Journal of PsychopharmacologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

593 records returned

ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Tint, P M Haddad, and I M Anderson. The effect of rate of antidepressant tapering on the incidence of discontinuation symptoms: a randomised study. Journal of Psychopharmacology first published this on May 30, 2008 as DOI: 10.1177/0269881107087488. This version is no longer available. The version of record is published in Vol. 22 No 3, DOI 10.1177/0269881107081550 (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Tags: Articles Source Type: journals

Book Review: Clinical Guide to the Diagnosis and Treatment of Mental Disorders Michael First, Allam Tasman, Wiley, Price: {pound}50Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Mitchell, A. Tags: Articles Source Type: journals

Lamotrigine-induced obsessional symptoms in a patient with bipolar II disorder: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the emergence of obsessive symptoms during treatment with lamotrigine in a patient who subsequently experienced significant improvement after dose reduction and stopping of this medication. The obsessive symptoms associated with lamotrigine treatment were observed after the lamotrigine dose was increased to 100 mg/day. The possible mechanisms, including inhibition on the presynaptic release of glutamate and alteration of striatal dopamine uptake, are discussed. It is unclear why lamotrigine induces obsessions in some patients. Controlled studies are necessary to identify the population at risk for obsessionality ...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Kuloglu, M., Caykoylu, A., Ekinci, O., Yilmaz, E. Tags: Articles Source Type: journals

Olanzapine treatment in Jarisch-Herxheimer reaction due to neurosyphilis with dementia: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We discussed a neurosyphilis case who had a risky sexual intercourse history nearly 10 years ago. After the neurosyphilis diagnosis, the patient has clinical symptoms of a demential case starting as a typical manic episode and Jarisch-Herxheimer reaction because of intravenous penicillin treatment that has improved with olanzapine treatment. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Ates, M., Algul, A., Gecici, O., Semiz, U., Yilmaz, O., Gulsun, M. Tags: Articles Source Type: journals

Positive interference of the analgesic nefopam in the urine immunoassay for benzodiazepines in a secure settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An inpatient on a secure unit with a history of bipolar affective disorder and physical complaints including pain was prescribed carbamazepine, quetiapine, dihydrocodeine, nefopam, paracetamol and various aperients. A benzodiazepine urine test by immunoassay was positive. Initial literature searches did not suggest a candidate drug for positive interference. Other explanations were excluded. Positive results continued, despite room searches and other disruptive security measures. Further literature searches revealed one experimental series demonstrating positive interference of nefopam in the relevant assay. Benzodiazepine...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Reid, K. Tags: Articles Source Type: journals

The potential relationship between QTc interval prolongation and ziprasidone treatment: three casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
QTc interval prolongation may appear as a consequence of both typical and atypical antipsychotic treatments. Ziprasidone, which is effective in treating schizophrenia, is associated with QTc prolongation. Although the prolongation of QTc with ziprasidone treatment is often pronounced, there is a scarce number of cases reported about the relationship between ziprasidone and QTc prolongation. Of the three cases presented in this case series, two cases showed values exceeding 0.50 s with ziprasidone treatment. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Eker, S., Sarandol, A., Akkaya, C., Sivrioglu, E., Kirli, S. Tags: Articles Source Type: journals

A 60-year-old woman with agitation and psychosis following ingestion of dextromethorphan and opioid analgesicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A patient presented with agitation, paranoia, and psychosis following ingestion of dextromethorphan, propoxyphene, and hydrocodone, a previously unreported combination. Symptoms resolved with antipsychotics and cessation of offending drugs. The pharmacodynamics of dextromethorphan and the opioids, including drug interactions are discussed, and several potential mechanisms for the production of the patient’s symptoms are proposed. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Jamison, S., Vasudeva, S. Tags: Articles Source Type: journals

