. In this model, the key organizing principle of self adaption is the motivation to minimize danger and maximize reward. This principle drives brain organization across a temporal continuum spanning milliseconds to seconds, minutes and hours. The INTEGRATE Model comprises three distinct processes across this continuum. Emotion is defined by automatic action tendencies triggered by signals that are significant due to their relevance to minimizing danger-maximizing reward (...
Source: Journal of Integrative Neuroscience - September 1, 2008 Category: Neuroscience Authors: Williams LM, Gatt JM, Hatch A, Palmer DM, Nagy M, Rennie C, Cooper NJ, Morris C, Grieve S, Dobson-Stone C, Schofield P, Clark CR, Gordon E, Arns M, Paul RH Tags: J Integr Neurosci Source Type: journals

An "integrative neuroscience" platform: application to profiles of negativity and positivity bias.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the paper is to describe a standardized "Integrative Neuroscience" Platform that can be applied to elucidate brain-body mechanisms. This infrastructure includes a theoretical integration (the INTEGRATE Model). To demonstrate this infrastructure, hypotheses from the INTEGRATE Model are applied in an example investigation of the cognitive, brain and body markers of individual differences in the trait characteristic of Negativity Bias (the tendency to see oneself and one's world as negative). A sample of 270 healthy participants (18-65 years old) were grouped into equal sized matched subsets of high "Negativity...
Source: Journal of Integrative Neuroscience - September 1, 2008 Category: Neuroscience Authors: Gordon E, Barnett KJ, Cooper NJ, Tran N, Williams LM Tags: J Integr Neurosci Source Type: journals

Simulating cortical background activity at rest with filtered noise.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report that phase interference in the distributed frequencies of oscillation in bandpass-filtered brown noise gives null power spikes like those in the electrocorticograms (ECoG) from test subjects. The null spikes coincide with the onsets of frames in which the spatial amplitude patterns are classifiable with respect to conditioned stimuli. We report similarity in the waveforms and amplitude distributions of null spikes upon filtering brown noise in bands corresponding to the theta, alpha, beta and gamma ranges in experimental and simulated ECoG. We estimate a threshold in null spike minimal amplitudes below which perc...
Source: Journal of Integrative Neuroscience - September 1, 2008 Category: Neuroscience Authors: Freeman WJ, O'Nuallain S, Rodriguez J Tags: J Integr Neurosci Source Type: journals

Journal of Integrative Neuroscience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19108360 [PubMed - in process]
Source: Journal of Integrative Neuroscience - September 1, 2008 Category: Neuroscience Authors: Gordon E Tags: J Integr Neurosci Source Type: journals

Metaplasticity: new insights through electrophysiological investigations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The term synaptic plasticity describes the ability of excitatory synapses to undergo activity-driven long-lasting changes in the efficacy of basal synaptic transmission. This change may be expressed as a long-term potentiation (LTP) or as a long-term depression (LTD). Metaplasticity is a higher-order form of synaptic plasticity that regulates the expression of both LTP and LTD through processes that are initiated by cellular activity that precedes a later bout of plasticity-inducing synaptic activity. Activation by prior synaptic activity and later expression as a facilitation or inhibition of activity-dependent synapt...
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Mockett BG, Hulme SR Tags: J Integr Neurosci Source Type: journals

Extracellular recordings of rodents in vivo: their contribution to integrative neuroscience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prevalent theory in learning and memory processes is that they are underlain by short and long-term changes in synaptic weight, which continuously modulates neural networks during acquisition and recall. This synaptic plasticity has been revealed by recording extracellular field potentials. The enhancement of synaptic transmission was primarily noted in the hippocampus and was named long-term potentiation (LTP). The opposite mechanism, long-term depression (LTD), a reduction of synaptic transmission, was first discovered in the cerebellum. Since then, the LTP-model has been studied mainly using in vitro and acute a...
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Chaillan FA, Truchet B, Roman FS Tags: J Integr Neurosci Source Type: journals

CELLULAR AUTOMATA APPROACH OF TRANSMEMBRANE IONIC CURRENTS.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ionic currents across neuron and glial cells membranes lie at the origin of the entire brain electrophysiology. They are the common root of functional brain dynamics and mesoscopic or macroscopic phenomena such as extracellular fields. In particular, they provide the relevant basis to relate cellular electrophysiology and macroscopic dipole models. In order to derive robust features and to envision the multi-scale approaches required to connect the different levels of observation, an essential prerequisite is to have minimal model of elementary ionic motions. In this paper, we propose a general cellular automata framew...
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Pezard L, Lesne A Tags: J Integr Neurosci Source Type: journals

