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Size and flow matter in the posterior circulation [Editorial commentaries]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Caplan, L. R Tags: Brain stem / cerebellum, Eating disorders Editorial commentaries Source Type: journals

Lacrimation, conjunctival injection, nasal symptoms... cluster headache, migraine and cranial autonomic symptoms in primary headache disorders--what's new? [Editorial commentaries]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Goadsby, P. J Tags: Brain stem / cerebellum, Cranial nerves, Drugs: CNS (not psychiatric), Headache (including migraine), Pain (Neurology), Ophthalmology Editorial commentaries Source Type: journals

Primary focal dystonia--a disease of brain and mind: motor and psychiatric manifestations have a common neurobiological basis [Editorial commentaries]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Ron, M. A Tags: Movement disorders (other than Parkinsons), Pain (Neurology), Stroke, Ophthalmology, Anxiety disorders (including OCD and PTSD), Mood disorders (including depression), Personality disorders Editorial commentaries Source Type: journals

Evaluation and treatment of inflammatory myopathies [Review]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The major types of idiopathic inflammatory myopathy include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune mediated necrotising myopathy (NM). These myositides appear clinically, histologically and pathogenically distinct. DM, PM and immune mediated NM are responsive to immunosuppressive therapy, in contrast with IBM which is generally refractory to therapy. Greater understanding of the pathogenic bases of these disorders should hopefully lead to better treatment. We need well designed, prospective, double blind, placebo controlled trials in order to determine the best therapeutic options...
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Amato, A A, Barohn, R J Tags: Immunology (including allergy), Muscle disease, Neuromuscular disease, Connective tissue disease, Musculoskeletal syndromes Review Source Type: journals

White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude that MCI subtypes may have different brain substrates, especially in older subjects. Isolated MTA was mainly associated with amnestic MCI subtypes, suggesting AD as the underlying cause. In non-amnestic MCI, the relatively higher prevalence of MTA in combination with WMH may suggest a different pathophysiological origin.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: van de Pol, L A, Verhey, F, Frisoni, G B, Tsolaki, M, Papapostolou, P, Nobili, F, Wahlund, L-O, Minthon, L, Frolich, L, Hampel, H, Soininen, H, Knol, D L, Barkhof, F, Scheltens, P, Visser, P J Tags: Stroke, Memory disorders (Psychiatry) Research papers Source Type: journals

Neuronal activity in the globus pallidus internus in patients with tics [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although the data are descriptive and preliminary, the tic related neuronal activity observed in GPi appears to indicate that the basal ganglia motor circuit is involved in tic movements. The early neuronal activity seen in GPi may reflect premonitory sensations that precede a tic.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Zhuang, P, Hallett, M, Zhang, X, Li, J, Zhang, Y, Li, Y Tags: Research papers Source Type: journals

Microbleeds and post-stroke emotional lability [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that MBs in the thalamus may play a role in the development of PSEL. The importance of MBs in PSEL and other psychiatric conditions in stroke survivors warrants further investigation.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Tang, W K, Chen, Y K, Lu, J Y, Mok, V C T, Xiang, Y T, Ungvari, G S, Ahuja, A T, Wong, K S Tags: Stroke Research papers Source Type: journals

Vertebral artery dominance contributes to basilar artery curvature and peri-vertebrobasilar junctional infarcts [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Unequal VA flow is an important haemodynamic contributor of BA curvature and development of peri-vertebrobasilar junctional infarcts.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Hong, J M, Chung, C-S, Bang, O Y, Yong, S W, Joo, I S, Huh, K Tags: Brain stem / cerebellum, Eating disorders, Radiology, Radiology (diagnostics) Research papers Source Type: journals

Cerebrovascular reactivity and dynamic autoregulation in ischaemic subcortical white matter disease [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cerebral autoregulation and CO2 reactivity are two distinct processes which are not related to WML volume but are related to BP levels and duration of hypertension, respectively. Greater nocturnal dipping was associated with higher ARI values, suggesting preservation of autoregulation in patients with increased vulnerability to reduced cerebral perfusion.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Birns, J, Jarosz, J, Markus, H S, Kalra, L Tags: Neuroimaging, Hypertension, Radiology, Radiology (diagnostics) Research papers Source Type: journals

