Journal of Neurology
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1444 records returned
Transient gender-related effects in Parkinson’s disease patients with subthalamic stimulation
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Abstract Little is known about the gender-related long-term efficacy and safety after subthalamic nucleus deep brain stimulation (STN
DBS) implant for Parkinson’s disease (PD), although some differences could be expected as recently stated in a short-term
report. We assessed the possible gender-related differences in clinical outcome and disease progression along a 5-year period
after STN DBS for PD. A prospective cohort of PD patients who underwent STN DBS and reached the 5-year follow-up (FU) was
considered. Clinical outcome, disease progression and side effects were assessed at baseline and 1, 3, and 5&...
Source: Journal of Neurology - November 17, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
CSF phospho-tau is independent of age, cognitive status and gender of neurological patientsEmail this article to a colleague.
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Abstract CSF phospho-tau (p-tau181) levels have shown good diagnostic utility in differential diagnosis of Alzheimer disease (AD). Unlike total-tau (t-tau),
age related changes of this promising biomarker are sparsely studied. The aim of the study was to determine whether p-tau181 is dependent on age, cognitive status or gender in patients with different neurological diseases who underwent diagnostic
lumbar puncture and who had no clinical evidence of neurodegenerative diseases. CSF levels of p-tau181 and total-tau (t-tau) of 46 neurologic patients (age range 22–89 years; 22 male, 24 female) were a...
Source: Journal of Neurology - November 17, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Improvement of health-related quality of life in relapsing remitting multiple sclerosis patients after 2 years of treatment with intramuscular interferon-beta-1aEmail this article to a colleague.
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The objective of this study is to assess HR-QoL during 2 years of treatment with
intramuscular INFb and its correlation with disability. In 36 neurological practices in the Netherlands (17), Belgium (16),
United Kingdom (2) and Luxemburg (1), 284 RRMS patients were treated with intramuscular INFb-1a. Physical and mental domains
of HR-QoL were measured by the MS54 Quality of Life (MS54QoL) questionnaire, and disability was assessed by the Multiple Sclerosis
Functional Composite (MSFC) (Timed 25-Foot Walk Test [Timed 25-FWT], 9 Hole Peg Test [9-HPT], Paced Auditory Serial Addition
Test [PASAT]) at baseline and at m...
Source: Journal of Neurology - November 17, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Development of oral cladribine for the treatment of multiple sclerosisEmail this article to a colleague.
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Abstract Multiple sclerosis (MS) is a chronic immune-mediated disorder of the CNS in which autoreactive CD4+ and CD8+ T lymphocytes,
B lymphocytes, antibodies, macrophages and cytokines synergize to attack myelin sheaths and injure underlying axons. Current
disease-modifying drugs (DMDs) for MS require regular and frequent parenteral administration and are associated with limited
long-term treatment adherence. Of all the potential new oral MS agents in development, cladribine is the only therapy with
the potential for short-course dosing. Cladribine is an immunosuppressant that offers targeted, sustained reg...
Source: Journal of Neurology - November 17, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Parkinson’s disease I: glucocerebrosidase mutations, family history of melanoma and questionable effects of rasagilineEmail this article to a colleague.
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Content Type Journal ArticleCategory Journal ClubDOI 10.1007/s00415-009-5383-0Authors
Michael Strupp, Ludwig Maximilian University Department of Neurology Klinikum Großhadern, Marchioninstr. 15 81377 Munich Germany
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - November 17, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Altered callosal function in cerebral microangiopathyEmail this article to a colleague.
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Abstract Callosal dysfunction is known to be evident in a variety of neurodegenerative and inflammatory diseases of the central nervous
system. Cerebral microangiopathy (CMA) may also affect callosal pathways by chronic demyelination. The aim of the present
study was to investigate callosal function with respect to the extent of CMA. Callosal function was tested by a bimanual tapping
task and by analysis of the ipsilateral silent period (iSP) and the transcallosal conduction time (TCT) using transcranial
magnetic stimulation. Results were correlated to the extent of CMA measured by cranial magnetic resonance...