Unveiling novel forms of hippocampal synaptic plasticity with microelectrode arrays.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we elucidate by use of microelectrode arrays novel forms of long-term depression and potentiation in the hippocampus which are triggered by low frequency afferent stimulation and which rely on the activation of metabotropic glutamate receptor of the fifth subtype (mGlu5 receptor). PMID: 18763723 [PubMed - in process]
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Lanté F, Crouzin N, Vignes M Tags: J Integr Neurosci Source Type: journals

Basic properties of electrical field coupling between neurons: an analytical approach.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The basic properties of the electrical field coupling between two parallel neurons, with linear electrical properties of the membranes, are investigated using a mathematical model-based on Laplace transform and matrix algebra, assuming that the system is unidimensional. This approach is extended to a ramified dendritic tree, and to a set of parallel neurons a subset of which is synaptically activated. We show that the electrical field effect is governed by certain geometrical and electrophysiological parameters, the most important being a coupling coefficient k, which depends on the extra- and intracellular resistivity...
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Costalat R, Chauvet G Tags: J Integr Neurosci Source Type: journals

Unexpected roles of scaffolding proteins in receptor patho-physiological functions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is well established that membrane receptors, transporters, and ion channels are organized into functional networks at the cell membrane by multiprotein complexes. The scaffolding proteins physically link these signaling membrane proteins to their intracellular effectors and actin skeleton. The last ten years of research in the field have revealed the nature, structure, and functions of some of these multiprotein complexes. Here, we will focus on those which are present at the excitatory glutamatergic synapse and describe some of their structural and functional aspects, as well as the main methods which are use to st...
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Fagni L, Bertaso F, Perroy J, Ango F Tags: J Integr Neurosci Source Type: journals

Estimating space and time constants for active neuronal models from measurements of conduction speed.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Space constants and time constants characterize the spatial and temporal behavior of the membrane potential of a neuronal membrane with constant conductance. However, more realistic models of membrane potential assume that membrane conductance depends on the membrane potential and its history, and therefore, it is not clear that space and time constants can be defined for membranes with this property. However, through a consideration of the properties of trains of action potentials treated as traveling waves, space and time constants for the total membrane current during a propagated action potential can be derived and...
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Lindsay KA, Rosenberg JR Tags: J Integr Neurosci Source Type: journals

Modeling glutamatergic synapses: insights into mechanisms regulating synaptic efficacy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article briefly summarizes the approach we are using and illustrates it by presenting data regarding the effects of changing the number of AMPA receptors on various features of glutamatergic transmission, including NMDA receptor-mediated responses and paired-pulse facilitation. We conclude by discussing the significance of these results and providing some ideas for future directions with this approach. PMID: 18763719 [PubMed - in process]
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Bouteiller JM, Baudry M, Allam SL, Greget RJ, Bischoff S, Berger TW Tags: J Integr Neurosci Source Type: journals

EDITORIAL.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract received. PMID: 18763718 [PubMed - as supplied by publisher]
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Roman FS Tags: J Integr Neurosci Source Type: journals

Integrative Neuroscience. Editorial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18763718 [PubMed - in process]
Source: Journal of Integrative Neuroscience - June 1, 2008 Category: Neuroscience Authors: Roman FS Tags: J Integr Neurosci Source Type: journals

The role of the hippocampus in long-term memory: is it memory store or comparator?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several attempts have been made to reconcile a number of rival theories on the role of the hippocampus in long-term memory. Those attempts fail to explain the basic effects of the theories from the same point of view. We are reviewing the four major theories, and shall demonstrate, with the use of mathematical models of attention and memory, that only one theory is capable of reconciling all of them by explaining the basic effects of each theory in a unified fashion, without altogether sacrificing their individual contributions. The key issue here is whether or not a memory trace is ever stored in the hippocampus itsel...
Source: Journal of Integrative Neuroscience - March 1, 2008 Category: Neuroscience Authors: Kryukov VI Tags: J Integr Neurosci Source Type: journals

Consciousness and the structure of matter.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This commentary article extends Vimal's [J Integr Neurosci 7:49-73, 2008] concept of protoexperience by outlining a two-factor approach to the localization of consciousness within the physical matter of the brain consistent with contemporary theoretical physics, molecular and system biology, and neuroscience. Specific hypotheses based on this approach predict on clearly stated grounds the occurrence or non-occurrence, and degrees of intensity of consciousness within the human brain and possibly in related species based on the combination of protoconsciousness with energetic activating agents. In this it comprises a mec...
Source: Journal of Integrative Neuroscience - March 1, 2008 Category: Neuroscience Authors: Macgregor RJ, Vimal RL Tags: J Integr Neurosci Source Type: journals