Improved stress response in bipolar affective disorder with adjunctive spironolactone (mineralocorticoid receptor antagonist): case seriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The psychopathologies underlying affective disorders are thought to involve persistent changes in the expression and function of both mineralocorticoid receptors and glucocorticoid receptors in the hippocampus. In addition, exposure to stressful stimuli can precipitate episodes in vulnerable individuals. The aim of this study is to determine if spironolactone as an adjunctive therapy is effective in improving residual symptoms in bipolar disorder. Four cases of euthymic bipolar disorder (BD) patients were treated with spironolactone as an adjunctive therapy in a private treatment sector. All patients met the DSM-IV diagnos...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Juruena, M., Gama, C., Berk, M., Belmonte-de-Abreu, P. Tags: Articles Source Type: journals

Cannabidiol for the treatment of psychosis in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The management of psychosis in Parkinson’s disease (PD) has been considered a great challenge for clinicians and there is a need for new pharmacological intervention. Previously an antipsychotic and neuroprotective effect of Cannabidiol (CBD) has been suggested. Therefore, the aim of the present study was to directly evaluate for the first time, the efficacy, tolerability and safety of CBD on PD patients with psychotic symptoms. This was an open-label pilot study. Six consecutive outpatients (four men and two women) with the diagnosis of PD and who had psychosis for at least 3 months were selected for the study. All ...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Zuardi, A., Crippa, J., Hallak, J., Pinto, J., Chagas, M., Rodrigues, G., Dursun, S., Tumas, V. Tags: Articles Source Type: journals

The effects of opioid receptor blockade on experimental panic provocation with CO 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to determine whether opioid blockade would increase panic-related symptomatology on provocation with 35% CO2 inhaled by healthy volunteers. Participants in a double-blind, randomised crossover design orally received either 50 mg of naltrexone or placebo. Most subjects undertook a double inhalation of 35% CO2 one hour after pre-medication, and a separate group did so after five hours. The reactivity to CO2 and the symptoms elicited by naltrexone alone were measured. Among other findings, naltrexone pre-medication alone elicited significant increments in panic-related symptoms. Responses to CO2 were not sign...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Esquivel, G., Fernandez-Torre, O., Schruers, K., Wijnhoven, L., Griez, E. Tags: Articles Source Type: journals

Review: Problems associated with long-term treatment with selective serotonin reuptake inhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is an overview of the more common adverse events, which are seen with non-acute treatment with the SSRIs. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Moret, C., Isaac, M., Briley, M. Tags: Articles Source Type: journals

Outcomes for schizophrenia patients with clozapine treatment: how good does it get?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to describe the extent/change (2000—2004) of clozapine prescribing in schizophrenia in New Zealand and examine the outcomes associated with increasing treatment duration, and vs. those who discontinue clozapine. Consecutive chart reviews were conducted for adult outpatients in Auckland/Northland regions (T1 = 31 March 2000, T2 = 31 October 2001, T3 = 31 March 2003, T4 = 31 October 2004). Data collected included: patient characteristics, social/functional indicators, diagnosis, duration of illness, psychiatric admissions and treatment information (psychotropic medication, dose, route of...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Wheeler, A., Humberstone, V., Robinson, G. Tags: Articles Source Type: journals

Sex-related differential response to clomipramine treatment in a rat model of depressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Research in affective disorders is often performed without considering sex differences, although women are predominantly affected. Consequently, the potential sex-dependent action of antidepressants remains elusive. We investigated whether Flinders sensitive line (FSL) of rats, a model of depression, would present sex-differentiated responses to antidepressant treatment. FSL and Sprague—Dawley rats were treated with clomipramine 10 mg/kg/day for 14 days. Subsequently, they were subjected to either a single session of the forced swim test or an estimation of serotonergic function in the prefrontal cortex, hippocampus,...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Kokras, N., Antoniou, K., Dalla, C., Bekris, S., Xagoraris, M., Ovestreet, D., Papadopoulou-Daifoti, Z. Tags: Articles Source Type: journals

