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Menopause impacts the relation of plasma adiponectin levels with the metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Low plasma levels of adiponectin are associated with increased prevalence of MetS, especially in postmenopausal women. Age and BMI have similar discriminatory accuracies for presence of MetS when compared with age and plasma adiponectin. Thus, we conclude that the association of plasma adiponectin with MetS is significantly affected by menopause but challenge the additional value of adiponectin for the discriminatory accuracy for presence of MetS. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 13, 2009 Category: Internal Medicine Authors: P. Henneman, A. C. J. W. Janssens, M. C. Zillikens, M. Frolich, R. R. Frants, B. A. Oostra, C. M. van Duijn, K. Willems van Dijk Source Type: journals

Osteoprotegerin concentrations and prognosis in acute ischaemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Osteoprotegerin concentrations measured at admission of acute ischaemic stroke are associated with long-term mortality. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 7, 2009 Category: Internal Medicine Authors: J. K. Jensen, T. Ueland, D. Atar, L. Gullestad, H. Mickley, P. Aukrust, J. L. Januzzi Source Type: journals

Predictive value of on-treatment response during full-dose antiviral therapy of patients with hepatitis C virus cirrhosis and portal hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Full-dose antiviral therapy with PEG-IFN and ribavirin can be safely carried out even in patients with compensated, fully established cirrhosis and portal hypertension. Selecting patients on the basis of HCV genotype and viral load, and application of on-treatment stopping rule may help rationalize treatment in patients who are unlikely to obtain SVR. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 21, 2009 Category: Internal Medicine Authors: E. G. Giannini, M. Basso, V. Savarino, A. Picciotto Source Type: journals

GRB10 gene and type 2 diabetes in WhitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 10, 2009 Category: Internal Medicine Authors: R. Di Paola, J. Wojcik, E. Succurro, A. Marucci, M. Chandalia, L. Padovano, C. Powers, G. Merla, N. Abate, G. Sesti, A. Doria, V. Trischitta Source Type: journals

Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic White Caucasians from Italy: evidence from a family-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Circulating levels of adiponectin isoforms are highly heritable. The genetic control of HMW adiponectin is shared in part with insulin resistance-related traits and involves, but is not limited to, the ADIPOQ locus. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 16, 2009 Category: Internal Medicine Authors: C. Menzaghi, L. Salvemini, G. Paroni, C. De Bonis, D. Mangiacotti, G. Fini, A. Doria, R. Di Paola, V. Trischitta Source Type: journals

Effects of atorvastatin on circulating CD34+/CD133+/ CD45− progenitor cells and indices of angiogenesis (vascular endothelial growth factor and the angiopoietins 1 and 2) in atherosclerotic vascular disease and diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. High-dose atorvastatin increased circulating CPCs, reduced VEGF and increased Ang-2 in patients with diabetes and CVD, providing another possible pathophysiological mechanism for the beneficial effects of statins in CVD. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 14, 2009 Category: Internal Medicine Authors: R. J. Jaumdally, P. K. Y. Goon, C. Varma, A. D. Blann, G. Y. H. Lip Source Type: journals

Impact of a high-dose nitrate strategy on cardiac stress in acute heart failure: a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. A noninvasive high-dose nitrate strategy on top of standard therapy is safe and notably accelerates cardiac recovery in patients observed on the general ward. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - August 17, 2009 Category: Internal Medicine Authors: T. Breidthardt, M. Noveanu, M. Potocki, T. Reichlin, P. Egli, S. Hartwiger, T. Socrates, E. Gayat, M. Christ, A. Mebazaa, C. Mueller Source Type: journals

Consistency of blood pressure and impact on cardiovascular structure over 20 years in young menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. BP elevation in young age predicts hypertension and adverse cardiovascular remodelling at the age of 40 years. Baseline office MAP is the best predictor of hypertension, 24-h MAP and LVMI. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - July 4, 2009 Category: Internal Medicine Authors: W. Ridderstråle, O. Saluveer, M. C. Johansson, A. Bergbrant, S. Jern, T. J. Hrafnkelsdóttir Source Type: journals

Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Serum amyloid A was associated with several metabolic risk factors but was not an independent predictor of IMT or carotid artery compliance. Further longitudinal studies will show whether SAA holds a prognostic value as a risk marker, analogously to CRP. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - June 30, 2009 Category: Internal Medicine Authors: J. Jylhävä, A. Haarala, C. Eklund, M. Pertovaara, M. Kähönen, N. Hutri-Kähönen, M. Levula, T. Lehtimäki, R. Huupponen, A. Jula, M. Juonala, J. Viikari, O. Raitakari, M. Hurme Source Type: journals

NOD2/CARD15 genotype and common gastrointestinal diseases in 43 600 individualsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. NOD2/CARD15 polymorphisms are not major risk factors for common gastrointestinal diseases; however, we cannot completely exclude association with appendicitis, anal fissure, fistula and abscess, and gastrointestinal cancer. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - June 29, 2009 Category: Internal Medicine Authors: S. Yazdanyar, B. G. Nordestgaard Source Type: journals

Telomere length and progression of diabetic nephropathy in patients with type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract. Abstract. Fyhrquist F, Tiitu A, Saijonmaa O, Forsblom C, Groop P-H, on behalf of the FinnDiane Study Group (Minerva Institute for Medical Research; Helsinki University Central Hospital; and Folkhälsan Institute of Genetics; Helsinki, Finland). Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes. J Intern Med 2009;doi: 10.1111/j.1365-2796.2009.02139.x.Objectives. To determine whether short telomere length of blood leucocytes from patients with type 1 diabetes is associated with or predictive of progression of diabetic nephropathy.Design and methods. Two consecutive DNA samples...
Source: Journal of Internal Medicine - June 26, 2009 Category: Internal Medicine Authors: F. Fyhrquist, A. Tiitu, O. Saijonmaa, C. Forsblom, P.-H. Groop Source Type: journals

Follow-ups of the Cardiovascular Risk in Young Finns Study in 2001 and 2007: Levels and 6-year changes in risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The 6-year changes in total cholesterol, LDL-cholesterol and HDL-cholesterol in young Finns were favourable between 2001 and 2007. However, waist circumference, glucose and blood pressure levels increased. Therefore, continuous efforts are still needed in fighting against cardiovascular risk factors. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - June 24, 2009 Category: Internal Medicine Authors: J. R. H. Raiko, J. S. A. Viikari, A. Ilmanen, N. Hutri-Kähönen, L. Taittonen, E. Jokinen, M. Pietikäinen, A. Jula, B.-M. Loo, J. Marniemi, T. Lehtimäki, M. Kähönen, T. Rönnemaa, O. T. Raitakari, M. Juonala Source Type: journals

Vaccinate your child and save its grandparents from a heart attack? Current perspectives in antipneumococcal vaccinationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reviews available data on the efficacy of the available vaccines in different age groups and disease presentations, and the advantages and shortcomings of each type of vaccine, including future perspectives. Special attention is given to controversies regarding the efficacy of PPV against pneumonia in adults and its protective effects against myocardial infarction. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - June 24, 2009 Category: Internal Medicine Authors: Angel Vila-Córcoles Source Type: journals

Persistent parvovirus B19 infection detected by specific CD4+ T-cell responses in a patient with hepatitis and polyarthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract. Pongratz G, Lindner J, Modrow S, Schimanski S, Schölmerich J, Fleck M (University Medical Center Regensburg, Regensburg; Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg; and Asklepios-Clinic, Bad Abbach; Germany). Persistent parvovirus B19 infection detected by specific CD4+ T-cell responses in a patient with hepatitis and polyarthritis (Case Report). J Intern Med 2009; We, here, report the case of a parvovirus B19 infection in an immunocompetent male patient presenting with acute hepatitis and polyarthritis. To follow the course of infection, we used a previously established...
Source: Journal of Internal Medicine - June 24, 2009 Category: Internal Medicine Authors: G. Pongratz, J. Lindner, S. Modrow, S. Schimanski, J. Schölmerich, M. Fleck Source Type: journals

