Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension
Publication date: Available online 7 July 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Ahmed Elassal, Jochen Steppan, Sofia Charania, Lakshmi Santhanam, Inderjit Singh, Paul M. Heerdt (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 8, 2021 Category: Drugs & Pharmacology Source Type: research

The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats
Publication date: Available online 7 July 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Morgan L. Crowley, Luis F. Restrepo, Lea R. Gamez-Jimenez, Avi Patel, Tobias Braun, Victoria L.C. Pallares, Nicholas P. Ho, Christopher R. McCurdy, Lance R. McMahon, Takato Hiranita (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 7, 2021 Category: Drugs & Pharmacology Source Type: research

Aggregation and analysis of secondary pharmacology data from investigational new drug submissions at the US Food and Drug Administration
Publication date: Available online 3 July 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Andrew Dodson, Kevin Mi, Daniel P. Russo, Christina Scott, Muriel Saulnier, Kevin Snyder, Rebecca Racz (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 4, 2021 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: July–August 2021Source: Journal of Pharmacological and Toxicological Methods, Volume 110Author(s): (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 2, 2021 Category: Drugs & Pharmacology Source Type: research

Safety pharmacology during the COVID pandemic
Publication date: Available online 26 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Michael K. Pugsley, Yevgeniya Koshman, Tessa de Korte, Simon Authier, Michael J. Curtis (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 27, 2021 Category: Drugs & Pharmacology Source Type: research

Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak
Publication date: Available online 26 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Matt Skinner, Ed Hale, Peter Ceuppens, Chris Pollard (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 27, 2021 Category: Drugs & Pharmacology Source Type: research

Alloxan as a better option than streptozotocin for studies involving painful diabetic neuropathy
Publication date: Available online 25 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Paulla Vieira Rodrigues, Bruna Moreira Silva Lemos, Maria Vitoria da Silva, Taís de Campos Lima, Débora de Oliveira Santos, Júlia Borges Paes Lemes, Celina Monteiro da Cruz Lotufo (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 25, 2021 Category: Drugs & Pharmacology Source Type: research

Assessment of intracellular accumulation of cadmium and thallium
Publication date: Available online 19 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Adela Krivohlavek, Željka Kuharić, Ana Marija Marjanović Čermak, Sandra Šikić, Ivan Pavičić, Ana-Marija Domijan (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 19, 2021 Category: Drugs & Pharmacology Source Type: research

The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification
Publication date: July–August 2021Source: Journal of Pharmacological and Toxicological Methods, Volume 110Author(s): Jose D. Suarez-Torres, Camilo A. Orozco, Carlos E. Ciangherotti (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 19, 2021 Category: Drugs & Pharmacology Source Type: research

Study design criteria for regulatory-based drug control action: Drug discrimination
Publication date: Available online 16 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): David V. Gauvin, Zachary J. Zimmermann (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 17, 2021 Category: Drugs & Pharmacology Source Type: research

Acute cell stress screen with supervised machine learning predicts cytotoxicity of excipients
Publication date: Available online 16 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Andrew A. Bieberich, Bartek Rajwa, Allison Irvine, Raymond O. Fatig, Alexander Fekete, Hong Jin, Elena Kutlina, Laszlo Urban (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 16, 2021 Category: Drugs & Pharmacology Source Type: research

Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model
Publication date: Available online 10 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Henk van der Linde, Mohamed Kreir, Ard Teisman, David J. Gallacher (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 11, 2021 Category: Drugs & Pharmacology Source Type: research

Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice
Publication date: Available online 5 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Seo-Kyoung Hwang, Cheryl Tyszkiewicz, Jeffrey Morin, Gary R. Point, Chang-Ning Liu (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 6, 2021 Category: Drugs & Pharmacology Source Type: research

Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes
Publication date: Available online 5 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Hisham Qosa, Alexandre J.S. Ribeiro, Neil R. Hartman, Donna A. Volpe (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 5, 2021 Category: Drugs & Pharmacology Source Type: research

Validation of using cardioplegic solutions for preserving cardiac function in isolated rabbit heart assays
Publication date: Available online 1 June 2021Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Ziva Arimura, BaoXi Gao, Mei Fang, Hugo M. Vargas, Yusheng Qu (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 1, 2021 Category: Drugs & Pharmacology Source Type: research