Pre- and postoperative fMRI and clinical memory performance in temporal lobe epilepsy [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Postoperative memory performance was significantly associated with functional activation contralateral to the side of resection in patients with unilateral TLE, and the function of the contralateral mesial temporal lobe might play an important role in supporting memory performance after temporal lobe resection.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Cheung, M-C, Chan, A S, Lam, J M K, Chan, Y-L Tags: Epilepsy and seizures, Neuroimaging, Radiology, Radiology (diagnostics) Research papers Source Type: journals

Prediction of conversion from clinically isolated syndrome to clinically definite multiple sclerosis according to baseline MRI findings: comparison of revised McDonald criteria and Swanton modified criteria [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In conclusion, Swanton’s modified criteria are more sensitive and accurate (but not significantly so). However, Swanton’s criteria are simpler to use and have equally high specificity and PPV.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Lo, C-P, Kao, H-W, Chen, S-Y, Hsueh, C-J, Lin, W-C, Hsu, W-L, Wu, D-K, Liu, G-C Tags: Immunology (including allergy), Multiple sclerosis Research papers Source Type: journals

Cerebrospinal fluid anti-myelin antibodies are related to magnetic resonance measures of disease activity in multiple sclerosis [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CSF anti-myelin IgG antibodies are promising specific biomarkers in CIS and relapse onset MS and correlate with MR measures of disease activity.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Vogt, M H J, Teunissen, C E, Iacobaeus, E, Heijnen, D A M, Breij, E C W, Olsson, T, Brundin, L, Killestein, J, Dijkstra, C. D Tags: Immunology (including allergy), Multiple sclerosis Research papers Source Type: journals

Cranial autonomic symptoms in migraine: characteristics and comparison with cluster headache [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CAS were present in half of our migraine patients and the clinical features may help differentiate migraine from CH.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Lai, T-H, Fuh, J-L, Wang, S-J Tags: Headache (including migraine), Pain (Neurology), Ophthalmology Research papers Source Type: journals

Evaluation of prednisolone treatment in the acute phase of neuralgic amyotrophy: an observational study [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Oral prednisolone seems effective in the acute phase of neuralgic amyotrophy with the current results supporting previous case reports. A regimen of oral prednisolone is therefore recommended in the acute phase of the syndrome pending a prospective, randomised trial verifying the results obtained.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: van Eijk, J J J, van Alfen, N, Berrevoets, M, van der Wilt, G J, Pillen, S, van Engelen, B G M Tags: Neuromuscular disease, Pain (Neurology), Peripheral nerve disease, Pain (palliative care), Pain (anaesthesia), Drugs: musculoskeletal and joint diseases Research papers Source Type: journals

Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The CACNA1A S218L mutation is associated with familial hemiplegic migraine, ataxia and/or ESCEATHT. A minority of S218L mutation carriers have the complete ESCEATHT phenotype but a high percentage of patients had one or more ESCEATHT symptoms. As the S218L mutation enhances the propensity for cortical spreading depression (CSD), we postulate a role for CSD not only in hemiplegic migraine but also in early seizures and cerebral oedema after trivial head trauma. As this combination of symptoms is part of the unexplained "juvenile head trauma syndrome", a similar molecular mechanism may underlie this disorder.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Stam, A H, Luijckx, G-J, Poll-The, B T, Ginjaar, I B, Frants, R R, Haan, J, Ferrari, M D, Terwindt, G M, van den Maagdenberg, A M J M Tags: Brain stem / cerebellum, Epilepsy and seizures, Headache (including migraine), Child and adolescent Psychiatry Research papers Source Type: journals

The longitudinal profile of CSF markers during external lumbar drainage [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Evidence is provided that ELD is producing measurable changes in the CSF composition of patients with iNPH. The present paper discusses how such changes may be implicated in the pathophysiology of the condition.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Tarnaris, A, Toma, A K, Chapman, M D, Petzold, A, Kitchen, N D, Keir, G, Watkins, L D Tags: Hydrocephalus Research papers Source Type: journals

Serial stereotactic biopsy of brainstem lesions in adults improves diagnostic accuracy compared with MRI only [Research papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Intra-axial brainstem lesions with a radiological pattern of glioma represent a very heterogeneous tumour group with completely different outcomes. Radiological features alone are not reliable for diagnostic classification. Stereotactic biopsy is a safe method to obtain a valid tissue diagnosis, which is indispensible for treatment decision.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Rachinger, W, Grau, S, Holtmannspotter, M, Herms, J, Tonn, J-C, Kreth, F W Tags: Immunology (including allergy), Neurooncology, CNS cancer, Radiology, Surgical diagnostic tests Research papers Source Type: journals

