Optimizing a five-factor cocktail to prepare reparative macrophages for wound healing
J Leukoc Biol. 2024 Apr 17:qiae096. doi: 10.1093/jleuko/qiae096. Online ahead of print.ABSTRACTThe treatment of non-healing wounds, such as diabetic ulcers, remains a critical clinical challenge. Recent breakthroughs in cell therapy have shown great promise, with one primary focus on preparing cells with comprehensive reparative functions and foreseeable safety. In our previous study, we recapitulated the pro-regenerative and immunosuppressive functions of tumor-associated macrophages (TAMs) in non-tumor-derived macrophages, endowing the latter with characteristics for promoting diabetic wound healing - termed TAMs-educate...
Source: Journal of Leukocyte Biology - April 17, 2024 Category: Hematology Authors: Rong Yong Ruoyu Mu Congwei Han Tzuwei Chao Yu Liu Lei Dong Chunming Wang Source Type: research
Induced Regulatory T Cells as Immunotherapy in Allotransplantation and Autoimmunity: Challenges and Opportunities
J Leukoc Biol. 2024 Apr 17:qiae062. doi: 10.1093/jleuko/qiae062. Online ahead of print.ABSTRACTRegulatory T cells (Tregs) play a crucial role in the homeostasis of the immune response. Tregs are mainly generated in the thymus and are characterized by the expression of Foxp3, which is considered the Treg master transcription factor. In addition, Tregs can be induced from naïve CD4+ T cells to express Foxp3 under specific conditions both in vivo (pTregs) and in vitro (iTregs). Both subsets tTregs and pTregs are necessary for the establishment of immune tolerance to self and non-self antigens. Although it has been postulated...
Source: Journal of Leukocyte Biology - April 17, 2024 Category: Hematology Authors: Evelyn Katy Alvarez-Salazar Arimelek Cort és-Hernández Sa úl Arteaga-Cruz Gloria Soldevila Source Type: research
The immunoregulatory effects of total glucosides of paeony in autoimmune diseases
J Leukoc Biol. 2024 Apr 16:qiae095. doi: 10.1093/jleuko/qiae095. Online ahead of print.ABSTRACTTotal glucoside of paeonia (TGP) and its main active ingredient paeoniflorin, extracted from the Chinese herb Paeonia Lactiflora Pallas, exhibit potent immunomodulatory effects. TGP has been shown to inhibit inflammatory responses and disease progression in experimental models of multiple autoimmune diseases (AIDs), including rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, psoriasis, etc. TGP shows broad immunomodulatory effects on many immune cells such as T cells, macrophages, and dendritic cells, by reg...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Mengna Zhao Na Peng Yingbo Zhou Yuan Qu Meng Cao Qinghua Zou Qinghong Yu Liwei Lu Fan Xiao Source Type: research
BCL2A1 neoepitopes-elicited cytotoxic T lymphocytes are a promising individualized immunotherapy of pancreatic cancer
J Leukoc Biol. 2024 Apr 16:qiae092. doi: 10.1093/jleuko/qiae092. Online ahead of print.ABSTRACTConventional treatments have shown a limited efficacy for pancreatic cancer, and immunotherapy is an emerging option for treatment of this highly fatal malignancy. Neoantigen is critical to improving the efficacy of tumor-specific immunotherapy. The cancer and peripheral blood specimens from human leukocyte antigen (HLA)-A0201 positive pancreatic cancer patient were subjected to next-generation sequencing and bioinformatics analyses were performed to screen high-affinity and highly stable neoepitopes. The activation of cytotoxic ...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Shengzhe Lin Jingwen Hong Suxin Wu Chenlu Zhu Fang Liu Wansong Lin Xinran Cai Yunbin Ye Yanling Chen Source Type: research
Eosinophil Plasticity and Diversity: Proceedings of the 2023 International Eosinophil Society Symposium
J Leukoc Biol. 2024 Apr 16:qiae089. doi: 10.1093/jleuko/qiae089. Online ahead of print.ABSTRACTThis issue highlights and details the programme and scientific presentations at the International Eosinophil Society's 12th biennial Symposium, which was held in Hamilton, Ontario, Canada in July 2023. The meeting included sessions on regulation of eosinophil development; cell death, stress, and autophagy in eosinophils; local immunity interactions of eosinophils with multiple cell types; eosinophils in host defense; eosinophils and mast cells in gastrointestinal disorders; reciprocal interactions between eosinophils and the micr...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Judah A Denburg Paul M O'Byrne Gail M Gauvreau Source Type: research
Regulation of ICAM-1 in human neutrophils
J Leukoc Biol. 2024 Apr 16:qiae090. doi: 10.1093/jleuko/qiae090. Online ahead of print.ABSTRACTIntercellular cell adhesion molecule 1 (ICAM-1) is a cell surface glycoprotein with a vital role in the immune response to pathogens. The expression pattern of ICAM-1 is wide-ranging, encompassing endothelial cells, epithelial cells and neutrophils. Recent work has characterized the role of ICAM-1 in murine neutrophils, but the function of human neutrophil ICAM-1 is incompletely understood. Herein, we investigated the expression and role of ICAMs in human neutrophils in vitro and in vivo. Our findings show clear expression of ICA...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Muralie Vignarajah Alexander J T Wood Elizabeth Nelmes Julien Subburayalu Jurgen Herre Sussan Nourshargh Charlotte Summers Edwin R Chilvers Neda Farahi Source Type: research