Clinical significance of low-grade renal artery stenosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract. Dechering DG, Kruis HME, Adiyaman A, Thien Th, Postma CT (Radboud University, Nijmegen, The Netherlands, and University Hospital Münster, Münster, Germany). Clinical significance of low-grade renal artery stenosis. J Intern Med 2009; doi: 10.1111/j.1365-2796.2009.02144.x.Background. Patients with a renal artery stenosis (RAS) >50% carry an increased risk for future cardiovascular (CV) events. Experimental literature on this topic suggests that this might as well be true for subjects with lower-grade RAS.Methods. Recruitment in this longitudinal cohort study was conducted from 1982 to 2002 in a Dutch University ...
Source: Journal of Internal Medicine - June 21, 2009 Category: Internal Medicine Authors: D. G. Dechering, H. M. E. Kruis, A. Adiyaman, Th. Thien, C. T. Postma Source Type: journals

An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Female carriers of the P291fsinsC mutation in HNF-1[alpha] displayed slightly lower apoM serum levels. This difference is too small for apoM to be reliably employed as a biomarker for HNF-1[alpha] mutation status. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - June 21, 2009 Category: Internal Medicine Authors: C. Cervin, O. Axler, J. Holmkvist, P. Almgren, E. Rantala, T. Tuomi, L. Groop, B. Dahlbäck, E. Karlsson Source Type: journals

Kidney function and discrimination of cardiovascular risk in middle-aged menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The GFR cut-off point for optimal discrimination of cardiovascular risk in the general population may be higher than previously suggested. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - June 5, 2009 Category: Internal Medicine Authors: I. Soveri, J. Ärnlöv, L. Berglund, L. Lind, B. Fellström, J. Sundström Source Type: journals

A functional variant in the gene 3' untranslated region regulates HSP70 expression and is a potential candidate for insulin resistance-related abnormalitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - May 30, 2009 Category: Internal Medicine Authors: A. Marucci, G. Miscio, L. Padovano, W. Boonyasrisawat, A. Doria, V. Trischitta, R. Di Paola Source Type: journals

Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in the diagnosis of heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Midregional pro-atrial natriuretic peptide is as accurate in the diagnosis of heart failure as NTproBNP. MRproANP seems to provide incremental information on top of BNP or NT-proBNP in some subgroups and should be further investigated in other studies. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - May 30, 2009 Category: Internal Medicine Authors: M. Potocki, T. Breidthardt, T. Reichlin, S. Hartwiger, N. G. Morgenthaler, A. Bergmann, M. Noveanu, H. Freidank, A. B. Taegtmeyer, K. Wetzel, T. Boldanova, C. Stelzig, R. Bingisser, M. Christ, C. Mueller Source Type: journals

Fitness and abdominal obesity are independently associated with cardiovascular riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Higher fitness and lower waist circumference are each independently associated to a similar extent with a lower CVD risk. Simultaneous evaluation of both fitness and abdominal obesity status in clinical practice is important. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - May 30, 2009 Category: Internal Medicine Authors: E. Ekblom-Bak, M.-L. Hellenius, Ö. Ekblom, L.-M. Engström, B. Ekblom Source Type: journals

Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417 734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Already moderate levels of UA appear to be associated with an increased incidence of AMI, stroke and CHF in middle-aged subjects without prior cardiovascular disease. These associations seem to increase gradually from lower to higher levels of UA. UA may be an important complementary indicator of cardiovascular risk in the general population. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - May 25, 2009 Category: Internal Medicine Authors: I. Holme, A. H. Aastveit, N. Hammar, I. Jungner, G. Walldius Source Type: journals

Obesity and trends in cardiovascular risk factors over 40 years in Swedish men aged 50Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract. Rosengren A, Eriksson H, Hansson PO, Svärdsudd K, Wilhelmsen L, Johansson S, Welin C, Welin L (Sahlgrenska University Hospital/Östra, Göteborg; Uppsala University, University Hospital, Uppsala; AstraZeneca R&D, Mölndal; University of Gothenburg, Institute of Health and Care Sciences, Gothenburg; Lidköping Hospital, Lidköping; Sweden). Obesity and trends in cardiovascular risk factors over 40 years in Swedish men aged 50. J Intern Med 2009; doi: 10.1111/j.1365-2796.2009.02116.xObjective. To study trends over 40 years in cardiovascular risk factors in normal weight, overweight and obese men, all aged 50 when ...
Source: Journal of Internal Medicine - May 21, 2009 Category: Internal Medicine Authors: A. Rosengren, H. Eriksson, P. O. Hansson, K. Svärdsudd, L. Wilhelmsen, S. Johansson, C. Welin, L. Welin Source Type: journals

Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The response of CFS patients to incremental exercise associates a lengthened and accentuated oxidative stress, which might result from delayed and insufficient Hsp production. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - May 19, 2009 Category: Internal Medicine Authors: Y. Jammes, J. G. Steinberg, S. Delliaux, F. Brégeon Source Type: journals

ANTI-HSP60 and ANTI-HSP70 antibody levels and micro/ macrovascular complications in type 1 diabetes: the EURODIAB StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In this large cohort of type 1 diabetic subjects, we found an independent and inverse association between serum anti-HSP70 antibody levels and diabetic micro/macrovascular complications. This suggests that anti-HSP70 antibody levels may be a novel marker of protection from chronic diabetic complications. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - May 7, 2009 Category: Internal Medicine Authors: G. Gruden, G. Bruno, N. Chaturvedi, D. Burt, S. Pinach, C. Schalkwijk, C. D. Stehouwer, D. R. Witte, J. H. Fuller, P. Cavallo-Perin Source Type: journals

Lipid lowering versus pleiotropic effects of statins on skin microvascular function in patients with dysglycaemia and coronary artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Lipid lowering improves microvascular function in patients with dysglycaemia and CAD. The data suggest that lipid lowering per se is more important than pleiotropic effects of statins for this effect. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - May 6, 2009 Category: Internal Medicine Authors: M. Settergren, F. Böhm, L. Rydén, J. Pernow, M. Kalani Source Type: journals

Apolipoprotein M predicts pre-β-HDL formation: studies in type 2 diabetic and nondiabetic subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Plasma apoM is modestly reduced in type 2 diabetes. Pre-[beta]-HDL and pre-[beta]-HDL formation are positively associated with apoM, supporting the hypothesis that apoM plays a role in HDL remodelling in humans. Lower apoM may provide a mechanism to explain why pre-[beta]-HDL formation is not increased in type 2 diabetes despite elevated PLTP activity. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - May 4, 2009 Category: Internal Medicine Authors: P. Plomgaard, R. P. F. Dullaart, R. de Vries, A. K. Groen, B. Dahlbäck, L. B. Nielsen Source Type: journals

25-hydroxyvitamin D accumulation during summer in elderly women at latitude 60ºNEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Women with high winter 25(OH)D serum concentrations, with preference of staying in the sun instead of shade during summer, a skin type allowing for longer sun exposure and a normal weight had the highest summer 25(OH)D concentrations. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - April 26, 2009 Category: Internal Medicine Authors: A. Burgaz, A. Åkesson, K. Michaëlsson, A. Wolk Source Type: journals

Rituximab in auto-immune haemolytic anaemia and immune thrombocytopenic purpura: a Belgian retrospective multicentric studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. This study confirms that rituximab induces responses in a majority of previously treated patients with AIHA and ITP. Response duration generally exceeds 1 year. Retreatment with rituximab in responding patients is most often successful. The outcome of patients who fail on rituximab is poor. We were not able to identify pretreatment patient characteristics predicting for response. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - April 26, 2009 Category: Internal Medicine Authors: D. Dierickx, G. Verhoef, A. Van Hoof, P. Mineur, A. Roest, A. Triffet, A. Kentos, P. Pierre, D. Boulet, G. Bries, P-Q Lê, A. Janssens, A. Delannoy Source Type: journals