The oldest old Creutzfeldt-Jakob disease case [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sporadic Creutzfeldt–Jakob Disease (sCJD) is a rapidly progressive neurodegenerative disorder usually affecting people between 60 and 70 years old, with only anecdotal cases presenting at 90 years or older. The clinical phenotype of sCJD is highly variable. Diagnosis of sCJD should be considered in the differential diagnosis of rapidly evolving ataxic or dementing syndromes with or without epileptic seizures, regardless of the patient age. While the recognition of atypical phenotypes in subject 90 years or older can provide additional diagnostic challenge, it must be underlined that neuropathology is still the "gold ...
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Buganza, M, Ferrari, S, Cecchini, M E, Orrico, D, Monaco, S, Zanusso, G Tags: Memory disorders (Neurology), Epilepsy and seizures, Infection (Neurology), Variant Creutzfeld-Jakob Disease, Neuropathology, Memory disorders (Psychiatry) Short reports Source Type: journals

Isolated toe paralysis caused by a small cortical infarction [Neurological pictures]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Cattaneo, L, Cucurachi, L, Pavesi, G Tags: Neuroimaging, Stroke Neurological pictures Source Type: journals

Emotion recognition in progressive supranuclear palsy [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the extent to which emotion recognition is affected by PSP. Although deficits in the recognition of emotion have been reported in several diseases which share clinicopathological characteristics with PSP, it has never been studied systematically in PSP. Twenty-four patients with probable or definite PSP and matched healthy controls were studied using tests of facial identity and facial emotion recognition. Patients were not impaired in recognising famous faces, but they showed significant deficits in the recognition of emotions, particularly negative emotions. Moreover, emotion recognition was strongly ...
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Ghosh, B C P, Rowe, J B, Calder, A J, Hodges, J R, Bak, T H Tags: Cranial nerves, Drugs: CNS (not psychiatric), Movement disorders (other than Parkinsons), Ophthalmology Short reports Source Type: journals

Prevalence of fatigue and depression in ALS patients and change over time [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Fatigue was more prevalent and persistent than depression, although 15% (34/223) of patients had both conditions. Fatigue but not depression was associated with ALS severity. The two conditions appear to be independent, although sometimes co-occurring, and both warrant consideration in evaluating patient functioning and treatment.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: McElhiney, M C, Rabkin, J G, Gordon, P H, Goetz, R, Mitsumoto, H Tags: Motor neurone disease, Neuromuscular disease, Spinal cord, Mood disorders (including depression) Short reports Source Type: journals

Huge primary intracranial hydatid cysts [Neurological pictures]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Taghipoor, M, Razmkon, A Tags: Cranial nerves, Headache (including migraine), Neuroimaging, Pain (Neurology), Ophthalmology, Surgical oncology Neurological pictures Source Type: journals

Craniopharyngiomas in the posterior fossa: a rare subgroup, diagnosis, management and outcomes [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Posterior fossa craniopharyngiomas are rare and may be considered an independent subgroup of classifications. Tumours arising from the sellar region and extending to the posterior fossa present with their own unusual set of characteristics. These tumours can be radically and safely removed with a combined supra- and intratentorial approach.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Zhou, L, Luo, L, Xu, J, Li, Q, Chen, J, Jiang, S, Cai, B, You, C Tags: Cranial nerves, Headache (including migraine), Pain (Neurology), Ophthalmology Short reports Source Type: journals

Bilateral internal carotid artery dissection due to elongated styloid processes and shaking dancing [Neurological pictures]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Faivre, A, Abdelfettah, Z, Rodriguez, S, Nicoli, F Tags: Cranial nerves, Drugs: CNS (not psychiatric), Headache (including migraine), Pain (Neurology), Stroke, Ophthalmology, Radiology, Radiology (diagnostics) Neurological pictures Source Type: journals

Thrombolysis targeting MRI defined tissue at risk in minor stroke [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Treatment with IV-tPA based on MRI criteria was safe and appeared to be effective in this small series of patients with minor stroke.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Kruetzelmann, A, Siemonsen, S, Gerloff, C, Rosenkranz, M, Rother, J, Fiehler, J, Thomalla, G Tags: Stroke Short reports Source Type: journals

