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Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectivelyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings indicate that the hIP is post-translationally modified by ubiquitination, which targets the immature species to the 26S proteasomal degradation pathway and the mature species to the lysosomal degradation pathway. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - September 24, 2009 Category: Molecular Biology Authors: Peter DonnellanB Therese Kinsella Source Type: journals

Overexpression of tissue inhibitors of metalloproteinase 2 up-regulates NF-kappaB activity in melanoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data demonstrate that the expression level of TIMP-2 protein can directly modulate the NF-kappaB pathway in human melanoma cells. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - July 22, 2009 Category: Molecular Biology Authors: Jun SunWilliam Stetler-Stevenson Source Type: journals

Expression analyses of nuclear receptor genes in breast cancer cell lines exposed to soy phytoestrogens after BRCA2 knockdown by TaqMan Low-Density Array (TLDA)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results seemed to implicate the oncosuppressor BRCA2 and the phytoestrogen pathways in different nuclear gene expressions via an ER-independent manner. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - May 14, 2009 Category: Molecular Biology Authors: Samir Satih, Helene Savinel, Nadege Rabiau, Luc Fontana, Yves-Jean Bignon and Dominique J Bernard-Gallon Source Type: journals

Membrane estrogen receptor-α-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Phytoestrogens were much more potent in mediating these nongenomic responses (activation of MAPKs, PRL release, and increased intracellular [Ca2+]) via mERα than was previously reported for genomic responses. The unique non-monotonic dose responses and variant signaling patterns caused by E2 and all tested phytoestrogens suggest that complex and multiple signaling pathways or binding partners could be involved. By activating these different nongenomic signaling pathways, phytoestrogens could have significant physiological consequences for pituitary cell functions. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - April 28, 2009 Category: Molecular Biology Authors: Yow-Jiun Jeng, Mikhail Y Kochukov and Cheryl S Watson Source Type: journals

AKT/eNOS signaling module functions as a potential feedback loop in the growth hormone signaling pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The MAP kinase and CDC2 kinase-dependent intracellular mechanisms are involved in or are the targets of the GH's action processes, and these activities are probably directly or indirectly modulated by AKT/PKB pathways. We propose that the AKT/PKB-eNOS module likely functions as a negative feedback mediator of GH actions. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - March 25, 2009 Category: Molecular Biology Authors: Cong-Jun Li, Theodore H Elsasser and Stanislaw Kahl Source Type: journals

Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings indicate that ubiquitination of β-arrestin has a distinct role in the differential trafficking and degradation of M1 and M2 mAChRs. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - December 3, 2008 Category: Molecular Biology Authors: Valerie A Mosser, Kymry T Jones, Katie M Hoffman, Nael A McCarty and Darrell A Jackson Source Type: journals

Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings indicate that ubiquitination of beta-arrestin has a distinct role in the differential trafficking and degradation of M1 and M2 mAChRs. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - December 3, 2008 Category: Molecular Biology Authors: Valerie A. Mosser, Kymry T. Jones, Katie M. Hoffman, Nael A. McCarty and Darrell A. Jackson Source Type: journals

Cell cycle arrest in metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cell cycle arrest in response to metformin requires CDK inhibitors in addition to AMPK activation and cyclin D1 downregulation. This is of interest because many cancers are associated with loss or downregulation of CDK inhibitors and the results may be relevant to the development of anti-tumor reagents that target the AMPK pathway (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - December 1, 2008 Category: Molecular Biology Authors: Yongxian Zhuang and W. KEITH Miskimins Source Type: journals

