Complement propagates visual system pathology following traumatic brain injury
Traumatic brain injury (TBI) is associated with the development of visual system disorders. Visual deficits can present with delay and worsen over time, and may be associated with an ongoing neuroinflammatory ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 17, 2024 Category: Neurology Authors: Davis M. Borucki, Baerbel Rohrer and Stephen Tomlinson Tags: Research Source Type: research
LXR agonism for CNS diseases: promises and challenges
The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while liver X receptor (LXR) may regu... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 16, 2024 Category: Neurology Authors: Ruiyi Zhang, Emily Wuerch, V. Wee Yong and Mengzhou Xue Tags: Review Source Type: research
GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy
Gasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits in sepsis-associated encephalopathy (SAE), yet the underlying mechanisms remain largely unclear. Dynam... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 16, 2024 Category: Neurology Authors: Qun Fu, Yi-Bao Zhang, Chang-Xi Shi, Ming Jiang, Kai Lu, Zi-Hui Fu, Jia-Ping Ruan, Jing Wu and Xiao-Ping Gu Tags: Research Source Type: research
Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
Traumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blood proteins into the brain. The impact of blood proteins, especially fibrinogen, on inf... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 15, 2024 Category: Neurology Authors: Terry Dean, Andrew S. Mendiola, Zhaoqi Yan, Rosa Meza-Acevedo, Belinda Cabriga, Katerina Akassoglou and Jae Kyu Ryu Tags: Research Source Type: research
Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease
The neuroinflammatory process in synucleinopathies of the aging population such as Parkinson ’s disease (PD) and dementia with Lewy bodies (DLB) involves microglial activation as well as infiltration of the CNS... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 15, 2024 Category: Neurology Authors: Michiyo Iba, Somin Kwon, Changyoun Kim, Marcell Szabo, Liam Horan-Portelance, Maria Lopez-Ocasio, Pradeep Dagur, Cassia Overk, Robert A. Rissman and Eliezer Masliah Tags: Research Source Type: research
A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies
Microglia are sexually dimorphic, yet, this critical aspect is often overlooked in neuroscientific studies. Decades of research have revealed the dynamic nature of microglial-neuronal interactions, but seldom ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 15, 2024 Category: Neurology Authors: Ogochukwu J. Uweru, Akhabue K. Okojie, Aparna Trivedi, Jordan Benderoth, Lauren S. Thomas, Georgia Davidson, Kendall Cox and Ukpong B. Eyo Tags: Research Source Type: research
Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 12, 2024 Category: Neurology Authors: Maria T. Cencioni, Roberta Magliozzi, Ilaria Palmisano, Keittisak Suwan, Antonella Mensi, Laura Fuentes-Font, Luisa M. Villar, Jos é I. Fernández-Velasco, Noelia Villarrubia Migallón, Lucienne Costa-Frossard, Enric Monreal, Rehiana Ali, Marina Romozzi, Tags: Research Source Type: research
Nigrostriatal degeneration determines dynamics of glial inflammatory and phagocytic activity
Glial cells are key players in the initiation of innate immunity in neurodegeneration. Upon damage, they switch their basal activation state and acquire new functions in a context and time-dependent manner. Si... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 12, 2024 Category: Neurology Authors: Leyre Ayerra, Miguel Angel Abellanas, Leyre Basurco, Ibon Tamayo, Enrique Conde, Adriana Tavira, Amaya Trigo, Clara Vidaurre, Amaia Vilas, Patxi San Martin-Uriz, Esther Luquin, Pedro Clavero, Elisa Mengual, Sandra Herv ás-Stubbs and Maria S. Aymerich Tags: Research Source Type: research
Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus
Neuropsychiatric lupus (NPSLE) describes the cognitive, memory, and affective emotional burdens faced by many lupus patients. While NPSLE ’s pathogenesis has not been fully elucidated, clinical imaging studies ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 10, 2024 Category: Neurology Authors: Joshua Reynolds, Michelle Huang, Yaxi Li, Myriam Meineck, Tamara Moeckel, Julia Weinmann-Menke, Chandra Mohan, Andreas Schwarting and Chaim Putterman Tags: Research Source Type: research
Correction: Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer ’s disease
(Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 10, 2024 Category: Neurology Authors: Carla Cun í‑López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White and Hazel Quek Tags: Correction Source Type: research
Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord
Mechanical softening of the glial scar region regulates axonal regeneration to impede neurological recovery in central nervous system (CNS) injury. Microglia, a crucial cellular component of the glial scar, fa... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 10, 2024 Category: Neurology Authors: Jinxin Huang, Xuyang Hu, Zeqiang Chen, Fangru Ouyang, Jianjian Li, Yixue Hu, Yuanzhe Zhao, Jingwen Wang, Fei Yao, Juehua Jing and Li Cheng Tags: Research Source Type: research
STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke
Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. The engulfment of stressed synapses by microglia further contributes to the disruption o... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 8, 2024 Category: Neurology Authors: Chaoran Wu, Shiwen Zhang, Hao Sun, Ao Li, Fengsheng Hou, Long Qi and Hong Liao Tags: Research Source Type: research
Impact of microglia isolation and culture methodology on transcriptional profile and function
This study aims to evaluate five differ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 8, 2024 Category: Neurology Authors: Mark Mizrachi and Betty Diamond Tags: Research Source Type: research
Profiling of long non-coding RNAs in hippocampal –entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease
Alzheimer ’s disease (AD) is recognized as the predominant cause of dementia, and neuroimmune processes play a pivotal role in its pathological progression. The involvement of long non-coding RNAs (lncRNAs) in ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 6, 2024 Category: Neurology Authors: Hanyou Liu, Jingying Li, Xue Wang, Shiqi Luo, Dan Luo, Wei Ge and Chao Ma Tags: Research Source Type: research
Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 6, 2024 Category: Neurology Authors: Xiaowei Fei, Li Wang, Ya-nan Dou, Fei Fei, Yanyu Zhang, Weihao Lv, Xin He, Xiuquan Wu, Wangshu Chao, Hongqing Chen, Jialiang Wei, Dakuan Gao and Zhou Fei Tags: Research Source Type: research