Role of two nutritional hepatic markers (insulin-like growth factor 1 and transthyretin) in the clinical assessment and follow-up of acute intermittent porphyria patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. This first study in humans suggests that the clinical expression AIP is associated with a state of under-nutrition and/or with hepatic inflammation due to the sustained accumulation of heme-precursors. We propose the use of both IGF-1 and transthyretin as biomarkers of disease morbidity/severity for the clinical follow-up of AIP patients. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - April 22, 2009 Category: Internal Medicine Authors: C. Delaby, J. To-Figueras, J. C. Deybach, R Casamitjana, H. Puy, C. Herrero Source Type: journals

Perceived stress as a risk factor for changes in health behaviour and cardiac risk profile: a longitudinal studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. This longitudinal study supports a causal relation between stress and cardiovascular diseases mediated through unfavourable changes in health behaviour and cardiac risk profile. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - April 22, 2009 Category: Internal Medicine Authors: N. H. Rod, M. Grønbæk, P. Schnohr, E. Prescott, T. S. Kristensen Source Type: journals

Influence of statin treatment on platelet inhibition by clopidogrel – a randomized comparison of rosuvastatin, atorvastatin and simvastatin co-treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Treatment with CYP3A4 metabolized statins, atorvastatin or simvastatin, did not attenuate the platelet inhibitory effect of clopidogrel maintenance treatment compared with the non-CYP3A4 metabolized, rosuvastatin. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - April 22, 2009 Category: Internal Medicine Authors: R. E. Malmström, J. Östergren, L. Jørgensen, P. Hjemdahl Source Type: journals

Prevalence and extent of calcification over aorta, coronary and carotid arteries in patients with rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Our results demonstrated that RA patients had earlier onset, more diffuse arterial calcification over multiple vascular beds and more preferential involvement of thoracic aorta, rather than coronary artery when compared with control. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - April 22, 2009 Category: Internal Medicine Authors: S. Wang, K.-H. Yiu, M.-Y. Mok, G. C. Ooi, P.-L. Khong, K.-F. H. Mak, C.-P. Lau, K.-F. LAM, C.-S. Lau, H.-F. Tse Source Type: journals

Exploring the link between inflammation and the vagus nerveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - April 10, 2009 Category: Internal Medicine Authors: J.-J. de Haan, T. Lubbers, J.-W. Greve, W. A. Buurman Source Type: journals

Chocolate consumption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Chocolate consumption was associated with lower cardiac mortality in a dose dependent manner in patients free of diabetes surviving their first AMI. Although our findings support increasing evidence that chocolate is a rich source of beneficial bioactive compounds, confirmation of this strong inverse relationship from other observational studies or large-scale, long-term, controlled randomized trials is needed. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - March 27, 2009 Category: Internal Medicine Authors: I. Janszky, K. J. Mukamal, R. Ljung, S. Ahnve, A. Ahlbom, J. Hallqvist Source Type: journals

Better adherence to antihypertensive agents and risk reduction of chronic heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Our study suggests that a better adherence is associated with a significant risk reduction of CHF. Adherence to AH therapy needs to be improved to optimize benefits. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - March 25, 2009 Category: Internal Medicine Authors: S. Perreault, A. Dragomir, M. White, L. Lalonde, L. Blais, A. Bérard Source Type: journals

Modulating T-cell homeostasis with IL-7: preclinical and clinical studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract. Capitini CM, Chisti AA, Mackall CL (National Cancer Institute, National Institutes of Health, Bethesda, MD; USA). Modulating T-cell homeostasis with IL-7: preclinical and clinical studies (Review). Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - March 25, 2009 Category: Internal Medicine Authors: C. M. Capitini, A. A. Chisti, C. L. Mackall Source Type: journals

Use of snus and risk for cardiovascular disease: results from the Swedish Twin RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. These data do not support any strong association between snus use and risk for cardiovascular disease. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - March 12, 2009 Category: Internal Medicine Authors: J. Hansson, N. L. Pedersen, M. R. Galanti, T. Andersson, A. Ahlbom, J. Hallqvist, C. Magnusson Source Type: journals

