National trends in contralateral prophylactic mastectomy in women with locally advanced breast cancer
ConclusionsIncreasing numbers of women with unilateral cT4M0 breast cancer are undergoing CPM. This rising trend warrants further research to understand stakeholders ’ preferences in surgical decision‐making for women with locally advanced breast cancer. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Hinaben Panchal, Melissa L. Pilewskie, Clifford C. Sheckter, Claudia R. Albornoz, Shantanu N. Razdan, Joseph J. Disa, Peter G. Cordeiro, Babak J. Mehrara, Evan Matros Tags: RESEARCH ARTICLE Source Type: research

Desmoplastic melanoma
(DM) is a rare melanoma variant that has unique biology and pathology compared with conventional melanoma (non ‐DM). Importantly, DM is classified into pure and mixed histologic subtypes, which have been correlated with outcomes. Management of DM broadly mirrors that of non‐DM; however, there are unique considerations for DM that influence treatment approaches. This paper will provide a contemporary over view of this disease and will review the literature regarding the management of DM. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Norman G Nicolson, Dale Han Tags: REVIEW ARTICLE Source Type: research

The impact of failure to achieve symptom control after resection of functional neuroendocrine tumors: An 8 ‐institution study from the US Neuroendocrine Tumor Study Group
ConclusionsFailure to achieve symptomatic improvement after resection of functional NETs is associated with worse RFS. These patients may benefit from short ‐interval surveillance imaging postoperatively to assess for earlier radiographical disease recurrence. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Mohammad Y. Zaidi, Alexandra G. Lopez ‐Aguiar, George A. Poultsides, Mary Dillhoff, Flavio G. Rocha, Kamran Idrees, Hari Nathan, Emily R. Winslow, Ryan C. Fields, Kenneth Cardona, Shishir K. Maithel, and other members of the US Neuroendocrine Tags: RESEARCH ARTICLE Source Type: research

Clinico ‐pathological features and survival of patients with malignant exocrine pancreatic neoplasms: The AC Camargo Cancer Center experience
ConclusionsThe features of our population match those of studies done in developed countries. We believe multicentric data from patients with pancreatic cancer in Brazil could enable more effective preventive and therapeutic approaches to the disease. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Victor Hugo Fonseca de Jesus, Marcos Pedro Guedes Camandaroba, Mauro Daniel Spina Donadio, Audrey Cabral, Thiago Pimentel Muniz, Luciana Moura Leite, Lucas Ferreira Sant ’Ana, Wilson Luiz da Costa, Maria Paula Curado, Felipe José Fernandez Coi Tags: RESEARCH ARTICLE Source Type: research

Melanoma of unknown primary
Formally described in the 1960s, melanoma of unknown primary (MUP) is characterized by the finding of metastatic melanoma within the lymph nodes, subcutaneous tissues, and other distant sites without an evident primary lesion. The most likely hypothesis of its etiology is an immune ‐mediated regression of the primary after metastasis has occurred. In addition, patients with MUP appear to have equivalent or better outcomes compared with patients with known primaries of a similar stage. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Yun Song, Giorgos C. Karakousis Tags: REVIEW ARTICLE Source Type: research

Updates in adjuvant systemic therapy for melanoma
We describe several pivotal clinical trials of systemic immune therapies, targeted immune therapies, and adjuvant vaccine strategies. Finally, we discuss the evidence for selecting the most appropriate treatment regimen(s) for the individual patient. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Minyoung Kwak, Norma E. Farrow, April K. S. Salama, Paul J. Mosca, Brent A. Hanks, Craig L. Slingluff, Georgia M. Beasley Tags: REVIEW ARTICLE Source Type: research

Assessment of hospital ‐level adjusted breast cancer sentinel lymph node positivity rates
ConclusionsThere is a wide variation in hospital SLNB positivity rates. Hospitals with lower ‐ or higher‐than‐expected SLNB positivity rates were associated with survival differences. Hospital SLNB positivity rates may be a novel ‘process measure’ to report to hospitals for internal quality assessment. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Elizabeth R. Berger, Karl Y. Bilimoria, Christine V. Kinnier, Christina A. Minami, Kevin P. Bethke, Nora M. Hansen, Ryan P. Merkow, David P. Winchester, Anthony D. Yang Tags: RESEARCH ARTICLE Source Type: research

