Journal of OncologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

• Contents
• Discussions

Pages: 1  2  

Targeting the Epidermal Growth Factor Receptor in Epithelial Ovarian Cancer: Current Knowledge and Future ChallengesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The epidermal growth factor receptor is overexpressed in up to 60% of ovarian epithelial malignancies. EGFR regulates complex cellular events due to the large number of ligands, dimerization partners, and diverse signaling pathways engaged. In ovarian cancer, EGFR activation is associated with increased malignant tumor phenotype and poorer patient outcome. However, unlike some other EGFR-positive solid tumors, treatment of ovarian tumors with anti-EGFR agents has induced minimal response. While the amount of information regarding EGFR-mediated signaling is considerable, current data provides little insight for the lack...
Source: Journal of Oncology - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Lenalidomide, Melphalan, and Prednisone Association Is an Effective Salvage Therapy in Relapsed Plasma Cell LeukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Plasma cell leukemia (PCL) is a rare and aggressive plasma cell disorder, characterized by the presence of a peripheral blood absolute plasma cell count of at least 2×109/l and more than 20% circulating plasma cells. The prognosis of PCL patients remains poor. Even by using autologous or allogenic transplant procedures, median survival does not exceed 3 years (Saccaro et al., 2005). Thalidomide, bortezomib and lenalidomide (Revlimid) have emerged as high active agents in the treatment of PCL (Johnston and abdalla, 2002; Musto et al., 2007; Finnegan et al., 2006). In particular, Lenalidomide is a structural analo...
Source: Journal of Oncology - November 18, 2009 Category: Cancer & Oncology Source Type: journals

Non-Cross Resistant Sequential Single Agent Chemotherapy in First-Line Advanced Non-Small Cell Lung Cancer Patients: Results of a Phase II StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. sequential administration of gemcitabine followed by paclitaxel in first line treatment of advanced NSCLC had a favourable toxicity profile, a median TTP and OS comparable with other sequential trials and might, therefore, be a treatment option for NSCLC patients with high ERCC1 expression. (Source: Journal of Oncology)
Source: Journal of Oncology - November 12, 2009 Category: Cancer & Oncology Source Type: journals

Circulating Tumor Cells in Gastrointestinal Malignancies: Current Techniques and Clinical ImplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since their introduction more than 50 years by Engell, circulating tumor cells (CTCs) have been evaluated in cancer patients and their detection has been correlated with clinical outcome, in esophageal, gastric, and colorectal cancer. With the availability of refined technologies, the identification of CTCs from peripheral blood is emerging as a useful tool for the detection of malignancy, monitoring disease progression, and measuring response to therapy. However, increasing evidence suggests a variety of factors to be responsible for disease progression. The analysis of a single CTC marker is therefore unlikely to accurat...
Source: Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Source Type: journals

Analysis of Candidate Genes in Occurrence and Growth of Colorectal AdenomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Predisposition to sporadic colorectal tumours is influenced by genes with minor phenotypic effects. A case-control study was set up on 295 patients treated for a large adenoma matched with polyp-free individuals on gender, age, and geographic origin in a 1 : 2 proportion. A second group of 302 patients treated for a small adenoma was also characterized to distinguish effects on adenoma occurrence and growth. We focussed the study on 38 single nucleotide polymorphisms (SNPs) encompassing 14 genes involved in colorectal carcinogenesis. Effect of SNPs was tested using unconditional logistic regression. Comparisons were made f...
Source: Journal of Oncology - October 29, 2009 Category: Cancer & Oncology Source Type: journals

Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to evaluate the patient tolerance and efficacy of delivering locoregional chemotherapy to metastatic colorectal (MC) hepatic metastases via hepatic trans-arterial approach using irinotecan loaded drug eluting beads. This open-label, multi-center, single arm study included 30 MC patients, who had failed first line therapy. Of the 57 total embolization sessions, 12 (21% of sessions) were associated with adverse reactions during or after the treatment. After a median followup of 9 months, response rates by modified RECIST were 75% at 3 months and 66% at 6 months. Hepatic trans-arteria...
Source: Journal of Oncology - October 29, 2009 Category: Cancer & Oncology Source Type: journals

