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The possible role of peripherally generated cross-reactive IgG in breakdown of the blood –brain barrier and initiation of multiple sclerosis
Publication date: July 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 2 Author(s): Aram Mokarizadeh, Mohammad Abdollahi, Mohammad-Amin Rezvanfar, Mohammad-Reza Rahmani The initiating event in multiple sclerosis (MS) pathogenesis is not known yet. However, in general, breakdown of the blood-brain barrier (BBB) and subsequent infiltration of immune cells into the central nervous system (CNS) has been thought to be the main initiating event. Nonetheless, the mechanism by which the BBB gets disrupted and allows immune cells to infiltrate into the CNS is not fully understood. Evidence indicates...
Source: Journal of Medical Hypotheses and Ideas - June 17, 2016 Category: Research Source Type: research

Combination of IMOD ™ and Arbidol to increase their immunomodulatory effects as a novel medicine to prevent and cure influenza and some other infectious diseases
Publication date: July 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 2 Author(s): Mahmoud Arastoo, Hamid Reza Khorram Khorshid, Ramin Radmanesh, Farhad Gharibdoust Viral diseases such as influenza, which are easily transferable from person to person or even country to country, pose one of the biggest threats to health today. Viruses such as avian influenza viruses (N1H5 and H9N1) have been reported to spread in the present decade and, very recently, the novel coronavirus that has caused many life-threatening illnesses and deaths all around the world has received much attention. To prevent...
Source: Journal of Medical Hypotheses and Ideas - June 17, 2016 Category: Research Source Type: research

IL-24: A novel gene therapy candidate for immune system upregulation in Hodgkin ’s lymphoma
Publication date: March 2015 Source:Journal of Medical Hypotheses and Ideas, Volume 9, Issue 1 Author(s): Maryam Erfan Manesh, Abdolreza Esmaeilzadeh, Mehri Hajikhan Mirzaei Hodgkin’s Lymphoma (HL) as a prevalent hematolymphoid malignancy begins in cells of immune system and is characterized by the specific histologic, clinical properties. Abnormality in apoptosis has been recognized as a crucial pathway in its progression. Nowadays, 35–40% of patients in stages III and IV show disease relapse or symptoms of refractory to first-line chemotherapy; therefore, novel treatment strategies are required. As apoptosi...
Source: Journal of Medical Hypotheses and Ideas - June 17, 2016 Category: Research Source Type: research

Blocking IRES-mediated translation pathway as a new method to treat Alzheimer ’s disease
Publication date: March 2015 Source:Journal of Medical Hypotheses and Ideas, Volume 9, Issue 1 Author(s): Q.Y. Liu Scientists theorized that β-amyloid (Aβ) plaques and tau tangles are involved in the development of Alzheimer’s disease (AD), and amyloid precursor protein (APP) produces Aβ to trigger the disease process. However, the normal synaptic function of APP itself is not fully understood. Several findings cast APP as a potential key player in learning and memory under normal condition. Nevertheless, the regular operation of APP will be disrupted by abnormal accumulation of Aβ under cellular pathological c...
Source: Journal of Medical Hypotheses and Ideas - June 17, 2016 Category: Research Source Type: research

The developmental perspective of the chronic alcoholism: Who ’s holding the burden of proof?
Publication date: December 2015 Source:Journal of Medical Hypotheses and Ideas, Volume 9, Issue 2 Author(s): Zihni Sulaj, Altin Kuqo, Gentian Vyshka Chronic alcoholism is a public health issue, and several theoretical frameworks have been proposed to explain its nature. The developmental approach to chronic alcoholism has a double contour, with neurobiological theories counting on several aspects of the deleterious effects exerted from ethanol over neural structures. Psychological and neurobiological theories are not intrinsically contradictory to each other. The importance of early experiences and the potential ...
Source: Journal of Medical Hypotheses and Ideas - June 17, 2016 Category: Research Source Type: research

How Psychotropic Drugs Are Used; an Explanatory Paradigm
Publication date: Available online 11 February 2016 Source:Journal of Medical Hypotheses and Ideas Author(s): F. Shaddel, M. Ghazirad, D. O’Leary, S. Banerjee Traditionally, two divergent approaches are used to explain the mechanism of action of psychotropic drugs. The dominant “Disease-centred” view emphasises the biochemical imbalance caused by ‘illnesses’. In contrast the “Drug-centred” view emphasises the psychoactive properties of these drugs and their ability to induce an ‘altered-state’ of mind. In this article we propose a new paradigm for classifying the therapeutic uses of psychotrop...
Source: Journal of Medical Hypotheses and Ideas - February 11, 2016 Category: Research Source Type: research

Towards a Histological Depiction in 3D Imaging PET
In this study we examinethe possibility of constructing metadata from Positron Emission Tomography images based on a Radial Basis Function neural network, which uses histological data extracted via the enzyme-linked immunosorbent assay abbreviation. The aim of constructing such metadata is to achieve a bringing between the Binding Potential receptor in vitro and in vivo Positron Emission Tomography procedures, which it is possible to calculate using a classic simplified reference tissue model. This knowledge representation procedure may then be transmitted in the Positron Emission Tomography using the testing neural networ...
Source: Journal of Medical Hypotheses and Ideas - February 9, 2016 Category: Research Source Type: research

