Journal of NeuroimmunologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 17, 2009 Category: Allergy & Immunology Source Type: journals

A change at the top!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 9, 2009 Category: Allergy & Immunology Authors: Cedric S. Raine Tags: Announcement Source Type: journals

Neuroimmunologia: Heri, hodie et crasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As the Journal of Neuroimmunology (JNI) approaches its thirtieth year, some peripatetic reflections on how the field and JNI have evolved might be of interest to our younger readers and to begin with a title embracing Yesterday, Today and Tomorrow, gives one sufficient latitude to cover both journal history and issues currently topical in the publishing arena. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 23, 2009 Category: Allergy & Immunology Authors: Cedric S. Raine Tags: Editorial Source Type: journals

Immune allergic response in Asperger syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Asperger's syndrome is a subgroup of autism characterized by social deficits without language delay, and high cognitive performance. The biological nature of autism is still unknown but there are controversial evidence associating an immune imbalance and autism. Clinical findings, including atopic family history, serum IgE levels as well as cutaneous tests showed that incidence of atopy was higher in the Asperger group compared to the healthy controls. These findings suggest that atopy is frequent in this subgroup of autism implying that allergic inflammation might be an important feature in Asperger syndrome. (S...
Source: Journal of Neuroimmunology - October 19, 2009 Category: Allergy & Immunology Authors: Elizabeth S. Magalhães, Fernanda Pinto-Mariz, Sandra Bastos-Pinto, Adailton T. Pontes, Evandro A. Prado, Leonardo C. deAzevedo Tags: Clinical Neuroimmunology Source Type: journals

Skew in the human caveolin 1 gene upstream purine complex homozygote haplotype compartment in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a skew in the homozygote haplotype compartment in the cases versus controls both in a qualitative and quantitative respect. Excess homozygosity for haplotypes was observed in the MS cases (corrected p (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 15, 2009 Category: Allergy & Immunology Authors: M. Zarif Yeganeh, M. Ghaffarpour, D.D. Farhud, M. Karimlou, M. Ghabaee, A. Haghighi Nazari, H. Najmabadi, M. Ohadi Tags: Clinical Neuroimmunology Source Type: journals

AnnouncementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 13, 2009 Category: Allergy & Immunology Tags: Announcement Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 13, 2009 Category: Allergy & Immunology Source Type: journals

Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Immunomodulatory effects of transplanted mesenchymal stem cells (MSCs) in the treatment of Parkinson's disease were studied in the MPTP-induced mouse model. MPTP treatment induced a significant loss of dopaminergic neurons, decreased expressions of claudin 1, claudin 5 and occludin in the substantia nigra compacta (SNc), and functional damage of the blood brain barrier (BBB). Our study further discovered that infiltration of MBLs into the brain to bind with microglia was detected in the SNc of MPTP-treated mice, suggesting that the BBB compromise and MBL infiltration might be involved in the pathogenesis of MPTP-...
Source: Journal of Neuroimmunology - October 12, 2009 Category: Allergy & Immunology Authors: Yin Xia Chao, Bei Ping He, Samuel Sam Wah Tay Tags: Research Papers Source Type: journals

Effects of facial nerve axotomy on Th2- and Th1-associated chemokine expression in the facial motor nucleus of wild-type and presymptomatic mSOD1 miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, the results indicate that CCL11 is constitutively expressed in the uninjured facial motor nucleus, but CXCL11 is not expressed at all. Facial nerve axotomy induced a shift in CCL11 expression from FMN to astrocytes, whereas CXCL11 was induced in FMN. Differences in the number of CCL11- and CXCL11-expressing cells were observed between WT and mSOD1 mice after facial nerve axotomy. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 9, 2009 Category: Allergy & Immunology Authors: Derek A. Wainwright, Junping Xin, Nichole A. Mesnard, Christine M. Politis, Virginia M. Sanders, Kathryn J. Jones Tags: Research Papers Source Type: journals