The immunoregulatory effects of total glucosides of paeony in autoimmune diseases
J Leukoc Biol. 2024 Apr 16:qiae095. doi: 10.1093/jleuko/qiae095. Online ahead of print.ABSTRACTTotal glucoside of paeonia (TGP) and its main active ingredient paeoniflorin, extracted from the Chinese herb Paeonia Lactiflora Pallas, exhibit potent immunomodulatory effects. TGP has been shown to inhibit inflammatory responses and disease progression in experimental models of multiple autoimmune diseases (AIDs), including rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, psoriasis, etc. TGP shows broad immunomodulatory effects on many immune cells such as T cells, macrophages, and dendritic cells, by reg...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Mengna Zhao Na Peng Yingbo Zhou Yuan Qu Meng Cao Qinghua Zou Qinghong Yu Liwei Lu Fan Xiao Source Type: research
BCL2A1 neoepitopes-elicited cytotoxic T lymphocytes are a promising individualized immunotherapy of pancreatic cancer
J Leukoc Biol. 2024 Apr 16:qiae092. doi: 10.1093/jleuko/qiae092. Online ahead of print.ABSTRACTConventional treatments have shown a limited efficacy for pancreatic cancer, and immunotherapy is an emerging option for treatment of this highly fatal malignancy. Neoantigen is critical to improving the efficacy of tumor-specific immunotherapy. The cancer and peripheral blood specimens from human leukocyte antigen (HLA)-A0201 positive pancreatic cancer patient were subjected to next-generation sequencing and bioinformatics analyses were performed to screen high-affinity and highly stable neoepitopes. The activation of cytotoxic ...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Shengzhe Lin Jingwen Hong Suxin Wu Chenlu Zhu Fang Liu Wansong Lin Xinran Cai Yunbin Ye Yanling Chen Source Type: research
Eosinophil Plasticity and Diversity: Proceedings of the 2023 International Eosinophil Society Symposium
J Leukoc Biol. 2024 Apr 16:qiae089. doi: 10.1093/jleuko/qiae089. Online ahead of print.ABSTRACTThis issue highlights and details the programme and scientific presentations at the International Eosinophil Society's 12th biennial Symposium, which was held in Hamilton, Ontario, Canada in July 2023. The meeting included sessions on regulation of eosinophil development; cell death, stress, and autophagy in eosinophils; local immunity interactions of eosinophils with multiple cell types; eosinophils in host defense; eosinophils and mast cells in gastrointestinal disorders; reciprocal interactions between eosinophils and the micr...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Judah A Denburg Paul M O'Byrne Gail M Gauvreau Source Type: research
Regulation of ICAM-1 in human neutrophils
J Leukoc Biol. 2024 Apr 16:qiae090. doi: 10.1093/jleuko/qiae090. Online ahead of print.ABSTRACTIntercellular cell adhesion molecule 1 (ICAM-1) is a cell surface glycoprotein with a vital role in the immune response to pathogens. The expression pattern of ICAM-1 is wide-ranging, encompassing endothelial cells, epithelial cells and neutrophils. Recent work has characterized the role of ICAM-1 in murine neutrophils, but the function of human neutrophil ICAM-1 is incompletely understood. Herein, we investigated the expression and role of ICAMs in human neutrophils in vitro and in vivo. Our findings show clear expression of ICA...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Muralie Vignarajah Alexander J T Wood Elizabeth Nelmes Julien Subburayalu Jurgen Herre Sussan Nourshargh Charlotte Summers Edwin R Chilvers Neda Farahi Source Type: research
Correction to: A novel selective leukocyte depletion human whole blood model reveals the specific roles of monocytes and granulocytes in the cytokine response to Escherichia coli
J Leukoc Biol. 2024 Apr 15:qiae088. doi: 10.1093/jleuko/qiae088. Online ahead of print.NO ABSTRACTPMID:38620070 | DOI:10.1093/jleuko/qiae088 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - April 15, 2024 Category: Hematology Source Type: research
Novel B cell subsets as potential biomarkers in Idiopathic Inflammatory Myopathies: insights into disease pathogenesis and disease activity
J Leukoc Biol. 2024 Mar 30:qiae083. doi: 10.1093/jleuko/qiae083. Online ahead of print.ABSTRACTIdiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune disorders characterized by progressive muscle weakness and the histopathologic findings of inflammatory infiltrates in muscle tissue. Although their pathogenesis remains indefinite, the association of autoantibodies with clinical manifestations and the evidence of high effectiveness of depleting therapies suggest that B cells could be implicated. Therefore, we explored the landscape of peripheral B cells in this disease by multiparametric flow cytomet...
