Correction: Efficacy and safety of endovascular therapy versus surgical clipping for patients with unruptured middle cerebral artery bifurcation aneurysms
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Tags: Correction Source Type: research
Correspondence on 'Low-dose thrombolysis for submassive pulmonary embolism by Yilmaz and Uzun
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Güner, A., Uzun, F., Güner, E. G., Akman, C., Ertürk, M. Tags: Letter to the editor Source Type: research
Trends and demographic patterns in biologic and corticosteroid prescriptions for inflammatory bowel disease: findings from electronic medical records, 2011-2020
Prescriptions for biologic therapy for treatment of Crohn’s disease (CD) and ulcerative colitis (UC) have increased during the past two decades; however, trends are less clear regarding corticosteroid prescriptions in this context. We designed a cross-sectional study using the IQVIA Ambulatory Electronic Medical Records databases. Weighted linear regressions by age group were used to estimate annual percentage change from 2011 to 2020 in prescriptions for biologics and for corticosteroids among patients with or without biologic prescriptions within the same calendar year. Using 2019 data, we compared patient demograp...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Xu, F., Liu, Y., Greenlund, K., Carlson, S. Tags: Brief report Source Type: research
How to write statistical analysis section in medical research
In this report, we highlight the global and critical steps to be reported in the statistical analysis of grants and research articles. We provide clarity and the importance of understanding study objective types, data generation process, effect size use, evidence-based biostatistical methods use, and development of statistical models through several thematic frameworks. We also provide published examples of adherence or non-adherence to methodological standards related to each step in the statistical analysis and their implications. We believe the suggestions provided in this report can have far-reaching implications for e...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Dwivedi, A. K. Tags: Open access Research tools and issues Source Type: research
Bronchodilatory effect of higenamine as antiallergic asthma treatment
Asthma is a complex airway disease that affects more than 350 million humans worldwide. Allergic asthma symptoms are induced by Th2 immune response with the release of cytokines and allegro-inflammatory mediators that amplify the inflammatory response, airway hyper-responsiveness (AHR) and hyperproduction of mucus. Higenamine, as a chemical compound, is a β2 adrenoreceptor agonist and can be used as bronchodilator in allergic asthma.
BALB/c mice were allocated in four groups and then allergic asthma was induced in three groups. One of the asthmatic groups was treated with albuterol and other one was treated with higen...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Du, J., Mehrabi Nasab, E., Athari, S. S., Qian, L. Tags: Original research Source Type: research
Altered degree centrality in patients with non-neuropsychiatric systemic lupus erythematosus: a resting-state fMRI study
This study used a voxel-wise degree centrality (DC) method to evaluate differences in brain activity between patients with non-neuropsychiatric systemic lupus erythematosus (non-NP-SLE) and healthy controls (HCs) and to assess the relationship of DC values with clinical and neuropsychological data. Thirty-two female patients with non-NP-SLE and 28 well-matched HCs were recruited and underwent resting-state functional MRI. Differences in spontaneous brain activity between the two groups were evaluated using a DC method. Correlations between the altered DC values of specific brain regions and clinical and neuropsychological ...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Li, X., Zhang, P., Zhou, W., Li, Y., Sun, Z., Chen, J., Xia, J., Zou, H. Tags: Original research Source Type: research
Organochlorine pesticides, oxidative stress biomarkers, and leukemia: a case-control study
Exposure to pesticides has been linked to an elevated risk of leukemia. The present research aimed to evaluate the relationship between organochlorine (OC) pesticides and biomarkers of oxidative stress in patients with leukemia. This work was conducted on 109 patients with leukemia and 109 healthy controls. The serum concentrations of seven derivatives of OCs including alpha-hexachlorocyclohexane (HCH), beta-HCH, gamma-HCH, 2,4-dichlorodiphenyltrichloroethane (DDT), 4,4-DDT, 2,4-dichlorodiphenyldichloroethylene (DDE), and 4,4-DDE along with acetylcholinesterase (AChE), glutathione peroxidase (GPx), superoxide dismutase (SO...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Rafeeinia, A., Asadikaram, G., Karimi-Darabi, M., Abolhassani, M., Abbasi-Jorjandi, M., Moazed, V. Tags: Original research Source Type: research
Opium may affect coronary artery disease by inducing inflammation but not through the expression of CD9, CD36, and CD68
The molecular mechanisms of opium with regard to coronary artery disease (CAD) have not yet been determined. The aim of the present study was to evaluate the effect of opium on the expression of scavenger receptors including CD36, CD68, and CD9 tetraspanin in monocytes and the plasma levels of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-), malondialdehyde (MDA), and nitric oxide metabolites (NOx) in patients with CAD with and without opium addiction. This case–control study was conducted in three groups: (1) opium-addicted patients with CAD (CAD+OA, n=30); (2) patients with CAD with no opium addi...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Momeni-Moghaddam, M. A., Asadikaram, G., Masoumi, M., Sadeghi, E., Akbari, H., Abolhassani, M., Farsinejad, A., Khaleghi, M., Nematollahi, M. H., Dabiri, S., Arababadi, M. K. Tags: Original research Source Type: research
Serum levels of IL-37 and correlation with inflammatory cytokines and clinical outcomes in patients with coronary artery disease