Primary angiitis of the central nervous system: response to mycophenolate mofetil [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary angiitis of the central nervous system (PACNS) is a rare inflammatory disease restricted to the CNS of unknown cause. Clinical presentation and evolution are highly variable with potentially fluctuating signs and symptoms. Brain imaging often shows supratentorial ischaemic lesions. Definite diagnosis is established by brain biopsy. Treatment usually combines glucocorticosteroids and cyclophosphamide. A case of PACNS is reported here, which was proved by a brain biopsy and characterised by unusually prominent involvement of the posterior cerebral fossa. Successful treatment with mycophenolate mofetil in combination ...
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Chenevier, F, Renoux, C, Marignier, R, Durand-Dubief, F, Hermier, M, Streichenberger, N, Vukusic, S, Confavreux, C Tags: Neuroimaging, Radiology, Drugs: musculoskeletal and joint diseases, Vascularitis, Surgical diagnostic tests Short reports Source Type: journals

Relapsing neuromyelitis optica: long term history and clinical predictors of death [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: RNMO is a very rapidly disabling disease affecting primarily young women. This study has identified clinical features that predict a poor outcome. These findings suggest that early and aggressive immunotherapy might be warranted in RNMO.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Cabre, P, Gonzalez-Quevedo, A, Bonnan, M, Saiz, A, Olindo, S, Graus, F, Smadja, D, Merle, H, Thomas, L, Cabrera-Gomez, J A Tags: Immunology (including allergy), Cranial nerves, Multiple sclerosis, Ophthalmology Short reports Source Type: journals

Patterns of hearing loss after microvascular decompression for hemifacial spasm [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this large study, permanent hearing loss occurred in 16 patients (2.2%). Patients with a mild hearing loss with a good SDS (cochlear type) demonstrated much better prognosis than those with poor SDS (retrocochlear type) or total deafness. In addition, total deafness after surgery had no chance of recovery to preoperative hearing capacity.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Park, K, Hong, S H, Hong, S D, Cho, Y-S, Chung, W-H, Ryu, N G. Tags: Disability, Ear, nose and throat/otolaryngology Short reports Source Type: journals

Increasing incidence of elderly onset patients with myasthenia gravis in a local area of Japan [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The increasing incidence of elderly onset MG in Japanese patients similar to that reported in Caucasians has been confirmed. The clinical features suggest different immunological backgrounds between young onset and elderly onset MG patients, irrespective of the ethnic background.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Matsui, N, Nakane, S, Nakagawa, Y, Kondo, K, Mitsui, T, Matsumoto, T, Arisawa, K, Kaji, R Tags: Immunology (including allergy), Neuromuscular disease Short reports Source Type: journals

Staged gamma knife radiosurgery for large critically located benign meningiomas: evaluation of a series comprising 20 patients [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: As a result of excellent tumour control at a low concomitant morbidity, staged radiosurgical treatment for meningiomas represents a safe treatment modality that can be recommended for meningiomas in critical locations either after incomplete surgery or as primary treatment for patients with significant comorbidity.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Haselsberger, K, Maier, T, Dominikus, K, Holl, E, Kurschel, S, Ofner-Kopeinig, P, Unger, F Tags: Neurooncology, CNS cancer, Radiology, Surgical oncology Short reports Source Type: journals

Primary focal dystonia: evidence for distinct neuropsychiatric and personality profiles [Short reports]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients with PFD show distinct neuropsychiatric and personality profiles of the anxiety spectrum. PFD should therefore be viewed as a neuropsychiatric disorder rather than a pure movement disorder.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Lencer, R, Steinlechner, S, Stahlberg, J, Rehling, H, Orth, M, Baeumer, T, Rumpf, H-J, Meyer, C, Klein, C, Muenchau, A, Hagenah, J Tags: Movement disorders (other than Parkinsons), Anxiety disorders (including OCD and PTSD), Personality disorders Short reports Source Type: journals

Complementary mutations in seipin gene in a patient with Berardinelli-Seip congenital lipodystrophy and dystonia: phenotype variability suggests multiple roles of seipin gene [PostScript]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Wu, Y-R, Hung, S-I, Chang, Y-C, Chen, S-T, Lin, Y-L, Chung, W-H Tags: PostScript Source Type: journals

A variable neurodegenerative phenotype with polymerase {gamma} mutation [PostScript]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 18, 2009 Category: Neurosurgery Authors: Stricker, S, Pruss, H, Horvath, R, Baruffini, E, Lodi, T, Siebert, E, Endres, M, Zschenderlein, R, Meisel, A Tags: PostScript Source Type: journals

[Editorial commentaries] Size and flow matter in the posterior circulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Caplan, L. R Tags: Brain stem / cerebellum, Eating disorders Editorial commentaries Source Type: journals