The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor ActionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endometrial cancer is the most common gynecological cancer. Estrogen-dependent endometrioid carcinoma is the most common type of endometrial cancer, and alterations in the expression of PTEN and K-ras have been associated with this disease. To study the roles of Pten and K-ras in endometrial cancer, we generated Pten ablation and oncogenic K-ras mutation in progesterone receptor positive cells (PRcre/+Ptenf/fK-rasG12D). Double mutant mice dramatically accelerated the development of endometrial cancer compared to a single mutation of either gene. Histological analysis showed that all of the 1-month old double mutant female ...
Source: Journal of Oncology - October 27, 2009 Category: Cancer & Oncology Source Type: journals

Investigation of the miR16-1 (C>T) + 7 Substitution in Seven Different Types of Cancer from Three Ethnic GroupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Considering the large scale of our study, the representation of different ethnicities and levels of hereditary risk, we conclude that the miR-16-1 (C>T)  + 7 mutation is not a good diagnostic or prognostic indicator of risk for the cancers tested. (Source: Journal of Oncology)
Source: Journal of Oncology - October 26, 2009 Category: Cancer & Oncology Source Type: journals

Repeated Intraperitoneal α-Radioimmunotherapy of Ovarian Cancer in MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Weekly repeated intraperitoneal injections of tolerable amounts of activity of A211t-MX35 F(ab′)2 of up to 6 times produced increased therapeutic efficacy without observed toxicity, indicating a potential increase of the therapeutic index. (Source: Journal of Oncology)
Source: Journal of Oncology - October 25, 2009 Category: Cancer & Oncology Source Type: journals

When Should Surgical Cytoreduction in Advanced Ovarian Cancer Take Place?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Initial surgical management is commonly accepted to date as paramount in the treatment of women presenting with epithelial ovarian cancer and permits the assessment of the disease (staging), the histological confirmation of disease type and grade, and the practice of maximal debulking preceding platinum-based chemotherapy. Many studies have shown that the volume of residual disease after initial surgical cytoreduction inversely correlates with survival. Thus, women with optimal debulking performed by a trained specialist have improved median survival. In this review, we will focus on the answers gleaned from clinical trial...
Source: Journal of Oncology - October 25, 2009 Category: Cancer & Oncology Source Type: journals

Conducting Molecular Epidemiological Research in the Age of HIPAA: A Multi-Institutional Case-Control Study of Breast Cancer in African-American and European-American WomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast cancer in African-American (AA) women occurs at an earlier age than in European-American (EA) women and is more likely to have aggressive features associated with poorer prognosis, such as high-grade and negative estrogen receptor (ER) status. The mechanisms underlying these differences are unknown. To address this, we conducted a case-control study to evaluate risk factors for high-grade ER- disease in both AA and EA women. With the onset of the Health Insurance Portability and Accountability Act of 1996, creative measures were needed to adapt case ascertainment and contact procedures to this new environment of pat...
Source: Journal of Oncology - October 25, 2009 Category: Cancer & Oncology Source Type: journals

A Case Report of Intraductal Papillary-Mucinous Neoplasm of the Pancreas Showing Morphologic Transformation during Followup PeriodsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 64-year-old man underwent MRCP for further examination of gallbladder stones and IPMN of branch-type (IPMN-Br) was pointed out. Yearly MRCP had revealed the gradual increase of the cystic components, marked dilation of the main pancreatic duct (MPD), and filling defects in the MPD. After follow-up for three years, he underwent pancreatoduodenectomy. Histologically, the dilated MPD and connecting dilated branch ducts were filled with nodular growth of tumor cells consisting of gastric-type adenoma with pyloric gland-like structures. In the MPD, a transition from gastric-type adenoma to intestinal-type carcinoma was observ...
Source: Journal of Oncology - October 15, 2009 Category: Cancer & Oncology Source Type: journals