Brevicompanine E reduces lipopolysaccharide-induced production of proinflammatory cytokines and enzymes in microglia by inhibiting activation of activator protein-1 and nuclear factor-κBEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Excessive release of proinflammatory cytokines by activated microglia can cause neurotoxicity in neurodegenerative diseases. We found that Brevicompanine E (BE), isolated from a deep ocean sediment derived fungus Penicillium sp., inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX-2) production in microglia. Moreover, electrophoretic mobility shift assay (EMSA) demonstrated that BE attenuated nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) DNA binding activity in LPS-induced microglia. Consistent...
Source: Journal of Neuroimmunology - October 8, 2009 Category: Allergy & Immunology Authors: Xinying Yang, Lin Du, Xuelian Tang, Suk-Yul Jung, Bing Zheng, Byoung Yul Soh, Sung-Yeon Kim, Qianqun Gu, Hyun Park Tags: Research Papers Source Type: journals

AUY954, a selective S1P1 modulator, prevents experimental autoimmune neuritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Experimental autoimmune neuritis (EAN) is a T cell-mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system and an animal model of human inflammatory demyelinating polyradiculoneuropathy. AUY954, which targets selectively the sphingosine-1-phosphate receptor 1 (S1P1), is known to sequester lymphocytes into secondary lymphoid tissues. In EAN rats, AUY954 greatly prevented paraparesis if administrated from the day of immunization. T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic n...
Source: Journal of Neuroimmunology - October 6, 2009 Category: Allergy & Immunology Authors: Zhi-Yuan Zhang, Zhiren Zhang, Caroline Zug, Barbara Nuesslein-Hildesheim, David Leppert, Hermann J. Schluesener Tags: Research Papers Source Type: journals

Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A potential role for TH17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular release of IL-17 and IL-23 following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMC) from children with ASD compared to age-matched typically developing controls. Following stimulation, the concentration of IL-23, but not IL-17, was significantly reduced (p=0.021) in ASD compared to controls. Decreased cellular IL-23 production in ASD warrants further research to determine its rol...
Source: Journal of Neuroimmunology - October 5, 2009 Category: Allergy & Immunology Authors: Charity Onore, Amanda Enstrom, Paula Krakowiak, Irva Hertz-Picciotto, Robin Hansen, Judy Van de Water, Paul Ashwood Tags: Short Communications Source Type: journals

Calprotectin levels in the cerebrospinal fluid reflect disease activity in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Calprotectin is produced by activated monocytes and microglia, and cerebrospinal fluid (CSF) levels could be a marker of neuroinflammation. Calprotectin was detectable in CSF from 13.8% of normal controls, compared to 90.5% of patients with neurological infections (p (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 5, 2009 Category: Allergy & Immunology Authors: Pål Berg-Hansen, Bodvar Vandvik, Magne Fagerhol, Trygve Holmøy Tags: Clinical Neuroimmunology Source Type: journals

The U937 macrophage cell line expresses enzymatically active l-Dopa decarboxylaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In the present study we demonstrate that enzymatically active l-Dopa decarboxylase (DDC) is expressed in U937 cells, an important model of human macrophage function. The mRNA coding for the enzyme was found to be of the neural-type. DDC was detected in both the soluble and membrane fractions. The active molecule is released from the membrane fraction in the absence of detergent. Furthermore, exposure of U937 cells to carbidopa and dopamine considerably affected cell viability. The expression of enzymatically active DDC shows the endogenous production of dopamine in U937 cells and raises new questions about the en...
Source: Journal of Neuroimmunology - October 5, 2009 Category: Allergy & Immunology Authors: Ioanna Kokkinou, Emmanuel G. Fragoulis, Dido Vassilacopoulou Tags: Research Papers Source Type: journals

Expanded TCR Vβ subsets of CD8+ T-cells in late-onset myasthenia gravis: Novel parallels with thymoma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Little is known about pathogenesis – and especially about involvement of CD8+ T-cells – in late-onset myasthenia gravis (LOMG). Remarkably, outstanding CD8+ TCRVβ-subset expansions were found in 64% and 72% of recent onset LOMG or thymoma-associated MG (vs. 16% with early-onset MG (p (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 25, 2009 Category: Allergy & Immunology Authors: B. Tackenberg, K. Schlegel, M. Happel, C. Eienbröker, K. Gellert, W.H. Oertel, A. Meager, N. Willcox, N. Sommer Tags: Clinical Neuroimmunology Source Type: journals