Intensive lipid lowering may reduce progression of carotid atherosclerosis within 12 months of treatment: the METEOR studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Aggressive LDL-C lowering seems to exert its beneficial effect on atherosclerosis progression during the first 12 months of treatment. This parallels the timing of event reduction seen in clinical trials and suggests that the efficacy of lipid lowering treatment on CIMT progression can be evaluated in trials with a duration of 1 year, given sufficient sample size, high precision of measurements and a treatment effect comparable to that seen in METEOR.Trial Registration: Clinicaltrials.gov identifier: NCT00225589. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - March 4, 2009 Category: Internal Medicine Authors: M. L. Bots, M. K. Palmer, S. Dogan, Y. Plantinga, J. S. Raichlen, G. W. Evans, D. H. O'Leary, D. E. Grobbee, J. R. Crouse III Source Type: journals

Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function. Although randomized trials of folic acid supplementation are needed to determine causality, our findings highlight the potential importance of folate, or sources of folate, in incident cardiovascular disease. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - February 28, 2009 Category: Internal Medicine Authors: B. Van Guelpen, J. Hultdin, I. Johansson, C. Witthöft, L. Weinehall, M. Eliasson, G. Hallmans, R. Palmqvist, J.-H. Jansson, A. Winkvist Source Type: journals

Temporal discrepancies in the association between the apoB/apoA-I ratio and mortality in incident dialysis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. A high apoB/apoA-I ratio and an increase in this ratio during the first year on dialysis were associated with short-term survival advantage in CKD patients. This paradoxical relationship represents an example of the so-called reverse epidemiology phenomenon in CKD patients and suggests that the apoB/apoA-I ratio should always be interpreted with caution in this patient population. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - February 27, 2009 Category: Internal Medicine Authors: M. Chmielewski, J. J. Carrero, A. R. Qureshi, J. Axelsson, O. Heimbürger, L. Berglund, P. Bárány, B. Rutkowski, B. Lindholm, P. Stenvinkel Source Type: journals

Effects of coronary artery disease and percutaneous intervention on the cardiac metabolism of nonesterified fatty acids and insulin: Implications of diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. There is an intracardiac gradient of NEFA and insulin in Groups I[ndash]III. Cardiac NEFA metabolism was higher in those with mild CAD compared with those with obstructive CAD whereas intracardiac insulin extraction was lower in Group III (diabetic) patients. PCI was associated with a systemic rise in NEFA, with a reduction in insulin levels and cardiac utilization, but these effects were blunted in diabetic patients. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - February 17, 2009 Category: Internal Medicine Authors: R. J. Jaumdally, G. Y. H. Lip, J. V. Patel, R. J. MacFadyen, C. Varma Source Type: journals

Immune responses against fibronectin modified by lipoprotein oxidation and their association with cardiovascular diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These observations demonstrate that oxidation of LDL in the arterial wall may lead to aldehyde-modification of surrounding extracellular matrix proteins and that these modifications may affect macrophage function and activate autoimmune responses of pathophysiological importance for the development of atherosclerosis. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - February 16, 2009 Category: Internal Medicine Authors: P. Dunér, F. To, R. Alm, I. Gonçalves, G. N. Fredrikson, B. Hedblad, G. Berglund, J. Nilsson, E. Bengtsson Source Type: journals

B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. C-terminal-pro-endothelin-1 is superior to BNP for the prediction of a peak VO2 < 14 mL kg[minus]1 min[minus]1 in patients referred for CPET. A score incorporating body mass index, diabetes status, spirometry, blood gases, BNP and CT-proET-1 improves the prediction of a peak VO2 < 14 mL kg[minus]1 min[minus]1 based on single biomarkers. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - February 16, 2009 Category: Internal Medicine Authors: M. T. Maeder, M. H. Brutsche, D. Staub, N. G. Morgenthaler, A. Bergmann, M. Noveanu, K. Laule, T. Breidthardt, A. Christ, T. Klima, T. Reichlin, M. Potocki, C. Mueller Source Type: journals