Source: Journal of Neurology - November 16, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Posterior cortical atrophy with [11C] Pittsburgh compound B accumulation in the primary visual cortexEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorsDOI 10.1007/s00415-009-5377-yAuthors
Taiki Kambe, Juntendo University School of Medicine Department of Neurology 2-1-1, Hongo Bunkyo-ku Tokyo 113-8421 JapanYumiko Motoi, Juntendo University School of Medicine Department of Neurology 2-1-1, Hongo Bunkyo-ku Tokyo 113-8421 JapanKenji Ishii, Tokyo Metropolitan Institute of Gerontology Positron Medical Center 1-1 Nakacho Itabashi Tokyo 173-0022 JapanNobutaka Hattori, Juntendo University School of Medicine Department of Neurology 2-1-1, Hongo Bunkyo-ku Tokyo 113-8421 Japan
Journal Journal of NeurologyOnline ISS...
Source: Journal of Neurology - November 14, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Erratum to: The number and nature of emergency department encounters in patients with deep brain stimulatorsEmail this article to a colleague.
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Content Type Journal ArticleCategory ErratumDOI 10.1007/s00415-009-5374-1Authors
Andrew S. Resnick, University of Florida Department of Neurology Gainesville USAKelly D. Foote, University of Florida Department of Neurosurgery Gainesville USARamon L. Rodriguez, University of Florida Department of Neurology Gainesville USAIrene A. Malaty, University of Florida Department of Neurology Gainesville USAJoel L. Moll, University of Florida Department of Emergency Medicine Gainesville USADonna L. Carden, University of Florida Department of Emergency Medicine Gainesville USANolie E. Krock, University of Florida Department of Neu...
Source: Journal of Neurology - November 13, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
The first Italian family with tibial muscular dystrophy caused by a novel titin mutationEmail this article to a colleague.
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We report here the first Italian cases of TTN mutated titinopathy. The proband, a 60 year-old female, had the first muscular signs at the age of 59 years, with difficulty
in walking and right foot drop. Muscle imaging showed selective fatty degenerative change in the anterior compartment of leg
muscles. Her 67 year-old brother, started to show muscle weakness, pain at lower limbs and hypertrophy of calf muscles at
the age of 66 years. Their mother began to show foot drop and impaired walking from the age of 60 years. Other relatives are
reported to be affected in a similar way. Because the phen...
Source: Journal of Neurology - November 13, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Erratum to: Alzheimer’s disease, but not ageing or depression, affects dual-taskingEmail this article to a colleague.
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Content Type Journal ArticleCategory ErratumDOI 10.1007/s00415-009-5375-0Authors
Reiner Kaschel, University of Osnabrück Institute of Psychology, Department of Human Sciences Seminarstr. 20 49074 Osnabrück GermanyRobert H. Logie, University of Edinburgh Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, Human Cognitive Neuroscience Edinburgh EH8 9JZ UKMiguel Kazén, University of Osnabrück Institute of Psychology, Department of Human Sciences Seminarstr. 20 49074 Osnabrück GermanySergio Della Sala, University of Edinburgh Department of Psychology, Centre for Cognitive Ageing and Cogni...
Source: Journal of Neurology - November 12, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Apraxia in progressive nonfluent aphasiaEmail this article to a colleague.
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Abstract The clinical and neuroanatomical correlates of specific apraxias in neurodegenerative disease are not well understood. Here
we addressed this issue in progressive nonfluent aphasia (PNFA), a canonical subtype of frontotemporal lobar degeneration
that has been consistently associated with apraxia of speech (AOS) and in some cases orofacial apraxia, limb apraxia and/or
parkinsonism. Sixteen patients with PNFA according to current consensus criteria were studied. Three patients had a corticobasal
syndrome (CBS) and two a progressive supranuclear palsy (PSP) syndrome. Speech, orofacial and limb praxis f...
Source: Journal of Neurology - November 12, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Communications of the European neurological societyEmail this article to a colleague.
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Content Type Journal ArticleCategory ENS CommunicationsDOI 10.1007/s00415-009-5373-2
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - November 11, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Use of the muscle volume analyzer to evaluate enzyme replacement therapy in late-onset Pompe diseaseEmail this article to a colleague.
