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A ‘cure’ for the current recdepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Based upon which pundit you believe, we are experiencing either a global recession or a depression. It is the rare economist (certainly none in public office) who will utter the ‘D’ word. No matter what one chooses to call it, the current economic crisis has affected all plastic surgeons in the United States. Recently, I heard a story about a well-known cosmetic surgeon who came home and told his wife that they would have to substantially decrease their household expenses. ‘If you could learn to cook,’ he said, ‘we could fire the kitchen staff’. After a well-timed pause, she glared at him and said, ‘If you co...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - September 16, 2009 Category: Cosmetic Surgery Authors: M. Felix Freshwater Tags: Letter from America Source Type: journals

Plastic, reconstructive and aesthetic surgeon: impact of managing perceptions on aesthetic publicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Perceptions about plastic surgery are a topical source of discussion. As a group of reconstructive surgeons who also practice aesthetic surgery, we are entering a period where we are trying to change public and peer perceptions of aesthetic surgery. The accessibility of cosmetic surgery, the emergence of cosmetic ‘tourism’ and the decline of aesthetic procedures from the NHS have left us needing to define to those around us, peers, stakeholders and the public, what it is exactly that we do. The recent collaboration between BAPRAS and Forster highlights the significance we place on how we are perceived. Plastic surgery ...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - September 16, 2009 Category: Cosmetic Surgery Authors: Ahid Abood, Patrick Mallucci Tags: Editorial Source Type: journals

Internet communication and educationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the revolutions in education in the United States has been through the Internet. Despite my background as a computer programmer in the days of machine language, assembly language and FORTAN IV, the ways in which the Internet has improved both communication and education in medicine continue to amaze me.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - July 16, 2009 Category: Cosmetic Surgery Authors: M. Felix Freshwater Tags: Letter from America Source Type: journals

Implications of the Human Tissue Act (2004) on tissue storage for UK plastic surgeonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In September 2006, the UK Human Tissue Act, which gained royal assent in 2004, came into effect. Covering all aspects of the use of human-derived tissue, it affects all Plastic Surgery units that have previously stored skin following the harvest of skin grafts, and other human tissue following trauma. This practice, in general, is no longer permitted under the new legislation and all plastic surgeons, trainees and allied health professionals must be aware of this. However, it does not preclude the storage of tissue for autologous use altogether and Plastic Surgeons should be aware of this also.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - July 16, 2009 Category: Cosmetic Surgery Authors: Animesh J.K. Patel Tags: Editorial Source Type: journals

Plastic and Reconstructive Surgery of the BreastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors have tried to write a comprehensive book on Plastic and Reconstructive Surgery of the Breast. The book has 11 chapters in 282 pages and contains a very large number of high quality photographs. The authors have invited Philip Blondeel with co-author Alain Gagnon, who added their significant experience with a chapter on SGAP breast reconstruction and Thomas Schoeller with Gottfried Wechselberger, who added their extensive experience with the TMG flap for breast reconstruction.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - June 1, 2009 Category: Cosmetic Surgery Authors: Stefan O.P. Hofer Tags: Book Review Source Type: journals

In vivo regeneration of small-diameter (2mm) arteries and veins using a polymer scaffoldEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The difficulty of obtaining significant long-term patency and good wall mechanical strength in vivo has been a significant obstacle in achieving small-diameter vascular prostheses. The aim of the present study was to develop a prosthetic graft that could perform as a small-diameter vascular conduit for artery and vein regeneration.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: V. Vindigni, L. Pandis, S. Lepidi, B. Zavan, G. Abatangelo Tags: ECSAPS Abstracts Source Type: journals

Mission ManiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Americans are madly in love with missions. Missions are part of our essence. The clearest missions are those most simply expressed. In the 19th Century, ‘Go West, young man’ exhorted us to fulfill our ‘manifest destiny’ and expand our country to the Pacific Ocean.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: M. Felix Freshwater Tags: Letter from America Source Type: journals