SFRP-4 abrogates Wnt-3a-induced β-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study demonstrates that Wnt-3a treatment activates the Wnt signalling pathway and interferes with in vitro differentiation of mammary co-cultures to β-casein production in response to lactogenic hormones. Similarly, in another measure of differentiation, following Wnt-3a treatment mammary epithelial cells could be shown to up-regulate the cyclin D1 and connexin-43 genes while phenotypically they show increased transepithelial resistance across the cell monolayer. All these behavioural changes can be blocked in mammary epithelial cells expressing SFRP-4. Thus, our data illustrate in an in vitro model a mec...
Source: Journal of Molecular Signaling - May 2, 2008 Category: Molecular Biology Authors: Thecla Constantinou, Fabrizio Baumann, Markus D Lacher, Susanne Saurer, Robert Friis and Arun Dharmarajan Source Type: journals

Enhanced catharanthine and vindoline production in suspension cultures of Catharanthus roseus by ultraviolet-B lightEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Suspension cultures of Catharanthus roseus were used to evaluate ultraviolet-B (UV-B) treatment as an abiotic elicitor of secondary metabolites. A dispersed cell suspension culture from C. roseus leaves in late exponential phase and stationary phase were irradiated with UV-B for 5 min. The stationary phase cultures were more responsive to UV-B irradiation than late exponential phase cultures. Catharanthine and vindoline increased 3-fold and 12-fold, respectively on treatment with a 5-min UV-B irradiation. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - April 25, 2008 Category: Molecular Biology Authors: Shilpa Ramani and Chelliah Jayabaskaran Source Type: journals

Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Taken together our results define the tyrosine residues of KDR that are regulated by SHP-1 and also elucidates a novel feed back loop where SHP-1 is activated upon VEGF treatment through c-Src and controls KDR induced DNA synthesis, eventually leading to controlled angiogenesis. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - March 31, 2008 Category: Molecular Biology Authors: Resham Bhattacharya, Junhye Kwon, Enfeng Wang, Priyabrata Mukherjee and Debabrata Mukhopadhyay Source Type: journals

Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to regulate antiangiogenic effects of EGCG through activation of FOXO transcription factors. The activation of FOXO transcription factors through inhibition of these two pathways may have physiological significance in management of diabetic retinopathy, rheumatoid arthritis, psoriasis, cardiovascular diseases, and cancer. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - March 20, 2008 Category: Molecular Biology Authors: Sharmila Shankar, Qinghe Chen and Rakesh K. Srivastava Source Type: journals

The alpha1D-adrenergic receptor is expressed intracellularly and coupled to increases in intracellular calcium and reactive oxygen species in human aortic smooth muscle cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that the dimerization of the alpha-1D-AR with other ARs does not alter the cellular expression or functional response characteristics of the alpha-1D-AR. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - February 27, 2008 Category: Molecular Biology Authors: Mary L Garcia-Cazarin, Jennifer L Smith, Kyle A Olszewski, Dan F McCune, Linda A Simmerman, Robert W Hadley, Susan D Kraner and Michael T Piascik Source Type: journals

Binding mode prediction of conformationally restricted anandamide analogs within the CB1 receptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Analyses of multiple poses of conformationally-restricted anandamide analogs permitted identification of favored amino acid interactions within the CB1 receptor binding pocket. A ligand possessing both high affinity and cannabinoid agonist efficacy was able to interact with both polar and hydrophobic interaction sites utilized by the potent and efficacious non-classical cannabinoid CP55940. In contrast, other analogs characterized by reduced affinity or efficacy exhibited less favorable interactions with those key residues. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - February 26, 2008 Category: Molecular Biology Authors: Lea W Padgett, Allyn C Howlett and Joong-Youn Shim Source Type: journals

Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wiskott Aldrich Syndrome protein (WASP) has a unique regulatory role in sealing ring formation and bone resorption in osteoclasts. Here, using the TAT-transduction method, we show the possible role of WASP domain(s) in sealing ring formation and bone resorption. Transduction of TAT-fused full-length WASP peptide induced Arp2/3 complex formation, F-actin content, sealing ring formation and bone resorption. Transduction of WASP peptides containing basic, verpolin-central, pTyr294, and proline-rich regions inhibited the processes listed above at various levels. The ability to resorb bone by WASP peptides containing basic, ver...
Source: Journal of Molecular Signaling - February 20, 2008 Category: Molecular Biology Authors: Tao Ma, Venkatesababa Samanna and Meenakshi A Chellaiah Source Type: journals

