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SPECT/CT for preoperative sentinel node localizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The value of SPECT/CT for detection and localization of sentinel nodes is reviewed. SPECT/CT depicts extra sentinel nodes and identifies non-nodal tracer accumulation. SPECT/CT is indicated in patients with complex lymphatic drainage as often present in patients with head, neck and scapular melanoma, breast cancer patients with extra-axillary sentinel nodes and patients with tumors draining to pelvic nodes. SPECT/CT also clarifies the drainage pattern of inconclusive conventional images (non-visualization or unclear location of the nodes). J. Surg. Oncol. © 2009 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 19, 2009 Category: Cancer & Oncology Authors: Lenka Vermeeren, Iris M.C. van der Ploeg, Renato A. Valdés Olmos, Willem Meinhardt, W. Martin C. Klop, Bin B.R. Kroon, Omgo E. Nieweg Source Type: journals

Longitudinal change of treatment-related upper limb dysfunction and its impact on late dysfunction in breast cancer survivors: A prospective cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To investigate the prevalence of upper limb dysfunction (ULD) and subtypes after breast cancer surgery and to identify factors associated with late ULD.Among 191 enrolled patients, 191 were evaluated at 3 months, 187 at 6 months, and 183 at 12 months after surgery. Pain, shoulder range of motion, muscle strength, and arm circumference were assessed. Based on symptoms and physical examinations, the types of ULD common after breast cancer treatment were diagnosed and categorized.The prevalence of ULD after surgery were 24.6%, 20.9%, and 26.8% at 3, 6, and 12 months, respectively. The most common types of ULD were pectoralis ...
Source: Journal of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Eun Joo Yang, Won-Beom Park, Kwan Sik Seo, Sung-Won Kim, Chan-Yeong Heo, Jae-Young Lim Source Type: journals

Tracheo-oesophageal party wall thickness in laryngectomised patients in India: Implications for surgical voice restorationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To document accurately the tracheo-oesophageal party wall thickness (PWT) intra-operatively in patients undergoing total laryngectomy and to correlate it with constitutional parameters like height, weight, body mass index (BMI), age, and gender. Also, to correlate PWT with the length of tract (LOT), that is prosthesis size, as measured using the standard valve length measuring device provided by the manufacturers.Twenty-eight patients of carcinoma larynx, following removal of the diseased larynx had their tracheo-oesophageal PWT measured using a special custom-designed and calibrated external (or outside) calliper and a pr...
Source: Journal of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Suhail I. Sayed, Kapila Manikantan, Shailesh Khode, Mohan Jagade, Vimal G. Kasbekar, Rajen Shah, Rajen S. Palav, Chris M. Nutting, Kevin J. Harrington, Peter Rhys-Evans, Rehan Kazi Source Type: journals

Advanced gastric cancer in the middle one-third of the stomach: Should surgenos perform total gastrectomy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine which optimal surgical procedure for middle-third advanced gastric cancer (AGC) based on comparative study of the long-term prognosis between total gastrectomy (TG) and distal gastrectomy (DG).Between March 1993 and December 2005, 402 patients with middle-third AGC who underwent gastric resection were enrolled in this study. We analyzed the long-term prognosis according to the length of the proximal resection margin (PRM) and the extent of gastric resection, and determined independent prognostic factors.TG was performed in 244 patients (60.7%) and DG was performed in 158 patients (39.3%). There were no signifi...
Source: Journal of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: You-Jin Jang, Man-Sik Park, Jong-Han Kim, Sung-Soo Park, Seung-Heum Park, Seung-Joo Kim, Chong-Suk Kim, Young-Jae Mok Source Type: journals

Labeling of cervical lymph node levels during neck dissection: From ex vivo to in situ mappingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To analyze the error rate of ex vivo mapping and to evaluate in situ mapping of lymph node (LN) levels during neck dissection (ND)We retrospectively reviewed the pathological data on metastatic LN levels in head and neck cancer patients that had ND and ex vivo mapping of LN levels. Among them, we included the data from 43 patients that had a high risk for metastatic nodes based on both the preoperative CT and PET/CT. We compared the metastatic node levels based on the radiological studies and surgical pathology. In addition, we prospectively evaluated the accuracy of in situ mapping (N = 20).With ex vivo mapping, the discr...
Source: Journal of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Seung Hoon Woo, Yoon Kyoung So, Jong-In Jeong, Hayoung Byun, Won-Yong Lee, Han-Sin Jeong Source Type: journals