Lack of association between AKT1 variances versus clinical manifestations and social function in patients with schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to examine the association of AKT1 polymorphisms with drug-free and post-treatment symptomatology and social function in patients with schizophrenia. One hundred and twenty newly hospitalised patients with acutely exacerbated schizophrenia who had never been treated by atypical antipsychotics were recruited. They received optimal treatment of risperidone for up to 42 days in the inpatient research unit. Clinical manifestations were monitored by Positive and Negative Syndrome Scale (PANSS) and social function by Nurses’ Observation Scale for Inpatients Evaluation (NOSIE). Patients were genotyped for ei...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Liu, Y., Huang, C., Wu, P., Chang, Y., Huang, C., Lane, H. Tags: Articles Source Type: journals

Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Serotonin (5-HT) release is the primary pharmacological mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) action in the primate brain. Dopamine release and direct stimulation of dopamine D2 and serotonin 5-HT2A receptors also contributes to the overall action of MDMA. The role of 5-HT1A receptors in the human psychopharmacology of MDMA, however, has not yet been elucidated. In order to reveal the consequences of manipulation at the 5-HT1A receptor system on cognitive and subjective effects of MDMA, a receptor blocking study using the mixed beta-adrenoreceptor blocker/5-HT1A antagonist pindolol wa...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Hasler, F., Studerus, E., Lindner, K., Ludewig, S., Vollenweider, F. Tags: Articles Source Type: journals

Metabolic syndrome in female patients with schizophrenia treated with second generation antipsychotics: a 3-month follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to determine the occurrence of metabolic abnormalities among previously unmedicated female patients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition schizophrenia spectrum disorders and their associations with olanzapine and risperidone treatment. We analysed 94 female patients who were treated with olanzapine or risperidone in the period of 3 months. Analysed variables included fasting glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoproteins and triglycerides in blood, blood pressure (BP), waist and hip circumferences and body mass index...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Medved, V., Kuzman, M., Jovanovic, N., Grubisin, J., Kuzman, T. Tags: Articles Source Type: journals

Risk of cerebrovascular events in elderly users of antipsychoticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It has been shown that elderly patients with dementia treated with atypical and conventional antipsychotics have a twofold increased risk of cerebrovascular adverse events (CVAEs). To investigate the temporal relationship between exposure to antipsychotics and the risk of CVAE, a case-control analysis nested within a cohort of 26,157 community-dwelling patients (mean age 76 ± 9.7) with at least one antipsychotic prescription was conducted. Data were used from Dutch community pharmacies and hospital discharge records. Five hundred and eighteen cases of hospital admission for CVAE were identified. For each case, four ...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Kleijer, B., van Marum, R., Egberts, A., Jansen, P., Knol, W., Heerdink, E. Tags: Articles Source Type: journals

Antimanic potency of typical neuroleptic drugs and affinity for dopamine D2 and serotonin 5-HT2A receptors -- a new analysis of data from the archives and implications for improved antimanic treatmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Datasets of antimanic potency ratings and receptor-binding affinities [inhibition constants (Ki)] at dopamine D2 and serotonin 5-HT2A brain receptors were accessed from published literature for a large series (n = 24) of typical neuroleptic drugs, many of which are now obsolete and unobtainable. There was a strong positive association between antimanic potency and affinity for D2 receptors, in support of a ‘dopamine-blockade hypothesis’ of antimanic drug action. Taking the series of neuroleptics as a whole, there was no association between antimanic potency and affinity for 5-HT2A receptors. Despite this, withi...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Harrison-Read, P. Tags: Articles Source Type: journals

Reduced cooperativeness and reward-dependence in depression with above-normal plasma vasopressin concentrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The neuropeptide vasopressin is centrally involved in the regulation of social behaviour and response to stress. We previously found support for a subcategory of depression defined by above-normal plasma vasopressin (AVP) concentration. This subcategory is validated by a positive family history of depression and correlating plasma AVP and cortisol concentrations. The data support the validity of above-normal plasma AVP concentration as a genetically determined biological marker for a subcategory of depression. The aim of the present study was to test whether above-normal plasma AVP concentration in depression is related to...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Goekoop, J., de Winter, R., Wolterbeek, R., Spinhoven, P., Zitman, F., Wiegant, V. Tags: Articles Source Type: journals

