Journal of Pharmacy and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Expression of Concern
(Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 9, 2021 Category: Drugs & Pharmacology Tags: Expression of Concern Source Type: research

Expression of Concern
Journal of Pharmacy and Pharmacology, EarlyView. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - January 4, 2021 Category: Drugs & Pharmacology Tags: Expression of Concern Source Type: research

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage
AbstractObjectivesThe myoblast cell line, C2C12, has been utilised extensively in vitro as an examination model in understanding metabolic disease progression. Although it is indispensable in both preclinical and pharmaceutical research, a comprehensive review of its use in the investigation of insulin resistance progression and pharmaceutical development is not available.Key findingsC2C12 is a well ‐documented model, which can facilitate our understanding in glucose metabolism, insulin signalling mechanism, insulin resistance, oxidative stress, reactive oxygen species and glucose transporters at cellular and molecular l...
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Chun Y. Wong, Hani Al ‐Salami, Crispin R. Dass Tags: Review Source Type: research

Recent trends in targeting miRNAs for cancer therapy
AbstractObjectivesMicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the expression of numerous genes. Over the past decade, the study of miRNA biology in the context of cancer has led to the development of new diagnostic and therapeutic opportunities.Key findingsMicroRNA dysregulation is commonly associated with cancer, in part because miRNAs are actively involved in the mechanisms like genomic instabilities, aberrant transcriptional control, altered epigenetic regulation and biogenesis machinery defects. MicroRNA...
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Vandit Shah, Jigna Shah Tags: Review Source Type: research

A comprehensive review of therapeutic approaches available for the treatment of cholera
ConclusionsKnowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Francisca B. M. Sousa, Isabela R. S. G. Nol êto, Leticia S. Chaves, Gabriella Pacheco, Ana P. Oliveira, Mikhail M. V. Fonseca, Jand V. R. Medeiros Tags: Review Source Type: research

Carissa carandas L. – phyto‐pharmacological review
ConclusionsThis current review offers primary data for further research work. The in ‐vitro evaluations as well as in‐vivo models/experiments have provided a biosynthetic observation for its various ethno‐pharmacological uses and even pharmacological properties. This review would provide all valuable information which will be beneficiary to conduct some important pharmacokinet ic and toxicological research works on human models with respect to ensure the effects of active ingredients in the body and even to validate its safety issues in clinical aspects. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Sonia Singh, Meenakshi Bajpai, Pradeep Mishra Tags: Review Source Type: research

Issue Information
(Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Pinoresinol ‐4‐O‐β‐D‐glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo
ConclusionsPinoresinol ‐4‐O‐β‐D‐glucopyranoside is a natural entity combating oxidative stress, hepatic damage and diabetes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Fadia S. Youssef, Mohamed L. Ashour, Hesham A. El ‐Beshbishy, Alaaeldin Ahmed Hamza, Abdel Nasser B. Singab, Michael Wink Tags: Research Paper Source Type: research

The hepatoprotective effect and mechanism of lotus leaf on liver injury induced by Genkwa Flos
ConclusionsThis study could be a meaningful investigation to provide mechanistic insights into the hepatoprotective effect of lotus leaf and further lay a theoretical basis for the clinical application of lotus leaf. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Zhipeng Wang, Panpan Zhao, Yuanyuan Zhang, Shan Shi, Xiaohui Chen Tags: Research Paper Source Type: research

Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence
ConclusionsThe study expands the understanding of the pharmacological properties of Berberine and its applicability as a radiosensitizer towards treating liver cancer. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Gautham Ramesh, Shubhankar Das, Satish Rao Bola Sadashiva Tags: Research Paper Source Type: research

Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?
ConclusionsA loading dose of up to 300  mg of micafungin is needed for the treatment of invasive candidiasis in ICU patients while a maintenance dose of up to 200 mg can be considered in empirical antifungal treatment. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Iasonas Kapralos, Efstratios Mainas, Efthymios Neroutsos, Stella Apostolidi, Maria Siopi, Olympia Apostolopoulou, George Dimopoulos, Helen Sambatakou, Georgia Valsami, Joseph Meletiadis, Aristides Dokoumetzidis Tags: Research Paper Source Type: research

Catechol protects against iron ‐mediated oxidative brain injury by restoring antioxidative metabolic pathways; and modulation of purinergic and cholinergic enzymes activities
ConclusionThese results suggest the neuroprotective effects of catechol in iron ‐mediated oxidative brain injury. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Veronica F. Salau, Ochuko L. Erukainure, Neil A. Koorbanally, Md. Shahidul Islam Tags: Research Paper Source Type: research

A comparative study on pharmacokinetics and tissue distribution of 5 ‐hydroxy‐4‐methoxycanthin‐6‐one and its metabolite in normal and dextran sodium sulfate‐induced colitis rats by HPLC‐MS/MS
ConclusionsThese results contributed to further illuminate the ADME process of PQ ‐A in different status and were prospected to be the reference to the clinical application of similar medicines in pathological states. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Fangle Liu, Qiuyu Zhang, Chaozhan Lin, Yufeng Yao, Meiqi Wang, Changhui Liu, Chenchen Zhu Tags: Research Paper Source Type: research

Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu ‐gu‐zhi) and its potential inhibition against human cytochrome P450s and UDP‐glucuronosyltransferases
ConclusionsCYP1A2, 2C19 and UGT1As play an important role in isobavachin metabolism. Isobavachin demonstrated broad ‐spectrum inhibition of CYPs and UGTs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Han Xing, Jing Yang, Kaidi Ren, Zifei Qin, Peile Wang, Xiaojian Zhang, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research