Medium to long-term results after reconstruction of bone defects at the knee with tumor endoprosthesesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Limb salvage and reconstruction with tumor endoprostheses is considered as therapeutic standard in the treatment of bone defects at the knee. Few studies report long-term results so far.Seventy-seven patients who had a cementless or cemented MUTARS® endoprosthesis implanted were followed-up for a mean period of 46 months (3-128 months). The defects were due to primary tumor lesions in 69 cases or metastases in 8 cases. The distal femur (n = 49) or the proximal tibia (n = 28) was reconstructed predominantly with cementless implants (femur: 69%, tibia: 92%). The resection of the tumor was intraarticular in 46 and extraartic...
Source: Journal of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: S. Kinkel, B. Lehner, J.A. Kleinhans, E. Jakubowitz, V. Ewerbeck, C. Heisel Source Type: journals

Impact of lymph-node metastasis site in patients with thoracic esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We retrospectively compared surgical outcomes between patients with intra-thoracic and extra-thoracic (cervical and abdominal) lymph-node metastasis.The study population comprised 96 patients with lymph-node metastasis who had undergone curative esophagectomy for thoracic esophageal cancer. The patients were grouped according to whether the site of lymph-node metastasis was intra-thoracic, extra-thoracic, or both intra-thoracic and extra-thoracic. The patient characteristics, survival time, and prognostic factors were compared.The most significant difference in disease-specific survival was detected at a threshold value of...
Source: Journal of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Chikara Kunisaki, Hirochika Makino, Jun Kimura, Takashi Oshima, Shoichi Fujii, Ryo Takagawa, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama Source Type: journals

Robot-assisted staging using three robotic arms for endometrial cancer: Comparison to laparoscopy and laparotomy at a single institutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To demonstrate the feasibility of robot-assisted staging surgery using three arms in patients with endometrial cancer.One hundred nine patients with clinical stage I endometrial cancer who underwent staging surgery at Yonsei University Health System were enrolled from May 2006 to January 2009. Patient demographics and operative outcomes were prospectively collected.Robotic surgery using three arms was performed in 28 patients, laparoscopy in 25, and laparotomy in 56. There were no differences among the three groups in terms of patient demographics. The number of harvested pelvic lymph nodes was lower in the laparoscopy gro...
Source: Journal of Surgical Oncology - November 10, 2009 Category: Cancer & Oncology Authors: Yong Wook Jung, Dae Woo Lee, Sang Wun Kim, Eun Ji Nam, Jae Hoon Kim, Jae Wook Kim, Young Tae Kim Source Type: journals

Middle pancreatectomy with pancreaticogastrostomy: A technique, operative outcomes, and long-term pancreatic functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluates a technique, operative outcomes, and long-term exocrine and endocrine pancreatic function of the middle pancreatectomy procedure.Nineteen patients who underwent middle pancreatectomy between 1996 and 2008 were reviewed. Indications included eight intraductal papillary-mucinous neoplasms, five endocrine tumors, one serous and two mucinous cystadenomas, and three other benign lesions. Reconstruction of the distal pancreatic remnant was performed with pancreaticogastrostomy using the duct-to-mucosa method in 16 patients and with Roux-en-Y end-to-end pancreaticojejunostomy in 3 patients.Median operative ti...
Source: Journal of Surgical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Takeshi Sudo, Yoshiaki Murakami, Kenichiro Uemura, Yasuo Hayashidani, Yasushi Hashimoto, Hiroki Ohge, Taijiro Sueda Source Type: journals

Aberrant methylation of DNA mismatch repair genes in elderly patients with sporadic gastric carcinoma: A comparison with younger patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypermethylation of promoters that regulate the expression of DNA repair genes is associated with gastric carcinoma (GC). Little is known regarding the association between age of disease onset and differences in molecular profiles.The two study groups consisted of 100 elderly patients and 100 younger patients. The aberrant DNA methylation patterns of four mismatch repair genes, hMLH1, hMSH2, hMSH3, and MGMT, were compared by bisulfite modification and methylation-specific PCR (MSP).The methylation frequencies for hMLH1 and hMSH3 were significantly higher for the elderly than for the younger GC patients (P < 0.001 and P = 0...
Source: Journal of Surgical Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Ho Gun Kim, Soon Lee, Dong Yi Kim, Seong Yeob Ryu, Jae Kyun Joo, Jung Chul Kim, Kyung Hwa Lee, Jae Hyuk Lee Source Type: journals

Predicting which patients with ovarian carcinoma are not suitable for primary cytoreductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstracts. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - October 30, 2009 Category: Cancer & Oncology Authors: Joel Noumoff Source Type: journals