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In this study, a 26-year-old female on invasive ventilation due to late-onset
Pompe disease was treated with enzyme replacement therapy (ERT) for 12 months. MVA measurements demonstrated time-dependent
improvement from the baseline compared to HHD measurements, showing remarkably fluctuating muscle strength. Thus, the MVA
can be used as an alternative, particularly for patients suffering from severe limb muscle weakness.
Content Type Journal ArticleCategory Letter to the editorsDOI 10.1007/s00415-009-5367-0Authors
Fuminobu Sugai, Osaka University Graduate School of Medicine Department of Neurology (D4) 2-2 Yam...
Source: Journal of Neurology - November 11, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Domenico Cotugno (1736–1822)Email this article to a colleague.
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Content Type Journal ArticleCategory Pioneers in NeurologyDOI 10.1007/s00415-009-5369-yAuthors
Ermanno Manni, Catholic University Human Physiology Rome ItalyLaura Petrosini, University “Sapienza” of Rome Department of Psychology Rome Italy
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - November 6, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Incidence and risk factors for seizures after heart transplantationEmail this article to a colleague.
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We examined the incidence of seizures
from a population of adult patients who had received heart transplants over a period of 3 years. Brain MRI and clinical data
were analysed to identify the risk factors for the seizures. Eight of the 166 post-transplant patients presented seizures
(4.8%). The first seizures occurred with a mean of 30 days after the transplantation. For seven patients, the mean delay was
8 days, and for one, it was longer, 172 days. The analysis of brain MRI showed two main epileptogenic factors in the early
post-transplant seizures: posterior reversible encephalopathy syndrome (...
Source: Journal of Neurology - November 6, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
VGKC antibody-associated encephalitis, microbleeds and progressive brain atrophyEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorsDOI 10.1007/s00415-009-5370-5Authors
Viktoria Kapina, University Hospital of Geneva and Faculty of Medicine Division of Neurology, Department of Neurosciences Rue Gabrielle Perret-Gentil 4 1211 Geneva 14 SwitzerlandMaria-Isabel Vargas, University Hospital of Geneva and Faculty of Medicine Division of Neuroradiology Rue Gabrielle Perret-Gentil 4 1211 Geneva 14 SwitzerlandSerge Vulliemoz, University Hospital of Geneva and Faculty of Medicine Division of Neurology, Department of Neurosciences Rue Gabrielle Perret-Gentil 4 1211 Geneva 14 SwitzerlandTheodor Landis, U...
Source: Journal of Neurology - November 6, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Vasomotor properties of the M2 segment of the middle cerebral arteryEmail this article to a colleague.
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Abstract Vasomotor response can be tested by means of transcranial Doppler sonography. It is assumed that flow changes during hyperventilation
or breath-holding are due to altered resistance caused by changes in the diameter of vessels distal to the M1 segment of the
middle cerebral artery. Evaluating velocities of the M2 and M1 segments together may help elucidate the vasomotor properties
of distal segments. We simultaneously evaluated the vasomotor properties of the M1 and M2 segments of the middle cerebral
artery in ten healthy volunteers (mean age 21.6 ± 0.9 years) with breath-holding and...
Source: Journal of Neurology - November 4, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Airhead with aurasEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to editorsDOI 10.1007/s00415-009-5368-zAuthors
Nico J. Weerkamp, Atrium Medical Center Department of Neurology Henri Dunantstraat 5 6401 CX Heerlen The NetherlandsPeter J. Koehler, Atrium Medical Center Department of Neurology Henri Dunantstraat 5 6401 CX Heerlen The NetherlandsEwa V. Bergshoeff, Atrium Medical Center Department of Laryngology and Head and Neck Surgery Henri Dunantstraat 5 6401 CX Heerlen The Netherlands
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - November 4, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Early onset probable linezolid-induced encephalopathyEmail this article to a colleague.
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We describe a 41-year-old male who
developed early onset encephalopathy after a day and a half of linezolid therapy. Our patient had at least one significant
risk factor (alcoholism), making linezolid-induced encephalopathy probable based upon the Naranjo probability scale. Clinicians
should be aware of the potential for early onset linezolid-induced neurotoxicity, particularly in patients with concomitant
risk factors.