Proto-experiences and subjective experiences: classical and quantum concepts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deterministic reductive monism and non-reductive substance dualism are two opposite views for consciousness, and both have serious problems. An alternative view is needed. For this, we hypothesize that strings or elementary particles (fermions and bosons) have two aspects: (i) elemental proto-experiences (PEs) as phenomenal aspect, and (ii) mass, charge, and spin as material aspect. Elemental PEs are hypothesized to be the properties of elementary particles and their interactions, which are composed of irreducible fundamental subjective experiences (SEs)/PEs that are in superimposed form in elementary particles and in ...
Source: Journal of Integrative Neuroscience - March 1, 2008 Category: Neuroscience Authors: Vimal RL Tags: J Integr Neurosci Source Type: journals

Intracellular cyclic-amp suppresses the permeability of gap junctions between retinal amacrine cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gap junctions are intercellular channels composed of subunit protein connexin and subserve electrotonic transmission between connected neurons. Retinal amacrine cells, as well as horizontal cells of the same class, are homologously connected by gap junctions. The gap junctions between these neurons extend their receptive fields, and may increase the inhibitory postsynaptic effects in the retina. In the present study, we investigated whether gap junctions between the neurons are modulated by internal messengers. The permeability of gap junctions was examined by the diffusion of intracellularly injected biotinylated trac...
Source: Journal of Integrative Neuroscience - March 1, 2008 Category: Neuroscience Authors: Hidaka S Tags: J Integr Neurosci Source Type: journals

Meg recordings of patients with CNS disorders before and after external magnetic stimulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Magnetoencephalographic (MEG) recordings of patients with CNS disorders were obtained using a whole-head 122-channel magnetometer SQUID and analyzed using Fourier statistical analysis. External transcranial magnetic stimulation in the order of pico Tesla (pTMS) was applied to the above patients with proper characteristics (magnetic intensity 1-7.5 pT; frequency: 8-13 Hz) which were obtained with MEG recordings prior to pTMS. The MEG recordings after the application of pTMS showed a rapid attenuation of the high abnormal activity followed by an increase in the number of the low frequency components toward the patients a...
Source: Journal of Integrative Neuroscience - March 1, 2008 Category: Neuroscience Authors: Anninos P, Kotini A, Anninou N, Adamopoulos A, Papastergiou A, Tsagas N Tags: J Integr Neurosci Source Type: journals

ROLE OF M1 RECEPTOR IN THE LOCOMOTION BEHAVIOR OF THE AFRICAN MOLE-RAT (Cryptomys sp).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Studies exploring the endogenous mechanism that modulates locomotion in Cryptomys sp, a bathyergid of the subterranean hystricomorph African mole-rat species might contribute to the understanding of the interrelations between external variables and internal mechanisms that controls the diverse patterns of locomotion in mole-rats. It has been shown that environmental variables contribute to the inter-individual variations in the daily patterns of locomotion, however, it is not well known if endogenous mechanism such as M1 receptor that regulates locomotion in surface dwelling rodents could as well regulate locomotion in...
Source: Journal of Integrative Neuroscience - March 1, 2008 Category: Neuroscience Authors: Nathaniel TI, Umesiri FE, Olajuyigbe F Tags: J Integr Neurosci Source Type: journals

Book Review: "The War of the Soups and of the Sparks: The Discovery of the Neurotransmitters and the Dispute Over How Nerves Communicate", In Praise of Famous Men, Elliot S. Valenstein (2005).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract received. PMID: 18181272 [PubMed - as supplied by publisher]
Source: Journal of Integrative Neuroscience - December 1, 2007 Category: Neuroscience Authors: Hutter O Tags: J Integr Neurosci Source Type: journals

Development and validation of a neural population model based on the dynamics of a discontinuous membrane potential neuron model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The major goal of this study was to develop a population density based model derived from statistical mechanics based on the dynamics of a discontinuous membrane potential neuron model. A secondary goal was to validate this model by comparing results from a direct simulation approach on the one hand and our population based approach on the other hand. Comparisons between the two approaches in the case of a synaptically uncoupled and a synaptically coupled neural population produced satisfactory qualitative agreement in terms of firing rate and mean membrane potential. Reasonable quantitative agreement was also obtained...
Source: Journal of Integrative Neuroscience - December 1, 2007 Category: Neuroscience Authors: Modolo J, Garenne A, Henry J, Beuter A Tags: J Integr Neurosci Source Type: journals

