De Novo Brain Vascular Malformation in an Adult with Hereditary Hemorrhagic Telangiectasia and Juvenile Polyposis Overlap Syndrome
The development of brain vascular malformation (BVM) is rare in adults. The Hereditary Hemorrhagic Telangiectasia (HHT) Clinical Guidelines recommend BVM screening with magnetic resonance imaging (MRI) at the time of diagnosis. However, these guidelines apply broadly to the HHT population and do not account for patients with Mothers Against Decapentaplegic Homolog 4 (MADH4) mutations, often presenting other hypermobility features and cardiovascular anomalies (e.g., Aortic root aneurysms, vascular kinking). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2024 Category: Neurology Authors: Elisa Guan, Carolina Vazquez, Ana Braslavsky, Cristina H. Besada, Akly Manuel S. Perez, Oscar Peralta, Monaco Ricardo Garc ía, Matteo Baccanelli, Nicolás M. Ciarrocchi, Marcelo M. Serra Tags: Case Report Source Type: research

The Predictive Value of Serum F-actin on the Severity and Early Neurological Deterioration of Acute Ischemic Stroke
F-actin is involved in the progression of ischemic stroke and is associated with the disruption of the blood-brain barrier. In this article, we evaluated serum F-actin as a biomarker in stroke severity and early neurological deterioration (END) in acute ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2024 Category: Neurology Authors: Jiaqian Li, Binda Wang, Fangyu Dai, Xuelian Kou, Guangyong Wu, Bin Wu, Jie Xu, Lulan Pan, Jingjing Liu, Songbin He, Feng Gao Source Type: research

Health Care-Associated Infections after Surgical Treatment of Ruptured Intracranial Aneurysms
Aneurysmal subarachnoid hemorrhage (SAH) is catastrophic, and microsurgery for ruptured intracranial aneurysms is one of the preventive modalities for rebleeding. However, patients remain at high risk of medical morbidities after surgery, one of the most important of which is health care-associated infections (HAIs). We analyzed the incidence and risk factors of HAIs, as well as their association with the outcomes after surgical treatment of ruptured aneurysms. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2024 Category: Neurology Authors: Yu-Hua Huang, Tsung-Han Lee Source Type: research

Differentiating Ischemic Stroke Patients from Healthy Subjects Using a Large-Scale, Retrospective EEG Database and Machine Learning Methods
We set out to develop a machine learning model capable of distinguishing patients presenting with ischemic stroke from a healthy cohort of subjects. The model relies on a 3-minute resting electroencephalogram (EEG) recording from which features can be computed. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2024 Category: Neurology Authors: William Peterson, Nithya Ramakrishnan, Krag Browder, Nerses Sanossian, Peggy Nguyen, Ezekiel Fink Source Type: research

Systolic Blood Pressure Reduction Strategies in Acute Ischemic Stroke Patients Following Endovascular Thrombectomy: A Systematic Review and Meta-analysis
This study intends to investigate the relationship between reducing SBP and clinical outcomes and to determine the therapeutic efficacy of moderate and intensive SBP reduction post EVT. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2024 Category: Neurology Authors: Mohammed Maan Al-Salihi, Syed A. Gillani, Ram Saha, Mouhammad A. Jumaa, Syed F. Zaidi, Farhan Siddiq, Camilo R. Gomez, Mikael Mazhigi, Adnan I. Qureshi Source Type: research

An algorithm for the National Institute of Health Stroke Scale assessment: a multicenter, two-arm and cluster randomized study
The NIH Stroke Scale (NIHSS) is a validated tool for assessing stroke severity, increasingly used by general practitioners in telemedicine services. Mobile apps may enhance its reliability. We aim to validate a digital platform (SPOKES) for NIHSS assessment in telemedicine and healthcare settings. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2024 Category: Neurology Authors: Joao Brainer Clares de Andrade, Evelyn de Paula Pacheco, Millene Rodrigues Camilo, Carlos Eduardo Lenis Rodriguez, Paula Sanchez Nascimento, Nath ália Souza de Oliveira, Thiago S Carneiro, Renato Andre Castro de Oliveira, Gisele Sampaio Silva Source Type: research

A comparison of endovascular therapy and medical management in patients with large vessel occlusion mild stroke treated between 2015 and 2023: a systematic review and meta-analysis
Endovascular therapy (EVT) is recommended for patients with acute large-vessel occlusion (LVO) However, its efficacy and safety compared to medical management (MM) in patients with a National Institutes of Health Stroke Scale (NIHSS) score of ≤6 remains unclear. This meta-analysis compared EVT with medical MM in patients with large vessel occlusion mild stroke treated between 2015 and 2023, following the publication of the first randomized controlled trial. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2024 Category: Neurology Authors: Yiqiao Xu, Xin Liu, Hao Li Source Type: research