Prognostic Factors in Patients with Multiple Recurrences of Well-Differentiated Thyroid CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Patients with multiple recurrences of WDTC follow a distinct clinical course, marked with multiple treatment failures and a substantial risk of mortality. (Source: Journal of Oncology)
Source: Journal of Oncology - October 15, 2009 Category: Cancer & Oncology Source Type: journals

Decreased Polyunsaturated Fatty Acid Content Contributes to Increased Survival in Human Colon CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the reduced content of arachidonic acid is likely related to carcinogenic process decreasing the susceptibility of cancer cells to apoptosis. (Source: Journal of Oncology)
Source: Journal of Oncology - October 15, 2009 Category: Cancer & Oncology Source Type: journals

Transcriptional Activity of Human Epidermal Growth Factor Receptor Family and Angiogenesis Effectors in Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma and Correlation with Patient OutcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Locoregional recurrence is the most common failure pattern in patients with head and neck squamous cell carcinoma (HNSCC). We retrospectively identified 41 HNSCC patients with locoregional relapse and used kinetic reverse transcription-polymerase chain reaction (kRT-PCR) in order to study fresh-frozen tumour messenger RNA (mRNA) levels of the Human Epidermal growth factor family members HER1-4, the Vascular Endothelial Growth Factors (VEGFs) A, B, C, D, and their receptors VEGFR1, 2, 3. High VEGF-C and VEGFR3 tumour mRNA expression correlated with relapse beyond the primary locus (neck nodes or soft tissues, P<.05)....
Source: Journal of Oncology - October 7, 2009 Category: Cancer & Oncology Source Type: journals

Prognostic and Therapeutic Potential of Nuclear Receptors in Head and Neck Squamous Cell CarcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Head and neck squamous cell carcinomas are among the most common neoplasms worldwide and characterized by local tumor aggressiveness, high rate of early recurrences, development of metastasis, and second primary cancers. Despite modern therapeutic strategies and sophisticated surgical management, overall survival-rates remained largely unchanged over the last decades. Thus, the need for novel treatment options for this tumor entity is undeniable. A key event in carcinogenesis is the uncontrolled modulation of genetic programs. Nuclear receptors belong to a large superfamily of transcription factors implicated in a broad sp...
Source: Journal of Oncology - September 24, 2009 Category: Cancer & Oncology Source Type: journals

Tumor Spreading to the Contralateral Ovary in Bilateral Ovarian Carcinoma Is a Late Event in Clonal EvolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a series of 32 bilateral ovarian carcinoma cases, analyzed by karyotyping and high-resolution CGH. Our karyotypic findings showed that spreading to the contralateral ovary had occurred in bilateral ovarian cancer cases and that it was a late event in the clonal evolution of the tumors. This was confirmed by the large number of similar changes detected by HR-CGH in the different lesions from the same patient. The chromosomal bands most frequently involved in structural rearrangements were 19p13 (n=12) and 19q13 (n=11). The chromosomal bands most frequently gained by both tumorous ovaries were 5p14 (70%), 8q23...
Source: Journal of Oncology - September 15, 2009 Category: Cancer & Oncology Source Type: journals

Update on Anti-EGFR TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Oncology)
Source: Journal of Oncology - September 10, 2009 Category: Cancer & Oncology Source Type: journals

Ovarian Cancer Pathogenesis: A Model in EvolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian cancer is a deadly disease for which there is no effective means of early detection. Ovarian carcinomas comprise a diverse group of neoplasms, exhibiting a wide range of morphological characteristics, clinical manifestations, genetic alterations, and tumor behaviors. This high degree of heterogeneity presents a major clinical challenge in both diagnosing and treating ovarian cancer. Furthermore, the early events leading to ovarian carcinoma development are poorly understood, thus complicating efforts to develop screening modalities for this disease. Here, we provide an overview of the current models of ovarian canc...
Source: Journal of Oncology - September 6, 2009 Category: Cancer & Oncology Source Type: journals

Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSSG) in FaDu, Cal-27, and SCC-25 HNSCCs as well as causing significant clonogenic cell killing in FaDu and Cal-27, which was suppressed by simultaneous treatment with N-acetylcysteine (NAC). An inhibitor of GSH synthesis, buthionine sulfoximine (BSO), sensitized Cal-27 and SCC-25 cells to PER-induced clonogenic killing as well...
Source: Journal of Oncology - September 2, 2009 Category: Cancer & Oncology Source Type: journals

Circulating Vitamin D and Risk of Epithelial Ovarian CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We conducted a nested case-control study within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Health and Disease Study, to examine the association between prediagnostic circulating levels of 25-hydroxy vitamin D (25(OH)D) and the risk of subsequent invasive epithelial ovarian cancer (EOC). The 25(OH)D levels were measured in serum or plasma from 170 incident cases of EOC and 373 matched controls. Overall, circulating 25(OH)D levels were not associated with the risk of EOC in combined cohort analysis: adjusted OR for the top tertile versus the reference tertile, 1.09 (95&#...
Source: Journal of Oncology - August 28, 2009 Category: Cancer & Oncology Source Type: journals

Clinical Applications of FDG PET and PET/CT in Head and Neck CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
18F-FDG PET plays an increasing role in diagnosis and management planning of head and neck cancer. Hybrid PET/CT has promoted the field of molecular imaging in head and neck cancer. This modality is particular relevant in the head and neck region, given the complex anatomy and variable physiologic FDG uptake patterns. The vast majority of 18F-FDG PET and PET/CT applications in head and neck cancer related to head and neck squamous cell carcinoma. Clinical applications of 18F-FDG PET and PET/CT in head and neck cancer include diagnosis of distant metastases, identification of synchronous 2nd primaries, detection of carcinom...
Source: Journal of Oncology - August 21, 2009 Category: Cancer & Oncology Source Type: journals

TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell LinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies suggest that TJ-41, a herbal drug, possesses chemotherapeutic effects. Accordingly, this study was undertaken to investigate the anticarcinogenic effects of TJ-41 on human breast cancer cells lines. TJ-41 inhibited the proliferation of human breast cancer cell lines dose dependently. Flow cytometric analysis showed that this decrease in DNA synthesis is to be associated with induction of apoptosis. In both cell lines, apoptosis was abolished by caspase-9 inhibitor Z-LEHD-fmk but was weakly inhibited by caspase-8 inhibitor Z-IETD-fmk, indicating that caspase-9 activation was involved in TJ-41 induced apoptosi...
Source: Journal of Oncology - August 21, 2009 Category: Cancer & Oncology Source Type: journals

Biomolecular Markers in Cancer of the TongueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning t...
Source: Journal of Oncology - August 19, 2009 Category: Cancer & Oncology Source Type: journals

Breast Carcinoma Cells in Primary Tumors and Effusions Have Different Gene Array ProfilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study compared the gene array signatures of breast carcinoma cells in primary carcinomas and effusions. The genetic signature of 10 primary tumors and 10 effusions was analyzed using the Array-Ready Oligo set for the Human Genome platform. Results for selected genes were validated using PCR, Western blotting, and immunohistochemistry. Array analysis identified 255 significantly downregulated and 96 upregulated genes in the effusion samples. The majority of differentially expressed genes were part of pathways involved in focal adhesion, extracellular matrix-cell interaction, and the regulation of the actin cytoskeleton...
Source: Journal of Oncology - August 11, 2009 Category: Cancer & Oncology Source Type: journals