Histopathological and immunohistochemical evaluations of breast cancer treated with radiofrequency ablationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although RF ablation is a promising non-surgical ablation technique for the treatment of breast cancer, assessment of the efficacy requires not only imaging of tumor necrosis but also histological confirmation.Two series of patients were treated with RF ablation. In the first series, 17 patients underwent surgical resection immediately and 17 underwent delayed mammotome excision in the second series. The ablated tumor tissue was examined histologically with H&E staining and NADH-diaphorase staining. Furthermore, ssDNA was immunohistochemically stained in the specimen where tumor cells were histologically detected.In the fi...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Ai Motoyoshi, Masakuni Noguchi, Mitsuharu Earashi, Yoh Zen, Hisatake Fujii Source Type: journals

Screening for malnutrition: Implications for upper gastrointestinal cancer servicesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Vanessa Halliday, Gemma Kierczuk, Srinivasan Madhusudan, Simon Parsons, Andrew Wilcock Source Type: journals

The role of PET CT to evaluate the response to neoadjuvant chemotherapy in advanced breast cancer: Comparison with ultrasonography and magnetic resonance imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is aimed to estimate the predictive role of PET CT and other imaging modalities (ultrasound, MRI) through NAC.PET CT was acquired before and after NAC from 41 patients. Pathologic results were classified as pathological complete response (pCR) and non-pCR. The results of clinical responses were assessed with imaging indexes (postTx, postchemotherapy size or peak standardized uptake values (pSUV); delta, the size difference between treatment; RR, reduction rate of tumor size or pSUV), and they were compared with pathologic results.Seven patients (17.1%) showed pCR. As a result of comparison of the image index, al...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Jae Hyuck Choi, Hye In Lim, Se Kyung Lee, Wan Wook Kim, Sang Min Kim, EunYoon Cho, Eun Young Ko, Boo-Kyung Han, Yeon Hee Park, Jin-Seok Ahn, Young-Hyuck Im, Jeong Eon Lee, Jung-Hyun Yang, Seok Jin Nam Source Type: journals

Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in patients with locally advanced rectal cancer (LARC).Between 2004 and 2006, 28 patients with LARC (cT2-T4, N0-N2) were treated with neoadjuvant chemoradiation. Total radiation dose was 50.4 Gy and daily dose was 1.8 Gy in 5.5 weeks. Capecitabine was administrated 1,650 mg/m2/day, 7 days/week. Preoperative staging was based on combined computer tomography and endorectal ultrasound. Tissue samples...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: C.S. Boskos, C. Liacos, D. Korkolis, K. Aygerinos, I. Lamproglou, E. Terpos, E. Stoupa, G. Baltatzis, K. Beroukas, P. Papasavvas, M.A. Dimopoulos, A. Bamias Source Type: journals

Long-term survivors of esophageal cancer: Disease-specific quality of life, general health and complicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of our study was to assess the quality of life as well as secondary cancers/diseases and esophagectomy-related or unrelated interventions in the long-term course of surgery.Out of 417 patients who underwent esophageal resection for cancer between September 1985 and November 2003, 85 were defined as long-term survivors ([ge]5 years). Fifty patients still alive in November 2008 complied with our inclusion criteria. The general (QLQ-C 30, version 3.0) as well as the esophagus specific quality of life (QLQ-OES 18) were analyzed with the help of the EORTC QLQ-questionnaires.The median observation interval since the oper...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: I. Gockel, U. Gönner, M. Domeyer, H. Lang, Th. Junginger Source Type: journals

Extra-abdominal desmoid tumors: A report of 234 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To report on the clinical presentation and outcome for 234 patients with extra-abdominal desmoids tumors.Since 1977, the authors have treated 234 patients with extra-abdominal desmoid tumors. The patients had an average age of 36.7 and 61% were female. The tumors arose adjacent to muscles or bones and the largest number were in the foot, shoulder thigh and calf. All of the patients were treated by primary surgery. Thirty-seven had additional radiation and eight had chemotherapy.Local recurrence occurred in 39 patients and 23% of the patients required additional surgery. Of great concern were 24 patients who developed multi...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Henry J. Mankin, Francis J. Hornicek, Dempsey S. Springfield Source Type: journals

