Sleep characteristics and risk of Alzheimer ’s disease: a systematic review and meta-analysis of longitudinal studies
ConclusionsOur study found the association between various types of sleep problems and an increased risk of AD development. However, these findings should be further validated through additional objective device-based assessments. Additional investigation is required to establish a definitive causal connection between sleep problems and AD. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Seizures in autoimmune-associated epilepsy: a long-term video-EEG monitoring study
(Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Rituximab in non-systemic vasculitic neuropathy: a single-center experience
DiscussionAnti-CD20 therapy might be an alternative in NSVN patients requiring further treatment escalation or treatment switch due to side effects of corticosteroids or cyclophosphamide. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Outcomes of mechanical thrombectomy in patients with acute ischemic stroke and thrombocytopenia: systematic review and meta-analysis
ConclusionAs compared to patients without thrombocytopenia, thrombocytopenic AIS patients undergoing MT displayed lower functional independence and higher mortality rates, with no significant differences in sICH or successful recanalization. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
GBA moderates cognitive reserve's effect on cognitive function in patients with Parkinson's disease
ConclusionsCR, established at different life stages, can be influenced by theGBA rs9628662 genotype, impacting later-life cognition. Validating genotypes and incorporating genotype information when assessing cognitive reserve effects is crucial and can enhance targeted cognitive training. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Rafael Lorente de N ó (1902–1990)
(Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study
ConclusionNeuropsychiatric complications of COVID-19, especially AMS, were common, varied, and associated with in-hospital mortality in a diverse multicenter cohort at an epicenter of the COVID-19 pandemic. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Gait asymmetry and symptom laterality in Parkinson ’s disease: two of a kind?
ConclusionsWe found a striking mismatch between the side and the degree of asymmetry in different motor domains, i.e., in gait, turning, and distal symptom severity in individuals with PD. We speculate that motor execution in different body parts relies on different neural control mechanisms. Our findings warrant further investigation to understand the complexity of gait asymmetry in PD. (Source: Journal of Neurology)
Source: Journal of Neurology - April 23, 2024 Category: Neurology Source Type: research
Improved quality of life and psychological symptoms following mindfulness and cognitive rehabilitation in multiple sclerosis and their mediating role for cognition: a randomized controlled trial
ConclusionsMBCT and CRT reduced a wide array of psychological symptoms and improved mental QoL. These improvements seemed to impact self-reported cognitive problems after both treatments, whereas objective cognitive improvements after MBCT seemed independent of improvement in psychological symptoms. Future studies should investigate long-term sustainability of these beneficial effects.Trial registrationThe trial was prospectively registered in the Dutch Trial registry on 31 May 2017 (NL6285;https://trialsearch.who.int/Trial2.aspx?TrialID=NTR6459). (Source: Journal of Neurology)
Source: Journal of Neurology - April 23, 2024 Category: Neurology Source Type: research
ENSEMBLE PLUS: final results of shorter ocrelizumab infusion from a randomized controlled trial
ConclusionENSEMBLE PLUS demonstrates the safety and tolerability of shorter ocrelizumab infusions. Most patients remained on/switched to shorter infusion after unblinding; IRRs did not strongly influence patient decisions.Clinical Trials Registration: Substudy of ENSEMBLE (NCT03085810). Registration: March 21, 2017. (Source: Journal of Neurology)
Source: Journal of Neurology - April 22, 2024 Category: Neurology Source Type: research
Age-specific prevalence of the different clinical presentations of AD and FTD in young-onset dementia
ConclusionsAmnestic AD is the clinical presentation that increases the most with advancing age, followed by bvFTD, suggesting that there is a differential vulnerability to the effect of ageing within the same neurodegenerative disease. (Source: Journal of Neurology)
Source: Journal of Neurology - April 21, 2024 Category: Neurology Source Type: research
Amyotrophic lateral sclerosis stratification: unveiling patterns with virome, inflammation, and metabolism molecules
AbstractAmyotrophic lateral sclerosis (ALS) is an untreatable and clinically heterogeneous condition primarily affecting motor neurons. The ongoing quest for reliable biomarkers that mirror the disease status and progression has led to investigations that extend beyond motor neurons ’ pathology, encompassing broader systemic factors such as metabolism, immunity, and the microbiome. Our study contributes to this effort by examining the potential role of microbiome-related components, including viral elements, such as torque tenovirus (TTV), and various inflammatory factors, in ALS. In our analysis of serum samples from 10...
Source: Journal of Neurology - April 21, 2024 Category: Neurology Source Type: research
Non-invasive biomarkers for spontaneous intracranial hypotension (SIH) through phase-contrast MRI
ConclusionPhase-contrast MRI might become a valuable tool for SIH diagnosis, especially in patients with CSF –venous fistulas without evidence of spinal extradural fluid collection. (Source: Journal of Neurology)
Source: Journal of Neurology - April 21, 2024 Category: Neurology Source Type: research
Respiratory comorbidities and treatments in Duchenne muscular dystrophy: impact on life expectancy and causes of death
ConclusionsOur results highlight the importance of identifying subclinical hypoventilation in a timely manner and the importance of an active treatment regime upon clinical signs of pneumonia. (Source: Journal of Neurology)
Source: Journal of Neurology - April 17, 2024 Category: Neurology Source Type: research
Effect of siponimod on lymphocyte subsets in active secondary progressive multiple sclerosis and clinical implications
ConclusionsPatients treated with siponimod showed a T and B lymphocyte reduction, especially CD4+, CD3+CD20+ and na ïve regulatory T cells and memory regulatory B cells. Disability progression while on siponimod treatment was associated with a less pronounced effect on B and CD3+CD20+ lymphocytes. (Source: Journal of Neurology)
Source: Journal of Neurology - April 17, 2024 Category: Neurology Source Type: research