Why tissue engineering of cartilage does not work for the human ear and nose: the role of proinflammatory cytokinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical trials and studies in the immunocompetent animals of tissue engineered cartilage constructs in the shape of a human ear resulted in resorption of neocartilage and chronic inflammatory processes with complete loss of anatomical shape. The mechanism behind this immunologic reaction remained unclear. The goal of this study was to determine the role of pro-inflammatory cytokines and the effect of immunoprotective device.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: A. Groger, M.A. Randolph, M.J. Yaremchuck, A. Haisch, M. Sittinger, N. Pallua Tags: ECSAPS Abstracts Source Type: journals

The nitric oxide downstream mediators cGMP and cAMP represent powerful tools for adipose tissue engineering by enhancing preadipocyte differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity and the Metabolic Sydrome are correlated with chronic low-grade inflammation characterized by increased plasma levels of proinflammatory mediators. Thus, the induction of inflammation could be used to stimulate adipose tisssue formation in tissue engineering approaches. Since nitric oxide (NO) is a key regulator of inflammation and has been demonstrated to have lipogenic properties we investigated the effect of NO and its downstream targets cGMP and cAMP, respectively, on preadipocytes in vitro.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: N.E. Paul, K. Hemmrich, C. Gummersbach, C.V. Suschek, K.D. Kröncke, N. Pallua Tags: ECSAPS Abstracts Source Type: journals

Massive weight gain of patients under neuroleptic treatment is due to increased adipose stem cell differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study therefore addressed the question of whether clozapine-induced weight gain might be due to neo-formation of adipose tissue from preadipocytes.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: B. Kappel, K. Hemmrich, N. Paul, D. Goy, N. Pallua Tags: ECSAPS Abstracts Source Type: journals

Adipose-derived stem cells for nerve repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adipose derived stem cells (ASC) offer tremendous potential for clinical applications due to their easy accessibility and multi-lineage differentiation capacity. We have investigated whether these cells can be differentiated into functional Schwann cells which could potentially be used to enhance nerve regeneration following injury. Rat visceral fat was enzymatically digested and putative stem cells were isolated from the mature adipocytes by centrifugation, and enriched following differential adhesion to tissue culture plastic. Under these conditions, the cells grew to confluence with a flattened, fibroblast-like morpholo...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: D.F. Kalbermatten, P.J. Kingham Tags: ECSAPS Abstracts Source Type: journals

Fibrin conduit and different regenerative cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Traumatic injuries resulting in peripheral nerve lesions often require a graft to bridge the gap. Although autologous nerve auto-graft is still the first choice strategy in reconstructions, it has the severe disadvantage of the sacrifice of a functional nerve. Cell transplantation in a bioartificial conduit is an alternative strategy to create a favorable environment for nerve regeneration. With this aim we analyzed effects of various regenerative cells in two different neural conduits.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: P.G. di Summa, P.J. Kingham, D. Espinoza, M. Wiberg, G. Terenghi, D.V. Egloff, W. Raffoul, D.F. Kalbermatten Tags: ECSAPS Abstracts Source Type: journals

Electrical Stimulation Enhances Distal Reinnervation without Increasing Regeneration SpeedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An increasing body of evidence indicates that one hour of electrical stimulation at the time of nerve repair enhances axon regeneration. However, the mechanism by which this occurs remains controversial. Brushart et al (2002) found that stimulation in the rat: 1) increased the number of neurons crossing the repair site at early times as determined by retrograde labeling, and 2) did not increase the speed of subsequent regeneration as measured by axon transport of radiolabel. English, in contrast (2004), found that stimulation doubled the distance traveled by axons expressing YFP in the mouse peroneal nerve after fibrin glu...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: C. Witzel, G. Koulaxouzidis, T.M. Brushart, M. Infanger Tags: ECSAPS Abstracts Source Type: journals