Extensive lymphadenectomy in colorectal cancer with isolated para-aortic lymph node metastasis below the level of renal vesselsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effects of isolated metastatic node dissection in the para-aortic region have not been established in colorectal cancer (CRC). The authors undertook to evaluate the role of para-aortic lymph node (PALN) dissection in CRC with isolated PALN metastasis.Between January 1993 and March 2006, 24 patients underwent PALN dissection for isolated PALN metastasis from CRC. Patients with distant metastases other than to PALNs, or with nodal metastasis above the celiac axis were excluded. The control group was composed of 53 patients with isolated PALN metastasis below the level of the renal hilum that was not surgically removed.Me...
Source: Journal of Surgical Oncology - October 19, 2009 Category: Cancer & Oncology Authors: Pyong Wha Choi, Hee Cheol Kim, Ah Young Kim, Sang Hun Jung, Chang Sik Yu, Jin Cheon Kim Source Type: journals

Genomic expression, chemotherapy response, and molecular targets in soft tissue sarcomas of the extremities: Promising strategies for treatment selectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neoadjuvant or adjuvant therapy in soft tissue sarcomas is still controversial, especially in regards to the use of chemotherapy. The identification of predictive factors is crucial to avoid the use of chemotherapy in patients with tumors that carry genetic characteristics associated with resistance. Focusing on gene expression data, we performed a review of the actual state of knowledge in molecular predictive factors for chemotherapy response and new targets of therapy in extremity sarcomas. J. Surg. Oncol. © 2009 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - October 15, 2009 Category: Cancer & Oncology Authors: Samuel Aguiar Jr., Isabela Werneck da Cunha, Ademar Lopes Source Type: journals

Aneurysmal bone cyst: The role of cryosurgery as local adjuvant treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is done to assess the outcome of curettage and cryosurgery as a treatment of ABC.We analyzed 80 consecutive cases of ABC treated with curettage and cryosurgery. Patients were followed minimal 24 months after surgery (average 55 months, range 24-122 months) with physical examination and radiographs. Functional outcome was evaluated using the musculoskeletal tumor society score (MSTS).The 80 patients were all treated with curettage and cryosurgery. Additional bone grafting was used in 73 patients, osteosynthesis in 12 and spondylodesis in 1 patient. Four local recurrences were found in this study, a recurrence rat...
Source: Journal of Surgical Oncology - October 9, 2009 Category: Cancer & Oncology Authors: S.P. Peeters, I.C.M. Van der Geest, J.W.J. de Rooy, R.P.H. Veth, H.W.B. Schreuder Source Type: journals

Particle beam radiotherapy with a surgical spacer placement for advanced abdominal leiomyosarcoma results in a significant clinical benefitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Takumi Fukumoto, Shohei Komatsu, Yuichi Hori, Masao Murakami, Yoshio Hishikawa, Yonson Ku Source Type: journals

Impact of postoperative irradiation after non-curative resection of hilar biliary cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this retrospective study was to determine the effect of surgical margin on the outcome of postoperative radiotherapy (RT) in patients with resected hilar biliary cancer.The study subjects were 87 patients with hilar biliary cancer resected surgically before 2008. Based on the Japanese Society of Biliary Surgery (JSBS) criteria for diagnosis of biliary cancer, the surgical margin status was categorized as margin 1 (histopathologically margin negative, but cancer cells identified within 5 mm from the margin), margin 2 (histopathologically margin positive), and margin 0 (other margin status).The surgical margin was...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Shogo Kobayashi, Hiroaki Nagano, Shigeru Marubashi, Yutaka Takeda, Masahiro Tanemura, Koji Konishi, Yasuo Yoshioka, Takehiro Inoue, Yuichiro Doki, Masaki Mori Source Type: journals

Diffusion lung capacity for carbon monoxide (DLCO) is an independent prognostic factor for long-term survival after curative lung resection for cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the early and late prognostic significance of DLCO and forced expiratory volume in 1 sec (FEV1) in patients who underwent surgical resection of lung cancer.From 1997 to 2004, 462 patients underwent successful complete resection of their lung cancer and had full pulmonary function testing including DLCO performed. Mean follow-up was over 5 years (64.8 months - range: 0-158 months).Postoperative 90-day mortality was 2.6% (12/462). At last follow-up, of the remaining 450 patients, 182 patients were alive, 130 had died of cancer, and 138 have died of other causes and did not have recurrent cancer. Mean DLCO values ...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Michael J. Liptay, Sanjib Basu, Michael C. Hoaglin, Neil Freedman, L. Penfield Faber, William H. Warren, Zane T. Hammoud, Anthony W. Kim Source Type: journals