Interferon-beta therapy for multiple sclerosis — Is the injection site the relevant action site?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews current concepts on the immunopathogenesis of MS and presents the hypothesis that the main effect of interferon-beta in MS is mediated by local effects on dendritic cells at the injection site. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 22, 2009 Category: Allergy & Immunology Authors: Derek Smith Tags: Point of View Source Type: journals

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study shows that TNF-α and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 22, 2009 Category: Allergy & Immunology Authors: Angela R. Kamer, Ronald G. Craig, Elizabeth Pirraglia, Ananda P. Dasanayake, Robert G. Norman, Robert J. Boylan, Andrea Nehorayoff, Lidia Glodzik, Miroslaw Brys, Mony J. de Leon Tags: Clinical Neuroimmunology Source Type: journals

Changes in T cell phenotype and activated MAPKs are correlated to impaired cellular responses to antigens and glucocorticoids during HTLV-I infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Lymphocytes of human T-lymphotropic virus type-I (HTLV-I) infected patients were previously found tolerant to mitogenic stimuli as well as glucocorticoid treatment. These data suggest that common signaling events are impaired during this infection. The underlying mechanisms of these phenomena may include changes in cellular composition, cytokine milieu and the differential activation of mitogen-activated protein kinases (MAPKs). We investigated the role of (i) p38 and ERK MAPKs, (ii) lymphocyte subpopulations, (iii) and cytokines implicated in antigen or glucocorticoid-induced immunomodulation. Twenty-one asympto...
Source: Journal of Neuroimmunology - September 22, 2009 Category: Allergy & Immunology Authors: Micheli M. Pillat, Bruna L. Correa, Cláudio F.K. da Rocha, Guilherme C. Müller, Rodrigo P. Lopes, Simone S. Lampert, Antônio L. Teixeira, Márcio Menna-Barreto, Moisés E. Bauer Tags: Clinical Neuroimmunology Source Type: journals

Translational neuroimmunology: A joint meeting of the Israel Society of Neuroimmunology and the Italian Neuroimmunology Association—Conference reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To celebrate ten years of activity for the Israel Society of Neuroimmunology (ISN) and the Italian Neuroimmunology Association (AINI; www.aini.it), a meeting was organized by Ariel Miller, Chairperson of ISN, in collaboration with Francesca Aloisi, President of AINI, on March 31–April 1, 2009 in Tel Aviv. This special event gathered together about 250 participants, 20 invited speakers from both countries and a special guest, Hartmut Wekerle (Germany), former President of the International Society of Neuroimmunology. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 22, 2009 Category: Allergy & Immunology Authors: Ariel Miller, Miriam C. Souroujon, Francesca Aloisi Tags: Conference Report Source Type: journals

Effects of interferon-beta therapy on innate and adaptive immune responses to the human endogenous retroviruses HERV-H and HERV-W, cytokine production, and the lectin complement activation pathway in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The effects of treatment of multiple sclerosis patients with IFN-β on elements in the innate and adaptive immune response were analysed in a longitudinal study. We demonstrate significant decreases in anti-Envelope antibody reactivity for the two closely related Gammaretroviral human endogenous retroviruses (HERVs), HERV-H and HERV-W, as a consequence of IFN-β therapy, closely linked to efficacy of therapy/low disease activity. We also show strong indications of a protective effect of high levels of two components in the innate pathogen-associated molecular pattern recognition: mannan-binding lectin (MBL), and ...
Source: Journal of Neuroimmunology - September 21, 2009 Category: Allergy & Immunology Authors: Thor Petersen, Anné Møller-Larsen, Steffen Thiel, Tomasz Brudek, Troels Krarup Hansen, Tove Christensen Tags: Clinical Neuroimmunology Source Type: journals

Transplanted myogenic progenitor cells express neuronal markers in the CNS and ameliorate disease in Experimental Autoimmune EncephalomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study explores the potential of non-neural progenitor cells for CNS cell therapy. Muscle progenitor cells (MPCs), transplanted either intraventricularly or intraperitonealy, incorporated into the CNS of EAE-induced but not of naïve mice. Some of the migrating MPCs expressed the neuronal marker β-III-Tubulin and gained neuronal morphology. Co-treatment of transplanted mice with the immunomodulatory agent glatiramer acetate (GA, Copaxone) resulted in improved MPCs incorporation and differentiation towards the neuronal pathway. The therapeutic potential of myogenic progenitor cells was demonstrated by amelioration of c...
Source: Journal of Neuroimmunology - September 21, 2009 Category: Allergy & Immunology Authors: Rina Aharoni, Elizabeta Aizman, Ora Fuchs, Ruth Arnon, David Yaffe, Rachel Sarig Tags: Research Papers Source Type: journals