[Editorial commentaries] Lacrimation, conjunctival injection, nasal symptoms... cluster headache, migraine and cranial autonomic symptoms in primary headache disorders--what's new?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Goadsby, P. J Tags: Brain stem / cerebellum, Cranial nerves, Drugs: CNS (not psychiatric), Headache (including migraine), Pain (Neurology), Ophthalmology Editorial commentaries Source Type: journals

[Editorial commentaries] Primary focal dystonia--a disease of brain and mind: motor and psychiatric manifestations have a common neurobiological basisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Ron, M. A Tags: Movement disorders (other than Parkinsons), Pain (Neurology), Stroke, Ophthalmology, Anxiety disorders (including OCD and PTSD), Mood disorders (including depression), Personality disorders Editorial commentaries Source Type: journals

[Review] Evaluation and treatment of inflammatory myopathiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The major types of idiopathic inflammatory myopathy include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune mediated necrotising myopathy (NM). These myositides appear clinically, histologically and pathogenically distinct. DM, PM and immune mediated NM are responsive to immunosuppressive therapy, in contrast with IBM which is generally refractory to therapy. Greater understanding of the pathogenic bases of these disorders should hopefully lead to better treatment. We need well designed, prospective, double blind, placebo controlled trials in order to determine the best therapeutic options...
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Amato, A A, Barohn, R J Tags: Immunology (including allergy), Muscle disease, Neuromuscular disease, Connective tissue disease, Musculoskeletal syndromes Review Source Type: journals

[Research papers] White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude that MCI subtypes may have different brain substrates, especially in older subjects. Isolated MTA was mainly associated with amnestic MCI subtypes, suggesting AD as the underlying cause. In non-amnestic MCI, the relatively higher prevalence of MTA in combination with WMH may suggest a different pathophysiological origin.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: van de Pol, L A, Verhey, F, Frisoni, G B, Tsolaki, M, Papapostolou, P, Nobili, F, Wahlund, L-O, Minthon, L, Frolich, L, Hampel, H, Soininen, H, Knol, D L, Barkhof, F, Scheltens, P, Visser, P J Tags: Stroke, Memory disorders (Psychiatry) Research papers Source Type: journals

[Research papers] Neuronal activity in the globus pallidus internus in patients with ticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although the data are descriptive and preliminary, the tic related neuronal activity observed in GPi appears to indicate that the basal ganglia motor circuit is involved in tic movements. The early neuronal activity seen in GPi may reflect premonitory sensations that precede a tic.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Zhuang, P, Hallett, M, Zhang, X, Li, J, Zhang, Y, Li, Y Tags: Research papers Source Type: journals

[Research papers] Microbleeds and post-stroke emotional labilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that MBs in the thalamus may play a role in the development of PSEL. The importance of MBs in PSEL and other psychiatric conditions in stroke survivors warrants further investigation.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Tang, W K, Chen, Y K, Lu, J Y, Mok, V C T, Xiang, Y T, Ungvari, G S, Ahuja, A T, Wong, K S Tags: Stroke Research papers Source Type: journals

[Research papers] Vertebral artery dominance contributes to basilar artery curvature and peri-vertebrobasilar junctional infarctsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Unequal VA flow is an important haemodynamic contributor of BA curvature and development of peri-vertebrobasilar junctional infarcts.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Hong, J M, Chung, C-S, Bang, O Y, Yong, S W, Joo, I S, Huh, K Tags: Brain stem / cerebellum, Eating disorders, Radiology, Radiology (diagnostics) Research papers Source Type: journals

[Research papers] Cerebrovascular reactivity and dynamic autoregulation in ischaemic subcortical white matter diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cerebral autoregulation and CO2 reactivity are two distinct processes which are not related to WML volume but are related to BP levels and duration of hypertension, respectively. Greater nocturnal dipping was associated with higher ARI values, suggesting preservation of autoregulation in patients with increased vulnerability to reduced cerebral perfusion.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Birns, J, Jarosz, J, Markus, H S, Kalra, L Tags: Neuroimaging, Hypertension, Radiology, Radiology (diagnostics) Research papers Source Type: journals

[Research papers] Pre- and postoperative fMRI and clinical memory performance in temporal lobe epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Postoperative memory performance was significantly associated with functional activation contralateral to the side of resection in patients with unilateral TLE, and the function of the contralateral mesial temporal lobe might play an important role in supporting memory performance after temporal lobe resection.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Cheung, M-C, Chan, A S, Lam, J M K, Chan, Y-L Tags: Epilepsy and seizures, Neuroimaging, Radiology, Radiology (diagnostics) Research papers Source Type: journals