Incidence of craving for and abuse of gamma-hydroxybutyric acid (GHB) in different populations of treated alcoholics: an open comparative studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gamma-hydroxybutyric acid (GHB) is a drug currently used for the treatment of alcohol dependence. The aim of our study was to investigate the incidence of craving for and abuse of GHB in 47 patients enrolled and divided into four groups: group A (pure alcoholics), group B (alcoholics with a sustained full remission from cocaine dependence), group C (alcoholics with a sustained full remission from heroin dependence) and group D (alcoholics in a methadone maintenance treatment [MMT] programme). All patients were treated with an oral dose of GHB (50 mg/kg of body weight t.i.d.) for three months. Craving for GHB was statistica...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Caputo, F., Francini, S., Stoppo, M., Lorenzini, F., Vignoli, T., Del Re, A., Comaschi, C., Leggio, L., Addolorato, G., Zoli, G., Bernardi, M. Tags: Articles Source Type: journals

Duloxetine for major depressive episodes in the course of psychotic disorders: an observational clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with psychotic disorders often suffer from intercurrent major depressive episodes (MDE). Case reports suggested successful antidepressive treatment with duloxetine, a selective dual reuptake inhibitor of serotonin and norepinephrine. We initiated this open prospective clinical trial to evaluate efficacy, safety and tolerability of this approach. Patients with a psychotic lifetime diagnosis suffering from mildly severe MDE were treated with duloxetine over a period of 6 weeks. We evaluated effects on mood, monitored the psychotic psychopathology and assessed side effects, basal clinical and pharmacological paramete...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Englisch, S., Knopf, U., Scharnholz, B., Kuwilsky, A., Deuschle, M., Zink, M. Tags: Articles Source Type: journals

Early onset anxiolytic efficacy after a single dose of pregabalin: double-blind, placebo- and active-comparator controlled evaluation using a dental anxiety modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate acute onset of anxiolytic activity using a dental anxiety model, 89 patients were randomised to double-blind single dose pregabalin 150 mg, alprazolam 0.5 mg or placebo 4 h before a scheduled dental procedure. A Dental Anxiety Total score >12 (moderate-to-severe) without meeting Diagnostic and Statistical Manual of Mental Disorders (Fourth edition) (DSM-IV) anxiety disorder criteria was required. Efficacy and safety, assessed 2, 2.5, 3, 3.5 and 4 h postdose, included 100 mm Visual Analogue Scale for Anxiety (VAS-Anxiety; primary outcome), 100 mm VAS-Sedation and Time-to-Onset of Action Scale (TOAS), a patien...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Nutt, D., Mandel, F., Baldinetti, F. Tags: Articles Source Type: journals

Prescribing antidepressants post Cipriani et alEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Nutt, D. J Tags: Articles Source Type: journals

ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Tags: Article Source Type: journals

High-dose venlafaxine in delusional and severely depressed patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Ruiz-Doblado, S, Rueda-Villar, T, Casillas-Lara, L Tags: Article Source Type: journals

Effects of bupropion augmentation on pro-inflammatory cytokines in escitalopram-resistant patients with major depressive disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractStudies so far have provided contradictory results on immune system markers during use of antidepressants. There are no data on changes in immune parameters after treatment augmentation. The present study aimed to clarify whether the addition of bupropion in escitalopram-resistant patients with major depression causes changes in the immune system and whether treatment response could be predicted by baseline levels of cytokines. We recruited 28 depressive patients (11 men and 17 women) who did not respond to 12-week treatment with escitalopram (20 mg/d) for an augmentation trial with bupropion (150–300&nb...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Eller, T, Vasar, V, Shlik, J, Maron, E Tags: Article Source Type: journals

Is there a neuroendocrinological rationale for testosterone as a therapeutic option in depression?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractDepression is a disease of growing incidence and economic burden worldwide. In view of increasing treatment resistance, new therapeutic approaches are urgently needed. In addition to its gonadal functions, testosterone has many effects on the central nervous system. An association between testosterone levels and depressive symptoms has been proposed. Many hormones and neurotransmitters are involved in the aetiology and the course of depression including serotonin, dopamine, noradrenaline, vasopressin and cortisol. Testosterone is known to interact with them. Preclinical data suggest that testosterone has antidepres...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Ebinger, M, Sievers, C, Ivan, D, Schneider, H., Stalla, G. Tags: Article Source Type: journals

Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractOmega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation may be beneficial in the treatment of several psychiatric disorders, including depression. A small number of studies have suggested that there may also be cognitive and mood effects in healthy samples. The purpose of the present study was to investigate the effects of n-3 PUFA on depression-relevant cognitive functioning in healthy individuals. Fifty-four healthy university students were randomized to receive either n-3 PUFA supplements or placebo for 4 weeks in a double-blind design. The test battery included measures of cognitive reactivity, atten...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Antypa, N, Van der Does, A., Smelt, A., Rogers, R. Tags: Article Source Type: journals

Paroxetine-induced increase in LDL cholesterol levelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractParoxetine is widely prescribed because it has the indication for multiple psychiatric disorders. Our objective was to assess the effect of short-term administration of paroxetine on low-density lipoprotein cholesterol (LDL-C) levels in both healthy controls (HCs) and in patients with panic disorder (PD). Blood samples for measurement of LDL-C were collected atbaseline, after 8 weeks of paroxetine administration and post-discontinuation in 24 male HCs and nine male patients suffering from PD, for a total of 33 subjects. Paroxetine treatment, both in HCs and PD patients, induced a mean 9% increase per subject i...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Le Melledo, J., Mailo, K, Lara, N, Abadia, M., Gil, L, Van Ameringen, M, Baker, G, Perez-Parada, J Tags: Article Source Type: journals

Effect of valproic acid on body weight, food intake, physical activity and hormones: results of a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to identify mechanisms through which valproic acid (VPA) causes weight gain. Healthy participants (N = 52) were randomized to VPA or placebo in a double-blind study. Energy intake (EI) was measured in the laboratory at lunch and dinner, and physical activity (PA) was measured with accelerometry. Glucose levels and hormones [Peptide YY3–36, glucagon-like peptide-1 (GLP-1), leptin, ghrelin, insulin] that regulate EI were measured. Assessments occurred at baseline and week 3. Change from baseline was evaluated with mixed models ( = 0.05). Weight significantly increased...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Martin, C., Han, H, Anton, S., Greenway, F., Smith, S. Tags: Article Source Type: journals

Long-term treatment with flupentixol results of a post-marketing surveillance studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractSchizophrenia is one of the most expensive illnesses. Antipsychotics are an essential component of the acute and preventative treatment of this illness, and long-term treatment is necessary to decrease the risk of psychotic relapse. The efficacy and tolerability of flupentixol was evaluated in a post-marketing surveillance study (PMS) in schizophrenic patients receiving long-term treatment in routine clinical practice. Psychiatrists in office practice treated patients for approximately 10 weeks, with a subsequent follow-up period of up to 18 months. We here report on the follow-up period in 128 patients. ...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Messer, T, Glaser, T, Landen, H, Schmauss, M Tags: Article Source Type: journals

Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension testsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, antagonism of central 4β2 and/or 7 nAChRs induced antidepressant-like effects in mice. A strategy involving antagonism of central nAChRs could potentially lead to the development of novel antidepressant therapeutics. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Andreasen, J., Olsen, G., Wiborg, O, Redrobe, J. Tags: Article Source Type: journals

Depot and oral antipsychotics: patient preferences and attitudes are not the same thingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractSome clinicians believe that antipsychotic depot injections are unacceptable to patients. This cross-sectional study investigated patients’ attitudes regarding antipsychotics, and included within-participant comparisons. Two hundred and twenty-two out-patients with schizophrenia/schizoaffective disorder completed the Drug Attitude Inventory (DAI-10), scales on insight, side effects and treatment preferences. Formulation preference was associated with current medication formulation: depots were preferred by 43% (33/76) on depot vs 6% (8/146) on orals (P < 0.001). Attitudes (DAI scores) regarding c...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Patel, M., De Zoysa, N, Bernadt, M, David, A Tags: Article Source Type: journals