Source: Journal of Leukocyte Biology - March 30, 2024 Category: Hematology Authors: Ra úl F Reyes-Huerta Vladimir Mandujano-L ópez Guadalupe Vel ásquez-Ortiz Beatriz Alcal á-Carmona Mar ía J Ostos-Prado Yatzil Reyna-Ju árez David E Meza-S ánchez Guillermo Ju árez-Vega Nancy R Mej ía-Domínguez Jiram Torres-Ruiz Diana G ómez-Mar Source Type: research
Novel B cell subsets as potential biomarkers in Idiopathic Inflammatory Myopathies: insights into disease pathogenesis and disease activity
J Leukoc Biol. 2024 Mar 30:qiae083. doi: 10.1093/jleuko/qiae083. Online ahead of print.ABSTRACTIdiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune disorders characterized by progressive muscle weakness and the histopathologic findings of inflammatory infiltrates in muscle tissue. Although their pathogenesis remains indefinite, the association of autoantibodies with clinical manifestations and the evidence of high effectiveness of depleting therapies suggest that B cells could be implicated. Therefore, we explored the landscape of peripheral B cells in this disease by multiparametric flow cytomet...
Source: Journal of Leukocyte Biology - March 30, 2024 Category: Hematology Authors: Ra úl F Reyes-Huerta Vladimir Mandujano-L ópez Guadalupe Vel ásquez-Ortiz Beatriz Alcal á-Carmona Mar ía J Ostos-Prado Yatzil Reyna-Ju árez David E Meza-S ánchez Guillermo Ju árez-Vega Nancy R Mej ía-Domínguez Jiram Torres-Ruiz Diana G ómez-Mar Source Type: research
Novel B cell subsets as potential biomarkers in Idiopathic Inflammatory Myopathies: insights into disease pathogenesis and disease activity
J Leukoc Biol. 2024 Mar 30:qiae083. doi: 10.1093/jleuko/qiae083. Online ahead of print.ABSTRACTIdiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune disorders characterized by progressive muscle weakness and the histopathologic findings of inflammatory infiltrates in muscle tissue. Although their pathogenesis remains indefinite, the association of autoantibodies with clinical manifestations and the evidence of high effectiveness of depleting therapies suggest that B cells could be implicated. Therefore, we explored the landscape of peripheral B cells in this disease by multiparametric flow cytomet...
Source: Journal of Leukocyte Biology - March 30, 2024 Category: Hematology Authors: Ra úl F Reyes-Huerta Vladimir Mandujano-L ópez Guadalupe Vel ásquez-Ortiz Beatriz Alcal á-Carmona Mar ía J Ostos-Prado Yatzil Reyna-Ju árez David E Meza-S ánchez Guillermo Ju árez-Vega Nancy R Mej ía-Domínguez Jiram Torres-Ruiz Diana G ómez-Mar Source Type: research
Novel B cell subsets as potential biomarkers in Idiopathic Inflammatory Myopathies: insights into disease pathogenesis and disease activity
J Leukoc Biol. 2024 Mar 30:qiae083. doi: 10.1093/jleuko/qiae083. Online ahead of print.ABSTRACTIdiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune disorders characterized by progressive muscle weakness and the histopathologic findings of inflammatory infiltrates in muscle tissue. Although their pathogenesis remains indefinite, the association of autoantibodies with clinical manifestations and the evidence of high effectiveness of depleting therapies suggest that B cells could be implicated. Therefore, we explored the landscape of peripheral B cells in this disease by multiparametric flow cytomet...
Source: Journal of Leukocyte Biology - March 30, 2024 Category: Hematology Authors: Ra úl F Reyes-Huerta Vladimir Mandujano-L ópez Guadalupe Vel ásquez-Ortiz Beatriz Alcal á-Carmona Mar ía J Ostos-Prado Yatzil Reyna-Ju árez David E Meza-S ánchez Guillermo Ju árez-Vega Nancy R Mej ía-Domínguez Jiram Torres-Ruiz Diana G ómez-Mar Source Type: research