Immunotherapy of Head and Neck Cancer: Current and Future ConsiderationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with head and neck squamous cell carcinoma (HNSCC) are at considerable risk for death, with 5-year relative survival rates of approximately 60%. The profound multifaceted deficiencies in cell-mediated immunity that persist in most patients after treatment may be related to the high rates of treatment failure and second primary malignancies. Radiotherapy and chemoradiotherapy commonly have severe acute and long-term side effects on immune responses. The development of immunotherapies reflects growing awareness that certain immune system deficiencies specific to HNSCC and some other cancers may contribute to the...
Source: Journal of Oncology - August 10, 2009 Category: Cancer & Oncology Source Type: journals

Recent Advances in Image-Guided Radiotherapy for Head and Neck CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Radiotherapy has a well-established role in the management of head and neck cancers. Over the past decade, a variety of new imaging modalities have been incorporated into the radiotherapy planning and delivery process. These technologies are collectively referred to as image-guided radiotherapy and may lead to significant gains in tumor control and radiation side effect profiles. In the following review, these techniques as they are applied to head and neck cancer patients are described, and clinical studies analyzing their use in target delineation, patient positioning, and adaptive radiotherapy are highlighted. Finally, ...
Source: Journal of Oncology - July 30, 2009 Category: Cancer & Oncology Source Type: journals

MicroRNAs as New Players for Diagnosis, Prognosis, and Therapeutic Targets in Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MicroRNAs are small nonprotein-coding RNAs that regulate the expressions of a wide variety of genes by sequence-specific base pairing on the 3′UTR of mRNA targets resulting in mRNA degradation or inhibition of translation. Aberrant expressions of miRNAs have been linked to tumor development, metastasis, diagnosis, prognosis, and therapy response in human breast cancer. Some miRNAs have been considered to have potential clinical applications as a tool for breast cancer prognosis and therapy. Here we describe and discuss lines of evidence supporting the important relationship between miRNAs and breast cancer, and its ...
Source: Journal of Oncology - July 28, 2009 Category: Cancer & Oncology Source Type: journals

MicroRNAs as Novel Biomarkers for Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a comprehensive and timely review of the role of miRNAs in cancer: addressing miRNA function, their putative role as oncogenes or tumor suppressors, with a particular emphasis on breast cancer throughout. We discuss the recent discovery of quantifiable circulating cancer-associated miRNAs, which heralds immense potential for their use as novel minimally invasive biomarkers for breast and other cancers. Finally, we comment on the potential role of miRNAs in breast cancer management, particularly in improving current prognostic tools and achieving the goal of individualized cancer treatment. (Source: Journal of Oncology)
Source: Journal of Oncology - July 20, 2009 Category: Cancer & Oncology Source Type: journals

Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The experimental findings clearly showed the inhibition of MMP-2 activity upon ATRA treatment. This inhibitory effect of ATRA on MMP-2 activity in human breast cancer cells (MCF-7) may result due to its inhibitory effect on MT1-MMP, EMMPRIN, and upregulation of TIMP-2. This study is focused on the effect of ATRA on MMP, MMP-integrin-E-cadherin interrelationship, and also the effect of the drug on different signaling molecules which may involve in the progression of malignant tumor development. (Source: Journal of Oncology)
Source: Journal of Oncology - July 19, 2009 Category: Cancer & Oncology Source Type: journals

Anti-EGFR-Targeted Therapy for Esophageal and Gastric Cancers: An Evolving ConceptEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancers of the esophagus and stomach present a major health burden worldwide. In the past 30 years we have witnessed some interesting shifts in terms of epidemiology of esophago gastric cancers. Regardless of a world region, the majority of patients diagnosed with esophageal or gastric cancers die from progression or recurrence of their disease. While there are many active cytotoxic agents for esophageal and stomach cancers, their impact on the disease course has been modest at best. Median survival for patients with advanced gastroesophageal cancer is still less than a year. Therefore, novel strategies, based on our under...
Source: Journal of Oncology - July 15, 2009 Category: Cancer & Oncology Source Type: journals