Does diabetes mellitus influence pathologic complete response and tumor downstaging after neoadjuvant chemoradiation for esophageal and gastroesophageal cancer? A two-institution reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Esophageal carcinoma is an aggressive disease that is often treated with neoadjuvant therapy followed by surgical resection. Diabetes mellitus (DM) has been associated with reduced efficacy of chemoradiation (CRT) in other gastrointestinal cancers. The goal of this study was to determine if DM affects response to neoadjuvant CRT in the management of gastroesophageal carcinoma.We retrospectively reviewed the esophageal cancer patient databases and subsequently analyzed those patients who received neoadjuvant CRT followed by surgical resection at two institutions, Thomas Jefferson University (TJUH) and Fox Chase Cancer Cente...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Shayna L. Showalter, Ernest L. Rosato, P. Rani Anne, Walter Scott, Edith Mitchell, Adam C. Berger Source Type: journals

Borderline ovarian tumors and extended patient follow-up: An individual institution's experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a physician group's retrospective experience treating BOT patients at a single institution. Patient demographics, disease pathology, treatment type (surgery, chemotherapy), and patient surveillance (e.g., disease-free survival (DFS), overall survival, follow-up via CA-125/radiology/physical exam) data were reviewed in all cases.In the present study, 78 BOT patients treated from April 2001 until February 2009 were identified and confirmed via pathologic diagnosis. The majority (87%) underwent surgery, although nearly 13% of patients also received adjuvant chemotherapy. In the study population, 12% of the patients ...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Mark A. Rettenmaier, Katrina Lopez, Lisa N. Abaid, John V. Brown III, John P. Micha, Bram H. Goldstein Source Type: journals

Liver transplantation versus liver resection for the treatment of hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Liver resection (LR) and liver transplantation (LT) are considered the only two potentially curative treatments for hepatocellular carcinoma (HCC). Recently, there has been an intense debate as to whether LR or LT is the optimal initial treatment for patients with Child A or B cirrhosis. The aim of this study was to compare the results of LR and LT in patients with HCC and with Child A or B cirrhosis in a single center over a 10-year period.Seventy-eight patients were treated with LT and 130 were treated with LR. We evaluated patient characteristics, short-term results such as hospital stay, postoperative complication, mor...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Kyung Keun Lee, Dong Goo Kim, In Sung Moon, Myung Duk Lee, Jung Hyun Park Source Type: journals

The impact of anatomical resection for hepatocellular carcinoma that meets the milan criteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to analyze the impact of anatomical resection for hepatocellular carcinoma (HCC) that meets the Milan criteria.Between 1990 and 2006, 322 consecutive patients with HCC who met the Milan criteria underwent curative resection (R0) and were classified into two groups: Group A (patients with a single HCC, with a tumor diameter of 5 cm or less) and Group B (patients with multiple tumors, no more than three tumor nodules, each with a diameter of 3 cm or less). Patient survival (PS), recurrence-free survival rates (RFS), and risk factors were analyzed.Univariate analysis revealed that in Group A, anatomi...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Toshiya Kamiyama, Kazuaki Nakanishi, Hideki Yokoo, Hirofumi Kamachi, Michiaki Matsushita, Satoru Todo Source Type: journals

Diagnosis of second head and neck tumors in primary laryngeal SCC is an indicator of overall survival and not associated with poorer overall survival: A single centre study in 987 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study assessed the incidence of SPTs; the SPT diagnostic time lag; the impact on OS; and the mean annual risk.Nine hundred eighty seven consecutive patients treated for primary larynx SCC (1967-2004) were analyzed in this study. 96.3% and 91.4% of patients reached a minimum follow-up period of 3 and 5 years.Two hundred eight (21.1%) patients were diagnosed with SPTs. One hundred forty three (14.5%) patients developed upper aero-digestive tract (UAD)-SPTs, 83 (8.4%) were HNSCCs, 56 (5.7%) were lung, and 4 (0.41%) were esophageal-SPTs. Survival analysis demonstrated clear superior OS rates for the UAD-SPT (P < 0.008) an...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Ross Darius Farhadieh, Arash Salardini, Jia Lin Yang, Pamela Russell, Robert Smee Source Type: journals

Relationship of polymorphism of the tandem repeat sequence in the thymidylate synthase gene and the survival of stage III colorectal cancer patients receiving adjuvant 5-flurouracil-based chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to determine whether the different polymorphisms in the thymidylate synthase (TS) gene, novel G>C single nucleotide polymorphism (SNP) and variable number of tandem repeat (VNTR), may be related with disease-free survival (DFS) in patients with stage III colorectal cancer receiving adjuvant chemotherapy.The study included 201 patients with pathologic TNM stage III colon cancer who received adjuvant 5-fluorouracil (5-FU)-based chemotherapy after surgery. DNA was extracted from fresh tumor tissue and sequenced. Patients with TS genotypes of 2R3G, 3C3G, or 3G3G were assigned to a high expression grou...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Chi-Min Park, Woo Yong Lee, Ho-Kyung Chun, Yong Beom Cho, Hae Ran Yun, Jin Seok Heo, Seong Hyeon Yun, Hee Cheol Kim Source Type: journals