Modeling analysis of the relationship between EEG rhythms and connectivity among different neural populations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In our research, a neural mass model consisting of four interconnected neural groups (pyramidal neurons, excitatory interneurons, inhibitory interneurons with slow synaptic kinetics, and inhibitory interneurons with fast synaptic kinetics) is used to investigate the mechanisms which cause the appearance of multiple rhythms in EEG spectra, and to assess how these rhythms can be affected by connectivity among different populations. First, we showed that a single neural population, stimulated with white noise, can oscillate with its intrinsic rhythm, and that the position of this rhythm can be finely tuned (in the alpha, ...
Source: Journal of Integrative Neuroscience - December 1, 2007 Category: Neuroscience Authors: Ursino M, Zavaglia M Tags: J Integr Neurosci Source Type: journals

Fronto-parietal connection asymmetry regulates working memory distractibility.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent functional magnetic resonance imaging studies demonstrate that increased task-related neural activity in parietal and frontal cortex during development and training is positively correlated with improved visuospatial working memory (vsWM) performance. Yet, the analysis of the corresponding underlying functional reorganization of the fronto-parietal network has received little attention. Here, we perform an integrative experimental and computational analysis to determine the effective balance between the superior frontal sulcus (SFS) and intraparietal sulcus (IPS) and their putative role(s) in protecting against ...
Source: Journal of Integrative Neuroscience - December 1, 2007 Category: Neuroscience Authors: Edin F, Klingberg T, Stödberg T, Tegnér J Tags: J Integr Neurosci Source Type: journals

Self: an adaptive pressure arising from self-organization, chaotic dynamics, and neural darwinism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this article, we establish a model to delineate the emergence of "self" in the brain making recourse to the theory of chaos. Self is considered as the subjective experience of a subject. As essential ingredients of subjective experiences, our model includes wakefulness, re-entry, attention, memory, and proto-experiences. The stability as stated by chaos theory can potentially describe the non-linear function of "self" as sensitive to initial conditions and can characterize it as underlying order from apparently random signals. Self-similarity is discussed as a latent menace of a pathological confusion between "self"...
Source: Journal of Integrative Neuroscience - December 1, 2007 Category: Neuroscience Authors: Bruzzo AA, Vimal RL Tags: J Integr Neurosci Source Type: journals

Neurobiological mechanisms underlying qualia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper argues that mechanisms underlying consciousness and qualia are likely to arise from the information processing that takes place within the detailed micro-structure of the cerebral cortex. It looks at two key issues: how any information processing system can recognize its own activity; and secondly, how this behavior could lead to the subjective experience of qualia. In particular, it explores the pattern processing capabilities of attractor networks, and the way that they can attribute meaning to their input patterns and goes on to show how these capabilities can lead to self-recognition. The paper suggests ...
Source: Journal of Integrative Neuroscience - December 1, 2007 Category: Neuroscience Authors: Orpwood R Tags: J Integr Neurosci Source Type: journals

A118g polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian origin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The opioidergic hypothesis suggests an association between genetic variations at the opioid receptor mu 1 (OPRM1) gene locus and opiate addiction. The OPRM1 gene, which encodes for mu opioid receptor, contains several single nucleotide polymorphisms (SNPs) in exon I. Two of these, C17T and A118G, have been reported to be associated with substance abuse. The present study aims to delineate the frequency of these variants in the subjects of Indian origin and study their association with the phenotype of opioid dependence. A118G (rs 1799971) and C17T (rs 1799972) were genotyped using polymerase chain reaction-restriction ...
Source: Journal of Integrative Neuroscience - December 1, 2007 Category: Neuroscience Authors: Kapur S, Sharad S, Singh RA, Gupta AK Tags: J Integr Neurosci Source Type: journals

Bio-inspired model of visual information encoding for localization: from the retina to the lateral geniculate nucleus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, a bio-inspired approach for extracting efficient features prior to the recognition of scenes is proposed. It is highly inspired from the model of the mammals visual system. The retina contains many levels of neurons (bipolar, amacrine, horizontal and ganglion cells) accurately organized from cones and rods to the optic nerve up till the lateral geniculate nucleus (LGN) which is the main thalamic relay for inputs to the visual cortex. This structure probably eases other brain areas tasks in preprocessing the visual information. This paper is focusing on the study of these specific structures, relying on a bot...
Source: Journal of Integrative Neuroscience - September 1, 2007 Category: Neuroscience Authors: Debaecker T, Benosman R Tags: J Integr Neurosci Source Type: journals