Improving Response Rates to EGFR-Targeted Therapies for Head and Neck Squamous Cell Carcinoma: Candidate Predictive Biomarkers and Combination Treatment with Src InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe candidate predictive markers for SCCHN response to EGFR-targeted therapies and their prevalence in SCCHN. Clinical response will likely be improved by targeted therapy combination treatments. Src family kinases mediate EGFR-dependent and -independent tumor progression pathways in many cancers including SCCHN. Several Src-targeting agents are in clinical development for solid malignancies. Molecular correlate studies for Src-targeting therapies are few and biomarkers correlated with patient response are limited. Identifying SCCHN patients who will respond to combined EGFR- and Src-targeting will require further ...
Source: Journal of Oncology - July 15, 2009 Category: Cancer & Oncology Source Type: journals

Synergistic Induction of Apoptosis in Primary B-CLL Cells after Treatment with Recombinant Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Histone Deacetylase InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is currently being investigated as a therapeutic agent for a variety of malignancies, as it triggers apoptosis specifically in transformed cells. However, TRAIL use as a stand alone therapeutic is hampered by the fact that many primary tumor cells are resistant to TRAIL-mediated apoptosis. Here, we investigated the extent to which pretreatment of TRAIL-resistant primary B-cell chronic lymphocytic leukemia (B-CLL) cells with histone deacetylase inhibitors (HDACis) could render them susceptible to killing by TRAIL. We found that HDAC inhibition in B-CLL cells le...
Source: Journal of Oncology - July 7, 2009 Category: Cancer & Oncology Source Type: journals

Response of Patient-Derived Non-Small Cell Lung Cancer Xenografts to Classical and Targeted Therapies Is Not Related to Multidrug Resistance MarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor cells that are nonsensitive to anticancer drugs frequently have a multidrug resistant (MDR) phenotype. Many studies with cell lines and patient material have been done to investigate the impact of different resistance markers at protein and mRNA level in drug resistance but with contradictory outcome. In the present study, 26 well-characterised patient-derived non-small cell lung cancer xenografts were used. The known chemosensitivity to etoposide, carboplatin, gemcitabine, paclitaxel and erlotinib was compared to the protein and mRNA expression of BCRP, LRP, MDR1, and MRP1. Further, four of these xenografts were sho...
Source: Journal of Oncology - July 7, 2009 Category: Cancer & Oncology Source Type: journals

Cell Cycle Regulating Kinase Cdk4 as a Potential Target for Tumor Cell Treatment and Tumor ImagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cyclin-dependent kinase (Cdk)-cyclin D/retinoblastoma (pRb)/E2F cascade, which controls the G1/S transition of cell cycle, has been found to be altered in many neoplasias. Inhibition of this pathway by using, for example, selective Cdk4 inhibitors has been suggested to be a promising approach for cancer therapy. We hypothesized that appropriately radiolabeled Cdk4 inhibitors are suitable probes for tumor imaging and may be helpful studying cell proliferation processes in vivo by positron emission tomography. Herein, we report the synthesis and biological, biochemical, and radiopharmacological characterizations of two I...
Source: Journal of Oncology - July 7, 2009 Category: Cancer & Oncology Source Type: journals

Clinical Significance of Skin Toxicity due to EGFR-Targeted TherapiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many small molecules and monoclonal antibodies blocking the activity of Epidermal Growth factor receptor (EGFR) have been developed and have shown clinical activity in patients with non-small cell lung cancer (NSCLC), pancreatic cancer, and colorectal cancer (CRC), and are in clinical development for a range of other solid tumors. The toxicity profile of such agents is characterized by a typical pattern of cutaneous reactions. In this paper we reviewed the current available data regarding the clinical significance of skin reaction due to EGFR targeted agents. We show that skin toxicity can be considered as predictive mark...
Source: Journal of Oncology - July 7, 2009 Category: Cancer & Oncology Source Type: journals

Estimation of Cachexia among Cancer Patients Based on Four DefinitionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The proportion of patients with cachexia varied considerably depending upon the definition employed, indicating that a standard operational definition is needed. (Source: Journal of Oncology)
Source: Journal of Oncology - July 7, 2009 Category: Cancer & Oncology Source Type: journals

