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Topical tacrolimus and pimecrolimus in the treatment of oral lichen planus: an updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There is need for larger placebo-controlled, randomized studies with carefully selected and standardized outcome measures. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 20, 2009 Category: Pathology Authors: Pía López-Jornet, Fabio Camacho-Alonso, Noemi Salazar-Sanchez Source Type: journals

DNA ploidy in oral lichen planus, determined by image cytometryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The most common degree of DNA ploidy in OLP lesions was diploidy. Comparing the two groups (chi-square test of association P = 0.021) demonstrated that diploidy was associated with the reticular clinical form of OLP, while aneuploidy was associated with the atrophic-erosive clinical form of oral lichen planus. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 20, 2009 Category: Pathology Authors: Elaini Sickert Hosni, Liliane Soares Yurgel, Vinicius Duval da Silva Source Type: journals

Expression of tenascin and nucleolar organizer region in ameloblastoma and ameloblastic fibromaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Expression of tenascin in these neoplasms suggest that it could play a role in epithelial- mesenchymal interaction, while AgNORs reveal that ameloblastomas are more aggressive when compared with ameloblastic fibromas. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 20, 2009 Category: Pathology Authors: Sunitha Carnelio, Hitesh Vij Source Type: journals

Significance of podoplanin expression in keratocystic odontogenic tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Podoplanin is strongly expressed in KCOTs in comparison with OOCs. The pattern of staining for podoplanin in KCOT could be related to its neoplastic nature, and suggests a role of the protein in tumor invasiveness. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 19, 2009 Category: Pathology Authors: Eri Okamoto, Kentaro Kikuchi, Yuji Miyazaki, Patricia González-Alva, Yuka Oku, Akio Tanaka, Noriaki Yoshida, Masahiro Fujinami, Fumio Ide, Hideaki Sakashita, Kaoru Kusama Source Type: journals

Expression of chondromodulin-1 in the temporomandibular joint condylar cartilage and discEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ChM-1 may play a role in the regulation of TMJ remodeling by preventing blood vessel invasion of the cartilage, thereby maintaining condylar cartilage and disc integrity. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 10, 2009 Category: Pathology Authors: Wei Fang, Thor Einar Friis, Xing Long, Yin Xiao Source Type: journals

Defensins in the oral cavity: distribution and biological roleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The oral cavity outreaches as a particular environment in which there is a continuous interplay between bacteria, fungi and viruses, and the epithelial barrier. Among the innate mechanisms that aim to establish a regulated equilibrium between health and disease, natural antimicrobial peptides, especially those part of the defensins' family, have emerged as fundamental mediators. Their biological role is emphasized by the large number of expressed genes, as well as the multiplicity of the individual molecules present on biological tissues and fluids, in physiological and pathological conditions. Furthermore, the direct anti...
Source: Journal of Oral Pathology and Medicine - November 7, 2009 Category: Pathology Authors: Pedro de Sousa Gomes, Maria Helena Fernandes Source Type: journals

Tissue inhibitor of metalloproteinase-2 inhibits ameloblastoma growth in a new mouse xenograft disease modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We successfully established a new experimental model of ameloblastoma consisting of subcutaneous human xenografts in nude mice. In addition, we demonstrated the successful introduction of the TIMP-2 gene in tumor xenograft cells in vivo, resulting in xenograft growth inhibition. This growth inhibition may have resulted from TIMP-2 overexpression specifically inhibiting MMP-2 protein expression and activity. J Oral Pathol Med (2009) (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 6, 2009 Category: Pathology Authors: L. Zhang, D. Zeng, H. Huang, J. Wang, Q. Tao, C. Pan, J. Xu, B. Zhang, A. Wang Source Type: journals