Regulation of CXCL12 and CXCR4 expression by human brain endothelial cells and their role in CD4+ and CD8+ T cell adhesion and transendothelial migrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Chemokines have emerged as important mediators of leukocyte recruitment to the CNS across the normally restrictive blood–brain barrier (BBB). In the present study we investigated the regulation of CXCL12 and its receptor, CXCR4, expression in human brain microvessel endothelial cells (HBMEC) and the effects of CXCL12 on the adhesion and migration of CD4+ and CD8+ T lymphocytes across HBMEC monolayers. Resting HBMEC constitutively expressed CXCL12 and CXCR4. Treatment with TNF-α, IFN-γ, IL-1β and LPS downregulated CXCL12 and CXCR4 expression and CXCL12 ligation induced internalization of CXCR4. The minimal ad...
Source: Journal of Neuroimmunology - September 21, 2009 Category: Allergy & Immunology Authors: Kenneth King Yin Liu, Katerina Dorovini-Zis Tags: Research Papers Source Type: journals

Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Disease modifying effects of interferon (IFN)-β therapy in patients with multiple sclerosis (MS) may be mediated in part through enhanced immunoregulation by the CD56bright subpopulation of natural killer (NK) cells and by Foxp3+ (not italicized) CD4+CD25+ regulatory T cells (Treg). We found that IFN-β-1a(IM) treatment of relapsing–remitting (RR)MS subjects over 12months significantly increased both percentage of CD56bright NK cells and Foxp3 mRNA expression compared to baseline values, untreated RRMS subjects and healthy controls (HC). This striking enhancement of two prominent immunoregulatory pathways lend...
Source: Journal of Neuroimmunology - September 15, 2009 Category: Allergy & Immunology Authors: Arthur A. Vandenbark, Jianya Huan, Marisa Agotsch, Dorian La Tocha, Susan Goelz, Halina Offner, Stefan Lanker, Dennis Bourdette Tags: Short Communications Source Type: journals

2010 Elsevier Awards for Young InvestigatorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 14, 2009 Category: Allergy & Immunology Tags: Announcement Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 14, 2009 Category: Allergy & Immunology Source Type: journals

Inhibition of experimental autoimmune uveitis by amino acid copolymersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Glatiramer acetate (GA), a synthetic random amino acid copolymer, poly(Y, E, A, K)n, is widely used for treatment of multiple sclerosis. It inhibits experimental autoimmune encephalomyelitis (EAE) in mice by competition with the antigen and by induction of regulatory T cells. A novel copolymer, poly (F, Y, A, K)n , designated FYAK, was more effective than GA in its immunomodulatory activity in EAE. Here, FYAK and GA were compared in the amelioration of another disease model in mice, experimental autoimmune uveoretinitis (EAU). When tested by co-immunization with an uveitogenic antigen, FYAK was superior to GA in ...
Source: Journal of Neuroimmunology - September 13, 2009 Category: Allergy & Immunology Authors: Hongen Yin, Barbara P. Vistica, Chi-Chao Chan, Jack L. Strominger, Igal Gery Tags: Research Papers Source Type: journals

Role of dopamine in the physiology of T-cells and dendritic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate effector cells. Because of their fundamental roles in controlling immunity, DCs and T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediate interactions into the nervous system, but can also contribute to the modulation of immunity. Here, we review the emerging role of this neurotransmitter as a regulator of DC and T-cell physiology and, in turn, immune response. Moreover, we discuss how alterations in the dopamine-mediated immune re...
Source: Journal of Neuroimmunology - September 7, 2009 Category: Allergy & Immunology Authors: Rodrigo Pacheco, Carolina E. Prado, Magaly J. Barrientos, Sebastián Bernales Tags: Reviews Source Type: journals