Enhancing Visual Performance in Individuals with Cortical Visual Impairment (Homonymous Hemianopsia): Tapping into Blindsight
Publication date: Available online 22 January 2016 Source:Journal of Medical Hypotheses and Ideas Author(s): Faith A. Birnbaum, Steven A. Hackley, Lenworth N. Johnson Homonymous hemianopsia is a type of cortical blindness in which vision is lost completely or partially in the left half or the right half of the field of vision. It is prevalent in approximately 12% of traumatic brain injury and 35% of strokes. Patients often experience difficulty with activities such as ambulating, eating, reading, and driving. Due to the high prevalence of homonymous hemianopsia and its associated difficulties, it is imperative to...
Source: Journal of Medical Hypotheses and Ideas - January 24, 2016 Category: Research Source Type: research

Psyllium seed may be effective in the treatment of gastroesophageal reflux disease (GERD) in patients with functional constipation
Publication date: Available online 2 December 2015 Source:Journal of Medical Hypotheses and Ideas Author(s): Mousalreza Hosseini, Masoumeh Salari, Roshanak Salari GERD, return of stomach contents into the esophagus, is one of the most common gastrointestinal disorders in medicine. Its common symptoms are heartburn and acid reflux. Usually, patients with GERD history develop clinical signs such as heartburn accompanied by functional constipation. Omeprazole, a proton pump inhibitor (PPIs), is a drug of choice for GERD but all patients do not respond to the drug and long-term use of these drugs leads to infections....
Source: Journal of Medical Hypotheses and Ideas - December 4, 2015 Category: Research Source Type: research

Mesenchymal Stem Cells Injection with Core Decompression in the Treatment of Kienbock disease
Publication date: Available online 1 December 2015 Source:Journal of Medical Hypotheses and Ideas Author(s): Saeed Reza Mehrpour, Alireza Mobasseri, Behzad Amoozgar Treatment of Kienbock disease (the avascular necrosis of the lunate) is a matter of debate. Current surgical modalities have their limitations and potential complications. Those modalities are also not based on pathophysiology of the disease. Here we introduce a novel therapeutic option by combining the autologous mesenchymal stem cell injection and the core decompression procedure in the treatment of Kienbock disease. We hypothesized that micro-drill...
Source: Journal of Medical Hypotheses and Ideas - December 1, 2015 Category: Research Source Type: research

“Post Modern Medicine” would be “calculable and energy-based medicine”: A hypothesis paper
Publication date: December 2015 Source:Journal of Medical Hypotheses and Ideas, Volume 9, Issue 2 Author(s): Hila Yousefi, Nima Rezaei The approach of current modern medicine towards human body system is solely molecular and cellular. Despite the great efforts, current medicine has not been successful enough, and spectrum of disorders has remained untreated. It emphasizes on the essential need for more careful approach to the body system. Prior to the molecules and cells human body system has been composed of countless of atomic and subatomic particles, considering laws of quantum physics and the principles of chem...
Source: Journal of Medical Hypotheses and Ideas - November 10, 2015 Category: Research Source Type: research

Induction of spontaneous neo-angiogenesis and tube formation in human endometrial stem cells by bioglass
In this study, we describe a novel choice for treatment of endothelial dysfunction in vascular regenerative medicine via the human endometrial stem cell culture (as a new source for the increasing the number of endothelial progenitor cells) with Bioglass(angiogenic agent) to investigate the enhancing expression of CD34, CD31 and gene markers of endothelial progenitor cells and endothelial cells. In the end, application of immuno-privileged, readily available sources of adult stem cells like human endometrial stem cells with bioglass would be a promising strategy to increase the number of endothelial progenitor cells and pr...
Source: Journal of Medical Hypotheses and Ideas - October 2, 2015 Category: Research Source Type: research

Reprogramming of Adult Stem/Progenitor Cells into iPSCs Without Reprogramming Factors
Publication date: Available online 30 September 2015 Source:Journal of Medical Hypotheses and Ideas Author(s): Behnam Ebrahimi Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) has attracted considerable attention in both the scientific and public communities. This is due to the importance of iPSCs in drug screening, disease modeling, cell transplantation therapies and regenerative medicine. A lot of efforts have been accomplished to generate iPSCs with fewer reprogramming factors and with higher efficiencies. It has been shown that removal of reprogramming barriers increases the effici...
Source: Journal of Medical Hypotheses and Ideas - October 2, 2015 Category: Research Source Type: research

Differentiation of human endometrial stem cells into germ cell – Like cell in fibrin scaffold
Publication date: December 2015 Source:Journal of Medical Hypotheses and Ideas, Volume 9, Issue 2 Author(s): Maryam Roya Ramzgouyan, Jafar Ai Recent studies on stem cells differentiation into germ cells have changed scientists’ attitude to reproductive problems as well as infertility topics. It is supposed there are promising and new approaches in treatment of infertile couples and numerous advances will be made in reproductive medicine in near future. Application of embryonic stem cells for clinical trials is limited due to high potent of tumorogenicity and ethical issues. Therefore, pluripotent cells taken from...
Source: Journal of Medical Hypotheses and Ideas - September 19, 2015 Category: Research Source Type: research

An appraisal of the Journal of Medical Hypotheses and Ideas: a medium for evidence-based scholarly communications
Publication date: Available online 9 September 2015 Source:Journal of Medical Hypotheses and Ideas Author(s): Armen Yuri Gasparyan (Source: Journal of Medical Hypotheses and Ideas)
Source: Journal of Medical Hypotheses and Ideas - September 11, 2015 Category: Research Source Type: research