Stromal laminin chain distribution in normal, hyperplastic and malignant oral mucosa: relation to myofibroblast occurrence and vessel formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Mediated by myofibroblasts, OSCC development is associated with a stromal up-regulation of laminin isoforms possibly contributing to a migration promoting microenvironment. A vascular basement membrane reorganization concerning [alpha]3 and [gamma]2 chain laminins during tumour angioneogenesis is suggested. J Oral Pathol Med (2009) (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 3, 2009 Category: Pathology Authors: Marcus Franz, Anke Wolheim, Petra Richter, Claudia Umbreit, Regine Dahse, Oliver Driemel, Peter Hyckel, Ismo Virtanen, Hartwig Kosmehl, Alexander Berndt Source Type: journals

Estimation of serum leptin in oral squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results of this study suggest that evaluation of serum leptin level can provide status of cachexia in oral squamous cell carcinoma patients. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 8, 2009 Category: Pathology Authors: Harshkant P. Gharote, R. N. Mody Source Type: journals

Adverse effects of Sudanese toombak vs. Swedish snuff on human oral cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study indicates a potential for toombak, higher than for Swedish snuff, to damage human oral epithelium. Dysplastic oral keratinocytes were less sensitive than their normal counterparts, suggesting that they might have acquired a partially resistant phenotype to toombak-induced cytotoxic effects while still being prone to DNA damage that could lead to further malignant progression. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 4, 2009 Category: Pathology Authors: Daniela Elena Costea, Ochiba Lukandu, Linh Bui, Muna Jaffar M. Ibrahim, Raymond Lygre, Evelyn Neppelberg, Salah Osman Ibrahim, Olav Karsten Vintermyr, Anne Christine Johannessen Source Type: journals

The role of bone marrow-derived mesenchymal stem cells in treating formocresol induced oral ulcers in dogsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Mesenchymal stem cells transplantation may help accelerate oral ulcer healing, possibly through the induction of angiogenesis by VEGF together with increased intracellular matrix formation as detected by increased collagen gene expression. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 3, 2009 Category: Pathology Authors: H. El-Menoufy, L. A. A. Aly, M. T. A. Aziz, H. M. Atta, N. K. Roshdy, L. A. Rashed, D. Sabry Source Type: journals

Oral pain perception and taste in Burning Mouth SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Both pain-related and gustatory sensitivies of the tongue are found to be decreased in BMS. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 3, 2009 Category: Pathology Authors: T. Just, S. Steiner, H. W. Pau Source Type: journals

Co-expression of Hif1α and CAIX is associated with poor prognosis in oral squamous cell carcinoma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A co-detection of low Hif1[alpha]/CAIX expression is significantly correlated with a better prognosis for OSCC patients, which may have implications for therapy options for these patients. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 24, 2009 Category: Pathology Authors: A. W. Eckert, M. H. W. Lautner, A. Schütze, K. Bolte, M. Bache, M. Kappler, J. Schubert, H. Taubert, U. Bilkenroth Source Type: journals

Immunohistochemical analysis of P53 and bcl-2 in benign and malignant salivary glands tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J Oral Pathol Med (2009)Background: Salivary glands tumors are relatively uncommon neoplasm with widely variable histopathologic and biologic characteristics. Alteration in some proto-oncogenes and tumor suppressor genes may lead to the development and progression of these tumors.Aims: The purpose of this study was to analyze the immunohistochemical expression of P53 and bcl-2 in some salivary gland tumors in relation to tumor size, histologic grade, and extent of invasion.Setting and design: The sample consisted of 22 formalin-fixed paraffin embedded blocks of benign and malignant salivary glands tumors.Material and metho...
Source: Journal of Oral Pathology and Medicine - September 15, 2009 Category: Pathology Authors: Natheer H. AL-Rawi, Husam Omer, Sausan AL Kawas Source Type: journals

Differential infiltration of CD8+ and NK cells in lip and oral cavity squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The differential CD8+ and NK cells infiltration in oral SCC might reflect a distinctive tumor microenvironment with a favorable local cytotoxic immune response against neoplastic cells. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 14, 2009 Category: Pathology Authors: E. Zancope, N. L. Costa, A. P. Junqueira-Kipnis, M. C. Valadares, T. A. Silva, C. R. Leles, E. F. Mendonça, A. C. Batista Source Type: journals

Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study shows that GLUT-1 served as a marker indicating that tumors with deep invasion tended to result in a worse prognosis in patients due to either lymph node metastasis, a recurrence of the primary lesion or distant metastasis. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 25, 2009 Category: Pathology Authors: Shinichi Ohba, Hiroaki Fujii, Shin Ito, Mitsuhisa Fujimaki, Fumihiko Matsumoto, Masayuki Furukawa, Junkichi Yokoyama, Takeshi Kusunoki, Katsuhisa Ikeda, Okio Hino Source Type: journals

Hyposalivation, xerostomia and oral health status of HIV-infected subjects in Thailand before HAART eraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Salivary flow rate of HIV-subjects in Thailand was affected by HIV infection. The rate was significantly decreased with advanced stage of the disease. Various factors including medication use were associated with hyposalivation and xerostomia among the subjects. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 25, 2009 Category: Pathology Authors: Wipawee Nittayananta, Nilnara Chanowanna, Sureerath Jealae, Birgitte Nauntofte, Kaj Stoltze Source Type: journals

Expression and role of metalloproteinase-2 and endogenous tissue regulator in ameloblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Of the MMP-2/TIMP-2/MMP-14 complex, a high expression of MMP-2, TIMP-2 and MMP-14 mRNA levels may contribute to the local invasive characteristics of ameloblastoma, whereas the local invasive capacity of ameloblastoma is more likely related to a high transcriptional levels of TIMP-2 and MMP-14. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 25, 2009 Category: Pathology Authors: Bin Zhang, Jin Zhang, Hong-Zhang Huang, Zhi-Ying Xu, Hong-Liang Xie Source Type: journals

Reduction of type II taste cells correlates with taste dysfunction after X-ray irradiation in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest that X-ray irradiation disrupts the basal cells, resulting in a decrease of the number of taste cells, particularly type II taste cells, which may be the cause of radiotherapy-induced taste dysfunction. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 23, 2009 Category: Pathology Authors: M. Yamazaki, S. Fujii, A. Ochiai Source Type: journals

FAS and ErbB2 expression in early local recurrent oral cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Histopathological characteristics and the expression of FAS and ErbB2 carry prognosis importance in local recurrence and overall survival in OSCC. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 18, 2009 Category: Pathology Authors: L. S. S. Pinto, F. C. A. de Aguiar Jr, L. P. Kowalski, E. Graner, M. A. Lopes Source Type: journals

Varicella zoster virus: review of its managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J Oral Pathol Med (2009) Varicella zoster virus (VZV) is one of eight herpes viruses known to infect humans. Primary infection causes varicella (chickenpox), after which virus becomes latent. Years later, VZV reactivates and causes a wide range of neurological diseases. The aim of the present report was to critically examine the published literature to evaluate advantages and limitations of therapy of VZV infection in both immunocompetent and immunocompromised patients. Aciclovir (ACV) has been the drug of choice for many years for the treatment of VZV infections. Recently, other antiviral agents have been developed to ove...
Source: Journal of Oral Pathology and Medicine - August 17, 2009 Category: Pathology Authors: M. B. Mustafa, P. G. Arduino, S. R. Porter Source Type: journals

HER family receptors expression in squamous cell carcinoma of the tongue: study of the possible prognostic and biological significanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that HER-1 and HER-2/neu when determined with stringent criteria are not useful indicators of prognosis in SCCT. Only HER-3 overexpression may help in identifying SCCT with greater malignant potential also when it is coexpressed with HER-4. Instead, as in other malignancies, HER-4 could play a protective role in SCCT. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 17, 2009 Category: Pathology Authors: Rachele Del Sordo, Francesca Angiero, Guido Bellezza, Antonio Cavaliere, Maria Grazia Mameli, Michele Stefani, Enrico Dessy, Angelo Sidoni Source Type: journals