Antibodies to specific EBNA-1 domains and HLA DRB1⁎1501 interact as risk factors for multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Epitope reactivity of multiple sclerosis (MS) plasma antibodies against the Epstein–Barr virus protein EBNA-1 and its association with HLA DRB1⁎1501 status was investigated in a case-referent study. Based on EBNA-1 fragment reactivity and the effect of peptide blocking, four 29–36 amino acid long EBNA-1 fragments were selected for detailed studies. MS cases had increased antibody reactivity against several EBNA-1 domains, of which antibodies against EBNA-1 (amino acid 385–420) in HLA DRB1⁎1501 positive individuals were associated with a 24-fold risk increase for MS. The data need confirmation in a large...
Source: Journal of Neuroimmunology - September 6, 2009 Category: Allergy & Immunology Authors: Peter Sundström, Maria Nyström, Kristina Ruuth, Erik Lundgren Tags: Clinical Neuroimmunology Source Type: journals

Intranasal delivery of ESBA105, a TNF-alpha-inhibitory scFv antibody fragment to the brainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Intranasal drug administration is an attractive route for targeted delivery of large molecular weight compounds to the central nervous system (CNS). The purpose of this study was to assess the feasibility of this non-invasive application method in mice, for delivery of ESBA105, a TNF-alpha inhibitory single-chain antibody fragment (scFv) with a molecular weight of 26.3kDa, to the brain. Pharmacokinetic parameters were determined for different brain regions (olfactory bulb, cerebrum, cerebellum, brain stem) and for serum, following both, intranasal and intravenous administrations of 400μg and 40μg ESBA105, respe...
Source: Journal of Neuroimmunology - September 6, 2009 Category: Allergy & Immunology Authors: Esther Furrer, Valérie Hulmann, David M. Urech Tags: Research Papers Source Type: journals

A tribute to Byron H. WaksmanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On June 19, 2009, a reception sponsored by the Waksman Foundation for Microbiology was held at Woods Hole, MA to honor the achievements of a true pioneer in Neuroimmunology, Dr. Byron H. Waksman. The event also celebrated Dr. Waksman's upcoming 90th birthday in September. In recognition of Byron's seminal contributions to Neuroimmunology, the Journal is providing a platform for the publication of letters received and assembled into a memorial album of the event by his daughter, Nan. Amusing to me was the personalized postage stamp on Nan's letters of invitation. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 6, 2009 Category: Allergy & Immunology Authors: Cedric Raine Tags: Editorial Source Type: journals

Increased serum levels of soluble tumor necrosis factor-α receptor-1 in patients with Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we assessed serum levels of TNF-α and the soluble forms of their receptors, sTNFR1 and sTNFR2, in 46 PD patients and 23 control subjects. Patients with PD had higher levels of sTNFR1 (p=0.048). The concentration of sTNFR1 and sTNFR2 correlated with age (p=0.006 and p=0.022, respectively). Higher levels of sTNFR1 were associated with later disease onset (p=0.048). These results corroborate the role of inflammatory events in the process of neurodegeneration in PD which can be of special relevance in the sporadic form of PD with later onset. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 4, 2009 Category: Allergy & Immunology Authors: Paula Scalzo, Arthur Kümmer, Francisco Cardoso, Antônio Lúcio Teixeira Tags: Short Communications Source Type: journals

A neurotransmitter system that regulates macrophage pro-inflammatory functionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Neurotransmitters released through peripheral and autonomic nerves play an important role in the signaling from the cells of the nervous system to lymphocytes, macrophages and other cells of the immune system. Macrophages are related to numerous physiological and pathological inflammatory processes since their cytokines play an important role in the defensive responses against invasive microorganisms, atherosclerosis progress, insulin resistance, behavior deviation, hematopoiesis feedback, degenerative chronic diseases and the stimulation of the hypothalamus–hypophysis–adrenal axis. Production of pro-inflamma...
Source: Journal of Neuroimmunology - September 4, 2009 Category: Allergy & Immunology Authors: María Guadalupe Reyes-García, Fernando García-Tamayo Tags: Reviews Source Type: journals