Content Type Journal ArticleCategory Original CommunicationDOI 10.1007/s00415-009-5340-yAuthors
Jeffery Fletcher, Bronson Methodist Hospital Department of Neurology (Neurocritical Care) 601 John St...
Source: Journal of Neurology - November 4, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Enhanced muscle shortening and impaired Ca2+ channel function in an acute septic myopathy modelEmail this article to a colleague.
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Abstract Myopathies in critically ill patients are increasingly documented. Various animal models of chronic sepsis have been employed
to investigate reduced membrane excitability or altered isometric contractility of skeletal muscle. In contrast, immediate
changes occurring during acute sepsis are significantly under-characterised; L-type Ca2+ channel function or isotonic shortening are examples. We recorded slowly activating L-type Ca2+ currents (I
Ca) in voltage-clamped single intact mouse skeletal muscle fibres and tested the effects of acute challenge with serum fractions
from critical illness myopathy ...
Source: Journal of Neurology - November 4, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Glucocerebrosidase mutations p.L444P and p.N370S are not associated with multisystem atrophy, progressive supranuclear palsy and corticobasal degeneration in Polish patientsEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorsDOI 10.1007/s00415-009-5363-4Authors
Zygmunt Jamrozik, Medical University of Warsaw Department of Neurology Warsaw PolandAgnieszka Lugowska, Institute of Psychiatry and Neurology Department of Genetics Warsaw PolandJaroslaw Slawek, Medical University Department of Neurological-Psychiatric Nursing Gdansk PolandHubert Kwiecinski, Medical University of Warsaw Department of Neurology Warsaw Poland
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - October 31, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Impact of stroke on therapeutic decision making in infective endocarditisEmail this article to a colleague.
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Abstract The diagnosis of infective endocarditis (IE) must be made as soon as possible to initiate antimicrobial therapy and identify
patients at high risk for complications who may be best managed by early surgery. Cerebral complications make the timing of
cardiac surgery difficult. The safety of cardiopulmonary bypass (CPB) surgery in stroke patients remains controversial. Stroke
complicates the outcome of left-sided IE in 20–40% of cases and is associated with poor outcome. The risk of stroke in IE
falls rapidly after the initiation of effective antimicrobial therapy. The risk of embolization is highest...
Source: Journal of Neurology - October 29, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Musty odour, mental retardation, and spastic paraplegia revealing phenylketonuria in adulthoodEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorDOI 10.1007/s00415-009-5358-1Authors
Guillemette Jousserand, University Hospital Department of Neurology 42055 Saint-Etienne Cedex 02 FranceJean-Christophe Antoine, University Hospital Department of Neurology 42055 Saint-Etienne Cedex 02 FranceJean-Philippe Camdessanché, University Hospital Department of Neurology 42055 Saint-Etienne Cedex 02 France
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - October 27, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Alaska, multiple sclerosis, and the vitamin D hypothesisEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorDOI 10.1007/s00415-009-5360-7Authors
Trygve Holmøy, University of Oslo Institute of Immunology Oslo NorwayMargitta T. Kampman, University Hospital of North Norway Department of Neurology Tromsø Norway
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - October 27, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Erratum to: Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosisEmail this article to a colleague.
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Content Type Journal ArticleCategory ErratumDOI 10.1007/s00415-009-5354-5Authors
Stefan Presslauer, Wilhelminenspital Dept. of Neurology Montleartstrasse 37 1160 Vienna AustriaDejan Milosavljevic, Wilhelminenspital Dept. of Laboratory Medicine Vienna AustriaThomas Brücke, Wilhelminenspital Dept. of Neurology Montleartstrasse 37 1160 Vienna AustriaPeter Bayer, Wilhelminenspital Dept. of Laboratory Medicine Vienna AustriaWolfgang Hübl, Wilhelminenspital Dept. of Laboratory Medicine Vienna Austria
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - October 22, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
An exploration of ocular fixation in Parkinson’s disease, multiple system atrophy and progressive supranuclear palsyEmail this article to a colleague.