Neural markers of symptomatic improvement during antidepressant therapy in severe depression: subgenual cingulate and visual cortical responses to sad, but not happy, facial stimuli are correlated with changes in symptom scoreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractResting state activity in the ventral cingulate may be an important neural marker of symptomatic improvement in depression. The number of task related functional magnetic resonance imaging (fMRI) studies correlating blood oxygenation level dependent (BOLD) response with symptomatic improvement is limited and methodologies are still evolving. We measured BOLD responses to sad and happy facial stimuli in 12 severely depressed individuals in the early stages of antidepressant treatment (Time 1) and 12 weeks later (Time 2) using event-related fMRI. We calculated correlations between temporal changes in BOLD respon...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Keedwell, P, Drapier, D, Surguladze, S, Giampietro, V, Brammer, M, Phillips, M Tags: Article Source Type: journals

Neuroendocrine and subjective responses to pharmacological challenge with citalopram: a controlled study in male and female ecstasy/MDMA usersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractDespite evidence that ±3,4-methylenedioxymethamphetamine (MDMA; ‘ecstasy’) causes persistent alterations to the serotonergic system of animals, evidence for long-term neurological effects of ecstasy/MDMA in humans remains equivocal. The current study assessed serotonin functioning of nine male and 11 female recreational ecstasy polydrug users by measuring neuroendocrine (prolactin, cortisol) responses to pharmacological challenge with the selective serotonin reuptake inhibitor citalopram, compared with nine male and five female cannabis polydrug users and 11 male and 11 female non-drug using cont...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Allott, K, Canny, B., Broadbear, J., Stepto, N., Murphy, B, Redman, J Tags: Article Source Type: journals

Attributions for psychobiological changes in ecstasy/MDMA and other polydrug usersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractEcstasy [3,4-methylenedioxymethamphetamine (MDMA)] use has been associated with a number of psychopathological problems. However, research suggests that reported symptoms might be associated more with heavy polydrug use in general rather than ecstasy per se. The current study aimed to determine the role of other drug use in reports of long-term effects by some ecstasy-polydrug users. Problematic ecstasy users (n = 53), reporting problems which they attributed to ecstasy use, were compared with non-problematic ecstasy users (n = 62), polydrug (n = 62) and alcohol/nicotine using controls...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Soar, K, Parrott, A, Turner, J Tags: Article Source Type: journals

Limits of meta-analysis: methylphenidate in the treatment of adult attention-deficit hyperactivity disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractGuidelines for the treatment of attention-deficit hyperactivity disorder (ADHD) in adults advocate methylphenidate as first-line treatment. The aim of this study was to review the effectiveness of methylphenidate treatment of adult ADHD and to examine the influence of methods on meta-analytic results. Electronic databases were searched to identify clinical trials comparing methylphenidate with placebo in the treatment of adult ADHD. Studies were summarised with meta-analytic methods. Subgroup analyses were conducted with respect to parallel group versus cross-over trials and self versus observer ratings. The relati...
Source: Journal of Psychopharmacology - August 13, 2009 Category: Psychiatry Authors: Koesters, M, Becker, T, Kilian, R, Fegert, J., Weinmann, S Tags: Article Source Type: journals

Clinical Manual of Geriatric Psychopharmacology: Sandra A. Jacobson, Ronald W. Pies & Ira R. Katz, American Psychiatric Publishing, Inc., paperback, 2007, 677 pp. + index. ISBN 1585622524Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Russ, D. T.C. Tags: Book review Source Type: journals

Risperidone-induced sexual dysfunction in a prepubertal child - a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a child with attention deficit hyperactivity disorder and motor tics, who developed frequent penile erections during treatment with risperidone and atomoxetine. On discontinuation of risperidone, he recovered fully. Clinicians should be alert to the adverse effects of atypical antipsychotics, which are used to treat a wide variety of paediatric psychiatric disorders. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Wadoo, O, Chalhoub, N Tags: Case reports Source Type: journals

