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Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure†Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 20, 2009 Category: Chemistry Tags: article Source Type: journals

Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ AgonistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 20, 2009 Category: Chemistry Tags: article Source Type: journals

9-Arylpurines as a Novel Class of Enterovirus InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 19, 2009 Category: Chemistry Tags: article Source Type: journals

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide HydrolaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 19, 2009 Category: Chemistry Tags: article Source Type: journals

Perspectives of P-Glycoprotein Modulating Agents in Oncology and Neurodegenerative Diseases: Pharmaceutical, Biological, and Diagnostic PotentialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 19, 2009 Category: Chemistry Tags: article Source Type: journals

The Structure−Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 19, 2009 Category: Chemistry Tags: article Source Type: journals

Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor ActivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 18, 2009 Category: Chemistry Tags: article Source Type: journals

Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue SelectivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 18, 2009 Category: Chemistry Tags: article Source Type: journals

Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic AzaindoleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 18, 2009 Category: Chemistry Tags: article Source Type: journals

Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization StrategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 17, 2009 Category: Chemistry Tags: article Source Type: journals

Novel Organic Proteasome Inhibitors Identified by Virtual and in Vitro ScreeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 17, 2009 Category: Chemistry Tags: article Source Type: journals

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the LeishmaniasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 16, 2009 Category: Chemistry Tags: article Source Type: journals

Morpholine Derivatives Greatly Enhance the Selectivity of Mammalian Target of Rapamycin (mTOR) InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 16, 2009 Category: Chemistry Tags: article Source Type: journals

DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex SelectivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 13, 2009 Category: Chemistry Tags: article Source Type: journals

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and ThiocoumarinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 13, 2009 Category: Chemistry Tags: article Source Type: journals

Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes¶Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 13, 2009 Category: Chemistry Tags: article Source Type: journals

Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues‡Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 13, 2009 Category: Chemistry Tags: article Source Type: journals

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for DiabesityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 12, 2009 Category: Chemistry Tags: article Source Type: journals

Enhancement of the Antimalarial Activity of Ciprofloxacin Using a Double Prodrug/Bioorganometallic ApproachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 12, 2009 Category: Chemistry Tags: article Source Type: journals

Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol ProteaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 12, 2009 Category: Chemistry Tags: article Source Type: journals

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular ChaperoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 12, 2009 Category: Chemistry Tags: article Source Type: journals

Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatBEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 12, 2009 Category: Chemistry Tags: article Source Type: journals

Erratum: Corrections to Multidentate Small-Molecule Inhibitors of Vaccinia H1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 11, 2009 Category: Chemistry Tags: article Source Type: journals

Discovery of (Z)-5-(4-Methoxybenzylidene)thiazolidine-2,4-dione, a Readily Available and Orally Active Glitazone for the Treatment of Concanavalin A-Induced Acute Liver Injury of BALB/c MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 11, 2009 Category: Chemistry Tags: article Source Type: journals

4-Oxo-β-lactams (Azetidine-2,4-diones) Are Potent and Selective Inhibitors of Human Leukocyte ElastaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 11, 2009 Category: Chemistry Tags: article Source Type: journals

Human P2Y14 Receptor Agonists: Truncation of the Hexose Moiety of Uridine-5′-Diphosphoglucose and Its Replacement with Alkyl and Aryl GroupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 10, 2009 Category: Chemistry Tags: article Source Type: journals

Erratum: Corrections to Design, Synthesis, and Biological Evaluation of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives as μ Opioid Receptor Selective AntagonistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 10, 2009 Category: Chemistry Tags: article Source Type: journals

Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor AgonistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 10, 2009 Category: Chemistry Tags: article Source Type: journals

Phosphinic Tripeptides as Dual Angiotensin-Converting Enzyme C-Domain and Endothelin-Converting Enzyme-1 InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 9, 2009 Category: Chemistry Tags: article Source Type: journals

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate SynthaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 9, 2009 Category: Chemistry Tags: article Source Type: journals

The Discodermolide Hairpin Structure Flows from Conformationally Stable Modular MotifsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 6, 2009 Category: Chemistry Tags: article Source Type: journals

Discovery of 4-Morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 6-Aryl SubstituentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 6, 2009 Category: Chemistry Tags: article Source Type: journals

Fluorinated Rhodacyanine (SJL-01) Possessing High Efficacy for Visceral Leishmaniasis (VL)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 6, 2009 Category: Chemistry Tags: article Source Type: journals

Design, Synthesis, and Characterization of Peptide-Based Rab Geranylgeranyl Transferase InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 6, 2009 Category: Chemistry Tags: article Source Type: journals

N-Sulfonylanthranilic Acid Derivatives as Allosteric Inhibitors of Dengue Viral RNA-Dependent RNA PolymeraseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 6, 2009 Category: Chemistry Tags: article Source Type: journals

Design, Synthesis, and Biological Evaluations of 2,5-Diaryl-2,3-dihydro-1,3,4-oxadiazoline Analogs of Combretastatin-A4Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 6, 2009 Category: Chemistry Tags: article Source Type: journals

In Vitro and In Vivo Isotope Effects with Hepatitis C Protease Inhibitors: Enhanced Plasma Exposure of Deuterated Telaprevir versus Telaprevir in RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 6, 2009 Category: Chemistry Tags: article Source Type: journals

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9aEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 5, 2009 Category: Chemistry Tags: article Source Type: journals

1,2,4-Triazolyl Azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Dopamine D3 Receptor AntagonistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 5, 2009 Category: Chemistry Tags: article Source Type: journals

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 AntagonistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 5, 2009 Category: Chemistry Tags: article Source Type: journals

Poly-N-methylated Amyloid β-Peptide (Aβ) C-Terminal Fragments Reduce Aβ Toxicity in Vitro and in Drosophila melanogasterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 5, 2009 Category: Chemistry Tags: article Source Type: journals

Drug Effects Viewed from a Signal Transduction Network PerspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 5, 2009 Category: Chemistry Tags: article Source Type: journals

Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 3, 2009 Category: Chemistry Tags: article Source Type: journals

Might Adrenergic α2C-Agonists/α2A-Antagonists Become Novel Therapeutic Tools for Pain Treatment with Morphine?(1)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 3, 2009 Category: Chemistry Tags: article Source Type: journals

Biaryl Ethers as Novel Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Key Mutant VirusesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 2, 2009 Category: Chemistry Tags: article Source Type: journals

Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 2, 2009 Category: Chemistry Tags: article Source Type: journals

Structure−Activity Relationship Studies of Chalcone Leading to 3-Hydroxy-4,3′,4′,5′-tetramethoxychalcone and Its Analogues as Potent Nuclear Factor κB Inhibitors and Their Anticancer ActivitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 2, 2009 Category: Chemistry Tags: article Source Type: journals

The Role of Membranes in the Organization of HIV-1 Gag p6 and Vpr: p6 Shows High Affinity for Membrane Bilayers Which Substantially Increases the Interaction between p6 and VprEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 2, 2009 Category: Chemistry Tags: article Source Type: journals

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Journal of Medicinal Chemistry - November 2, 2009 Category: Chemistry Tags: article Source Type: journals

Discovery of Novel Benzoxazinones as Potent and Orally Active Long Chain Fatty Acid Elongase 6 InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Medicinal Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 2, 2009 Category: Chemistry Tags: article Source Type: journals