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Abstract Since the basal ganglia are thought to have a role in controlling ocular fixation it is expected that patients with parkinsonian
conditions would show impaired performance in fixation tasks. Our study examines ocular fixation in patients with a range
of parkinsonian conditions (Idiopathic Parkinson’s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy). Eye
movements were recorded from 44 patients and 50 age matched control subjects during ocular fixation both with and without
a visible target. The data for each patient were then characterised in terms of fixation periods and sacca...
Source: Journal of Neurology - October 22, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson’s diseaseEmail this article to a colleague.
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Abstract The brain-derived neurotrophic factor (BDNF) is a potent inhibitor of apoptosis-mediated cell death and neurotoxin-induced
degeneration of dopaminergic neurons. There is a growing body of evidence implicating BDNF in the pathogenesis of Parkinson’s
disease (PD), suggesting it may eventually be used in the development of neuroprotective therapies for PD. The serum BDNF
of 47 PD patients and of 23 control subjects was assessed, and serum BNDF levels were significantly decreased in PD patients
when compared with controls (p = 0.046). Interestingly enough, BDNF correlated positively with a l...
Source: Journal of Neurology - October 22, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Monoamines, BDNF, IL-6 and corticosterone in CSF in patients with Parkinson’s disease and major depressionEmail this article to a colleague.
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Abstract The biochemical basis of major depression (MD) in Parkinson’s disease (PD) is largely unknown. To increase our understanding
of MD in PD patients, the levels of monoamine metabolites (HVA, 5-HIAA and MHPG), BDNF, orexin-A, IL-6 and corticosterone
were examined in cerebrospinal fluid. The analyses were performed in MD patients with (n = 11) and without (n = 12) PD at baseline and after 12 weeks’ of treatment with the antidepressant citalopram, and in patients with solely PD
(n = 14) at baseline and after 12 weeks. The major findings were that PD patients wit...
Source: Journal of Neurology - October 21, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Modafinil for Parkinson’s disease fatigueEmail this article to a colleague.
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This study highlights the problems with recruitment when trialing treatments of non-motor symptoms in PD. A significant
improvement in EDS was seen.
Content Type Journal ArticleCategory Original CommunicationDOI 10.1007/s00415-009-5351-8Authors
Hilary L. Tyne, University of Liverpool, The Walton Centre for Neurology and Neurosurgery Department of Neurological Sciences Lower Lane Liverpool L9 7LJ UKJoanne Taylor, University of Liverpool, The Walton Centre for Neurology and Neurosurgery Department of Neurological Sciences Lower Lane Liverpool L9 7LJ UKGus A. Baker, University of Liverpool, The Walton Centre for Neurolo...
Source: Journal of Neurology - October 20, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Beevor’s sign in facioscapulohumeral muscular dystrophy: an old sign with new implicationsEmail this article to a colleague.
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Abstract Beevor’s sign, an upward deflection of the umbilicus on flexion of the neck, is the result of paralysis of the inferior portion
of the rectus abdominis muscle, so that the upper fibers predominate, pulling the umbilicus upwards. The condition may be
caused by spinal cord injury at or below the level of Th10. It has also been observed in patients with facioscapulohumeral
muscular dystrophy (FSHD). Positive Beevor’s sign has been described as a sign of more than 90% sensitivity and specificity
with regard to diagnosis of FSHD. We investigated 28 patients with FSHD, proven by genetic analysis, and ...
Source: Journal of Neurology - October 17, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Clinical skills and bedside testing: how to teach and assess themEmail this article to a colleague.
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Content Type Journal ArticleCategory Journal ClubDOI 10.1007/s00415-009-5355-4Authors
M. Strupp, Ludwig Maximilian University Department of Neurology, Klinikum Großhadern Marchioninstr. 15 81377 Munich Germany
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - October 16, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Isolated facial diplegia and very late-onset myopathy in two siblings: atypical presentations of facioscapulohumeral dystrophyEmail this article to a colleague.
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This report highlights the clinical heterogeneity and
intrafamily variability of FSHD.
