Activation of Nrf2/ARE pathway alleviates the cognitive deficits in PS1V97L ‐Tg mouse model of Alzheimer’s disease through modulation of oxidative stress
In PS1V97L ‐Tg mice, oxidative stress became evident and the endogenous antioxidative pathway decreased. Activating the Nrf2/ARE pathway suppressed oxidative stress, decreased amyloid‐β, and improved the cognitive function. Lack of Nrf2 exacerbates the oxidative stress, induces Aβ accumulation, and facil itates the death of neurons. Our results highlight the role of the Nrf2/ARE pathway in regulating oxidative stress of the PS1V97L‐Tg mice and may indicate a potential therapeutic avenue for AD treatment. AbstractOxidative stress refers to an imbalance between oxidative and antioxidative systems due to environmental...
Source: Journal of Neuroscience Research - November 21, 2018 Category: Neuroscience Authors: Yuanruhua Tian, Wei Wang, Lingzhi Xu, Haitao Li, Yiping Wei, Qiaoqi Wu, Jianping Jia Tags: RESEARCH ARTICLE Source Type: research

The role of satellite glial cells in orofacial pain
AbstractSome chronic pain conditions in the orofacial region are common, the mechanisms underlying which are unresolved. Satellite glial cells (SGCs) are the glial cells of the peripheral nervous system. In the sensory ganglia, each neuronal body is surrounded by SGCs forming distinct functional units. The unique structural organization enables SGCs to communicate with each other and with their enwrapped neurons via a variety of ways. There is a growing body of evidence that SGCs can influence the level of neuronal excitability and are involved in the development and/or maintenance of pain. The aim of this review was to su...
Source: Journal of Neuroscience Research - November 19, 2018 Category: Neuroscience Authors: Wenguo Fan, Xiao Zhu, Yifan He, Mengzhu Zhu, Zhi Wu, Fang Huang, Hongwen He Tags: MINIREVIEW Source Type: research

Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction
Purkinje neurons myelinated fibers require intact axonal cytoskeletal organization and axonal transport to effectively transmit neural signals. We show that proteins Band 4.1B and Whirlin cooperatively maintain axonal cytoskeletal integrity at the paranodal and juxtaparanodal regions, and their loss leads to axonal cytoskeletal disorganization and formation of swellings leading to axonal degeneration. AbstractThe cerebellar cortex receives neural information from other brain regions to allow fine motor coordination and motor learning. The primary output neurons from the cerebellum are the Purkinje neurons that transmit inh...
Source: Journal of Neuroscience Research - November 17, 2018 Category: Neuroscience Authors: Julia Saifetiarova, Manzoor A. Bhat Tags: RESEARCH ARTICLE Source Type: research

Cover Image
(Source: Journal of Neuroscience Research)
Source: Journal of Neuroscience Research - November 16, 2018 Category: Neuroscience Tags: COVER IMAGE Source Type: research

Issue Information
Journal of Neuroscience Research, Volume 97, Issue 1, Page 1-2, January 2019. (Source: Journal of Neuroscience Research)
Source: Journal of Neuroscience Research - November 16, 2018 Category: Neuroscience Tags: ISSUE INFORMATION Source Type: research

Eye of the beholder: Rare eye diseases in focus
Journal of Neuroscience Research, Volume 97, Issue 1, Page 3-6, January 2019. (Source: Journal of Neuroscience Research)
Source: Journal of Neuroscience Research - November 16, 2018 Category: Neuroscience Authors: Royce Mohan Tags: PREFACE Source Type: research

Cover Image
(Source: Journal of Neuroscience Research)
Source: Journal of Neuroscience Research - November 16, 2018 Category: Neuroscience Tags: COVER IMAGE Source Type: research

Issue Information
Journal of Neuroscience Research, Volume 97, Issue 1, Page 1-2, January 2019. (Source: Journal of Neuroscience Research)
Source: Journal of Neuroscience Research - November 16, 2018 Category: Neuroscience Tags: ISSUE INFORMATION Source Type: research

Eye of the beholder: Rare eye diseases in focus
Journal of Neuroscience Research, Volume 97, Issue 1, Page 3-6, January 2019. (Source: Journal of Neuroscience Research)
Source: Journal of Neuroscience Research - November 16, 2018 Category: Neuroscience Authors: Royce Mohan Tags: PREFACE Source Type: research

Aquaporins in brain edema
Following brain injury, the astrocyte water channel AQP4 mediates edema formation and resolution. Several factors modulate the actions of AQP4 including: (a) AQP4 membrane distribution into arrays, depending on the ratio of AQP4 isoforms; (b) AQP4 interactions with ion channels and gap junctions; (c) temporal variations in AQP4 expression. AbstractBrain edema is a common feature of brain injuries, which leads to increased intracranial pressure (ICP) and ischemia that worsen outcome. Current management of edema focuses on reduction of ICP, but there are no treatments targeting the molecular players directly involved in edem...
Source: Journal of Neuroscience Research - November 15, 2018 Category: Neuroscience Authors: Tifenn Cl ément, Beatriz Rodriguez‐Grande, Jérôme Badaut Tags: REVIEW Source Type: research

Protective effects of the ROCK inhibitor fasudil against cognitive dysfunction following status epilepticus in male rats
Rho/ROCK signaling activated following status epilepticus (SE) may be involved in the pathological process of hippocampus damages, epileptogenesis, and cognitive deficits. AbstractDespite remarkable advances in epilepsy research, prevention and reversal of cognitive deficits following epilepsy remain a challenge. It was reported that the Rho kinase (ROCK) inhibitor fasudil hydrochloride (FH) could improve cognitive deficits in animal models of Alzheimer ’s disease (AD). Thus, the aim of the present study was to determine whether FH–mediated inhibition of the effects of ROCK signaling could improve cognitive deficits in...
Source: Journal of Neuroscience Research - November 12, 2018 Category: Neuroscience Authors: Xiaojie Song, Rong He, Wei Han, Tianyi Li, Lingling Xie, Li Cheng, Hengsheng Chen, Mingdan Xie, Li Jiang Tags: RESEARCH ARTICLE Source Type: research