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Silver nanoparticles inhibit VEGF-and IL-1beta-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report that VEGF and IL-1beta-stimulate endothelial permeability via Src dependent pathway by increasing the Src phosphorylation and Ag-NP block the VEGF-and IL-1beta-induced Src phosphorylation at Y419. These results demonstrate that Ag-NP may inhibit the VEGF-and IL-1beta-induced permeability through inactivation of Src kinase pathway and this pathway may represent a potential therapeutic target to inhibit the ocular diseases such as diabetic retinopathy. (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - October 30, 2009 Category: Nanotechnology Authors: Sardarpasha SheikpranbabuKalimuthu KalishwaralalDeepak VenkataramanSoo Hyun EomJongsun ParkSangiliyandi Gurunathan Source Type: journals

Co-transfection of plasmid DNA and laser-generated gold nanoparticles does not disturb the bioactivity of GFP-HMGB1 fusion proteinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our data indicate that laser-generated AuNPs present a good alternative to chemically synthesized nanoparticles for use in biomedical applications. (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - October 23, 2009 Category: Nanotechnology Authors: Svea PetersenJan SollerSiegfried WagnerAndreas RichterJorn BullerdiekIngo NolteStephan BarcikowskiHugo Murua Escobar Source Type: journals

Real time in vitro studies of doxorubicin release from PHEMA nanoparticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Suspension polymerization of 2-hydroxyethyl methacrylate (HEMA) results in the formation of swellable nanoparticles of defined composition. PHEMA nanoparticles can potentially be used for the controlled release of the anticancer drug doxorubicin. (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - October 19, 2009 Category: Nanotechnology Authors: Raje ChouhanA. Bajpai Source Type: journals

Two-stimuli manipulation of a biological motorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
F1-ATPase is an enzyme acting as a rotary nano-motor. During catalysis subunits of this enzyme complex rotate relative to other parts of the enzyme. Here we demonstrate that the combination of two input stimuli causes stop of motor rotation. Application of either individual stimulus did not significantly influence motor motion. These findings may contribute to the development of logic gates using single biological motor molecules. (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - May 15, 2009 Category: Nanotechnology Authors: Zorica Ristic, Marco Vitali, Alessandro Duci, Christian Gotze, Klaus Kemnitz, Werner Zuschratter, Holger Lill and Dirk Bald Source Type: journals

Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antisense oligonucleotides (AOs) have been shown to induce dystrophin expression in muscles cells of patients with Duchenne Muscular Dystrophy (DMD) and in the mdx mouse, the murine model of DMD. However, ineffective delivery of AOs limits their therapeutic potential. Copolymers of cationic poly(ethylene imine) (PEI) and non-ionic poly(ethylene glycol) (PEG) form stable nanoparticles when complexed with AOs, but the positive surface charge on the resultant PEG-PEI-AO nanoparticles limits their biodistribution. We adapted a modified double emulsion procedure for encapsulating PEG-PEI-AO polyplexes into degradable polylactid...
Source: Journal of Nanobiotechnology - April 7, 2009 Category: Nanotechnology Authors: Shashank R Sirsi, Rebecca C Schray, Margaret A Wheatley and Gordon J Lutz Source Type: journals