Improved Regeneration of Autologous Nerve Transplants by Means of VEGF-Gene TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The impact of the Vascular Endothelial Growth Factor (VEGF) on the angiogenic cascade is proven. Recently its neuroprotective effect after peripheral nerve injuries on α-motoneurons in the spinal cord was shown. The biological effect is mainly mediated by the binding of two tyrosine kinase receptors (VEGFR1&VEGFR2), but in addition an effect via Neuropilin (NP)-1 and NP-2, receptors essential for the development of the nervous system, was reported. Thus a sprouting of axons could be monitored as well as an improved survival of neurons and glial cells. Experiments on α-motoneurons demonstrated a decreased sensitivity to i...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: T. Holzbach, R. Milojcic, M. Anton, T. Brill, M.A. Konerding, B. Gänsbacher, H.G. Machens, R.E. Giunta Tags: ECSAPS Abstracts Source Type: journals

Hemodynamic changes related to arteriogenesis and angiogenesis in view of flap survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiogenesis and arteriogenesis have been reported as two different processes of vascular regeneration aiming to encounter critical ischemia. We have recently established a model that allowed us to assess both morphological and hemodynamic changes in the microvasculature of a critically ischemic mouse skin flap over time. The purpose of this study was to elucidate the orchestration of vascular regeneration and hemodynamic changes in terms of a temporal profile in order to question which of the two – arteriogenesis or angiogenesis – may be more effective in improving microcirculation and survival in critically ischemic flaps.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: J. Plock, K. Merz, S. Schlosser, A. Banic, D. Erni Tags: ECSAPS Abstracts Source Type: journals

Analyses of collateral vessel growth in a rat cell therapy model of ischemia hindlimb: a computer tomography based research about angiogenesis and arteriogenesis assessment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cell and gene based therapy are proved to be promising in angiogenesis and arteriogenesis research. In rat hindlimb ischemia models, angiography is the most used technique. However analysis of vessels growth is always limited by the flat image visualization. The micro computer tomography system makes three dimensional visualization and quantification of the new vascular net possible. In the present study, we developed several methods based on computer tomography technology for the assessment of angiogenesis and arteriogenesis in the rat hindlimb ischemia model.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: Z. Zhang, W. Ito, A. Slobodianski, A. Kathöfer, J. Frenz, H.G. Machens Tags: ECSAPS Abstracts Source Type: journals

Revascularization of skin grafts in a new in vivo model– HIF1-α-mediated angiogenesis within the wound bed results in reperfusion of the graft capillariesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite widespread clinical use the exact process of skin graft revascularisation remains unclear. Therefore we developed a new animal model allowing for continuous monitoring of the microcirculation during revascularization of a skin graft. The aim of this study was, to visualize the microvascular architecture during engraftment, and, by this, to gain further insights into the time course and potential vascular transformations during revascularization.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: N. Lindenblatt, M. Calcagni, C.A. Schmidt, C. Contaldo, M.D. Menger, P. Giovanoli, B. Vollmar Tags: ECSAPS Abstracts Source Type: journals

Development of “therapeutic angiogenesis” - a technique to induce angiogenic reaction in ischemic tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We use the term “Therapeutic angiogenesis” to refer a concept to induce angiogenic reaction to enhance collateral vessel development for treatment of vascular occlusive disease. A variety of procedures, which have been presented for effective development of collateral vessels, are based on the knowledge that local delivery of several angiogenic factors has positive effect in ischemic tissue.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: A. Slobodianski, A. Kathöfer, J. Frenz, Z. Zhang, G. Middeler, H.G. Machens Tags: ECSAPS Abstracts Source Type: journals

Vascular Anatomy Facilitates Microvascular Transfer of the Hamster Retractor MuscleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The hamster retractor muscle (RET) is used as an in vivo model in studies of skeletal muscle ischemia and reperfusion. The RET is unique in that the muscle can be isolated while preserving the primary vascular supply so that its contractile function can be measured simultaneously with local microvascular responses to experimental interventions. The goal of this study was to understand the anatomical origin of the vascular supply to the RET and to determine whether the RET can be used as a free flap after surgical isolation on the thoracodorsal vessels. Microdissection was performed to determine the anatomy of the vasculatu...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: M.C. de With, A.B. Kroese, A.M. de Vries, E.P. van der Heijden, R.L. Bleys, S.S. Segal, M. Kon Tags: ECSAPS Abstracts Source Type: journals