Circulating biomarkers of angiogenesis as indicators of left ventricular systolic dysfunction amongst patients with coronary artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract. Patel JV, Abraheem A, Chackathayil J, Gunning M, Creamer J, Hughes EA, Lip GYH (City Hospital, Birmingham; and University Hospital of North Staffordshire, Stoke-on-Trent, UK). Circulating biomarkers of angiogenesis as indicators of left ventricular systolic dysfunction amongst patients with coronary artery disease. J Intern Med 2009; doi: 10.1111/j.1365-2796.2008.02057.xBackground. Patients with coronary artery disease (CAD) and left ventricular systolic dysfunction (LVSD) are often asymptomatic. Angiogenesis is implicated in the physiology of vascular repair and cardiac remodelling, and is one of many pathophysi...
Source: Journal of Internal Medicine - February 2, 2009 Category: Internal Medicine Authors: J. V. Patel, A. Abraheem, J. Chackathayil, M. Gunning, J. Creamer, E. A. Hughes, G. Y. H. Lip Source Type: journals

Clinical consequences of hospital variation in use of oral anticoagulant therapy after first-time admission for atrial fibrillationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. In Denmark between 1995 and 2004, there was a major hospital variation in AF patients receiving OAC, and consequently, more thromboembolic events were observed amongst patients from low OAC use hospitals. Our study emphasizes the need for a continued vigilance on implementation of international AF management guidelines. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - January 10, 2009 Category: Internal Medicine Authors: M. L. Hansen, N. Gadsbøll, S. Rasmussen, G. H. Gislason, F. Folke, S. S. Andersen, T. K. Schramm, R. Sørensen, E. L. Fosbøl, S. Z. Abildstrøm, M. Madsen, H. E. Poulsen, L. Køber, C. Torp-Pedersen Source Type: journals

Atrial fibrillation in fracture patients treated with oral bisphosphonatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The increased occurrence of AF in fracture patients who are users of oral bisphosphonates should be attributed to targeting of bisphosphonates to patients who are already at increased risk of cardiovascular events. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - January 7, 2009 Category: Internal Medicine Authors: B. Abrahamsen, P. Eiken, K. Brixen Source Type: journals

Improved outcome in Wegener's granulomatosis and microscopic polyangiitis? A retrospective analysis of 95 cases in two cohortsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Patient survival in WG and MPA analysed with SMR may be better than previously believed. Severe renal disease and disease relapse were the major predictors of reduced survival. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - December 23, 2008 Category: Internal Medicine Authors: P. Eriksson, L. Jacobsson, Å. Lindell, J.-Å. Nilsson, T. Skogh Source Type: journals

Ezetimibe monotherapy for cholesterol lowering in 2,722 people: systematic review and meta-analysis of randomized controlled trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In a meta-analysis restricted to short-term trials in hypercholesterolaemia, significant potentially favourable changes in lipid and lipoprotein levels relative to baseline occurred with ezetimibe monotherapy. Further long-term studies with cardiovascular and other clinical outcome data are needed to assess the efficacy and safety of ezetimibe more fully. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - December 23, 2008 Category: Internal Medicine Authors: A. Pandor, R. M. Ara, I. Tumur, A. J. Wilkinson, S. Paisley, A. Duenas, P. N. Durrington, J. Chilcott Source Type: journals

Myelodysplastic syndromes: biology and treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract. Jädersten M, Hellström-Lindberg E (Karolinska Institutet, Karolinska University Hospital Stockholm, Sweden). Myelodysplastic syndromes: biology and treatment (Review). J Intern Med 2008; doi: 10.1111/j.1365-2796.2008.02052.x Optimal management of patients with myelodysplastic syndromes (MDS) requires an insight into the biology of the disease and the mechanisms of action of the available therapies. This review focuses on low-risk MDS, for which chronic anaemia and eventual progression to acute myeloid leukaemia are the main concerns. We cover the updated World Health Organization classification, the latest prog...
Source: Journal of Internal Medicine - December 19, 2008 Category: Internal Medicine Authors: M. Jädersten, E. Hellström-Lindberg Source Type: journals

Free fatty acid kinetics during long-term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Long-term improvements in adipose tissue insulin sensitivity and reduction in fasting FFAs with pioglitazone may help to reduce lipotoxicity in Type 2 diabetes. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 26, 2008 Category: Internal Medicine Authors: M. Roden, S. Mariz, A. R. Brazzale, G. Pacini Source Type: journals