Coronary artery disease (CAD) due to atherosclerosis is one of the important reasons for death worldwide. Recent evidence has suggested the essential role of inflammation in the progression of atherosclerosis. Interleukin (IL)-37 is a critical anti-inflammatory member of the IL-1 family which regulates the inflammatory processes. The aim of this study was to compare the serum levels of IL-37 in patients with CAD compared with the control group and its correlation with oxidative stress, cholesterol homeostasis, and inflammation in patients with CAD. A total of 42 patients with CAD and 42 sex-matched and age- matched control...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Rafiei, A., Ahmadi, R., Kazemian, S., Rahimzadeh-Fallah, T., Mohammad-Rezaei, M., Azadegan-Dehkordi, F., Sanami, S., Mirzaei, Y., Aghaei, F., Bagheri, N. Tags: Open access Original research Source Type: research
Acute myocardial infarction and concomitant acute intracranial hemorrhage: clinical characteristics and outcomes
This study aimed to evaluate the demographic and clinical characteristics, treatments and outcomes of concomitant acute myocardial infarction (AMI) and acute intracranial hemorrhage (ICH). All patients diagnosed with concomitant AMI and acute ICH admitted to our institution were included retrospectively. The patient demographics, clinical characteristics, neuroimaging and treatment approaches were analyzed, and the outcomes of interest included disability as defined by the modified Rankin Scale (mRS) score and all-cause mortality within 1 year of follow-up. Of a total of 4972 patients with AMI, 8 patients (0.2%) with conco...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Cao, X., Wei, M., Tang, M., Jian, Z., Liu, H., Yue, X., Luo, G., Sun, C., Guo, F. Tags: Open access Original research Source Type: research
Temporal trends and disparities in gastroenterology care use before, during, and after COVID-19 lockdown
In conclusion, socioeconomic and ethnic disparities persist in healthcare use even a year after the onset of the COVID-19 pandemic. There is an alarming increase in missed visits and substance abuse. Therefore, efforts should be targeted on improving healthcare access for these aforementioned vulnerable groups. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Sanaka, H., Garg, R., Patel, V., McMichael, J., Macaron, C. Tags: COVID-19 Original research Source Type: research
Effects of statins on outcomes in Hispanic patients with COVID-19
The Hispanic population is regarded among those who are at greater risk of adverse prognoses due to higher rates of diabetes and obesity in the USA during the COVID-19 pandemic. Statin medications are speculated to help treat the infection by decreasing inflammation caused by COVID-19. In this retrospective, observational study, outcomes of statin use were assessed among Hispanic patients with COVID-19 by screening all patients hospitalized between March, 2020 and March, 2021 at a tertiary care hospital in El Paso, Texas, resulting in a total of 1039 patients. The patients were categorized into a group of either being on s...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Khalafi, S., Evans, J., Lumbreras, T., Tiula, K., Helmsdoerfer, K., Dwivedi, A. K., Dihowm, F. Tags: COVID-19 Original research Source Type: research
Evaluating reporting of patient-reported outcomes in randomized controlled trials regarding inflammatory bowel disease: a methodological study
Patient-reported outcomes (PROs) in randomized controlled trials pertaining to inflammatory bowel disease are important in identifying patients’ perspective of treatment. Incompletely reported PROs within trials could misrepresent information for clinicians and may contribute to treatment which lacks accommodation of patient input. Our study evaluates completeness of reporting of PROs and risk of bias (RoB) to identify how well trialists are adhering to known resources for trials. We used MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify eligible trials from 2006 to 2020 with at leas...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: McIntire, R., Waters, P., Tanner, D., Dhillon, J., Hillman, C., Wise, A., Kee, M., Anderson, R., Ottwell, R., Hartwell, M., Vassar, M. Tags: Original research Source Type: research
Remote patient monitoring in the management of chronic obstructive pulmonary disease
Remote patient monitoring allows monitoring high-risk patients through implementation of an expanding number of technologies in coordination with a healthcare team to augment care, with the potential to provide early detection of exacerbation, prompt access to therapy and clinical services, and ultimately improved patient outcomes and decreased healthcare utilization.
In this review, we describe the application of remote patient monitoring in chronic obstructive pulmonary disease including the potential benefits and possible barriers to implementation both for the individual and the healthcare system. (Source: Journal of I...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Chalupsky, M. R., Craddock, K. M., Schivo, M., Kuhn, B. T. Tags: Review Source Type: research
Glucocorticoid therapy in respiratory illness: bench to bedside
Each year, hundreds of millions of individuals are affected by respiratory disease leading to approximately 4 million deaths. Most respiratory pathologies involve substantially dysregulated immune processes that either fail to resolve the underlying process or actively exacerbate the disease. Therefore, clinicians have long considered immune-modulating corticosteroids (CSs), particularly glucocorticoids (GCs), as a critical tool for management of a wide spectrum of respiratory conditions. However, the complex interplay between effectiveness, risks and side effects can lead to different results, depending on the disease in ...
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: Amratia, D. A., Viola, H., Ioachimescu, O. C. Tags: Open access, Editor's choice, COVID-19 Review Source Type: research