Subtractive single-chain antibody (scFv) phage-display: A novel strategy for the development of non-immunogenic antibodies for the therapeutic reduction of ischemia/ reperfusion injuriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The leukocyte integrin Mac-1 (αM\β2, CD11b/CD18) plays a pivotal role in inflammatory diseases, such as ischemia/reperfusion injury after microvascular free tissue transfer. Several studies have demonstrated the benefits of a therapeutic Mac-1 blockade. However, side effects are an unsolved problem of anti-inflammatory agents. Upon leukocyte activation, Mac-1 undergoes a conformational change exposing interaction sites for multiple ligands and consequently leading to leukocyte adhesion to the inflamed endothelium and leukocyte transmigration. We aimed to generate scFvs directed against activation-specific Mac-1 ligand bi...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: S.U. Eisenhardt, M. Schwarz, N Schallner, N. Bassler, C. Bode, K. Peter Tags: ECSAPS Abstracts Source Type: journals

Pharmacological mimicry of surgical delay: Ghrelin, a gastric peptide to save failing flapsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Persistent ischemia after flap transfer may lead to wound breakdown and necrosis. Pharmacological preconditioning has been shown to be an effective, non-invasive approach to contain ischemic complications by mimicking the process of surgical delay. Recently, Ghrelin, a peptide-hormone predominantly produced in the gastric mucosa, has been reported to exhibit vasodilatory, anti-inflammatory and angiogenic properties. Herein we studied the effectiveness of Ghrelin to reduce tissue necrosis in a flap model with sustained acute ischemia permitting analysis of elementary microcirculatory and cellular mechanisms.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: F. Rezaeian, R. Wettstein, M.D. Menger, B. Pittet, Y. Harder Tags: ECSAPS Abstracts Source Type: journals

Pancreas derived stem cells significantly improve the in vivo epidermalization of wounds in scaffold based skin regenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we present the first in vivo attempt to use PSCs in skin regeneration.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: H. Salem, D.H. Rapoport, J.T. Egana, P. Ciba, M. Kadry, K. Reithmayer, C. Kruse, H.G. Machens Tags: ECSAPS Abstracts Source Type: journals

Effects of Extracorporeal Shock Wave Energy on Normal Murine MicrocirculationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Shock wave energy generated for medical purposes is characterized by a biphasic pressure pulse, whereby a cavitation phenomen is induced causing the formation of tiny vesicles. As these microvesicles collapse a multidirectional fluid stream is induced within the tissue. Recently the application spectrum of extracorporeal shock waves (esw) has been widened from treatment of urinary calculi and bony non-union to soft tissue pathologies such as chronic wounds and flap ischemia. The aim of this study was to assess the effects of esw energy on normal microcirculation.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: C. Contaldo, C. Fanfan, N. Forster, S. Vetter, N. Lindenblatt, M. Calcagni, P. Giovanoli Tags: ECSAPS Abstracts Source Type: journals

Use of Pancreas-derived Stem Cells to improve vascularization in skin tissue engineeringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical success in skin tissue engineering requires improvements in the vascularization capacity of scaffolds for dermal regeneration (SDR). Several efforts have been done in this field including cellular and acellular technologies. In this work we combined the use of GFP+ Pancreas-derived stem cells (PSCs) with a commercially available SDR (Integra matrix, IM). 1x106 cells were seeded and cultured in a 15mm diameter SDR. Cell viability, proliferation and cytokine release from SDR-containing cells was assayed in vitro. In vivo, scaffolds containing cells were used to induce dermal regeneration in a 15mm diameter full skin...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: M. Kremer, J.T. Egaña, S. Danner, D.H. Rapoport, S. Lavandero, P. Mailänder, C. Kruse, H.G. Machens Tags: ECSAPS Abstracts Source Type: journals

