Cervical human papillomavirus among 19,753 women attending gynecological department of a major comprehensive hospital in north Anhui China 2013 ‐2016: implication for cervical cancer screening and prevention
This article is protected by copyright. All rights reserved. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 26, 2018 Category: Virology Authors: Hongli Liu, Xueting Wei, Zongyu Xie, Xiaojing Wang, Xiaomeng Gong, Wujian Ke, Huachun Zou Tags: RESEARCH ARTICLE Source Type: research

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71
Severe hand, foot, and mouth disease (HFMD) is sometimes associated with critical complications that can cause substantial child mortality. Activity of the vitamin D receptor (VDR) may influence the outcomes of enterovirus 71 (EV71) infection. This case ‐control study aimed to assess the association of single‐nucleotide polymorphisms (SNPs) in the gene encoding theVDR with the severity of EV71 ‐associated HFMD. We selected four VDR SNPs based on linkage disequilibrium and functional prediction, and we tested them using the SNPscan multiple SNP typing method for potential association with severity of EV71‐associated...
Source: Journal of Medical Virology - November 22, 2018 Category: Virology Authors: Ya ‐Ping Li, Hui‐Ling Deng, Li‐Hong Xu, Mu‐Qi Wang, Mei Li, Xin Zhang, Shuang‐Suo Dang Tags: RESEARCH ARTICLE Source Type: research

Hepatitis C virus genotypes in hemodialysis patients in Angola
This study aimed at assessing the distribution of HCV genotypes in seropositive hemodialysis patients in Luanda. Among 51 HCV ‐positive subjects included, viremia was detected in 27 (53%). HCV genotyping was performed by bidirectional sequencing of the 5'‐untranslated region by the Sanger method. HCV genotype 4 was largely predominant (20 cases; 74%), followed by genotypes 1b (5 cases; 18.5%), 1a and 2 (one case each; 3.7%). These results suggest that the distribution of HCV genotypes in Angola is similar to that reported from other Central African countries. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 21, 2018 Category: Virology Authors: Luis Filipe da Costa Marques Borges, Mariano Gustavo Zalis, Guilherme Santoro ‐Lopes, Rafael Brandão Varella Tags: SHORT COMMUNICATION Source Type: research

Demographic and seasonal characteristics of respiratory pathogens in neonates and infants aged 0 to 12 months in the Central ‐East region of Tunisia
ConclusionA predominance of the rhinovirus infection was observed in this study. Coronavirus subtypes were described for the first time in Tunisia. The observed different pathogenic profiles across age groups could be helpful to avoid the misclassification of patients presenting with ARIs at the triage level when no standardized protocol is available. This study will provide clues for physicians informing decisions regarding preventive strategies and medication in Tunisia. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 21, 2018 Category: Virology Authors: Ines Brini Khalifa, Naila Hannachi, Aida Guerrero, Dorothea Orth ‐Höller, Sana Bhiri, Jihene Bougila, Lamia Boughamoura, Sonia Nouri Merchaoui, Hassen Sboui, Nabiha Mahdhaoui, Britta Schiela, Dorothee Holm‐von Laer, Jalel Boukadida, Heri Tags: RESEARCH ARTICLE Source Type: research

Broadly reactive real ‐time reverse transcription‐polymerase chain reaction assay for the detection of human sapovirus genotypes
In this study, we report the development of a broader‐range sapovirus real‐time RT‐PCR assay. The assay can detect 2.5 × 107 and 2.5  × 101 copies of sapovirus  and therefore is as sensitive as the previous test. Analysis using clinical stool specimens or synthetic DNA revealed that the new system detected strains representative of all the 18 human sapovirus genotypes: GI.1‐7, GII.1‐8, GIV.1, and GV.1, 2. No cross‐reactivity was observed against oth er representative common enteric viruses (norovirus, rotavirus, astrovirus, and adenovirus). This new assay will be useful as an improved, broadly reacti...
Source: Journal of Medical Virology - November 15, 2018 Category: Virology Authors: Tomoichiro Oka, Nobuhiro Iritani, Seiji P. Yamamoto, Kohji Mori, Tomoko Ogawa, Chika Tatsumi, Shinichiro Shibata, Seiya Harada, Fang ‐Tzy Wu Tags: RESEARCH ARTICLE Source Type: research

Polymorphism in IFNL3/IL28B gene and risk to non ‐cirrhotic chronic hepatitis C genotype 3 virus infection and its effect on the response to combined daclatasvir and sofosbuvir therapy
This article is protected by copyright. All rights reserved. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 15, 2018 Category: Virology Authors: Anwar Jamal Khan, Vivek Aanand Saraswat, Prabhat Ranjan, Devendra Parmar, Tajwar Singh Negi, Samir Mohindra Tags: RESEARCH ARTICLE Source Type: research

Perspectives towards antiviral drug discovery against Ebola virus
This article is protected by copyright. All rights reserved. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 15, 2018 Category: Virology Authors: Muhammad Usman Mirza, Michiel Vanmeert, Amjad Ali, Kanzal Iman, Matheus Froeyen, Muhammad Idrees Tags: REVIEW Source Type: research