Triple negative phenotype and N-ratio are important for prognosis in patients with stage IIIB non-inflammatory breast carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim is to evaluate novel prognostic factors such as triple negative (TN) phenotype and ratio between positive nodes and total dissected lymph nodes (N-ratio) in stage IIIB breast carcinoma patients.In this retrospective study, primary endpoints were local recurrence (LR), distant recurrence (DR), and overall survival (OS). Univariate and multivariate prognostic factor analyses were carried out using Cox and Kaplan-Meier methods in the data of 185 patients.The median observation time was 36 (range 16-86) months. Pathological tumor size (continuous [cont.], P = 0.002; Hazard ratio [HR], 1.2; 95% confidence interval [CI],...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Hakan Mersin, Emin Yildirim, Ugur Berberoglu, Kaptan Gulben Source Type: journals

Staging laparoscopy enhances the detection of occult metastases in patients with pancreatic adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of staging laparoscopy has been highly institutional dependent. We sought to assess the incidence of occult intra-abdominal metastases identified at the time of staging laparoscopy for patients with either potentially resectable or locally advanced pancreatic adenocarcinoma (LAPC). We also compared the rate of occult metastases in patients who underwent staging laparoscopy versus laparotomy.Patients were confirmed to have potentially resectable or LAPC at a multidisciplinary hepatopancreaticobiliary conference. Patients with potentially resectable lesions were initially explored via staging laparoscopy or laparotom...
Source: Journal of Surgical Oncology - September 23, 2009 Category: Cancer & Oncology Authors: Carlo M. Contreras, Eric J. Stanelle, John Mansour, J. Louis Hinshaw, Layton F. Rikkers, Robert Rettammel, David M. Mahvi, Clifford S. Cho, Sharon M. Weber Source Type: journals

Expression of X-linked inhibitor of apoptosis protein in human colorectal cancer and its correlation with prognosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the prognostic significance of XIAP expression in colorectal cancer (CRC).RT-PCR was performed to detect the expression of XIAP mRNA in CRC cells and tissues. The expression of XIAP protein in tissues was measured by immunohistochemistry. The correlation of XIAP expression with clinicopathologic factors and prognosis of CRC patients was evaluated.CRC cells showed significantly higher levels of XIAP mRNA expression than normal human intestinal epithelial cell. The expression level of XIAP mRNA in CRC samples was significantly higher than that in corresponding non-tumor samples. XI...
Source: Journal of Surgical Oncology - September 23, 2009 Category: Cancer & Oncology Authors: Xiang Guoan, Wen Xiaomin, Wang Hanning, Chen Kaiyun, Liu Hao Source Type: journals

Mammographic casting-type calcifications is not a prognostic factor in unifocal small invasive breast cancer: A population-based retrospective cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The role of mammographic casting-type microcalcifications as a prognostic factor in breast cancer has been debated. We studied the relation between mammographic features and prognosis in a population-based cohort.In 515 women with 1-15 mm invasive breast cancer mammogrammes were re-classified according to Tabar et al. The relation to breast cancer death was studied.During the follow-up (median 155 months) 44 of 515 women died from breast cancer. Twenty-nine of 515 presented with casting-type calcifications and three of these died from breast cancer. The adjusted odds ratio for breast cancer death was 1.6 (0.5-5.8) for pati...
Source: Journal of Surgical Oncology - September 20, 2009 Category: Cancer & Oncology Authors: Emeli Månsson, Leif Bergkvist, Gunilla Christenson, Carina Persson, Fredrik Wärnberg Source Type: journals

Resected colorectal liver metastases: Does the survival differ according to postoperative chemotherapy regimen?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We compared clinical outcomes in patients who were treated with different chemotherapeutic regimens after resection of hepatic metastases from colorectal cancer (CRC).Between August 2001 and June 2008, 156 patients who entered into chemotherapy of adjuvant intent after hepatic metastasectomy were reviewed retrospectively.Of the 156 patients, 58 patients were treated with oxaliplatin/fluoropyrimidines (group I), 48 with irinotecan/fluoropyrimidines (group II), and 50 with fluoropyrimidines alone (group III). In the univariate analysis, there was a marginally significant difference among the three groups with respect to the ...
Source: Journal of Surgical Oncology - September 20, 2009 Category: Cancer & Oncology Authors: Sun Young Kim, Hee Jun Kim, Yong Sang Hong, Kyung Hae Jung, Ji Won Park, Hyo Seong Choi, Jae Hwan Oh, Sang-Jae Park, Seong Hoon Kim, Byung-Ho Nam, Hee Jin Chang, Dae Yong Kim Source Type: journals