Content Type Journal ArticleCategory Original CommunicationDOI 10.1007/s00415-009-5346-5Authors
Juan J. Figueroa, University of New Mexico Department of Neurology Albuquerque NM USAJohn E. Chapin, University of New Mexico Department of Neurology Albuquerque NM USA
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - October 14, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
A young patient with type C multiple system atrophy and hereditary hemochromatosisEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorsDOI 10.1007/s00415-009-5345-6Authors
Massimiliano Di Filippo, Università degli Studi di Perugia Clinica Neurologica, Ospedale S. Maria della Misericordia Perugia ItalyPiero Floridi, Ospedale S. Maria della Misericordia Sezione di Neuroradiologia Perugia ItalyVera Rossi, Università degli Studi di Perugia Clinica Neurologica, Ospedale S. Maria della Misericordia Perugia ItalyEmanuele Mattucci, Università degli Studi di Perugia Clinica Neurologica, Ospedale S. Maria della Misericordia Perugia ItalyAroldo Rossi, Università degli Studi di Perugia Clinica Neurolog...
Source: Journal of Neurology - October 14, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
The efficacy of radiation monotherapy for Tolosa-Hunt syndromeEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorsDOI 10.1007/s00415-009-5335-8Authors
Yutaka Furukawa, Fukui Prefectural Hospital Department of Neurology Fukui JapanWataru Yamaguchi, Fukui Prefectural Hospital Department of Neurology Fukui JapanKiyoaki Ito, Fukui Prefectural Hospital Department of Neurology Fukui JapanToshio Hamada, Fukui Prefectural Hospital Department of Neurology Fukui JapanHirobumi Miyaji, Fukui Prefectural Hospital Department of Neurology Fukui JapanHiroyasu Tamamura, Fukui Prefectural Hospital Department of Nuclear Medicine Fukui JapanMasahito Yamada, Kanazawa University Graduate School ...
Source: Journal of Neurology - October 13, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Massive intraventricular haemorrhage from aneurysmal rupture: patient proportions and eligibility for intraventricular fibrinolysisEmail this article to a colleague.
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Abstract Massive intraventricular haemorrhage (IVH) complicating aneurysmal subarachnoid haemorrhage (SAH) is associated with a poor
prognosis. Small observational studies suggest favourable results from fibrinolysis of the intraventricular blood. We performed
an observational study on IVH in a large series of patients with SAH to assess the proportion of patients that may benefit
from fibrinolytic treatment. From our prospective database we retrieved patients with aneurysmal SAH admitted between January
2000 and January 2005. We calculated the proportion of patients with massive IVH and the proportion of pa...
Source: Journal of Neurology - October 13, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Magnetization transfer imaging in ‘premanifest’ Huntington’s diseaseEmail this article to a colleague.
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Abstract To investigate whether magnetization transfer imaging (MTI) is a useful detector of diffuse brain abnormalities in ‘premanifest’
carriers of the Huntington’s disease (HD) gene mutation. Furthermore we examined the relations between MTI, clinical measures
and CAG repeat length. Sixteen premanifest carriers of the HD gene without motor manifestation and 14 non-carriers underwent
a clinical evaluation and a MRI scan. MTI analysis of whole brain, grey matter and white matter was performed producing magnetization
transfer ratio (MTR) histograms. A lower peak height of the grey matter MTR histogram ...
Source: Journal of Neurology - October 13, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
A comparison of three measures of upper limb function in Friedreich ataxiaEmail this article to a colleague.
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This study was undertaken to
ascertain the best test for inclusion in a Friedreich Ataxia Functional Composite (FAFC) test for use in clinical studies
and therapeutic trials. The three tests were administered to the dominant and non-dominant upper limbs of 38 individuals with
genetically proven FRDA on two occasions, 12 months apart. The results of testing were correlated with the following disease
parameters; age at disease onset, disease duration and score for the Friedreich Ataxia Rating Scale (FARS). The responsiveness
to change of each test was assessed by measuring the effect size and calculations of the nu...