Umifenovir Susceptibility Monitoring and Characterization of Influenza Viruses Isolated during ARBITR Clinical Study
This article is protected by copyright. All rights reserved. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 15, 2018 Category: Virology Authors: Irina A. Leneva, Irina N. Falynskova, Nailya R. Makhmudova, Artem A. Poromov, Svetlana B. Yatsyshina, Viktor V. Maleev Tags: RESEARCH ARTICLE Source Type: research

Hepatitis B virus genotype G and liver fibrosis progression in chronic hepatitis B and human immunodeficiency virus coinfection
ConclusionIn HIV ‐HBV coinfected patients, HBV‐genotype G is an independent risk factor for liver fibrosis progression as determined by non‐invasive markers. HBV genotype G infected patients with low initial liver fibrosis levels may require more careful monitoring.This article is protected by copyright. All rights reserved. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 15, 2018 Category: Virology Authors: Vincenzo Malagnino, Julie Bottero, Patrick Miailhes, Caroline Lascoux ‐Combe, Pierre‐Marie Girard, Fabien Zoulim, Karine Lacombe, Anders Boyd Tags: RESEARCH ARTICLE Source Type: research

Genetic characterization of human metapneumovirus identified through community and facility ‐based surveillance of infants in Dhaka, Bangladesh
ConclusionThis study describes both the epidemiology of hMPV infection and its genotypic strain diversity in Dhaka, Bangladesh. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 13, 2018 Category: Virology Authors: Mohammed Ziaur Rahman, Mariya Sumiya, Mohammed Sahabuddin, Lisa G Pell, Jonathan B Gubbay, Rajibur Rahman, Farhana Momtaz, Nafisa Azmuda, Shaila S Shanta, Ishrat Jahan, Mustafizur Rahman, Abdullah A Mahmud, Daniel E Roth, Shaun K Morris Tags: RESEARCH ARTICLE Source Type: research

Human leukocyte antigen polymorphisms and Kaposi's sarcoma ‐associated herpesvirus infection outcomes: A call for deeper exploration
Host genetic background may influence the immunity to resist viral infection. As the most polymorphic loci in the entire human genome, the human leukocyte antigen (HLA) system plays an important role in innate and adaptive immune responses to many invading pathogens. Studies have shown that an association might exist between HLA polymorphisms and susceptibility to Kaposi's sarcoma ‐associated herpesvirus (KSHV) infection and associated diseases. However, discrepant conclusions were reached among different subjects with different detection methods. Therefore, it is now urgent to summarize current results and figure out th...
Source: Journal of Medical Virology - November 13, 2018 Category: Virology Authors: Qiwen Fang, Zhenqiu Liu, Tiejun Zhang Tags: REVIEW Source Type: research

Comparing the Cobas Liat Influenza A/B and respiratory syncytial virus assay with multiplex nucleic acid testing
Influenza virus and respiratory syncytial virus (RSV) detection with short turn ‐around‐time (TAT) is pivotal for rapid decisions regarding treatment and infection control. However, negative rapid testing results may come from poor assay sensitivity or from influenza‐like illnesses caused by other community‐acquired respiratory viruses (CARVs). We prospectively compared the performance of Cobas Liat Influenza A/B and RSV assay (LIAT) with our routine multiplexNAT‐1 (xTAG Respiratory Pathogen Panel; Luminex) and multiplexNAT‐2 (ePlex‐RPP; GenMark Diagnostics) using 194 consecutive nasopharyngeal swabs from pat...
Source: Journal of Medical Virology - November 13, 2018 Category: Virology Authors: Rainer Gosert, Klaudia Naegele, Hans H. Hirsch Tags: RESEARCH ARTICLE Source Type: research

Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study
ConclusionDiffering patterns of HHV infection in tonsils in a large age ‐stratified population were described. This study is by far the largest available and shows that EBV, HHV6B, and HHV7 are commonly detected in the tonsils in both men and women, in contrast to other HHVs. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 13, 2018 Category: Virology Authors: Aboud Kourieh, Tarik Gheit, Massimo Tommasino, V éronique Dalstein, Gary M. Clifford, Jean Lacau St Guily, Christine Clavel, Silvia Franceschi, Jean‐Damien Combes, for the SPLIT study group Tags: RESEARCH ARTICLE Source Type: research

Epidemiology, risk factors, and molecular characterization of occult hepatitis B infection among anti ‐hepatitis B core antigen alone subjects
ConclusionOur study suggests that OBI should be considered among anti ‐HBc seropositive subjects. This form of HBV infection was accompanied with some mutations, risk factors, and diseases. However, further investigations are needed to determine virological importance of documented mutations. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 8, 2018 Category: Virology Authors: Zohreh Azarkar, Masood Ziaee, Azadeh Ebrahimzadeh, Gholamreza Sharifzadeh, Davod Javanmard Tags: RESEARCH ARTICLE Source Type: research

Serological evidence of human infection by bat orthoreovirus in Singapore
This article is protected by copyright. All rights reserved. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 8, 2018 Category: Virology Authors: Anna Uehara, Chee Wah Tan, Shailendra Mani, Kaw Bing Chua, Yee Sin Leo, Danielle E. Anderson, Lin ‐Fa Wang Tags: SHORT COMMUNICATION Source Type: research