Enhanced expression of podoplanin in ameloblastomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Expression of podoplanin in AMs is considered to be associated with neoplastic odontogenic tissues; this molecule might play a role in the collective cell migration of tumor nests in AMs. The pattern of expression of E-cadherin and vimentin suggests that invasion in AMs occurs in the absence of EMT. The migration and invasion mediated by podoplanin in AMs could be related to cytoskeletal reorganization. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 17, 2009 Category: Pathology Authors: Patricia González-Alva, Akio Tanaka, Yuka Oku, Yuji Miyazaki, Eri Okamoto, Masahiro Fujinami, Noriaki Yoshida, Kentaro Kikuchi, Fumio Ide, Hideaki Sakashita, Kaoru Kusama Source Type: journals

Oral cancer cells with different potential of lymphatic metastasis displayed distinct biologic behaviors and gene expression profilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggested that LNMTca8113 and Tca8113 cells were proper models for lymphatic metastasis study because there were differences in biologic behaviors and metastasis-related genes between them. Additionally, the differentially expressed gene profiles in cancer progression may be helpful in exploring therapeutic targets and provide the foundation for further functional validation of these specific candidate genes for OSCC. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 12, 2009 Category: Pathology Authors: Zhang Zhuang, Pan Jian, Li Longjiang, Han Bo, Xiao Wenlin Source Type: journals

Morphometric analysis of CD34-positive vessels in salivary gland adenoid cystic and mucoepidermoid carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The staining intensity of CD34 positive vessels in MEC was higher than in AdCC. In MEC, higher staining intensity of vessels in high-grade tumors and lower vessel density in all MEC patients, predicted poor survival. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 6, 2009 Category: Pathology Authors: H. Luukkaa, J. Laitakari, T. Vahlberg, P. Klemi, F. Stenbäck, R. Grénman Source Type: journals

Detection of CD133, Bmi-1, and ABCG2 in ameloblastic tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Expression of CD133, Bmi-1, and ABCG2 in tooth germs and ameloblastic tumors suggests that stem cell-related molecules might control the maintenance of odontogenic tissues. Expression of these molecules is possibly involved in oncogenesis, cell differentiation, and malignant potential of odontogenic epithelium. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 31, 2009 Category: Pathology Authors: Hiroyuki Kumamoto, Kousuke Ohki Source Type: journals

Differential expression of galectin-3, β-catenin, and cyclin D1 in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that in ACC galectin-3 may play a role in cellular proliferation through cyclin D1 activation. In addition, nuclear expression of galectin-3 in ACC may be related to a more aggressive behavior of this lesion. Although [beta]-catenin seems to play a role in carcinogenesis in both lesions, it seems that it does not bind to galectin-3 for cyclin D1 stimulation. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 30, 2009 Category: Pathology Authors: K. L. Ferrazzo, M. M. Neto, E. dos Santos, D. dos Santos Pinto, S. O. M. de Sousa Source Type: journals

Antifungal drug susceptibility of oral Candida albicans isolates may be associated with apoptotic responses to Amphotericin BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Apoptosis of oral C. albicans isolates can be induced by AmB. The feature of antifungal drug susceptibility of the oral C. albicans clinical isolates may associate with the response of apoptosis inducing. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 27, 2009 Category: Pathology Authors: Chengzhe Yang, Weiyu Gong, Jingting Lu, Xiujuan Zhu, Qingguo Qi Source Type: journals

Oral verrucous hyperplasia: histologic classification, prognosis, and clinical implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that OVH lesions occur more commonly on the buccal mucosa and are highly associated with the areca quid chewing and cigarette smoking habits. The overall 5-year malignant transformation rate of 60 OVH lesions was 10%. The mass-typed OVH lesions had a higher malignant transformation rate than the plaque-typed OVH lesions and thus should receive an immediate treatment, such as total surgical excision or photodynamic therapy, after the histopathologic diagnosis. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 26, 2009 Category: Pathology Authors: Yi-Ping Wang, Hsin-Ming Chen, Ru-Cheng Kuo, Chuan-Hang Yu, Andy Sun, Bu-Yuan Liu, Ying-Shiung Kuo, Chun-Pin Chiang Source Type: journals