The Assessment of Neovascularisation of a novel Dermal ScaffoldEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Full-thickness burns and skin loss provide a significant challenge to both clinician and patient. A number of successful options exist to replace the epidermal layer; but there is still an urgent need for optimum tissue reconstruction of the dermis. At present, the commercially available options are mainly collagen-based. Although these have revolutionised burn care, they integrate slowly (1–2 weeks) and can fail. This important problem prompted research to develop a 2nd generation dermal replacement to expedite wound healing.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: S.C. Dann, F. Edwards, A. Taheri, L. Irvine, J.F. Dye Tags: ECSAPS Abstracts Source Type: journals

Effects of Radiation on Tissue Engineered MucosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oral cancer accounts for approximately 4% of all cancers in the world. After oncological resection the defects is reconstructed using free skin flaps. Drawbacks of this procedure include donor site defects, lack and saliva production and hair bearing of the flaps. Tissue-engineered mucosa (TEM) can be used to reconstruct the defects after resection.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: W. Tra, H. Rakhorst, S.E.R. Hovius, J.W.van Neck, S. Perez-Amodio Tags: ECSAPS Abstracts Source Type: journals

The cytotoxic and inflammatory potential of physiological calcium phosphate formation at a prototype biomaterial interfaceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study sought to identify and characterise the inflammatory agent. Scaffold constituents and supernatants from scaffolds soaked for 24hours in PBS were assayed in vitro for cytotoxic and inflammatory effects. Of all components tested only calcium phosphate was identified as an inflammatory stimulant. Calcium ions are commonly utilised for cross-bridging in biomaterials and heat-stabilised calcium phosphates are used in bone replacement scaffolds. However, calcium phosphate particles have also been used experimentally to model arthritis and inflammation. The question therefore arises whether the formation of hydrated ca...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: F.C. Edwards, Y. Di, S.C. Dann, A. Taheri, J.F. Dye Tags: ECSAPS Abstracts Source Type: journals

Hypoxia modulates matrix metalloproteinase-9 secretion on tissue-engineered mucosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oral cancer is the sixth most common cancer in the world. After oncological resection the defect is reconstructed using free skin flaps such as the radial forearm flap. Drawbacks of this procedure include donor site defects, bulkiness, lack of saliva production and hair bearing of flaps.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: S. Perez-Amodio, W. Tra, H. Rakhorst, S.E.R. Hovius, J. van Neck Tags: ECSAPS Abstracts Source Type: journals

S-nitrozation-dependent regulation of MMP-1 activity: Impact of redox-active oxygen and nitrogen speciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Matrix metalloproteinases (MMPs) represent a family of structurally related, zinc-dependent proteinases participating in remodeling and degradation of the extracellular matrix. In skin physiology MMPs are for instance important in wound healing and pathological changes of MMP-1 expression are often associated with impaired wound healing but also with premature skin ageing. Another naturally occurring skin constituent is nitrite, which decomposes upon skin-specific low pH or UVA-challenge to nitric oxide (NO) and several strongly oxidizing compounds upon them hydroxyl and nitrogen dioxide radicals. Under physiological condi...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: C. Volkmar, S. Koch, V. Kolb-Bachofen, N. Pallua, C.V. Suschek Tags: ECSAPS Abstracts Source Type: journals

EC-SOD (SOD3) regulates oxidative stress induced cellular senescence and fibrosis in oral mucosal and dermal fibroblastsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oral mucosal and dermal wound proceeds through the same stages of healing, oral mucosal wounds are characterised by minimal inflammation, rapid healing/remodelling and minimal fibrosis. Given the correlations between fibroblast susceptibility to oxidative stress and the extent of scarring/fibrosis, this study examined (i) patient-matched, oral mucosal (OMF) and skin fibroblasts (SF) susceptibility to oxidative stress-induced cellular senescence, (ii) cellular reactive oxygen species (ROS) generation, (iii) ROS-induced DNA damage, (iv) the antioxidant expression profiles of the OMF/SF, to determine whether any differences c...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: P. Lohana, D.W. Thomas, P. Stephens, R. Moseley Tags: ECSAPS Abstracts Source Type: journals