Progression and prognosis of gastric stump cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - September 16, 2009 Category: Cancer & Oncology Authors: Xiang Hu, Da-Yu Tian, Liang Cao, Yi Yu Source Type: journals

Predictive factors of early relapse in UICC stage I-III colorectal cancer patients after curative resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that vascular invasion, perineural invasion, and postoperative CEA level may be significant factors for postoperative early relapse of colon cancer; while only perineural invasion is considered to be a significant predictor in rectal cancer patients. Identification of these high-risk UICC stage I-III CRC patients of early relapse is important, and thus could help to define patients with this tumor entity for an enhanced follow-up and therapeutic program. J. Surg. Oncol. © 2009 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - September 15, 2009 Category: Cancer & Oncology Authors: Hsiang-Lin Tsai, Koung-Shing Chu, Yu-Ho Huang, Yu-Chung Su, Jeng-Yih Wu, Chao-Hung Kuo, Chao-Wen Chen, Jaw-Yuan Wang Source Type: journals

The impact of breast MRI on surgical decision-making: Are patients at risk for mastectomy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The goal of the current study was to determine whether MRI impacts multidisciplinary treatment planning and if it leads to increased mastectomy rates.A retrospective review was conducted of 441 patients treated for breast cancer between January 2005 and May 2008 who underwent breast MRI. Data included number of additional findings and their imaging and pathologic work-up. This was analyzed to determine impact of MRI on treatment planning.Of 441 patients, 45% had [ge]1 additional finding on MRI. Of 410 patients with complete records, 29% had changes in the treatment plan, including 36 patients who were initially considered ...
Source: Journal of Surgical Oncology - September 14, 2009 Category: Cancer & Oncology Authors: Kelli Pettit, Mary Ellen Swatske, Feng Gao, Lorena Salavaggione, William E. Gillanders, Rebecca L. Aft, Barbara S. Monsees, Timothy J. Eberlein, Julie A. Margenthaler Source Type: journals

Biological significance of the maximum standardized uptake values on positron emission tomography in non-small cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) has recently become an important non-invasive tool for the diagnosis and staging in several cancers. The standardized uptake value (SUV) of primary tumor has been reported to relate to cancer progression and prognosis, however, biological mechanism is still unclear.Seventy-nine patients with non-small cell lung cancer (NSCLC) who had undergone preoperative FDG-PET and a surgical resection were enrolled in this study. NSCLC tissue samples prepared from the surgical specimens were subjected to an immunohistochemical analysis for the expression of Ki-...
Source: Journal of Surgical Oncology - September 3, 2009 Category: Cancer & Oncology Authors: Tomoyoshi Takenaka, Tokujiro Yano, Kensaku Ito, Yousuke Morodomi, Naoko Miura, Daigo Kawano, Fumihiro Shoji, Koichiro Abe, Hiroshi Honda, Yoshihiko Maehara Source Type: journals

Routine or on demand radiological contrast examination in the diagnosis of anastomotic leakage after esophagectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To detect anastomotic leakage after esophagectomy in esophageal carcinoma patients, many surgeons perform a radiological contrast examination routinely. The aim of this retrospective study is to determine the clinical relevance of a routine contrast examination after esophagectomy and to evaluate criteria for contrast examination on demand.Data were obtained from 211 patients with cancer of the esophagus or gastro-esophageal junction who underwent an esophagectomy during the period 1991-2004. Retrospectively, we analyzed patients regarding anastomosis-related characteristics and clinical signs including sepsis, fever [ge]3...
Source: Journal of Surgical Oncology - September 2, 2009 Category: Cancer & Oncology Authors: Judith Honing, Bareld B. Pultrum, Eric J. van der Jagt, Henk Groen, John Th.M. Plukker Source Type: journals