Salivary profile and oxidative stress in children and adolescents with cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cystic fibrosis patients demonstrated altered salivary profile, especially in antioxidant enzymatic and molecular activity, possibly resulting from the oral cavity's ongoing inflammatory and oxidative process. Free radical mechanisms may be involved in CF pathogenesis. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 26, 2009 Category: Pathology Authors: G. Livnat, L. Bentur, E. Kuzmisnsky, R. M. Nagler Source Type: journals

N1-guanyl-1,7,-diamineoheptane, an inhibitor of deoxyhypusine synthase, suppresses differentiation and induces apoptosis via mitochondrial and AMPK pathways in immortalized and malignant human oral keratinocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results demonstrate that GC7 blocks immortalized and malignant keratinocyte cell proliferation and differentiation by inducing apoptosis through the mitochondrial and AMPK pathways. On the basis of these observations, we propose that a strategy combining GC7 and AMPK inhibition could be developed into a novel chemotherapeutic modality in oral cancer. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 26, 2009 Category: Pathology Authors: S.-K. Lee, J. Lee, S.-I. Lee, W.-J. Bae, Y.-M. Lee, J.-S. Park, S.-K. Lee, S.-J. Park, S.-K. Min, E.-C. Kim Source Type: journals

Parotid sialosis: morphometrical analysis of the glandular parenchyme and stroma among diabetic and alcoholic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate that the glandular hypertrophy in the diabetic parotid sialosis is not directly associated with the ductal and acinar size, amount of fatty tissue and ductal hyperplasy. Nevertheless, these findings show that the ductal dimensions and the proportion of adipose tissue are variables that allow us to establish histopathological differences between diabetic and alcoholic sialosis. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 19, 2009 Category: Pathology Authors: Carolina Merlo, Luciana Bohl, Carmen Carda, María Elsa Gómez de Ferraris, Miriam Carranza Source Type: journals

Oral manifestations in human immunodeficiency virus infected children in highly active antiretroviral therapy eraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The frequency and severity of oral disease associated with HIV infection have reduced considerably, although the use of HAART may be associated with an increased appearance of oral lesions associated with human papillomavirus and potentially increase the risk of later oral squamous cell carcinoma. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 14, 2009 Category: Pathology Authors: Raquel dos Santos Pinheiro, Talita Tenório França, Camila Maria Beder Ribeiro, Jair Carneiro Leão, Ivete Pomarico Ribeiro de Souza, Gloria Fernanda Castro Source Type: journals

A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The presented CI as an oral ulcer activity index seems to be a reliable and suitable tool for evaluating the clinical impact and disease-specific problems in BD and RAS. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 14, 2009 Category: Pathology Authors: G. Mumcu, H. Sur, N. Inanc, U. Karacayli, H. Cimilli, N. Sisman, T. Ergun, H. Direskeneli Source Type: journals

Expression of IFN-γ before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that IFN-[gamma] expression in OLP tissue may involve in the immunopathogenesis and the treatment with 0.1% FAO had an immunomodulating effect on the decrease of IFN-[gamma]. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 14, 2009 Category: Pathology Authors: Pornpan Youngnak-Piboonratanakit, Kittipong Dhanuthai, Kobkan Thongprasom, Pimporn Luckprom, Wilairat Sarideechaigul, Lakana Luangjarmekorn, Miyuki Azuma Source Type: journals

Use of quantum dots to detect human papillomavirus in oral squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results demonstrate that the QD might be an efficient method for determination of HPV infection and HPV-associated oral squamous cell carcinoma. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 28, 2009 Category: Pathology Authors: J. Xue, H. Chen, M. Fan, F. Zhu, L. Diao, X. Chen, L. Fan, P. Li, D. Xia Source Type: journals

