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Gingival crevicular fluid can degrade Emdogain and inhibit Emdogain-induced proliferation of periodontal ligament fibroblastsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We suggest that diseased gingival crevicular fluid containing various proteases leads to degradation of EMD and decreased proliferation of periodontal ligament fibroblasts. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 10, 2009 Category: Dentistry Authors: M. Laaksonen, T. Salo, S. Vardar-Sengul, G. Atilla, B. Han Saygan, J. P. Simmer, H. Baylas, T. Sorsa Source Type: journals

Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data suggest that EMD may affect gingival health by ways other than cell proliferation/survival, i.e. by stimulation of TIMP-3 production, which could improve the MMP[ndash]TIMP balance in gingival tissue and curb extracellular matrix destruction. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 9, 2009 Category: Dentistry Authors: E. Zeldich, R. Koren, M. Dard, E. Weinberg, M. Weinreb, C. E. Nemcovsky Source Type: journals

Systematic review on the effect of rinsing with povidone-iodine during nonsurgical periodontal therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The adjunctive use of PVP-iodine during scaling and root planing may increase the clinical pocket depth reduction, although the clinical significance is small to moderate. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 9, 2009 Category: Dentistry Authors: P. Sahrmann, M. A. Puhan, T. Attin, P. R. Schmidlin Source Type: journals

Single nucleotide polymorphisms of complement component 5 and periodontitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 9, 2009 Category: Dentistry Authors: L. Chai, Y.-Q. Song, K.-Y. Zee, W. K. Leung Source Type: journals

The adjunctive use of platelet-rich plasma in the therapy of periodontal intraosseous defects: a systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Diverse outcomes (positive and negative) have been reported for the efficacy of PRP combined with various therapeutic bioactive agents/procedures, reflecting the limited and heterogeneous data available and possibly suggesting that the specific selection of agents/procedures combined with PRP could be important. Additional research on the efficacy of each specific combination of PRP is necessary. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 9, 2009 Category: Dentistry Authors: S. Kotsovilis, N. Markou, E. Pepelassi, D. Nikolidakis Source Type: journals

Induction of MMP-2 at the interface between epithelial cells and fibroblasts from human periodontal ligamentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings indicate that putative epithelial rests of Malassez cells stimulate the production of MMP-2 in human periodontal ligament fibroblasts. Up-regulated proMMP-2 bound by MMP-14 expressed in epithelial rests of Malassez cells can degrade matrix molecules, such as type IV collagen, in the basal membrane between putative epithelial rests of Malassez cells and human periodontal ligament fibroblasts. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 9, 2009 Category: Dentistry Authors: M. Shimonishi, I. Takahashi, F. Terao, M. Komatsu, M. Kikuchi Source Type: journals

The upregulation of heat shock protein 47 in human gingival fibroblasts stimulated with cyclosporine AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Expression of Hsp47 is significantly upregulated in cyclosporine A-induced gingival overgrowth specimens, and Hsp47 expression induced by cyclosporine A in fibroblasts may be mediated by the MEK signal transduction pathway. The expression of Hsp47 could be significantly enhanced by A. actinomycetemcomitans and interlukin-1[alpha]. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 9, 2009 Category: Dentistry Authors: T.-Y. Chang, C.-H. Tsai, Y.-C. Chang Source Type: journals

Expression of heat shock proteins, Hsp70 and Hsp25, in the rat gingiva after irradiation with a CO2 laser in coagulation modeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The CO2 laser treatment in coagulation mode produced the expression of heat shock proteins, and the findings suggest that while Hsp70 mainly conferred cell protection, Hsp25 was involved in the progress of wound repair as well as cell protection. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 9, 2009 Category: Dentistry Authors: A. Yamasaki, H. Ito, J. Yusa, Y. Sakurai, N. Okuyama, R. Ozawa Source Type: journals

