A traceless catch ‐and‐release method for rapid peptide purification
A novel catch ‐and‐release technology is introduced, employing the fast and robust oxime‐ and hydrazone‐based ligation to immobilize peptides on agarose support. The rapid and traceless release relies on a base‐induced elimination of sulfonylethoxycarbonyl linkers. The system is showcased by the purific ation of difficult peptides as two HIV‐transcriptase sequences, ß amyloid (1‐20) and liraglutide. In contrast to peptide synthesis, peptide purification by high performance liquid chromatography (HPLC) cannot be easily varied in number and scale, which results in production restraints. Catch ‐and‐release ...
Source: Journal of Peptide Science - November 26, 2018 Category: Biochemistry Authors: Oliver Reimann,
Oliver Seitz,
Dominik Sarma,
Robert Zitterbart Tags: RESEARCH ARTICLE Source Type: research
Synthesis, in vitro stability, and antiproliferative effect of d ‐cysteine modified GnRH‐doxorubicin conjugates
A novel [d‐Cys6, des ‐Gly10, Pro9‐NHEt]‐GnRH‐Doxorubicin conjugate was designed and synthesized. It showed improved human serum stability and targeting antiproliferative effect on GnRH receptor positive MCF‐7 human breast cancer cells. Overexpression of gonadotropin ‐releasing hormone (GnRH) receptor in many tumors but not in normal tissues makes it possible to use GnRH analogs as targeting peptides for selective delivery of cytotoxic agents, which may help to enhance the uptake of anticancer drugs by cancer cells and reduce toxicity to normal cells. The GnRH analogs [d‐Cys6, desGly10, Pro9‐NH2] ‐GnRH, ...
Source: Journal of Peptide Science - November 22, 2018 Category: Biochemistry Authors: Songtao Li,
Hongling Zhao,
Xiaomin Chang,
Jianping Wang,
Enhong Zhao,
Zhifeng Yin,
Xiaoxia Mao,
Shuhua Deng,
Ting Hao,
Huina Wang,
Yaqi Yang Tags: RESEARCH ARTICLE Source Type: research
Issue information
No abstract is available for this article. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - November 20, 2018 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Chemical synthesis of a two ‐domain scorpion toxin LaIT2 and its single‐domain analogs to elucidate structural factors important for insecticidal and antimicrobial activities
Journal of Peptide Science, EarlyView. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - November 5, 2018 Category: Biochemistry Authors: Hironori Juichi,
Ryo Ando,
Takafumi Ishido,
Masahiro Miyashita,
Yoshiaki Nakagawa,
Hisashi Miyagawa Source Type: research
Piezoelectric property of bundled peptide nanotubes stapled by bis ‐cyclic‐β‐peptide
Journal of Peptide Science, EarlyView. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - November 4, 2018 Category: Biochemistry Authors: Yuki Tabata,
Kazushi Takagaki,
Hirotaka Uji,
Shunsaku Kimura Source Type: research
Antibacterial effects of gold nanoparticles functionalized with the extracted peptide from Vespa orientalis wasp venom
Journal of Peptide Science, EarlyView. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - October 25, 2018 Category: Biochemistry Authors: Jafar Jalaei,
Somayeh Layeghi ‐Ghalehsoukhteh,
Arsalan Hosseini,
Mehdi Fazeli Source Type: research
Issue information
Journal of Peptide Science,Volume 24, Issue 11, November 2018. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - October 24, 2018 Category: Biochemistry Source Type: research
Reduction of cysteine ‐S‐protecting groups by triisopropylsilane
Journal of Peptide Science,Volume 24, Issue 11, November 2018. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - October 24, 2018 Category: Biochemistry Authors: Emma J. Ste.Marie,
Robert J. Hondal Source Type: research
Chemical synthesis of the crustacean insulin ‐like peptide with four disulfide bonds
Journal of Peptide Science, EarlyView. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - October 22, 2018 Category: Biochemistry Authors: Hidekazu Katayama,
Takafumi Mukainakano,
Junya Kogure,
Tsuyoshi Ohira Source Type: research
An explorative study towards the chemical synthesis of the immunoglobulin G1 Fc CH3 domain
Journal of Peptide Science, EarlyView. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - October 22, 2018 Category: Biochemistry Authors: Luigi Grassi,
Cornelia Roschger,
Vesna Stanojlovi ć,
Chiara Cabrele Source Type: research
Development of lipopolyplexes for gene delivery: A comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes
Journal of Peptide Science, EarlyView. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - October 16, 2018 Category: Biochemistry Authors: Robin Bofinger,
May Zaw ‐Thin,
Nicholas J. Mitchell,
P. Stephen Patrick,
Cassandra Stowe,
Ana Gomez‐Ramirez,
Helen C. Hailes,
Tammy L. Kalber,
Alethea B. Tabor Source Type: research
Properties of novel surfactin ‐derived biosurfactants obtained through solid‐phase synthesis
Journal of Peptide Science, EarlyView. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - October 16, 2018 Category: Biochemistry Authors: Leonardo Vazquez,
Andre Teixeira da Silva Ferreira,
Fernanda Sampaio Cavalcante,
Israel Jos é P. Garcia,
Katia Regina Netto Santos,
Leandro Augusto de Oliveira Barbosa,
Marcius da Silva Almeida,
Julio Alberto Mignaco,
Carlos Frederico Leite Fonte Source Type: research
Characterization of a peptide containing the major heparin binding domain of human hepatic lipase
Journal of Peptide Science, EarlyView. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - October 5, 2018 Category: Biochemistry Authors: Breanne M. Coady,
Jenika D. Marshall,
Luke E. Hattie,
Alexander M. Brannan,
Madeline N. Fitzpatrick,
Kala E. Hickey,
Stefan Wallin,
Valerie Booth,
Robert J. Brown Source Type: research
Recombinant human follicle stimulating hormone purification by a short peptide affinity chromatography
Journal of Peptide Science, EarlyView. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - October 5, 2018 Category: Biochemistry Authors: Juan M. Gurevich Messina,
Silvana L. Giudicessi,
Mar ía C. Martínez Ceron,
Nicolás Urtasun,
Guillermina Forno,
Laura Mauro,
Osvaldo Cascone,
Silvia A. Camperi Source Type: research
Issue information
Journal of Peptide Science,Volume 24, Issue 10, October 2018. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - September 27, 2018 Category: Biochemistry Source Type: research