Source: Journal of Neurology - October 13, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Frequency of the FKRP mutation c.826C>A in isolated hyperCKemia and in limb girdle muscular dystrophy type 2 in German patientsEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorsDOI 10.1007/s00415-009-5349-2Authors
Frank Hanisch, Martin-Luther-Universität Halle-Wittenberg Klinik und Poliklinik für Neurologie Ernst-Grube Str. 40 06097 Halle/Saale GermanyDörte Grimm, Martin-Luther-Universität Halle-Wittenberg Klinik und Poliklinik für Neurologie Ernst-Grube Str. 40 06097 Halle/Saale GermanyStephan Zierz, Martin-Luther-Universität Halle-Wittenberg Klinik und Poliklinik für Neurologie Ernst-Grube Str. 40 06097 Halle/Saale GermanyMarcus Deschauer, Martin-Luther-Universität Halle-Wittenberg Klinik und Poliklinik für Neurologie Ernst-...
Source: Journal of Neurology - October 10, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Olfactory dysfunction following herpetic meningoencephalitisEmail this article to a colleague.
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In conclusion, the present findings show
that olfactory function is often permanently damaged in patients who have had HME. Lesions lead to various patterns of olfactory
loss. Together with histological and clinical data from the literature this suggests further that the olfactory pathway plays
a major role in the spread of herpetic meningoencephalitis. It also raises the question whether the olfactory epithelium serves
as an entry into the brain for other pathogens.
Content Type Journal ArticleCategory Original CommunicationDOI 10.1007/s00415-009-5344-7Authors
Basile Nicolas Landis, Technische Universität Dresde...
Source: Journal of Neurology - October 10, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Effects of immunotherapy on motor cortex excitability in Stiff Person SyndromeEmail this article to a colleague.
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Abstract A number of cortical and spinal excitability variables have been tested in a patient with Stiff Person Syndrome (SPS), before
and after immunotherapy with mycophenolate mofetil, intravenous immunoglobulin and corticosteroids, which normalized plasma
levels of anti-GAD antibodies and dramatically improved the clinical picture. The overlapping time-course of neurophysiological,
clinical and bio-umoral findings suggests that immunotherapy might have changed GABA/Glutamate balance at cortical level,
favoring the former, as reflected by normalization of the startle reflex, lengthening of the cortical sil...
Source: Journal of Neurology - October 10, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Blind spot heterotopia by automated static perimetry to assess static ocular torsion: centro-cecal axis rotation in normalsEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorsDOI 10.1007/s00415-009-5341-xAuthors
Maurizio Versino, Fondazione Istituto Neurologico C. Mondino, IRCCS, Dipartimento Scienze Neurologiche Università di Pavia, UCADH Pavia Via Mondino 2 27100 Pavia ItalyDavid E. Newman-Toker, The Johns Hopkins University School of Medicine, Johns Hopkins Hospital Departments of Neurology and Ophthalmology Baltimore MD USA
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - October 10, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Episodic dysarthria related to vascular medullary compressionEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorsDOI 10.1007/s00415-009-5348-3Authors
Christina Haubrich, University Hospital Aachen Department of Neurology Pauwelsstrasse 30 52074 Aachen GermanyNina Kleiser, University Hospital, RWTH Aachen University Section Neurolinguistics Aachen GermanyChristoph Kosinski, Medical Center Aachen/Bardenberg Department of Neurology Aachen GermanyMichael Mull, University Hospital, RWTH Aachen University Department of Neuroradiology Aachen GermanyBernd J. Kröger, University Hospital, RWTH Aachen University Department of Phoniatry and Pedaudiology Aachen GermanyDagny Esser, Med...
Source: Journal of Neurology - October 10, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
The heart in sporadic inclusion body myositis: a study in 51 patientsEmail this article to a colleague.
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Abstract The purpose of this study was to explore the prevalence and nature of cardiac abnormalities in sporadic inclusion body myositis
(sIBM). Fifty-one sIBM patients were cross-sectionally studied using history-taking, physical examination, measurements of
serum creatine kinase activity, the MB fraction (CK-MB), cardiac troponin T (cTnT) and I (cTnI), a 12-lead electrocardiogram
(ECG) and 2-dimensional echocardiography. Present cardiac history was abnormal in 12 (24%) out of 51 patients, 12 (24%) patients
had abnormalities on ECG, mostly aspecific, and in 12 (24%) patients the echocardiograph showed abnor...