Co-purified gelatinases alter the stability and biological activities of human plasma fibronectin preparationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present experiments devised a time- and cost-efficient protocol for eliminating gelatinases during purification of human plasma FN. Gelatinase-free FN preparations had greater stability, which may be essential for experiments because FN fragments have altered biological activities compared with intact FN. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 9, 2009 Category: Dentistry Authors: S. Pal, Z. Chen, X. Xu, M. Mikhailova, B. Steffensen Source Type: journals

Molecular analysis of aortic intimal hyperplasia caused by Porphyromonas gingivalis infection in mice with endothelial damageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We found that bacteremia induced by P. gingivalis leads to intimal hyperplasia associated with overexpressions of S100A9 and SMemb. Our results strongly suggest that oral[ndash]hematogenous spreading of P. gingivalis is a causative event in the development of aortic hyperplasia in periodontitis patients. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 9, 2009 Category: Dentistry Authors: K. Hokamura, H. Inaba, K. Nakano, R. Nomura, H. Yoshioka, K. Taniguchi, T. Ooshima, K. Wada, A. Amano, K. Umemura Source Type: journals

Expression of receptor activator of nuclear factor κB ligand in ligature-induced periodontitis in osteoporotic and non-osteoporotic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The increased bone loss observed in group 4 compared with either group 2 or group 3 supports the existence of an additive pathological effect of the two disease conditions. This is consistent with the increased RANKL expression observed in group 4. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: E. Allam, A. Draz, A. Hassan, A. Neamat, M. Galal, L. J. Windsor Source Type: journals

Analysis of matrix metalloproteinase (MMP-8 and MMP-2) activity in gingival crevicular fluid from children with Down's syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest an increase in MMP-2 and MMP-8 in Down's syndrome patients, regardless of whether inflammation of periodontal tissue is present or not. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: T. Yamazaki-Kubota, M. Miyamoto, Y. Sano, M. Kusumoto, T. Yonezu, K. Sugita, K. Okuda, M. Yakushiji, K. Ishihara Source Type: journals

Short-term induction of thrombocytopenia delays periodontal healing in rats with periodontal disease: participation of endostatin and vascular endothelial growth factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Thrombocytopenia leads to a delay of periodontal healing in the situation of experimental periodontitis, which might be mediated in part by a decrease in the serum concentration of VEGF and endostatin derived from the platelets. However, other factors derived from the platelets may also have contributed to a delay of periodontal healing in the rats with thrombocytopenia. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: L. C. Spolidorio, B. S. Herrera, L. S. Coimbra, M. N. Figueiredo, D. M. P. Spolidorio, M. N. Muscará Source Type: journals

Changes in cell characteristics due to retinoic acid; specifically, a decrease in the expression of claudin-1 and increase in claudin-4 within tight junctions in stratified oral keratinocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Retinoic acid changed the expression of tight junction constituent molecules, such as claudin-1 and claudin-4, in oral keratinocytes. These findings suggest that long-term application of retinoids in clinical therapy should be carefully performed. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: S. Hatakeyama, K. Ishida, Y. Takeda Source Type: journals

Periodontitis as a risk factor for cerebrovascular accident: a case–control study in the Indian populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data from this study support the proposed link between periodontitis and cerebrovascular accident in the Indian population. However, further studies are necessary to verify and quantify the role of oral infections and genetic factors in the process of atherosclerosis. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: A. R. Pradeep, P. Hadge, P. Arjun Raju, S. R. Shetty, K. Shareef, C. N. Guruprasad Source Type: journals

Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: No association between MMP-3 gene polymorphism and gingival overgrowth was revealed in kidney transplant patients administered cyclosporine A. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: A. Drozdzik, M. Kurzawski, A. Lener, M. Kozak, J. Banach, M. Drozdzik Source Type: journals