Does IgG therapy prevent Alzheimer's disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have recently performed a nationwide survey among individuals suffering from humoral immunodeficiencies (primary antibody deficiencies, PAD) and therefore treated with prophylactic, regular replacement therapy of immunoglobulin G (IgG). The survey was undertaken in order to collect patient-reported data on satisfaction with therapy, worries and fears (disease, IgG therapy) and quality of life (QoL) (). As a side finding of the survey, we observed that none of the participants ≥65years (n=237) suffered from Alzheimer's disease (AD) although we, based on prevalence figures in Sweden, would expect to find 13 patients wit...
Source: Journal of Neuroimmunology - September 1, 2009 Category: Allergy & Immunology Authors: L. Hammarström, S. Hansen, A. Gardulf Tags: Short Communications Source Type: journals

LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We have examined how the chemokine fractalkine/CX3CL1 influences long-term potentiation (LTP) in CA1 mouse hippocampal slices. Field potentials (fEPSPs) were recorded upon electrical stimulation of Schaffer collaterals. It was found that application of CX3CL1 inhibits LTP when present during the critical induction period. LTP impairment (i) failed to occur in CX3CR1 deficient mice (CX3CR1GFP/GFP) and in the presence of okadaic acid (OA); (ii) required the activation of adenosine receptor 3 (A3R), since it was prevented in A3R-deficient mice or by MRS1523, a selective A3R antagonist. Together, these findings indic...
Source: Journal of Neuroimmunology - August 26, 2009 Category: Allergy & Immunology Authors: Laura Maggi, Flavia Trettel, Maria Scianni, Cristina Bertollini, Fabrizio Eusebi, Bertil B. Fredholm, Cristina Limatola Tags: Research Papers Source Type: journals

NaV1.5 sodium channels in a human microglial cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Microglial cells are the major immuno-competent cells in the mammalian brain where they play a crucial role in maintaining the CNS environment in the face of various potentially pathological insults. We have used electrophysiological and pharmacological methods to study a microglial cell line (C13-NJ) derived from the human CNS. In whole-cell patch clamp experiments we identified an inward current that exhibited biophysical hallmarks of a classical voltage-gated Na+ channel. This identification was confirmed by further experiments in which the current was eliminated by removal of Na+ from the bathing medium. Rela...
Source: Journal of Neuroimmunology - August 20, 2009 Category: Allergy & Immunology Authors: E. Nicholson, A.D. Randall Tags: Research Papers Source Type: journals

Expression of TH1 and TH17 cytokines and transcription factors in multiple sclerosis patients: Does baseline T-Bet mRNA predict the response to interferon-beta treatment?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We studied the effect of one-year interferon (IFN)-beta treatment on the in vivo mRNA expression of IFN-γ, interleukin (IL)-17, T-bet and RoR-γt, on peripheral blood mononuclear cells (PBMC) from 36 multiple sclerosis (MS) patients. In the total MS group, IFN-beta induced decrease in mRNA levels of IFN-γ and T-bet (p (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 19, 2009 Category: Allergy & Immunology Authors: Jelena Drulovic, Emina Savic, Tatjana Pekmezovic, Sarlota Mesaros, Nebojsa Stojsavljevic, Irena Dujmovic-Basuroski, Jelena Kostic, Vladimir Vasic, Marija Mostarica Stojkovic, Dusan Popadic Tags: Clinical Neuroimmunology Source Type: journals

Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct siteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and some inflammatory variables. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 19, 2009 Category: Allergy & Immunology Authors: Antonino Tuttolomondo, Riccardo Di Sciacca, Domenico Di Raimondo, Antonia Serio, Gisella D'Aguanno, Sergio La Placa, Rosaria Pecoraro, Valentina Arnao, Luciana Marino, Serena Monaco, Eraldo Natalè, Giuseppe Licata, Antonio Pinto Tags: Clinical Neuroimmunology Source Type: journals

Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: An in vitro studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we show that serum samples from seropositive NMO patients (21) induce a higher rate of cell death compared with sera from seronegative NMO (16), relapsing–remitting MS (20) patients, and healthy controls (24) on primary cultures of astrocytes. Similar results were obtained by two different techniques: lactate dehydrogenase release and tetrazolium-based viability assay. Cell death was only observed in the presence of active complement. The complement-dependent cytotoxicity was not accompanied by caspase-3/7 activation or increase in the percentage of apoptotic cells. Our data show that NMO-IgG induces a comp...
Source: Journal of Neuroimmunology - August 19, 2009 Category: Allergy & Immunology Authors: Lidia Sabater, Albert Giralt, Anna Boronat, Karolina Hankiewicz, Yolanda Blanco, Sara Llufriu, Jordi Alberch, Francesc Graus, Albert Saiz Tags: Research Papers Source Type: journals

Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Th1/Th17 cells, secreting both IFNγ and IL-17, are often associated with inflammatory pathology. We cloned and studied the cytokine phenotypes of MBP-specific, TCR-identical encephalitogenic CD4+ cells in relationship to Th1- and Th17-associated transcription factors T-bet and RORγt. IFNγ-producing cells could be sub-divided into those that are T-bet+/RORγt− and those that are T-bet+/RORγt+. The latter comprises a spectrum of phenotypes, as defined by IL-17 production, and can be induced to up-regulate IL-23R with IL-12 or IL-23. The former, bona fide Th1 cells, lack IL-23R expression under all conditions....
Source: Journal of Neuroimmunology - August 18, 2009 Category: Allergy & Immunology Authors: Sara Abromson-Leeman, Roderick T. Bronson, Martin E. Dorf Tags: Research Papers Source Type: journals

Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Activated microglial cells generate reactive oxygen species (ROS), which have detrimental effects in neuroinflammatory and neurodegenerative diseases. In the present study, we have identified a novel mechanism involved in microglial NADPH oxidase-mediated ROS production. In PMA-stimulated microglia, ROS production was substantially reduced upon inhibition of the non-selective cation channel TRPV1 with La3+, ruthenium red, capsazepine and 5-iodo-resinferatoxin. Furthermore, sustained membrane depolarization, a hallmark of NADPH oxidase activity in phagocytes, was found to induce non-selective cation/TRPV1 channel ...
Source: Journal of Neuroimmunology - August 17, 2009 Category: Allergy & Immunology Authors: Tom Schilling, Claudia Eder Tags: Short Communications Source Type: journals

Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In ALS, evidence suggests immune reactions in disease pathogenesis. Although immunological changes point to adaptive immune response, whether humoral or cellular response dominates during disease course is unknown. The study aim was to evaluate humoral immune response in ALS patients during disease progression. Circulating immune complexes (CICs), IgG, and IgM in sera of ALS patients and matching controls were evaluated after each of two visits. Results showed significantly elevated CICs and IgG in ALS patient sera. CICs decreased to control levels at the second visit, yet IgG remained higher than controls. Serum...
Source: Journal of Neuroimmunology - August 16, 2009 Category: Allergy & Immunology Authors: Islam A. Saleh, Theresa Zesiewicz, Yong Xie, Kelly L. Sullivan, Amber M. Miller, Nicole Kuzmin-Nichols, Paul R. Sanberg, Svitlana Garbuzova-Davis Tags: Clinical Neuroimmunology Source Type: journals

AnnouncementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 8, 2009 Category: Allergy & Immunology Tags: Announcement Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 8, 2009 Category: Allergy & Immunology Source Type: journals

Corrigendum to “Combined treatment with minocycline and prednisone attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice” [J. Neuroimmunol. 210 (2009)22–29]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors regret that an error occurred in the above published article. On the first page, second paragraph, line 7 (Brundula et al., 2002) should read as (Popovic et al., 2002; Brundula et al., 2002). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 6, 2009 Category: Allergy & Immunology Authors: Xiaohong Chen, Xueqiang Hu, Yan Zou, Rongbiao Pi, Mei Liu, Tieqiao Wang, Xueping Zheng, Meng Liu, Mingdong Lin, Peiqing Liu, Liang Tao Tags: Corrigenda Source Type: journals

Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The beneficial effects of estrogens in multiple sclerosis are thought to be mediated exclusively by the classical nuclear estrogen receptors ERα and ERβ. However, recently many reports revealed that estrogens are able to mediate rapid signals through a G protein-coupled receptor (GPCR), known as GPR30. In the present study, we set out to explore whether effects mediated through this receptor were anti-inflammatory and could account for some of the beneficial effects of estrogen. We demonstrate that GPR30 is expressed in both human and mouse immune cells. Furthermore a GPR30-selective agonist, G-1, previously de...
Source: Journal of Neuroimmunology - August 6, 2009 Category: Allergy & Immunology Authors: Eric Blasko, Christopher A. Haskell, Stewart Leung, Giovanna Gualtieri, Meredith Halks-Miller, Mithra Mahmoudi, Megan K. Dennis, Eric R. Prossnitz, William J. Karpus, Richard Horuk Tags: Research Papers Source Type: journals

Erratum to "GABA, a natural immunomodulator of T lymphocytes" [J. Neuroimmunol. 205 (2008) 44-50]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The publisher regrets that the author listing was published incorrectly in the above article. The correct author listing is given above. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 5, 2009 Category: Allergy & Immunology Authors: Helen Bjurström, JunYang Wang, Ida Ericsson, Martin Bengtsson, Yawei Liu, Suresh Kumar-Mendu, Shohreh Issazadeh-Navikas, Bryndis Birnir Tags: Errata Source Type: journals

Prothrombin kringle-2-induced oxidative stress contributes to the death of cortical neurons in vivo and in vitro: Role of microglial NADPH oxidaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In the present study, we examine whether prothrombin kringle-2 (pKr-2), a domain of prothrombin distinct from thrombin and a potent microglial activator induces reactive oxygen species (ROS) generation through stimulation of microglial NADPH oxidase activity, and whether this phenomenon contributes to oxidative damage and consequent neurodegeneration. Intracortical injection of pKr-2 caused significant loss of cortical neurons in vivo after seven days, as evident from Nissl staining and immunohistochemical analysis using the neuronal-specific nuclear protein (NeuN) antibody. In parallel, pKr-2-activated microglia...
Source: Journal of Neuroimmunology - August 5, 2009 Category: Allergy & Immunology Authors: So Y. Won, Sang-Ho Choi, Byung K. Jin Tags: Research Papers Source Type: journals

Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: LPS activates microglia, which are normally maintained in a quiescent state by CD200–CD200 receptor (CD200R) interaction. MAC-1 (a microglia marker) mRNA expression was increased in mice brains up to 1 year post LPS administration (i.p.). Minocycline treatment did not prevent LPS (5 mg/kg)-induced increase in MAC-1 mRNA but reduced that induced by 0.1 mg/kg LPS. CD200R mRNA decreased starting at 4 h, whereas CD200 mRNA increased at 4 h and decreased at 1 year post LPS inoculation. Thus, LPS-induced changes in CD200–CD200R equilibrium might keep microglia chronically activated. Minocycline does not effec...
Source: Journal of Neuroimmunology - August 4, 2009 Category: Allergy & Immunology Authors: Willias Masocha Tags: Research Papers Source Type: journals

Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4+CD25+FOXP3+CD31+ T-cells in patients with multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Naturally occurring regulatory T-cells (Treg) exhibit impaired function in patients with relapsing-remitting multiple sclerosis (RRMS) resulting from an age-inappropriate disproportion between prevalences of newly generated CD31-coexpressing naive Treg and long-lived memory Treg in the periphery. Recent evidence suggests that the immunomodulatory action of glatiramer acetate (GA) includes effects on Treg function and frequencies. We prospectively assessed suppressive activities and frequencies of Treg and Treg subsets in 15 patients with RRMS undergoing long-term therapy with GA. Treatment for up to six months re...
Source: Journal of Neuroimmunology - August 3, 2009 Category: Allergy & Immunology Authors: Juergen Haas, Mirjam Korporal, Bettina Balint, Benedikt Fritzsching, Alexander Schwarz, Brigitte Wildemann Tags: Short Communications Source Type: journals

Corrigendum to “Suppression of experimental autoimmune myasthenia gravis by combination therapy: Pentoxifylline as a steroid-sparing agent” [J. Neuroimmunol. 201–202 (2008) 128–135]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors regret that during the publication of their paper an error occurred in the Acknowledgement section. The correct Acknowledgements are reproduced below: (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 2, 2009 Category: Allergy & Immunology Authors: Renuka T.R. Menon, Tali Feferman, Revital Aricha, Miriam C. Souroujon, Sara Fuchs Tags: Corrigenda Source Type: journals