Cell Cycle Regulating Kinase Cdk4 as a Potential Target for Tumor Cell Treatment and Tumor ImagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cyclin-dependent kinase (Cdk)-cyclin D/retinoblastoma (pRb)/E2F cascade, which controls the G1/S transition of cell cycle, has been found to be altered in many neoplasias. Inhibition of this pathway by using, for example, selective Cdk4 inhibitors has been suggested to be a promising approach for cancer therapy. We hypothesized that appropriately radiolabeled Cdk4 inhibitors are suitable probes for tumor imaging and may be helpful studying cell proliferation processes in vivo by positron emission tomography. Herein, we report the synthesis and biological, biochemical, and radiopharmacological characterizations of two I...
Source: Journal of Oncology - June 25, 2009 Category: Cancer & Oncology Source Type: journals

Clinical Significance of Skin Toxicity due to EGFR-Targeted TherapiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many small molecules and monoclonal antibodies blocking the activity of Epidermal Growth factor receptor (EGFR) have been developed and have shown clinical activity in patients with non-small cell lung cancer (NSCLC), pancreatic cancer, and colorectal cancer (CRC), and are in clinical development for a range of other solid tumors. The toxicity profile of such agents is characterized by a typical pattern of cutaneous reactions. In this paper we reviewed the current available data regarding the clinical significance of skin reaction due to EGFR targeted agents. We show that skin toxicity can be considered as predictive mark...
Source: Journal of Oncology - June 25, 2009 Category: Cancer & Oncology Source Type: journals

Synergistic Induction of Apoptosis in Primary B-CLL Cells after Treatment with Recombinant Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Histone Deacetylase InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is currently being investigated as a therapeutic agent for a variety of malignancies, as it triggers apoptosis specifically in transformed cells. However, TRAIL use as a stand alone therapeutic is hampered by the fact that many primary tumor cells are resistant to TRAIL-mediated apoptosis. Here, we investigated the extent to which pretreatment of TRAIL-resistant primary B-cell chronic lymphocytic leukemia (B-CLL) cells with histone deacetylase inhibitors (HDACis) could render them susceptible to killing by TRAIL. We found that HDAC inhibition in B-CLL cells le...
Source: Journal of Oncology - June 14, 2009 Category: Cancer & Oncology Source Type: journals

Response of Patient-Derived Non-Small Cell Lung Cancer Xenografts to Classical and Targeted Therapies Is Not Related to Multidrug Resistance MarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor cells that are nonsensitive to anticancer drugs frequently have a multidrug resistant (MDR) phenotype. Many studies with cell lines and patient material have been done to investigate the impact of different resistance markers at protein and mRNA level in drug resistance but with contradictory outcome. In the present study, 26 well-characterised patient-derived non-small cell lung cancer xenografts were used. The known chemosensitivity to etoposide, carboplatin, gemcitabine, paclitaxel and erlotinib was compared to the protein and mRNA expression of BCRP, LRP, MDR1, and MRP1. Further, four of these xenografts were sho...
Source: Journal of Oncology - June 14, 2009 Category: Cancer & Oncology Source Type: journals

Chemotherapy Administration during Pelvic Radiation for Cervical Cancer Patients Aged ≥ 55 Years in the SEER-Medicare PopulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Our study evaluated whether 1999 National Cancer Institute (NCI) chemoradiation guidelines for cervical cancer impacted treatment of women ≥55 years. We identified 385 women ≥55 years (median, 72 years) diagnosed with stage II-IVA cervical cancer between January, 1998 and December, 2002 in the United States Surveillance, Epidemiology, and End Results (SEER)-Medicare registries. Chemoradiation frequency tables were constructed for age, race, community setting, socioeconomic status, and comorbidity index. Of 385 women, 166 (43%) received chemoradiation as primary treatment. Prior to the 1999 NCI clinical al...
Source: Journal of Oncology - June 9, 2009 Category: Cancer & Oncology Source Type: journals