Influence of serum on interaction of Porphyromonas gingivalis ATCC 33277 and Aggregatibacter actinomycetemcomitans Y4 with an epithelial cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Serum promotes the release of the cytokines IL-6 and IL-8 by epithelial cells. This mechanism is influenced by periodontal pathogens and may maintain clinical periodontal inflammation. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: A. Guentsch, M. Rönnebeck, M. Puklo, P. M. Preshaw, W. Pfister, S. Eick Source Type: journals

Enhanced monocyte migration and pro-inflammatory cytokine production by Porphyromonas gingivalis infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Since monocyte recruitment and activation are important steps in the development of vascular inflammation and atherosclerosis, these results suggest that P. gingivalis infection may be involved in these processes. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: A. Pollreisz, Y. Huang, G. A. Roth, B. Cheng, M. Kebschull, P. N. Papapanou, A. M. Schmidt, E. Lalla Source Type: journals

Detection of oxidized low-density lipoproteins in gingival crevicular fluid from dental patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This is the first report to show the presence of apolipoprotein B and apolipoprotein B[ndash] oxidized phosphatidylcholine complex, which correspond to LDL and OxLDL, respectively, in gingival crevicular fluid. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: Y. Sakiyama, R. Kato, S. Inoue, K. Suzuki, H. Itabe, M. Yamamoto Source Type: journals

Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The identification of SOST/sclerostin in cementocytes and mineralizing periodontal ligament cells adds to our understanding of the biology of the periodontium, but the functional meaning of these findings can only be unravelled after additional in vitro and in vivo studies. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: A. Jäger, W. Götz, S. Lossdörfer, B. Rath-Deschner Source Type: journals

Effects of N-acyl homoserine lactone analogues on Porphyromonas gingivalis biofilm formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Three synthetic N-acyl HSL analogues inhibited biofilm formation in P. gingivalis. We suggest that these analogues influence the development stage of P. gingivalis biofilm formation. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: Y. Asahi, Y. Noiri, J. Igarashi, H. Asai, H. Suga, S. Ebisu Source Type: journals

Gingival and periodontal ligament fibroblasts differ in their inflammatory response to viable Porphyromonas gingivalisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Considerable heterogeneity in responsiveness to P. gingivalis exists both between GF and PDLF and between individuals, which may be crucial determinants for the susceptibility to develop periodontitis. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: N. Scheres, M. L. Laine, T. J. de Vries, V. Everts, A. J. van Winkelhoff Source Type: journals

Overeruption of periodontally affected unopposed molars in adult ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The loss of antagonist causes overeruption of the unopposed tooth, which becomes more prominent in the presence of periodontitis. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 22, 2009 Category: Dentistry Authors: T. Fujita, X. Montet, K. Tanne, S. Kiliaridis Source Type: journals

Relationship of smoking and smoking cessation with oral health status in Japanese menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Smoking has a positive association with missing teeth and periodontitis. However, smoking cessation is beneficial for oral health. The odds of having more than eight missing teeth, or of having periodontitis, in those who had never smoked was similar to that of individuals who reported that they had stopped smoking for 11 years or more. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - September 9, 2009 Category: Dentistry Authors: T. Yanagisawa, M. Ueno, K. Shinada, S. Ohara, F. A. C. Wright, Y. Kawaguchi Source Type: journals

Effects of topical application of lipopolysaccharide and proteases on hepatic injury induced by high-cholesterol diet in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In a rat model, application of lipopolysaccharide and proteases to the gingival sulcus augmented the effect of a high-cholesterol diet on steatosis, inflammation and oxidative damage in the liver. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 8, 2009 Category: Dentistry Authors: T. Yamamoto, T. Tomofuji, N. Tamaki, D. Ekuni, T. Azuma, T. Sanbe Source Type: journals