Mechanical stimulation of cell proliferation and angiogenesis in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, a custom designed stretch device was used to systematically investigate the role of mechanical stimulation in vivo.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: G. Pietramaggiori, S.S. Scherer, L. Lancerotto, A. Modaressi, D.P. Orgill, B. Hinz, B. Pittet Tags: ECSAPS Abstracts Source Type: journals

RGTA OTR4120, a heparan sulfate mimentic, improves wound regeneration of rat ischemic woundsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Regenerating agent (RGTA), a chemically modified dextran polymer, mimics the properties of heparan sulfate proteoglycans by protecting and potentiating endogenously released growth factors. This way, RGTA improves tissue repair as has been reported in a variety of experimental animal models and tissues. Here, we investigate the effect of RGTA-OTR4120 on wound repair in ischemic wounds, particularly with respect to visualization and skin breaking strength.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: M. Tong, B. Tuk, J.M. Hekking, S.E.R. Hovius, J.W. van Neck Tags: ECSAPS Abstracts Source Type: journals

Erythropoietin improves wound healing by increasing red blood cell perfusion in hypercholesteremic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inadequate blood supply is the most common cause of altered wound healing representing a considerable source of morbidity in daily plastic surgery practice. Erythropoietin (EPO) is intensively investigated for its nonhematopoietic vasculoprotective effects. The present study demonstrates the potential of repetitive systemical EPO treatment to accelerate angiogenesis in hypercholesteremic and microangiopathic murine ischemic wounds.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: C. Contaldo, A. Elsherbiny, D. Högger, S. Vetter, N. Lindenblatt, M. Calcagni, P. Giovanoli Tags: ECSAPS Abstracts Source Type: journals

Extending the time limits in macroreplantation using an extracorporeal limb-perfusion model in pigsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Macroreplantations have to be performed within six hours from amputation. Extracorporeal limb perfusion may prolong this replantation window. Following proof of feasibility in a pilot study, the potential of this technique was investigated in the current study.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: F. Vollbach, D. Kiermeir, T. Meszaros, S. Müller, H. Jenni, J.A. Plock, E. Knall, M. Ochs, A. Banic, R. Rieben, E. Vögelin, M.A. Constantinescu Tags: ECSAPS Abstracts Source Type: journals

In vivo efficacy of the novel hemostatic agent Poly DHA in an experimental rat modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the efficacy of our novel compound in obtaining hemostasis in a clinically relevant rat liver injury model.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: D.J. Kadouch, P. Henderson, S.P. Singh, P.N. Zawaneh, D. Putnam, J.A. Spector Tags: ECSAPS Abstracts Source Type: journals

Intraoperative haemodynamic evaluation of the radial and ulnar arteries during free radial forearm flap procedureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to assess intra-operatively the blood flow in the radial and ulnar arteries before and after radial forearm flap raising. Twenty-two consecutive patients underwent to radial forearm microvascular reconstruction for head, neck and lower leg soft tissue defects. By using transit-time and ultra-sonic flowmeter we measured intra-operatively the blood flow in the radial and ulnar artery before and after the transplantation. The recipient arteries were assessed as well.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: S. Giordano, F. Lorenzetti, S. Suominen, E. Tukiainen Tags: ECSAPS Abstracts Source Type: journals

Evaluation of extra-arterial freezing in microsurgical anastomosis of the femoral artery of the ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Freezing of small arteries causes a reversal of vessel spasm and prevent aneurismal and thrombotic phenomena. Over the last few years, vascular spasm of little diameter arteries has been managed with different drugs applied topically or systemically. However, controversial results appeared in several studies in this field.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: S.S. Qiu, B. Hontanilla Tags: ECSAPS Abstracts Source Type: journals