Hyperprolactinemia and possibly related development of prolactinoma during amisulpride treatment; three casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Schizophrenia is a chronic and debilitating psychotic mental disorder that affects about 1% of the world's population. Antipsychotic drugs are the mainstay of treatment in schizophrenia. Hyperprolactinemia, which is a common side effect of typical antipsychotics, is also associated with the use of some of the newer atypical agents. Antipsychotics may enhance prolactinoma growth as manifested by an increase in serum prolactin concentration. Prolactin-secreting pituitary adenomas possibly related with antipsychotics have been described in the literature. To our ...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Akkaya, C, Kaya, B, Kotan, Z, Sarandol, A, Ersoy, C, Kirli, S Tags: Case reports Source Type: journals

Long-term effects of cannabis on oculomotor function in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Cannabis is known to affect human cognitive and visuomotor skills directly after consumption. Some studies even point to rather long-lasting effects, especially after chronic tetrahydrocannabinol (THC) abuse. However, it is still unknown whether long-term effects on basic visual and oculomotor processing may exist. In the present study, the performance of 20 healthy long-term cannabis users without acute THC intoxication and 20 control subjects were examined in four basic visuomotor paradigms to search for specific long-term impairments. Subjects were asked to ...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Huestegge, L, Radach, R, Kunert, H. Tags: Short report Source Type: journals

Efficacy of venlafaxine compared with tricyclic antidepressants in depressive disorder: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractWith respect to the pharmacological characteristic, venlafaxine is comparable with tricyclic antidepressants (TCAs), and venlafaxine might be comparable in efficacy. We performed a systematic review investigating the relative efficacy and tolerability of venlafaxine compared with TCAs (imipramine, clomipramine, amitriptyline, nortriptyline and desipramine). Relevant double-blind randomised trials were identified from systematic searches of electronic databases. An exact analysis of the estimated odds ratios of response of the TCA relative to venlafaxine showed no overall significance of treatment effect (P = 0.38)....
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: van den Broek, W., Mulder, P., van Os, E, Birkenhager, T., Pluijms, E, Bruijn, J. Tags: Review Source Type: journals

Cardiovascular variability during treatment with haloperidol, olanzapine or risperidone in recent-onset schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate the effects of treatment with haloperidol, olanzapine and risperidone on cardiovascular variability in patients with recent-onset schizophrenia by means of spectral analysis. Unmedicated patients (n = 18) had a higher mean heart rate and a tendency for a lower high-frequency power of heart rate variability than healthy control subjects (n = 57), indicating a decreased cardiac vagal control in unmedicated patients with schizophrenia. Patients treated with haloperidol (n = 10) showed significantly lower low-frequency power of heart rate and systolic blood pressure variability compared with ola...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Hempel, R., Tulen, J., van Beveren, N., Roder, C., Hengeveld, M. Tags: Original papers Source Type: journals

Cholinergic agonism alters cognitive processing and enhances brain functional connectivity in patients with multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractThe aim of this study is to define mechanisms underlying the pharmacological effects of brain cholinesterase inhibition on cognitive function in patients with multiple sclerosis (MS). Both a Stroop task and an N-back task were used to probe the changes in brain activity using functional magnetic resonance imaging (fMRI) in a single (investigator)-blind, crossover treatment design studying 15 patients with multiple sclerosis (12 relapsing remitting, 3 secondary progressive) taking rivastigmine (4.5 mg po bid) and domperidone (10 mg po qd) or domperidone alone. Administration of rivastigmine increased Stroop function...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Cader, S, Palace, J, Matthews, P. Tags: Original papers Source Type: journals

D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontalityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the following experiment was to induce a pathogenic hypofrontal condition by administering a dopamine-1 receptor (D1R) antagonist to rats. The pathophysiological effect of this manipulation upon glutamate-based long-term potentiation (LTP) in the medial prefrontal cortex (mPFC) was examined in vivo. Subjects were surgically implanted with stimulating electrodes into the corpus callosum and recording electrodes into the mPFC. High-frequency stimulation (HFS) was combined with the administration of the selective D1R family agonist A68930 hydrochloride (0.4 mg/kg/mL) and the selective D1R family antagonist SK...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Coppa-Hopman, R., Galle, J, Pimkine, D Tags: Original papers Source Type: journals

