Angiotensin II receptor blockers are safe in patients with prior angioedema related to angiotensin converting enzyme inhibitors – a nation‐wide registry‐based cohort study
ConclusionsCompared with other antihypertensive drugs, AT2s do not increase the incidence of angioedema in patients with previous ACEi –related angioedema.This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 28, 2018 Category: Internal Medicine Authors: Eva Rye Rasmussen, Anton Potteg ård, Anette Bygum, Christian von Buchwald, Preben Homøe, Jesper Hallas Tags: Original Article Source Type: research

Is there a need for an emergency card in hypoparathyroidism?
ConclusionsThe majority answered that an acute card is highly needed or useful. Hospitalization for acute hypocalcemia was more common (44%) than for acute hypercalcemia (16%). As a result of this survey an emergency card will be distributed in three European countries to test its utility.This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 28, 2018 Category: Internal Medicine Authors: Marianne C. Astor, Wendy Zhu, Sigridur Bj örnsdottir, Jens Bollerslev, Olle Kämpe, Eystein S. Husebye Tags: Original Article Source Type: research

Head trauma in sports – clinical characteristics, epidemiology and biomarkers
This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 27, 2018 Category: Internal Medicine Authors: Henrik Zetterberg, Bengt Winblad, Charles Bernick, Kristine Yaffe, Marek Majdan, Gunilla Johansson, Virginia Newcombe, Lars Nyberg, David Sharp, Olli Tenovuo, Kaj Blennow Tags: Review ‐Symposium Source Type: research

Oxysterols in intestinal immunity and inflammation
AbstractCholesterol is an essential molecule for life. It is a component of the cell membrane, and it is a precursor molecule for bile acids, vitamin D and steroid hormones. Cholesterol is actively metabolized, but the impact of endogenous cholesterol metabolites on immune function, especially in the intestine, is poorly understood. In this review, I focus on oxysterols, hydroxylated forms of cholesterol, and their specialized functions in intestinal immunity. Oxysterols act through various intracellular and extracellular receptors and serve as key metabolic signals, coordinating immune activity and inflammation. Our recen...
Source: Journal of Internal Medicine - November 26, 2018 Category: Internal Medicine Authors: T. Willinger Tags: Review Source Type: research

MicroRNA detection in the pathogenesis of BAV ‐associated aortopathy‐mediated vascular remodelling through EndMT/EMT
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 26, 2018 Category: Internal Medicine Authors: S. A. Mohamed Tags: Editorial Comment Source Type: research

Morbidity and cause ‐specific mortality in first‐time myocardial infarction with nonobstructive coronary arteries
ConclusionsPatients with first ‐time MINOCA have a considerable risk of adverse events. This stresses the need for a comprehensive search of the cause of MINOCA, thorough treatment of underlying disease triggers and close follow‐up. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 25, 2018 Category: Internal Medicine Authors: K. M. Eggers, M. Hjort, T. Baron, T. Jernberg, A. M. Nordenskj öld, P. Tornvall, B. Lindahl Tags: Original Article Source Type: research

Anti ‐Inflammatory Therapy for Atherosclerosis:Interpreting Divergent Results from the CANTOS and CIRT Clinical Trials
This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 25, 2018 Category: Internal Medicine Authors: Paul M Ridker Tags: Commentary Source Type: research

Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management
AbstractPostural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder characterized by an excessive heart rate increase on standing and orthostatic intolerance. POTS affects  younger individuals 15–45 years old with a distinct female predominance (≈80%). The prevalence ranges between 0.2% and 1.0% in developed countries. The onset of POTS is typically precipitated by immunological stressors such as viral infection, vaccination, trauma, pregnancy, surgery or psycho social stress. The most common complaints are dizziness, weakness, rapid heartbeat and palpitation on standing. Moreov...
Source: Journal of Internal Medicine - November 23, 2018 Category: Internal Medicine Authors: A. Fedorowski Tags: Review Source Type: research

Iron deficiency anaemia due to proton pump inhibitors: clinical impact revealed
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 22, 2018 Category: Internal Medicine Authors: D. McCarthy Tags: Editorial Comment Source Type: research

Multimorbidity and functional impairment –bidirectional interplay, synergistic effects and common pathways
AbstractThis review discusses the interplay between multimorbidity (i.e. co ‐occurrence of more than one chronic health condition in an individual) and functional impairment (i.e. limitations in mobility, strength or cognition that may eventually hamper a person's ability to perform everyday tasks). On the one hand, diseases belonging to common patterns of multimorbidity may interact, curtailing compensatory mechanisms and resulting in physical and cognitive decline. On the other hand, physical and cognitive impairment impact the severity and burden of multimorbidity, contributing to the establishment of a vicious circle...
Source: Journal of Internal Medicine - November 22, 2018 Category: Internal Medicine Authors: A. Calder ón‐Larrañaga, D. L. Vetrano, L. Ferrucci, S. W. Mercer, A. Marengoni, G. Onder, M. Eriksdotter, L. Fratiglioni Tags: Review Symposium Source Type: research

Health consequences of androgenic anabolic steroid use
ConclusionAndrogenic anabolic steroid users have an increased risk of dying and significantly more hospital admissions than their nonuser peers. Side effects of AAS and their metabolites were highly prevalent. Given the high rate of androgenic anabolic steroid abuse, these side effects are of public health concern. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 20, 2018 Category: Internal Medicine Authors: H. Horwitz, J. T. Andersen, K. P. Dalhoff Tags: Original Article Source Type: research

SYMPOSIUM: Neuroendocrine interfaces in physiology and disease
Journal of Internal Medicine, Volume 284, Issue 6, Page 562-562, December 2018. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 19, 2018 Category: Internal Medicine Tags: Symposium Source Type: research

Issue Information
Journal of Internal Medicine, Volume 284, Issue 6, Page 561-561, December 2018. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 19, 2018 Category: Internal Medicine Tags: Issue Information Source Type: research

Anti ‐inflammatory diet to reduce mortality: is it time for a precision medicine approach?
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 18, 2018 Category: Internal Medicine Authors: M. Leggio, A. Fusco, A. Villano, G. Limongelli, A. Mazza Tags: Letter to the Editor Source Type: research

Systemic features of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: a monogenic small vessel disease
ConclusionsRetinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations is a rare, but likely underdiagnosed, systemic small vessel disease typically starting with vascular retinopathy, followed by multiple internal organ disease, progressive brain dysfunction, and ultimately premature death. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 8, 2018 Category: Internal Medicine Authors: N. Pelzer, E. S. Hoogeveen, J. Haan, R. Bunnik, C. C. Poot, E. W. van Zwet, A. Inderson, A. J. Fogteloo, M. E. J. Reinders, H. A. M. Middelkoop, M. C. Kruit, A. M. J. M. van den Maagdenberg, M. D. Ferrari, G. M. Terwindt Tags: Original Article Source Type: research