[Research papers] Prediction of conversion from clinically isolated syndrome to clinically definite multiple sclerosis according to baseline MRI findings: comparison of revised McDonald criteria and Swanton modified criteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In conclusion, Swanton’s modified criteria are more sensitive and accurate (but not significantly so). However, Swanton’s criteria are simpler to use and have equally high specificity and PPV.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Lo, C-P, Kao, H-W, Chen, S-Y, Hsueh, C-J, Lin, W-C, Hsu, W-L, Wu, D-K, Liu, G-C Tags: Immunology (including allergy), Multiple sclerosis Research papers Source Type: journals

[Research papers] Cerebrospinal fluid anti-myelin antibodies are related to magnetic resonance measures of disease activity in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CSF anti-myelin IgG antibodies are promising specific biomarkers in CIS and relapse onset MS and correlate with MR measures of disease activity.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Vogt, M H J, Teunissen, C E, Iacobaeus, E, Heijnen, D A M, Breij, E C W, Olsson, T, Brundin, L, Killestein, J, Dijkstra, C. D Tags: Immunology (including allergy), Multiple sclerosis Research papers Source Type: journals

[Research papers] Cranial autonomic symptoms in migraine: characteristics and comparison with cluster headacheEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CAS were present in half of our migraine patients and the clinical features may help differentiate migraine from CH.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Lai, T-H, Fuh, J-L, Wang, S-J Tags: Headache (including migraine), Pain (Neurology), Ophthalmology Research papers Source Type: journals

[Research papers] Evaluation of prednisolone treatment in the acute phase of neuralgic amyotrophy: an observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Oral prednisolone seems effective in the acute phase of neuralgic amyotrophy with the current results supporting previous case reports. A regimen of oral prednisolone is therefore recommended in the acute phase of the syndrome pending a prospective, randomised trial verifying the results obtained.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: van Eijk, J J J, van Alfen, N, Berrevoets, M, van der Wilt, G J, Pillen, S, van Engelen, B G M Tags: Neuromuscular disease, Pain (Neurology), Peripheral nerve disease, Pain (palliative care), Pain (anaesthesia), Drugs: musculoskeletal and joint diseases Research papers Source Type: journals

[Research papers] Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The CACNA1A S218L mutation is associated with familial hemiplegic migraine, ataxia and/or ESCEATHT. A minority of S218L mutation carriers have the complete ESCEATHT phenotype but a high percentage of patients had one or more ESCEATHT symptoms. As the S218L mutation enhances the propensity for cortical spreading depression (CSD), we postulate a role for CSD not only in hemiplegic migraine but also in early seizures and cerebral oedema after trivial head trauma. As this combination of symptoms is part of the unexplained "juvenile head trauma syndrome", a similar molecular mechanism may underlie this disorder.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Stam, A H, Luijckx, G-J, Poll-The, B T, Ginjaar, I B, Frants, R R, Haan, J, Ferrari, M D, Terwindt, G M, van den Maagdenberg, A M J M Tags: Brain stem / cerebellum, Epilepsy and seizures, Headache (including migraine), Child and adolescent Psychiatry Research papers Source Type: journals

[Research papers] The longitudinal profile of CSF markers during external lumbar drainageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Evidence is provided that ELD is producing measurable changes in the CSF composition of patients with iNPH. The present paper discusses how such changes may be implicated in the pathophysiology of the condition.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Tarnaris, A, Toma, A K, Chapman, M D, Petzold, A, Kitchen, N D, Keir, G, Watkins, L D Tags: Hydrocephalus Research papers Source Type: journals

[Research papers] Serial stereotactic biopsy of brainstem lesions in adults improves diagnostic accuracy compared with MRI onlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Intra-axial brainstem lesions with a radiological pattern of glioma represent a very heterogeneous tumour group with completely different outcomes. Radiological features alone are not reliable for diagnostic classification. Stereotactic biopsy is a safe method to obtain a valid tissue diagnosis, which is indispensible for treatment decision.
Source: Journal of Neurology, Neurosurgery & Psychiatry - September 17, 2009 Category: Neurosurgery Authors: Rachinger, W, Grau, S, Holtmannspotter, M, Herms, J, Tonn, J-C, Kreth, F W Tags: Immunology (including allergy), Neurooncology, CNS cancer, Radiology, Surgical diagnostic tests Research papers Source Type: journals

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