Distribution and quantity of label-retaining cells in rat oral epitheliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study showed that the number and the distribution of BrdU-labeled epithelial cells stabilized from 10 weeks after labeling. Therefore, these BrdU-labeled cells after a 10-week chase were considered oral epithelial LRCs. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 27, 2009 Category: Pathology Authors: Yu-Lei Huang, Xiaoan Tao, Juan Xia, Chun-Yang Li, Bin Cheng Source Type: journals

Expression of CXCR4 in oral squamous cell carcinoma: correlations with clinicopathology and pivotal role of proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that CXCR4 might be a novel biomarker to evaluate the biological behavior of oral SCC. CXCR4 inhibitors or antagonists might be potential anticancer agents to suppress tumor proliferation. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 27, 2009 Category: Pathology Authors: Xu Meng, Li Wuyi, Xu Yuhong, Chen Xinming Source Type: journals

Immunohistochemical expression of RANKL, RANK, and OPG in human oral squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest the potential value of the RANK/RANKL/OPG pathway as biomarkers in human oral SCCs. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 27, 2009 Category: Pathology Authors: Fu-Hsiung Chuang, Shue-Sang Hsue, Chung-Wei Wu, Yuk-Kwan Chen Source Type: journals

The 434(G>C) polymorphism in the eosinophil cationic protein gene and its association with tissue eosinophilia in oral squamous cell carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results suggest a tendency towards a poor clinical outcome in OSCC patients with intense TATE and 434GC/CC genotypes, probably due to an ECP genetic variant with altered cytotoxic activity. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 27, 2009 Category: Pathology Authors: Michele C. Pereira, Denise T. Oliveira, Eloísa H. R. Olivieri, Sílvia R. Rogatto, André L. Carvalho, Gilles Landman, Luiz P. Kowalski Source Type: journals

The prognostic significance of histological features in oral squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Tumour depth and grade were strong prognostic factors for nodal metastasis, independently of other histological features. Tumour diameter and margins independently predict local recurrences in the oral cavity as well as cause-specific survival. Nodal involvement and ECS were associated with adverse prognosis. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 25, 2009 Category: Pathology Authors: S. R. Larsen, J. Johansen, J. A. Sørensen, A. Krogdahl Source Type: journals

Angiogenic and lymphangiogenic microvessel density in recurrent pleomorphic adenomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study shows that although RPA presents more aggressive clinical behavior than PA, there is no difference between tumor blood and lymphatic vascularization, suggesting that there is no correlation between vascularity and risk of recurrence. Furthermore, vascularized stroma in PA, as well as RPA, depends on the proportion of the cellular composition. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 24, 2009 Category: Pathology Authors: Andresa B. Soares, Vera C. de Araújo, Priscila B. Juliano, Albina Altemani Source Type: journals

Targeted drug delivery system for oral cancer therapy using sonoporationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J Oral Pathol Med (2009) Ultrasound-mediated destruction of microbubbles has been proposed as an innovative non-invasive drug delivery system for cancer therapy. We developed a specific drug delivery system for squamous cell carcinoma that uses sonoporation with the anti-epidermal growth factor receptor (EGFR) antibody. Administration of a low dose of bleomycin (BLM) by sonoporation with the anti-EGFR antibody produced a marked growth inhibition of Ca9-22 cells in vitro. In addition, scanning electron microscopic analysis revealed apparent surface deformation of Ca9-22 cells treated with sonoporation in the presence of the...
Source: Journal of Oral Pathology and Medicine - June 24, 2009 Category: Pathology Authors: Hironobu Maeda, Kazuhiro Tominaga, Kenjiro Iwanaga, Fuminori Nagao, Manabu Habu, Toshiyuki Tsujisawa, Yuji Seta, Kuniaki Toyoshima, Jin-ichi Fukuda, Tatsuji Nishihara Source Type: journals