The application of a new laser Doppler imaging system in planning and monitoring of surgical flapsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite the latest technical improvements in reconstructive flap surgery, the operative success may still be jeopardized by ischemia. Therefore, there is a demand of technologies enabling to assess flap microcirculation quantitatively and reliably. We tested a new high-speed laser Doppler imaging (LDI) system developed for 2D high-definition imaging of superficial blood flow in skin. We assessed the potential of the new LDI system in the use of preoperative flap design and intra- and postoperative monitoring.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: S. Schlosser, R. Wirth, J.A. Plock, A. Serov, I. Pavlov, A. Banic, D. Erni Tags: ECSAPS Abstracts Source Type: journals

The effect of radial artery reconstruction on the radial forearm donor siteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to evaluate the effect of radial artery reconstruction after radial forearm flap elevation and to study whether a vein graft can stay patent in this position.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: S. Suominen, S. Giordano, F. Lorenzetti, E. Tukiainen Tags: ECSAPS Abstracts Source Type: journals

Preserving skin microcirculation with “Dolphin” Bed TechnologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pressure ulcers remain a major concern for healthcare facilities, from both economical and quality-of-care points of view, but with proper patient care their occurrence can be reduced. Interestingly, studies as rare as they are on this particular subject demonstrate that even though a 7 to 29 % range of incidents for pressure sores exists in the general acute care population, the incidence increases to an alarming 12 to 66 % rate for pressure sores acquired intra-operatively. Studies examining factors most likely associated with intra-operatively acquired pressure ulcers have not resulted in the development of reliable ris...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: L.H. Evers, D. Bhavsar, K. Broder, A. Breithaupt, R. Bodor Tags: ECSAPS Abstracts Source Type: journals

The use of Spectrophotometric Intracutaneous Analysis (SIAscopy) in reduction mammaplasty and its clinical application in predicting ‘T-junction’ wound breakdownEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reduction mammaplasty or breast reduction is one of the most frequently performed breast surgeries worldwide. The commonest complication reported in up to 24 percent of breast reduction surgeries is T-junction wound breakdown. The ‘T-junction’ is the area at the base of the breast where skin flaps are approximated. It is widely accepted that the general cause of this phenomenon is reduced vascularity secondary to skin tension, smoking, diabetes and obesity.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: A. Law, P. Vaiude, A. Magdum, H. Tehrani, M. Dalal Tags: ECSAPS Abstracts Source Type: journals

Biomechanical Properties of Fascia Lata GraftsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fascia lata grafts are commonly employed as support structures in plastic and reconstructive surgery. Despite this widespread application, little objective testing has been published regarding the biomechanical features of this graft particularly as related to the clinical relevance of directional orientation.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: L.H. Evers, D. Bhavsar, R. Bodor, G. Lemperle Tags: ECSAPS Abstracts Source Type: journals

EMSEN [E (Reversed) – M (Sided) Skin Extending] Repair In Unilateral Cleft Lips: A Personal Technique and Postoperative ResultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ideally repaired cleft lip should provide a symmetrical Cupid's bow, philtrum and minimal scar. In the appearance of the upper lip, the philtrum plays a key role. The most popular method for unilateral cleft lip repair is the rotation-advancement technique introduced by Millard.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: I.M. Emsen Tags: ECSAPS Abstracts Source Type: journals

The use of Integra dermal regeneration template in treating Hidradenitis suppurativa – A clinical evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hidradenitis suppurativa is a disabling disease. Although medical management can at times control the disease, the treatment of choice is surgical excision. Surgical defects have been managed by second-intention healing, simple surgical closure, or complex surgical repairs with composite flaps. Integra was initially developed for the primary coverage of acute burns. It acts as a network for dermal reconstruction. An epidermal graft overlay is necessary after 3 weeks to achieve the in vivo reconstruction of a full-thickness skin equivalent.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: U. Giovannini, L. Teot Tags: ECSAPS Abstracts Source Type: journals