Source: Journal of Neurology - October 8, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
The number and nature of emergency department encounters in patients with deep brain stimulatorsEmail this article to a colleague.
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The objective of the present study was to review the number and nature of ED encounters in patients
with deep brain stimulation (DBS) devices implanted for movement and neuropsychiatric disorders. Methods: The series of encounters
reviewed included 215 unique patients with DBS implantation who were identified using an IRB approved database and a paper
chart review. Patients in the study included those implanted at University of Florida (UF), as well as those implanted at
outside institutions, so long as they were followed at UF. The cohort included n = 215 DBS patients. 25.6% of all 215 patients presented to ...
Source: Journal of Neurology - October 8, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Communications of the European Neurological SocietyEmail this article to a colleague.
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Content Type Journal ArticleCategory ENS CommunicationsDOI 10.1007/s00415-009-5347-4
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - October 1, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Albert Gombault (1844–1904)Email this article to a colleague.
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Content Type Journal ArticleCategory Pioneers in NeurologyDOI 10.1007/s00415-009-5330-0Authors
François Y. Clarac, CNRS Cedex 20 France
Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
Source: Journal of Neurology - October 1, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Predictors and prevalence of low bone mineral density in fully ambulatory persons with multiple sclerosisEmail this article to a colleague.
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This study shows that MS-related variables as well as past exposures differentially
affect BMD at three clinically important skeletal sites. Low BMD is prevalent in these young patients. Bone health should
receive attention in care for persons with MS.
Content Type Journal ArticleCategory Original CommunicationDOI 10.1007/s00415-009-5337-6Authors
Linn Hofsøy Steffensen, University Hospital of North Norway Department of Neurology P.O. Box 33 9038 Tromsø NorwaySvein Ivar Mellgren, University Hospital of North Norway Department of Neurology P.O. Box 33 9038 Tromsø NorwayMargitta T. Kampman, University Hospital of No...
Source: Journal of Neurology - September 30, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Low sensitivity in clinical diagnoses of dementia with Lewy bodiesEmail this article to a colleague.
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Abstract The success of future neurodegenerative disease (ND) therapies depends partly on accurate antemortem diagnoses. Relatively
few prior studies have been performed on large, multicenter-derived datasets to test the accuracy of final clinical ND diagnoses
in relation to definitive neuropathological findings. Data were analyzed from the University of Kentucky Alzheimer’s Disease
Center autopsy series and from the National Alzheimer’s Coordinating Center (NACC) registry. NACC data are derived from 31
different academic medical centers, each with strong clinical expertise and infrastructure pertaining ...
Source: Journal of Neurology - September 30, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Mother–child blood group incompatibility and the risk of multiple sclerosisEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the editorDOI 10.1007/s00415-009-5325-xAuthors
Sreeram V. Ramagopalan, University of Oxford Wellcome Trust Centre for Human Genetics Oxford UKDavid A. Dyment, University of Oxford Wellcome Trust Centre for Human Genetics Oxford UKColleen Guimond, University of British Columbia Department of Medical Genetics Vancouver CanadaSarah-Michelle Orton, University of Oxford Wellcome Trust Centre for Human Genetics Oxford UKIrene M. Yee, University of British Columbia Department of Medical Genetics Vancouver CanadaGeorge C. Ebers, University of Oxford Wellcome Trust Centre for Human...
Source: Journal of Neurology - September 30, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
REM sleep behaviour disorder and visuoperceptive dysfunction: a disorder of the ventral visual stream?Email this article to a colleague.
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Abstract In idiopathic rapid eye movement sleep behaviour disorder (RBD), an association with visuoperceptive disorders has been described.
However, such an association has not been clearly established in RBD secondary to Parkinson’s disease (PD). We compared visuoperceptive
function in four groups of non-demented patients (parkinsonian patients with or without RBD, patients with idiopathic RBD
and control participants) via a procedure enabling the analysis of the various components of visual information processing
and in order to answer the following question: is RBD associated with visuoperceptive and/or...
Source: Journal of Neurology - September 29, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