Oral distribution of Candida species and presence of oral lesions in Brazilian leprosy patients under multidrug therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Within the limits of the study, we concluded that Brazilian leprosy patients under MDT showed similar levels of carriage and Candida species distribution in relation to the controls. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 21, 2009 Category: Pathology Authors: Edna Aparecida Ferraz de Araújo Navas, Aline Cássia Inocêncio, Janete Dias Almeida, Graziella Nuernberg Back-Brito, Adolfo José Mota, Antonio Olavo Cardoso Jorge, Silvia Maria Rodrigues Querido, Ivan Balducci, Cristiane Yumi Koga-Ito Source Type: journals

The efficacy of topical intralesional BCG-PSN injection in the treatment of erosive oral lichen planus: a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Topical intralesional BCG-PSN injection is as effective as TA for erosive OLP, which suggests that topical intralesional BCG-PSN injection can be a promising therapeutic alternative for erosive OLP, especially for those insensitive, or even resistant, to glucocorticoids. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - May 28, 2009 Category: Pathology Authors: C. Xiong, Q. Li, M. Lin, X. Li, W. Meng, Y. Wu, X. Zeng, H. Zhou, G. Zhou Source Type: journals

Laminin-511 and fibronectin degradation with Candida yeastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It seems that cleavage of different laminin isoforms by Candida yeast is a laminin-specific process. The ability to cleave human plasma fibronectin is species- and pH-dependent but not hyphal-dependent and also this degradation may affect epithelial integrity. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - May 23, 2009 Category: Pathology Authors: Pirjo Pärnänen, Jukka H. Meurman, Ismo Virtanen Source Type: journals

Outcome of oral dysplasia: a retrospective hospital-based study of 207 patients with a long follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J Oral Pathol Med (2009) The aim of this retrospective hospital-based study was to review and evaluate the long-term outcome of patients with oral epithelial dysplasia (OED), with or without surgical intervention, to identify factors affecting clinical course and malignant evolution. Patients with a follow-up of at least 12 months were included. Data collected were statistically analyzed. The mean age was 63.58 years for women (n = 100) and 64.17 years for men (n = 107). One hundred and thirty-five of the patients had lesions with histopathological features of mild OED, 50 had moderate OED and 22 had severe OED. Gender and...
Source: Journal of Oral Pathology and Medicine - May 19, 2009 Category: Pathology Authors: Paolo G. Arduino, Antonio Surace, Mario Carbone, Alessandra Elia, Gianluca Massolini, Sergio Gandolfo, Roberto Broccoletti Source Type: journals

Activation of nuclear factor-kappa B correlates with tumor necrosis factor-alpha in oral lichen planus: a clinicopathologic study in atrophic-erosive and reticular formEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Nuclear factor-kappa B activation and its correlation with overexpression of TNF-[alpha] may play an important role in pathogenesis of OLP. There might be a positive regulatory loop between NF-[kappa]B and TNF-[alpha], which may contribute to inflammation in OLP; NF-[kappa]B may also protect epithelial keratinocytes from excessive apoptosis. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - May 15, 2009 Category: Pathology Authors: Gang Zhou, Kun Xia, Ge-fei Du, Xin-ming Chen, Xue-yi Xu, Rui Lu, Hong-mei Zhou Source Type: journals

Cellular effects of genotoxic stress and gene silencing of the checkpoint kinases in human oral cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data indicate that not only stress response mechanism may be different in oral primary and cancer cells but also Chk1/2 proteins may have essential roles in oral primary cells. Based on these data, checkpoint proteins may be crucial drug targets for oral cancer therapy. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - May 7, 2009 Category: Pathology Authors: Jae-Hoon Ji, Young-Joo Jang Source Type: journals

Production of proinflammatory and immunoregulatory cytokines by inflammatory cells from periapical lesions in cultureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Symptomatic lesions are characterized by higher production of proinflammatory cytokines. Immunoregulatory cytokines are more important for suppression of inflammation in asymptomatic lesions and in this context the effect of TGF-[beta] is more potent and different from IL-10. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - May 7, 2009 Category: Pathology Authors: Dragan Gazivoda, Tanja Dzopalic, Biljana Bozic, Zeljka Tatomirovic, Zlata Brkic, Miodrag Colic Source Type: journals