Reinduction of Bevacizumab in Combination with Pegylated Liposomal Doxorubicin in a Patient with Recurrent Glioblastoma Multiforme Who Progressed on Bevacizumab/IrinotecanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 56-year-old male patient with GBM who declined surgical resection and received chemoradiation with temozolomide. This treatment was withheld secondary to significant thrombocytopenia. Subsequently, he achieved stable disease for 10 months with a regimen consisting of thalidomide and tamoxifen before progressing. This was followed by bevacizumab with irinotecan [BI], for which he had a significant partial response for 8 months with subsequent progression. Reinducing the patient with bevacizumab in combination with a pegylated liposomal doxorubicin [PLD] (a topoisomerase II inhibitor) demonstrated antit...
Source: Journal of Oncology - June 9, 2009 Category: Cancer & Oncology Source Type: journals

CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The results suggest that exon 4 mEH and GSTM1 null polymorphisms might influence oral and pharyngeal cancer. (Source: Journal of Oncology)
Source: Journal of Oncology - June 9, 2009 Category: Cancer & Oncology Source Type: journals

Have Changes in Systemic Treatment Improved Survival in Patients with Breast Cancer Metastatic to the Brain?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Newly developed systemic treatment regimens might lead to improved survival also in the subgroup of breast cancer patients that harbour brain metastases. In order to examine this hypothesis, a matched pairs analysis was performed that involved one group of patients, which were treated after these new drugs were introduced, and one group of patients, which were treated approximately 10 years earlier. The two groups were well balanced for the known prognostic factors age, KPS, extracranial disease status, and recursive partitioning analysis class, as well as for the extent of brain treatment. The results show that the use of...
Source: Journal of Oncology - June 9, 2009 Category: Cancer & Oncology Source Type: journals

New Pathways for Alimentary MucositisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alimentary mucositis is a major dose-limiting toxicity associated with anticancer treatment. It is responsible for reducing patient quality of life and represents a significant economic burden in oncology. The pathobiology of alimentary mucositis is extremely complex, and an increased understanding of mechanisms and pathway interactions is required to rationally design improved therapies. This review describes the latest advances in defining mechanisms of alimentary mucositis pathobiology in the context of pathway activation. It focuses particularly on the recent genome-wide analyses of regimen-related mucosal injury and t...
Source: Journal of Oncology - June 9, 2009 Category: Cancer & Oncology Source Type: journals

Aspirin Has Antitumor Effects via Expression of Calpain Gene in Cervical Cancer CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aspirin and other nonsteroidal anti-inflammatory drugs show efficacy in the prevention of cancers. It is known that they can inhibit cyclooxygenases, and some studies have shown that they can induce apoptosis. Our objective in this study was to investigate the mechanism by which aspirin exerts its apoptosis effects in human cervical cancer HeLa cells. The effect of aspirin on the gene expression was studied by differential mRNA display RT-PCR. Among the isolated genes, mu-type calpain gene was upregulated by aspirin treatment. To examine whether calpain mediates the antitumor effects, HeLa cells were stably transfected wit...
Source: Journal of Oncology - June 9, 2009 Category: Cancer & Oncology Source Type: journals

Small-Cell Lung Cancer: 8 Years Experience of a Single Multidisciplinary TeamEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. We have documented changes in treatment practice and service delivery of SCLC over the 8 years during which the MDT has been operating. However, there has not achieve any significant improvement in outcome for the population of patients with SCLC. (Source: Journal of Oncology)
Source: Journal of Oncology - June 9, 2009 Category: Cancer & Oncology Source Type: journals

Primary Mesenteric Sertoli-Leydig Cell Tumor: A Case Report and Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a new case of Sertoli-Leydig cell tumor in the mesentery of a 78-year-old woman who presented with occlusive syndrome and reviewed the previously reported cases of extraovarian sex cord-stromal tumors in the English literature. (Source: Journal of Oncology)
Source: Journal of Oncology - June 9, 2009 Category: Cancer & Oncology Source Type: journals