Hypomethylation of mismatch repair genes MLH1 and MSH2 is associated with chemotolerance of breast carcinoma: Clinical significance
ConclusionMLH1/MSH2 genes play a critical role in the development of BC. Hypomethylation of MLH1/MSH2 genes might be important in chemotolerance of the disease. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Hemantika Dasgupta, Saimul Islam, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda Tags: RESEARCH ARTICLE Source Type: research

New lymph node staging for rectal neuroendocrine tumors
ConclusionsThe number of positive locoregional lymph nodes is an independent prognostic factor in rectal NETs. The next AJCC edition should consider classifying patients with rectal NETs as N0, N1, and N2 to provide better estimates of survival for patients. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Adam C. Fields, Justin C. McCarty, Linda Ma ‐Pak, Pamela Lu, Jennifer Irani, Joel E. Goldberg, Ronald Bleday, Jennifer Chan, Nelya Melnitchouk Tags: RESEARCH ARTICLE Source Type: research

Identifying the barriers to gastric cancer care at safety ‐net hospitals: A novel comparison of a safety‐net hospital to a neighboring quaternary referral academic center in the same healthcare system
ConclusionAlthough vulnerable patients with GAC within a safety ‐net hospital present with later stages of the disease, those who received surgery have acceptable outcomes. Thus, efforts should be made to overcome barriers in seeking care. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Mohammad Y. Zaidi, Jesse M. Rappaport, Cecilia G. Ethun, Theresa Gillespie, Natalyn Hawk, Saurabh Chawla, Kenneth Cardona, Shishir K. Maithel, Maria C. Russell Tags: RESEARCH ARTICLE Source Type: research

Current management of regional lymph nodes in patients with melanoma
The publication of recent randomized trials has prompted a significant shift in both our understanding and the management of patients with melanoma. Here, the current management of the regional lymph nodes in patients with melanoma is discussed. This review focuses on selection for sentinel lymph node biopsy, management of the positive sentinel node, management of the clinically positive node, and the controversy over the therapeutic value of early nodal intervention. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Edmund K. Bartlett Tags: REVIEW ARTICLE Source Type: research

Laparoscopic synchronous resection of colorectal cancer and liver metastases: A systematic review
While colorectal and hepatic resections are commonly performed through a laparoscopic approach, the safety and feasibility of total laparoscopic synchronous resections (LSR) of colorectal liver metastasis (CRLM) have not been established. In this systematic review, short ‐ and long‐term outcomes were comparable for patients undergoing LSR and open synchronous resection. LSR was safe and feasible for patients with synchronous CRLM and should be considered in well‐selected patients. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Dimitrios Moris, Diamantis I. Tsilimigras, Nikolaos Machairas, Katiuscha Merath, Marcelo Cerullo, Natasha Hasemaki, Anastasia Prodromidou, Jordan M Cloyd, Timothy M Pawlik Tags: REVIEW ARTICLE Source Type: research

A 96 ‐hour continuous wound infiltration with ropivacaine reduces analgesic consumption after liver resection: A randomized, double‐blind, controlled trial
ConclusionPreperitoneal CWI of 2  mg/mL ROP significantly reduces intravenous morphine consumption during the 96 postoperative hours resulting in an absolute reduction of 0.5 mg/kg. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: V éronique Peres‐Bachelot, Ellen Blanc, Nadia Oussaid, David Pérol, Anne Laure Daunizeau‐Walker, Stéphanie Pouderoux, Patrice Peyrat, Michel Rivoire, Aurélien Dupré Tags: RESEARCH ARTICLE Source Type: research

Specific prognostic factors in hepatitis B virus ‐related and non‐hepatitis B virus–related intrahepatic cholangiocarcinoma after macroscopic curative resection
ConclusionsThe HBV ‐ and non‐HBV–related iCCA have different prognostic factors for the OS. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 27, 2018 Category: Cancer & Oncology Authors: Jianbo Huang, Xiangyu Wang, Ying Zhu, Zheng Wang, Jianhua Li, Da Xu, Shenghao Wang, Tian ‐En Li, Lu Lu Tags: RESEARCH ARTICLE Source Type: research

Cover Image, Volume 118, Number 8, December 15, 2018
(Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 22, 2018 Category: Cancer & Oncology Tags: COVER Source Type: research