Retinoic Acid decreases ATF-2 phosphorylation and sensitizes melanoma cells to taxol-mediated growth inhibitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cutaneous melanoma is often resistant to chemo- and radiotherapy. This resistance has recently been demonstrated to be due, at least in part, to high activating transcription factor 2 (ATF 2) activity in these tumors. In concordance with these reports, we found that B16 mouse melanoma cells had higher levels of ATF-2 than immortalized, but non-malignant mouse melanocytes. In addition, the melanoma cells had a much higher amount of phosphorylated (active) ATF-2 than the immortalized melanocytes. In the course of determining how retinoic acid (RA) stimulates activating protein-1 (AP-1) activity in B16 melanoma, we discovered...
Source: Journal of Molecular Signaling - February 12, 2008 Category: Molecular Biology Authors: Ying Huang, Jennifer Minigh, Sarah Miles and Richard M Niles Source Type: journals

Scaffolding proteins in G-protein signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heterotrimeric G proteins are ubiquitous signaling partners of seven transmembrane-domain G-protein-coupled receptors (GPCRs), the largest (and most important pharmacologically) receptor family in mammals. A number of scaffolding proteins have been identified that regulate various facets of GPCR signaling. In this review, we summarize current knowledge concerning those scaffolding proteins that are known to directly bind heterotrimeric G proteins, and discuss the composition of the protein complexes they assemble and their effects on signal transduction. Emerging evidence about possible ways of regulation of activity of th...
Source: Journal of Molecular Signaling - October 30, 2007 Category: Molecular Biology Authors: Alexandra V Andreeva, Mikhail A Kutuzov and Tatyana A Voyno-Yasenetskaya Source Type: journals

Abundance, complexation, and trafficking of Wnt/beta-catenin signaling elements in response to Wnt3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study provides a detailed biochemical analysis of signaling elements key to Wnt3a regulation of the canonical pathway. We quantify, for the first time, the Wnt-dependent regulation of cellular abundance and intracellular trafficking of these signaling molecules. In contrast, we observe little effect of Wnt3a stimulation on the level of protein-protein interactions among these constituents of Axin-based complexes themselves. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - October 25, 2007 Category: Molecular Biology Authors: Noriko Yokoyama, Dezhong Yin and Craig C Malbon Source Type: journals

Phosphoprotein phosphatase-2A docks to Dishevelled and counterregulates Wnt3a/beta-catenin signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In current study, we showed new roles of phosphoprotein phosphatase-2A in Wnt/beta-catenin signaling pathway: effect on protein expression, effect on protein trafficking, retention of molecules in subcellular compartments, and regulation of enzymatic activity of several key players. Docking of phosphoprotein phosphatase-2A by Dishevelled-2 suppresses phosphatase activity and explains in part the central role of this phosphatase in the counterregulation of the Wnt/beta-catenin signaling pathway. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - October 25, 2007 Category: Molecular Biology Authors: Noriko Yokoyama and Craig C Malbon Source Type: journals

Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The ability of curcumin to inhibit capillary tube formation and cell migration, and enhance the therapeutic potential of TRAIL suggests that curcumin alone or in combination with TRAIL can be used for prostate cancer prevention and/or therapy. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - October 4, 2007 Category: Molecular Biology Authors: Sharmila Shankar, Qinghe Chen, Krishna Sarva, Imtiaz Siddiqui and Rakesh K Srivastava Source Type: journals

PI3 K/Akt/mTOR-mediated translational control regulates proliferation and differentiation of lineage-restricted RoSH stem cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study highlights translation regulation as a critical regulatory mechanism during proliferation and differentiation in stem cells. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - September 25, 2007 Category: Molecular Biology Authors: Jianwen Que, Qizhou Lian, Reida M El Oakley, Bing Lim and Sai-Kiang Lim Source Type: journals

Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Ligand activated sigma-1 receptors translocate into FAC from a pool of receptors stored in ER lipid rafts presumably for inhibition of Kv1.4 channels. Stabilization of actin filaments is likely to be important for targeting sigma-1 receptors to Focal Adhesion Contacts in CHO-K1 cells. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - September 20, 2007 Category: Molecular Biology Authors: Timur A Mavlyutov and Arnold E Ruoho Source Type: journals

Clusterin expression can be modulated by changes in TCF1-mediated Wnt signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, we have demonstrated that the Wnt signaling pathway specifically regulates one out of three CLU mRNA variants via TCF1. This CLU transcript is shorter at the 5' end than reported by the RefSeq database, and produces the intracellular 60 kDa CLU protein isoform which is secreted as a ~80 kDa protein after post-translational processing. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - July 16, 2007 Category: Molecular Biology Authors: Troels Schepeler, Francisco Mansilla, Lise L Christensen, Torben F Orntoft and Claus L Andersen Source Type: journals

Role of RGM coreceptors in bone morphogenetic protein signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results demonstrate that the RGMs play a significant role in BMP signaling and reveal that these molecules cannot functionally compensate for one another. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - July 5, 2007 Category: Molecular Biology Authors: Peter J Halbrooks, Ru Ding, John M Wozney and Gerard Bain Source Type: journals

PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcriptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Here, we demonstrate that human PNRC stimulates RNA pol III transcription through its interaction with the subunit RPC39 of RNA pol III. PNRC is a unique coactivator that has profound effects on many aspects of cellular function by directly influencing both RNA pol II- and RNA pol III-dependent transcription. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - July 5, 2007 Category: Molecular Biology Authors: Dujin Zhou, Shuping Zhong, Jing Jing Ye, Keith M Qauch, Deborah L Johnson and Shiuan Chen Source Type: journals

Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
G protein-coupled receptors are key regulators of cellular communication, mediating the efficient coordination of a cell's responses to extracellular stimuli. When stimulated these receptors modulate the activity of a wide range of intracellular signalling pathways that facilitate the ordered development, growth and reproduction of the organism. There is now a growing body of evidence examining the mechanisms by which G protein-coupled receptors are able to regulate the expression, activity, localization and stability of cell cycle regulatory proteins that either promote or inhibit the initiation of DNA synthesis. In this ...
Source: Journal of Molecular Signaling - February 26, 2007 Category: Molecular Biology Authors: David C New and Yung H Wong Source Type: journals

ArhGAP9, a novel MAP kinase docking protein, inhibits Erk and p38 activation through WW domain bindingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have identified human ArhGAP9 as a novel MAP kinase docking protein that interacts with Erk2 and p38alpha through complementarily charged residues in the WW domain of ArhGAP9 and the CD domains of Erk2 and p38alpha. This interaction sequesters the MAP kinases in their inactive states through displacement of MAP kinase kinases targeting the same sites. While over-expression of wild type ArhGAP9 caused MAP kinase activation by the epidermal growth factor receptor (EGFR) to be suppressed and preserved the actin stress fibres in quiescent Swiss 3T3 fibroblasts, over-expression of an ArhGAP9 mutant defective in MAP kinase bi...
Source: Journal of Molecular Signaling - February 6, 2007 Category: Molecular Biology Authors: Boon K Ang, Chun Y Lim, Sharon S Koh, Neelamegam Sivakumar, Shahrizan Taib, Kim B Lim, Sohail Ahmed, Guna Rajagopal and Siew H Ong Source Type: journals

Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The strict spatio-temporal control of Rho GTPases is critical for many cellular functions, including cell motility, contractility, and growth. In this regard, the prototypical Rho family GTPases, Rho, Rac, and Cdc42 regulate the activity of each other by a still poorly understood mechanism. Indeed, we found that constitutively active forms of Rac inhibit stress fiber formation and Rho stimulation by thrombin. Surprisingly, a mutant of Rac that is unable to activate Pak1 failed to inhibit thrombin signaling to Rho. To explore the underlying mechanism, we investigated whether Pak1 could regulate guanine nucleotide exchange f...
Source: Journal of Molecular Signaling - December 6, 2006 Category: Molecular Biology Authors: Hans Rosenfeldt, Maria Domenica Castellone, Paul A Randazzo and J Silvio Gutkind Source Type: journals

Estradiol effects on the dopamine transporter – protein levels, subcellular location, and functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that physiological levels of E2 may act to sequester DAT in intracellular compartments where the transporter's second extramembrane loop is inaccessible (inside vesicles) and that rapid estrogenic actions on this differentiated neuronal cell type may be regulated via membrane ERs of several types. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - December 5, 2006 Category: Molecular Biology Authors: Cheryl S Watson, Rebecca A Alyea, Bridget E Hawkins, Mary L Thomas, Kathryn A Cunningham and Adrian A Jakubas Source Type: journals

Amino terminal tyrosine phosphorylation of human MIXL1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Seven members of the Mix family of paired-type homeoproteins regulate mesoderm/endoderm differentiation in amphibians. In mammals, the MIXL1 (Mix. 1 homeobox [Xenopus laevis]-like gene 1) gene is the sole representative of this family. Unlike the amphibian Mix genes that encode an open reading frame of >300 amino acids, mammalian MIXL1 encodes a smaller protein (~230aa). However, mammalian MIXL1 contains a unique proline-rich domain (PRD) with a potential to interact with signal transducing Src homolgy 3 (SH3) domains. Notably, human MIXL1 also contains a unique tyrosine residue Tyr20 that is amino-terminal to the PRD. Her...
Source: Journal of Molecular Signaling - December 5, 2006 Category: Molecular Biology Authors: Wei Guo and Lalitha Nagarajan Source Type: journals

Agonist mediated internalization of M2 mAChR is β-arrestin-dependentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In summary, this study demonstrates that agonist-promoted internalization of M2 mAChRs is β-arrestin- and clathrin-dependent, and that the receptor stably co-localizes with β-arrestin in early endosomal vesicles. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - December 5, 2006 Category: Molecular Biology Authors: Kymry T Jones, Maria Echeverry, Valerie A Mosser, Alicia Gates and Darrell A Jackson Source Type: journals

An open access journal of molecular signaling: a critical need at a critical timeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Molecular signaling is an exponentially growing field that encompasses different molecular aspects of cell signaling underlying normal and pathological conditions. This area also focuses on defining the genetic and epigenetic changes that modulate the signaling properties of cells and the resultant physiological as well as pathological conditions. Therefore, rapid publication of results from these endeavors and, more importantly, free access to such publications can truly accelerate the progress in this field leading to the development of novel targeted drugs. With this goal in mind, Journal of Molecular Signaling, a journ...
Source: Journal of Molecular Signaling - November 10, 2006 Category: Molecular Biology Authors: Danny N Dhanasekaran Source Type: journals

Differential partitioning of Gαi1 with the cellular microtubules: a possible mechanism of development of Taxol resistance in human ovarian carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Based on the opposing effects of taxol and the Gαi1 protein on the microtubule dynamic instability (taxol suppresses microtubule dynamic instability whilst the Gαi1 protein inhibits the suppression) our results indicate the operation of a novel pathway that would enable the cells to escape the cytotoxic effects of taxol. (Source: Journal of Molecular Signaling)
Source: Journal of Molecular Signaling - November 10, 2006 Category: Molecular Biology Authors: Hemant K Parekh, Mahesha Adikari and Bharathi Vennapusa Source Type: journals