The antibacterial effect of photodynamic therapy in dental plaque-derived biofilmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Oral bacteria in biofilms are affected less by photodynamic therapy than bacteria in the planktonic phase. The antibacterial effect of photodynamic therapy is reduced in biofilm bacteria but not to the same degree as has been reported for treatment with antibiotics under similar conditions. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: C. R. Fontana, A. D. Abernethy, S. Som, K. Ruggiero, S. Doucette, R. C. Marcantonio, C. I. Boussios, R. Kent, J. M. Goodson, A. C. R. Tanner, N. S. Soukos Source Type: journals

Up-regulation of osteolytic mediators in human osteosarcoma cells stimulated with nicotineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Taken together, the results of the present study indicated that smoking modulation of bone destruction in periodontal disease may involve various osteolytic mediators, such as interleukin-1, interleukin-8, RANKL, MMP-2, MMP-9, and tissue-type plasminogen activator. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: Y.-C. Ho, S.-F. Yang, F.-M. Huang, Y.-C. Chang Source Type: journals

Osteoprotegerin induces osteopontin via syndecan-1 and phosphoinositol 3-kinase/Akt in human periodontal ligament cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: An increased level of osteoprotegerin can generate signals via a RANKL/syndecan-1/phosphoinositol 3-kinase/Akt pathway. The results also suggest that osteopontin is one of the downstream targets of the pathway mediated by osteoprotegerin in human periodontal ligament cells. Thus, in addition to counteracting RANKL in the RANKL[ndash]osteoprotegerin system, osteoprotegerin may play a role in periodontal tissue remodeling through modulation of the extracellular matrix. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: T. Yongchaitrakul, J. Manokawinchoke, P. Pavasant Source Type: journals

Expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and extracellular metalloproteinase inducer in human periodontal ligament cells stimulated with interleukin-1betaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Interleukin-1beta up-regulated the levels of MMP-1 and MMP-2, but it did not alter the expression of extracellular MMP inducer. Expression of MMP-1 and MMP-2 might be elevated by interleukin-1beta and extracellular MMP inducer via two different signal pathways. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: J. Xiang, C. Li, W. Dong, Z. Cao, L. Liu Source Type: journals

Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by basic fibroblast growth factor and dexamethasone in periodontal ligament cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The addition of Dex to culture reversed bFGF-mediated inhibition of mineralization. Use of combined bFGF and Dex to regulate PDL cell function may be a good therapeutic option to obtain periodontal regeneration. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: S. S. Hakki, E. E. Hakki, R. M. Nohutcu Source Type: journals

Effect of cyclic mechanical loading on osteoclast recruitment in periodontal tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A new device was developed that allows various levels of cyclic mechanical loading to be exerted. By using this device in rats, early events of osteoclast recruitment in the periodontal tissues were observed with excessive loadings in a time-dependent manner, indicating the usefulness of this model. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: K. Nozaki, M. Kaku, Y. Yamashita, M. Yamauchi, H. Miura Source Type: journals

The association of psychosocial factors and smoking with periodontal health in a community populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Poor mental health had a stronger association with periodontal disease among smokers than among nonsmokers, especially in accumulative attachment loss. Our findings suggest that mental health and smoking might have a synergistic effect on the risk of developing periodontal disease. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: L.-J. Chiou, Y.-H. Yang, H.-C. Hung, C.-C. Tsai, T.-Y. Shieh, Y.-M. Wu, W.-C. Wang, T.-C. Hsu Source Type: journals

Effects of mechanical stimulation by a powered toothbrush on the healing of periodontal tissue in a rat model of periodontal diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Mechanical stimulation accelerated the healing of gingival inflammation by reducing the infiltration of polymorphonuclear leukocytes and enhancing fibroblast proliferation and collagen synthesis. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: D. Ekuni, R. Yamanaka, T. Yamamoto, M. Miyauchi, T. Takata, T. Watanabe Source Type: journals

