Suberanilohydroxamic acid (SAHA), a HDAC inhibitor, suppresses the effect of Treg cells by targeting the c-Myc/CCL1 pathway in glioma stem cells and improves PD-L1 blockade therapy
ConclusionSAHA inhibited the binding of c-Myc with the CCL1 promoter and then suppressed the transcription of CCL1.Additionally, it effectively blocked the interplay of CCL1-CCR8, resulting in reduced activity of Tregs and alleviation of tumor immunosuppression. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Intraoperative radiotherapy combined with spinal stabilization surgery —a novel treatment strategy for spinal metastases based on a first single-center experiences
Conclusion50 kV photon IORT for SM and consecutive unstable spine needing surgical intervention is safe and feasible and can be a promising technique in selected cases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Screening and surveillance recommendations for central nervous system hemangioblastomas in pediatric patients with Von Hippel-Lindau disease
ConclusionWe recommend starting MRI imaging at the age of 12 years with examination intervals every (1-) 2 years depending on CNS involvement. Special attention should be paid to patients with truncating variants. Affected families should be educated regularly on potential tumor-associated symptoms to enable timely MRI imaging and eventually intervention, as CNS hemangioblastoma may develop before screening begins.German clinical trials Register registration numberDRKS00029553, date of registration 08/16/2022, retrospectively registered. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Impact of concurrent antibody –drug conjugates and radiotherapy on symptomatic radiation necrosis in breast cancer patients with brain metastases: a multicenter retrospective study
ConclusionsThis study suggests that concurrent ADC and radiotherapy are associated with a higher risk of SRN in HER2-positive breast cancer patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Comment in reply to Chen et al. Journal of Neuro-Oncology (2023) 165:535 –545 “Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study”
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse
ConclusionCNS embryonal tumors with EWSR1-PLAGL1 rearrangements acquire or include a population of cells with SMARCB1 alterations that are the component that predominate at relapse, suggesting treatment aimed at this disease component at diagnosis should be considered. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Personalized prognosis stratification of newly diagnosed glioblastoma applying a statistical decision tree model
ConclusionA risk stratification algorithm based on significant prognostic factors allowed a personalized early prognosis estimation at the time of GBM diagnosis, that can contribute to a more personalized patient counseling. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
National trends in the treatment of adult diffuse midline gliomas: a rare clinical scenario
ConclusionsDespite being considered ineffective, chemotherapy is still administered in most adult patients diagnosed with DMG. Significant predictors of survival were Charlson-Deyo comorbidity index and race. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research
Improved outcomes for triple negative breast cancer brain metastases patients after stereotactic radiosurgery and new systemic approaches
ConclusionsTNBC patients with BM can achieve longer survival than might have been previously anticipated with median survival now surpassing one year. The use of immunotherapy is associated with increased median OS of 23 months. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research
Neuroradiological features of patients with bilateral macronodular adrenocortical disease and meningiomas associated or not with genetic variants of ARMC5 – a case series
ConclusionRelevant results were found considering the rate of multiple meningiomas and tumor location. This finding reinforces the need for further research into the neurological effects caused by genetic variants ofARMC5 in patients with BMAD. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research
Exploring management and outcomes of elderly patients with glioblastoma using data from two randomised trials (GEINO1401/EX-TEM)
ConclusionIn this trial population of predominantly fit EP, survival was similar to YP despite a proportion receiving less aggressive therapy at diagnosis and recurrence. Advancing age does not appear to be an adverse prognostic factor for glioblastoma when patients are fit for treatment, and a less aggressive approach in selected patients may not compromise outcomes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines
ConclusionTaken together, these data indicate rapid MAPK reactivation upon MAPKi withdrawal as a tumor cell intrinsic rebound-driving mechanism. Furthermore, increased secretion of microglia-recruiting cytokines may play a role in treatment response and rebound growth upon withdrawal, warranting further evaluation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research
Comparative analysis of bevacizumab and LITT for treating radiation necrosis in previously radiated CNS neoplasms: a systematic review and meta-analysis
ConclusionBoth bevacizumab and LITT exhibited favorable clinical and radiological outcomes in managing RN. Bevacizumab was found to be associated with better symptomatic control compared to LITT. Patient-, diagnosis- and lesion-related factors should be considered when choosing the ideal treatment modality for RN to enhance overall patient outcomes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Preoperative neoadjuvant bevacizumab and temozolomide for newly diagnosed and resectable glioblastoma
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Tissue biopsy before resection in glioblastoma: is there an opportunity to improve outcomes with liquid biopsies and pre-operative stereotactic radiosurgery?
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 11, 2024 Category: Cancer & Oncology Source Type: research