Overview to the Reconstructive Approaches of The Frontal Bone DefectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The search for the ideal bone-graft or alloplastic material substitutes of the frontal bone defects have been the focus of many research and clinical studies. Autografts and alloplastics are various material that combines osseointegration with maintenance of implant volume and excellent durability.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - May 23, 2009 Category: Cosmetic Surgery Authors: I.M. Emsen Tags: ECSAPS Abstracts Source Type: journals

Management of a case of arhiniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a female patient aged 6 years, who underwent internal and external nose reconstruction using a staged procedure: a nasal airway was obtained through maxillary osteotomy and ostectomy, and lined with a local skin flap and split-thickness skin grafts; then the external nose was reconstructed with an expanded frontal flap, armed with an autogenous rib framework.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - April 29, 2009 Category: Cosmetic Surgery Authors: R. Brusati, V. Donati, S. Marelli, M. Ferrari Tags: Case Reports: E-only Publication Source Type: journals

Surgical correction of pseudoainhum in chronic epidermolysis bullosa: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Pseudoainhum is a rare condition of unknown aetiology that is characterised by the presence of constriction bands of extremities due to a variety of underlying causes that progress to irreversible damage and auto-amputation of the affected digit. Epidermolysis bullosa is a group of disorders characterised by extremely fragile skin and recurrent blister formation resulting from minor mechanical trauma. The association of epidermolysis bullosa with other hand defects, such as hand contracture and pseudosyndactyly, have been reported; however, ainhum-like digital constriction bands have not been reported in associati...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - April 27, 2009 Category: Cosmetic Surgery Authors: Young Seok Kim, Hyun Joon Hong, Tai Suk Roh Tags: Case Reports: E-only Publication Source Type: journals

A papule arising in a skin graft – To biopsy or not to biopsy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of an 80-year-old man who presented with an enlarging nodule on his left heel. Histology showed an acral lentiginous melanoma, Breslow thickness 2.3mm, with no ulceration and no angiolymphatic or perineural invasion. He was treated with a 2cm margin wide excision and split skin grafting, and placed on a 3-monthly follow-up. Eight months post-surgery, he presented with a painless papule on his heel in the middle of the skin graft, which had developed since his previous review.
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - April 27, 2009 Category: Cosmetic Surgery Authors: A. Wiberg, O. Cassell, J. Bowling Tags: Correspondence and Communications: E-Only Publication Source Type: journals

The ‘underwire bra’ mastopexy: a new optionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All the mastopexy techniques addressing severe grade 2 or grade 3 ptosis entail a dermal interruption opposite to the base of the areolar-bearing flap. When gland resections are needed there is no alternative. When ptosis is isolated with no volume excess, dermal interruption primarily provides additional sustain or fills the breast cone (auto-prosthesis). The re-allocation of gland portions and the interposition of dermal flaps behind the gland raise some concern about possible interferences with the imaging techniques and alteration of neoplasm diffusion pathways and the reliability of sentinel lymph node biopsy (SLNB). ...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - April 27, 2009 Category: Cosmetic Surgery Authors: Pietro Panettiere, Lucio Marchetti, Danilo Accorsi Tags: Correspondence and Communications: E-Only Publication Source Type: journals

The ‘hand-in-gloves’ technique: vacuum-assisted closure dressing for multiple finger woundsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are a number of aspects to be considered when applying vacuum-assisted closure dressings (VAC; Kinetic Concepts Inc, San Antonio, TX, USA) to multiple digital wounds. In particular, it is difficult to achieve an airtight seal while limiting the bulk of the dressing to allow mobilisation. Another important aspect is appropriate positioning of the suction tubing for maximal patient comfort and allowing finger mobilisation. Ng et al. described a technique using a copolymer glove to ensure a better airtight seal for a dorsal hand wound. We modified it using an additional glove and ‘mesenterisation’ of the tubing for...
Source: Journal of Plastic, Reconstructive & Aesthetic Surgery - April 24, 2009 Category: Cosmetic Surgery Authors: Anthony Foo, N. Shenthilkumar, Alphonsus Kin-Sze Chong Tags: Correspondence and Communications: E-Only Publication Source Type: journals

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