Immunohistochemical localization of elastin, fibrillins and microfibril-associated glycoprotein-1 in the developing periodontal ligament of the rat molarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Elastin expressed in the periodontal ligament assembled into elaunin fibers in the vicinity of blood vessels. Both fibrillin-2 and MAGP-1 are structural components not only of the elastin-associated microfibrils but also of elastin-free microfibrils, with possible roles in elastogenesis and in periodontal ligament homeostasis. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: Y. Sugawara, T. Sawada, S. Inoue, K. Shibayama, T. Yanagisawa Source Type: journals

Host β-globin gene fragments in crevicular fluid as a biomarker in periodontal health and diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study shows the different DNA profiles of cell-free gingival crevicular fluid in periodontal health and disease. It suggests that the quantity and quality of host DNA are dependent on the disease conditions. Therefore, the [beta]-globin gene fragments in cell-free gingival crevicular fluid may be a potential biomarker of periodontal disease progression. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: B. Thaweboon, P. Laohapand, C. Amornchat, J. Matsuyama, T. Sato, P. P. Nunez, H. Uematsu, E. Hoshino Source Type: journals

Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that GTC suppresses LPS-induced bone resorption by inhibiting IL-1[beta] production or by directly inhibiting osteoclastogenesis. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: H. Nakamura, T. Ukai, A. Yoshimura, Y. Kozuka, H. Yoshioka, Y. Yoshinaga, Y. Abe, Y. Hara Source Type: journals

Oral malodorous compound triggers mitochondrial-dependent apoptosis and causes genomic DNA damage in human gingival epithelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Hydrogen sulfide induces apoptosis in human gingival epithelial cells by activating the mitochondrial pathway. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: B. Calenic, K. Yaegaki, T. Murata, T. Imai, I. Aoyama, T. Sato, H. Ii Source Type: journals

Hydrogen sulfide induces apoptosis in human periodontium cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results showed that physiological concentrations of H2S can induce apoptosis of PDL cells and HGFs in periodontitis, suggesting that H2S may play an important role in periodontal tissue damage in periodontal diseases. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: J.-H. Zhang, Z. Dong, L. Chu Source Type: journals

Shosaikoto increases calprotectin expression in human oral epithelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that SST increases the expression of calprotectin and S100A7 in oral epithelial cells. In response to SST, up-regulation of calprotectin may be partially induced via IL-1[alpha]. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: Y. Hiroshima, M. Bando, M. Kataoka, Y. Shinohara, M. C. Herzberg, K. F. Ross, Y. Inagaki, T. Nagata, J. Kido Source Type: journals

A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This is the first study, to our knowledge, to evaluate such an extensive panel of gingival crevicular fluid mediators within the same sample prior to and following initial therapy. The results confirm that periodontal therapy effectively reduces pro-inflammatory cytokines and chemokines, including less well-described mediators that may be important in initiation and progression of periodontitis. The multiplex assay will prove useful for future gingival crevicular fluid studies. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: D. H. Thunell, K. D. Tymkiw, G. K. Johnson, S. Joly, K. K. Burnell, J. E. Cavanaugh, K. A. Brogden, J. M. Guthmiller Source Type: journals

Epidermal growth factor released from platelet-rich plasma promotes endothelial cell proliferation in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study showed that PRP supernatants are highly mitogenic for endothelial cells and provided evidence that this effect may be due, at least in part, to the presence of EGF. In vivo experiments are needed to confirm the roles of specific growth factors released from PRP in the healing of oral surgical and/or periodontal wounds. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: M.-P. Bertrand-Duchesne, D. Grenier, G. Gagnon Source Type: journals

Preconditioning with Porphyromonas gingivalis lipopolysaccharide may confer cardioprotection and improve recovery of the electrically induced intracellular calcium transient during ischemia and reperfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: At a dosage of 0.5 mg/kg, P. gingivalis LPS confers cardioprotection against ischemia[ndash]reperfusion-induced injury and improved intracellular E[Ca2+]i transient recovery, hence improving myocyte contractile recovery. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: M. H. M. Fan, K. L. Wong, S. Wu, W. K. Leung, W. C. Yam, T. M. Wong Source Type: journals