Outcomes of endovascular thrombectomy for ischaemic stroke among nonagenarians with and without pre-existing dependency
Our aim was to compare the outcomes of treatment with endovascular thrombectomy for pre-stroke dependent versus pre-stroke independent among the very elderly ≥90 years. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2024 Category: Neurology Authors: Shyue Xian (Joshua) Chong, Timothy Phillips, Alicia Massarotto, Darshan Ghia Source Type: research

External Validation of the SI2NCAL2C Score for Outcomes Following Cerebral Venous Thrombosis
Prognostication for cerebral venous thrombosis (CVT) remains difficult. We sought to validate the SI2NCAL2C score in an international cohort. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 11, 2024 Category: Neurology Authors: Piers Klein, Liqi Shu, Erik Lindgren, Maria A. de Winter, James E. Siegler, Alexis N. Simpkins, Satareh Salehi Omran, Mirjam R. Heldner, Adam de Havenon, Mohamad Abdalkader, Sami al Kasab, Christoph Stretz, Teddy Y. Wu, Duncan Wilson, Syed Daniyal Asad, E Source Type: research

Correlation between non-marker inflammatory indices and carotid intima-media thickness in the middle-aged and elderly adults
This study aimed to investigate the correlations between carotid intima-media thickness (IMT) and systemic immune inflammation index (SII), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte (NLR) ratio. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2024 Category: Neurology Authors: Pangpang Zhang, Dehua Cui, Peng Zhang, Hongjun Wang, Yongnan Hao, Jinfeng Ma, Qiuhua Li, Aimei Zhang, Xiang Li, Daojing Li Source Type: research

SDF-1/CXCR4 axis participants in the pathophysiology of adult patients with moyamoya disease
Moyamoya disease (MMD) is characterized by an abundance of moyamoya vessels; however, the precise mechanism driving the spontaneous angiogenesis of these compensatory vessels remains unclear. Previous research has established a link between the stromal cell-derived factor-1 (SDF-1)/ CXC receptor 4 (CXCR4) axis and angiogenesis under hypoxic conditions. Nevertheless, the alterations in this axis within the cerebrospinal fluid, arachnoid membranes and vascular tissue of MMD patients have not been fully investigated. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2024 Category: Neurology Authors: Shuaiyu Ren, Qingdong Han, Peng Zhou, Zongqi Wang, Yabo Huang Source Type: research

Predictors of Post Stroke Cognitive Impairment: VITATOPS Cognition Substudy
Post stroke cognitive impairment (PSCI) is a common complication of ischemic stroke. PSCI can involve different depending on clinical and stroke related characteristics. The aim of this study is to determine the factors associated with impairments in specific cognitive domains. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2024 Category: Neurology Authors: Isabel Siow, Kaavya Narasimhalu, Keng Siang Lee, Hong Kuang Tan, Simon Kang Seng Ting, Shahul Hameed, Hui Meng Chang, Deidre Anne De Silva, Christopher Li Hsian Chen, Eng King Tan Source Type: research

Decompressive craniectomy for patients with malignant infarction of the middle cerebral artery: a pooled analysis of two randomized controlled trials
Decompressive craniectomy (DC) reduces mortality without increasing the risk of very severe disability among patients with life-threatening massive cerebral infarction. However, its efficacy was demonstrated before the era of endovascular thrombectomy trials. It remains uncertain whether DC improves the prognosis of patients with malignant middle cerebral artery (MCA) infarction receiving endovascular therapy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2024 Category: Neurology Authors: Xiaojun Luo, Bo Yang, Junjie Yuan, Huijie An, Dongjing Xie, Qin Han, Simin Zhou, Chengsong Yue, Hongfei Sang, Zhongming Qiu, Zhenyu Kong, Zhonghua Shi Source Type: research

The Impact of Pre-Stroke Metformin Use on Clinical Outcomes after Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
Stroke stands as one of the most devastating medical conditions and societal burdens, ranking as the third-leading cause of both death and disability on a global scale1. Diabetes mellitus, specifically type 2 diabetes mellitus (T2DM), is not just a prevalent medical condition but also a known risk factor for stroke, contributing to both its occurrence and recurrence2-5. The complexities tied to diabetes make it a focal point of investigation, especially given that hyperglycemia upon admission has been correlated with unfavorable outcomes post-stroke2, 6-8. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2024 Category: Neurology Authors: Madona Pakkam, Atakan Orscelik, Basel Musmar, Hatem Tolba, Sherief Ghozy, Yigit Can Senol, Cem Bilgin, Sandeep Samethadka Nayak, Ramanathan Kadirvel, Waleed Brinjikji, Alejandro A Rabinstein, David F Kallmes Source Type: research

The prevalence and characteristics of alexithymia in stroke patients: a systematic review and meta-analysis
Previous studies have indicated the potential occurrence of alexithymia among stroke patients, yet the prevalence of alexithymia in this population remains disparate across different investigations without a synthesized overview. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2024 Category: Neurology Authors: Yue Yuan, Yuxia Ma, Jiangxia Qin, Guifen Ma, Juhong Pei, Xiaoqin Wei, Yiyi Yang, Juanjuan Feng, Jinhan Nan, Bailing Yan, Lin Han Source Type: research