Effects of the atypical stimulant modafinil on a brief gambling episode in pathological gamblers with high vs. low impulsivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractPathological gambling (PG) is a serious psychiatric disorder afflicting 1-3% of the general population. Experimental evidence indicates shared neurochemical substrates for PG and psychostimulant addiction. Impulsivity characterizes one key subtype of PG. Therefore, medications that ameliorate psychostimulant addiction and impulsive syndromes might also benefit impulsive PG subjects. The atypical stimulant, modafinil reduces cocaine abuse and impulsivity in patients with ADHD. The present study sought to determine if modafinil (200 mg) would reduce the reinforcing effects of slot machine gambling in PG subjects, and...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Zack, M, Poulos, C. Tags: Original papers Source Type: journals

The role of dopamine D3, 5-HT2A and 5-HT2C receptor variants as pharmacogenetic determinants in tardive dyskinesia in African-Caribbean patients under chronic antipsychotic treatment: Curacao extrapyramidal syndromes study IXEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the possible relationship between TD and the polymorphisms Ser9Gly (DRD3), 102T>C (HTR2A), –1438G>A(HTR2A) and Cys23Ser (HTR2C) in African-Caribbean inpatients. One hundred and twenty-six patients under chronic antipsychotic treatment were genotyped. The assessment of TD was carried out with the abnormal involuntary movement scale (AIMS). The relationships between the carriership of the least frequent alleles and the respective orofaciolingual dyskinesia (TDof) (sum of the items 1-4 of the AIMS), limb-truncal dyskinesia (TDlt) (sum of items 5-7 of the AIMS) and TD (sum of items 1-7 of th...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Wilffert, B, Al Hadithy, A., Sing, V., Matroos, G, Hoek, H., van Os, J, Bruggeman, R, Brouwers, J., van Harten, P. Tags: Original papers Source Type: journals

Repeated administrations of dopamine receptor agents affect lithium-induced state-dependent learning in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractThe influence of repeated administration of dopamine receptor agents on the effect of lithium on lithium-induced state-dependent learning was examined in mice. Immediate post-training intraperitoneal (i.p.) administrations of lithium (10 and 20 m/kg) decreased the step-down latency of a single-trial inhibitory avoidance task. This was fully or partly reversed by pre-test administration of the same doses of the drug, with maximum response at the dose of 10 mg/kg, suggesting state-dependent learning was induced by lithium. Here, it has also been shown that repeated intracerebroventricular administrations of a mixed D...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Zarrindast, M., Madadi, F, Ahmadi, S Tags: Original papers Source Type: journals

Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractCB1/CB2 agonists are reported to have sedative, amnestic, analgesic and anti-emetic properties, which would make them ideal drugs for outpatient treatments under conscious sedation. The main objective of this in human study was to assess the sedative properties of Org 28611, a potent water-soluble CB1 agonist. Single ascending doses were administered during a slow 25 min infusion and after a 1 min bolus administration to healthy male volunteers. In addition, the pharmacokinetics, amnestic properties, postural stability, electro-encephalography, behavioural and cardiovascular effects were studied. Midazolam 0.1 mg/k...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: Zuurman, L, Passier, P., de Kam, M., Kleijn, H., Cohen, A., van Gerven, J. Tags: Original papers Source Type: journals

The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A 2,3 selective agonist, in comparison with lorazepam in healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was a double-blind, five-way cross-over study to investigate the effects of three doses of SL65.1498 in comparison with placebo and lorazepam 2 mg in healthy volunteers. The objective was to select a dose level (expected to be therapeutically active), free of any significant deleterious effect. Psychomotor and cognitive effects were measured using a validated battery of measurements, including eye movements, body sway, memory tests, reaction-time assessments, and visual analogue scales. The highest dose of SL65.1498 showed slight effects on saccadic peak velocity and smooth pursuit performance, although to a muc...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: de Haas, S., Franson, K., Schmitt, J., Cohen, A., Fau, J., Dubruc, C, van Gerven, J. Tags: Original papers Source Type: journals