A novel murine model for chronic inflammatory alveolar bone lossEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data show that oral administration of TNBS or DSS provokes alveolar bone loss in concert with the autochthonous oral microbiota. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: H. S. Oz, J. L. Ebersole Source Type: journals

Effect of matrix metalloproteinase-1 promoter genotype on interleukin-1beta-induced matrix metalloproteinase-1 production in human periodontal ligament cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results of the present study suggest that the single nucleotide polymorphism at nucleotide [minus]1607 of the human MMP-1 promoter might influence the interleukin-1beta-induced expression of MMP-1 in periodontal ligament cells. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: Z. Cao, C. Li, J. Xiang Source Type: journals

Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although periodontal infection does affect the concentration of hs-CRP and IL-6 in serum, a subgroup of patients exist who are highly susceptible to an increased risk of CHD associated with periodontitis, suggesting that there may be subjects who have an elevated risk of CHD independent of susceptibility to periodontal tissue destruction per se. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: T. Nakajima, T. Honda, H. Domon, T. Okui, K. Kajita, H. Ito, N. Takahashi, T. Maekawa, K. Tabeta, K. Yamazaki Source Type: journals

A quinol peroxidase inhibitor prevents secretion of a leukotoxin from Aggregatibacter actinomycetemcomitansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Quinol peroxidase inhibitors are promising candidates as alternative drugs for the treatment and prevention of the onset of localized aggressive periodontitis. Using ascofuranone as a seed compound, further study of QPO inhibitors could provide novel chemotherapeutic strategies for controlling localized aggressive periodontitis. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 7, 2009 Category: Dentistry Authors: E. Takashima, H. Yamada, A. Yajima, K. Shiomi, S. Ōmura, K. Kiyoshi Source Type: journals

Cyclosporine A enhances apoptosis in gingival keratinocytes of rats and in OECM1 cells via the mitochondrial pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Based on the above findings, we suggest that cyclosporine A might enhance the apoptosis of gingival keratinocytes, mainly via the mitochondrial pathway. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - July 6, 2009 Category: Dentistry Authors: H.-P. Tu, Y.-T. Chen, H.-C. Chiu, Y.-T. Chin, S.-M. Huang, L.-C. Cheng, E. Fu, C.-Y. Chiang Source Type: journals

Defining a visual marker of osteoprogenitor cells within the periodontiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data indicate that the [alpha]SMA promoter can be used to identify a population of osteoprogenitor cells residing within the dental follicle and periodontal ligament that can differentiate into mature osteoblasts. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - June 15, 2009 Category: Dentistry Authors: S. M. San Miguel, M. R. Fatahi, H. Li, J. C. Igwe, H. L. Aguila, I. Kalajzic Source Type: journals

Runt-related gene 2 is involved in the inhibition of matrix metalloproteinase-13 expression by roxithromycin in human gingival epithelial cell cultures.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results indicate that RXM suppresses MMP-13 via the downregulation of Runx2 in human gingival epithelial cell cultures. PMID: 19453496 [PubMed - in process] (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - June 1, 2009 Category: Dentistry Authors: Tabuchi S, Sakuta T, Oyama T, Tokuda M, Tatsuyama S, Kajihara T, Nagaoka S, Beppu M, Sugihara K, Ikebe T, Shirasuna K, Torii M Tags: J Periodontal Res Source Type: journals

Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The results indicate that nicotine enhances the susceptibility to periodontitis via nicotinic acetylcholine receptors, which may act by suppressing protective immune responses through the cholinergic anti-inflammatory pathway. PMID: 19453497 [PubMed - in process] (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - June 1, 2009 Category: Dentistry Authors: Breivik T, Gundersen Y, Gjermo P, von Hörsten S, Opstad PK Tags: J Periodontal Res Source Type: journals