Long-term outcomes after laparoscopy-assisted gastrectomy for advanced gastric cancer: Analysis of consecutive 106 experiencesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this retrospective study is to suggest the possibility of laparoscopy-assisted gastrectomy (LAG) for advanced gastric cancer (AGC) through long-term outcomes.Of 283 patients with gastric cancer who underwent LAG with extraperigastric (D2) lymphadenectomy between January 2004 and February 2009, 106 were pathologically confirmed with AGC and analyzed.There were 75 men and 31 women, with a mean age of 61.4 ± 11.7 years. There were 32 total gastrectomies and 74 distal gastrectomies with D2 lymphadenectomy. The mean tumor size was 4.8 ± 2.6 cm. The mean numbers of retrieved and metastatic lymph nodes were 34.3 ...
Source: Journal of Surgical Oncology - September 2, 2009 Category: Cancer & Oncology Authors: Junhyun Lee, Wook Kim Source Type: journals

The long-term outcome of atomic bomb survivors with gastric carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the long-term clinical outcome of gastric cancer and second primary cancer in atomic bomb survivors.Results of surgical treatment of gastric cancer were reviewed in 231 atomic bomb survivors and 759 control patients between 1995 and 2006.Long-term prognosis of gastric cancer in atomic bomb survivors was significantly poorer than that in control patients (P < 0.05). In a multivariate analysis, age, depth of tumor invasion, lymph node metastases, and curability were found to be significant and independent prognostic factors for gastric cancer. The incidence of second primary cancer after gastric cancer was signif...
Source: Journal of Surgical Oncology - September 2, 2009 Category: Cancer & Oncology Authors: Manabu Yamamoto, Ayumi Matsuyama, Toshifumi Kameyama, Masahiro Okamoto, Jin Okazaki, Tohru Utsunomiya, Shinichi Tsutsui, Teruyoshi Ishida Source Type: journals

Ultrasonographically guided vacuum-assisted excision for multiple breast masses: Non-randomized comparison with conventional open excisionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to evaluate the safety, efficacy, and patient acceptance of ultrasonographically guided vacuum-assisted excision (UGVAE) for multiple breast masses.Ninty-eight patients with low-risk multiple breast masses were non-randomized to either UGVAE or conventional open excision (COE). Clinical data were prospectively collected and analyzed.The two groups were similar with age, side predilection, size and number of lesions. Forty-seven patients had UGVAE with 8-gauge probe and 15 patients with 11-gauge probe. All lesions were removed through same incision. Patients both in UGVAE and COE had complete removal of all...
Source: Journal of Surgical Oncology - September 2, 2009 Category: Cancer & Oncology Authors: Wei Jun Wang, Qiang Wang, Qing Ping Cai, Jian Quan Zhang Source Type: journals

Role of surgery in the treatment of ovarian metastases from colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The role of surgical resection in the treatment of metastatic ovarian tumors originating from colorectal cancer (CRC) remains uncertain. We sought to identify a subgroup of patients who would benefit from surgical resection.We analyzed the clinicopathological and follow-up data on 34 patients who underwent surgical resection of metastatic ovarian tumors originating from CRC.Synchronous ovarian metastasis was detected in 27 patients (79.4%) and metachronous metastasis in 7 (20.6%). The histologic type of the primary CRC was adenocarcinoma in 26 patients (76.5%), mucinous carcinoma in 7 (20.6%), and signet ring cell carcinom...
Source: Journal of Surgical Oncology - August 31, 2009 Category: Cancer & Oncology Authors: Tae-Sung Chung, Hee Jin Chang, Kyung Hae Jung, Sang-Yoon Park, Seok-Byung Lim, Hyo Seong Choi, Seung-Yong Jeong Source Type: journals

Role of the surgeon as a variable in long-term survival after liver resection for colorectal metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Survival analyses after hepatectomy for colorectal liver metastases (CRLM) mostly address tumor-related factors; this study has simultaneously evaluated interventional factors which may be influenced by the surgeon.Operative and long-term results of 251 consecutive patients undergoing hepatectomy for CRLM between 1992 and 2007 were analyzed.Mortality was 0.8%, morbidity 22.9%, intraoperative blood transfusion rate 23.1% (19.4% with pedicle clamping, 35.0% without clamping, P = 0.01), R0-resection 93.6% (2/3 with tumor-free margin >5 mm). The 3-, 5-, 10-year overall and disease-free survival rates were 55.2%, 38.9%, 24.2%, ...
Source: Journal of Surgical Oncology - August 30, 2009 Category: Cancer & Oncology Authors: Felice Giuliante, Francesco Ardito, Maria Vellone, Giuseppina Ranucci, Bruno Federico, Ivo Giovannini, Gennaro Nuzzo Source Type: journals

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammation plays a multifaceted role in cancer progression, and NF-[kappa]B is one of the key factors connecting inflammation with cancer progression. We have shown that lipopolysaccharide (LPS) promotes NF-[kappa]B activation in colon cancer cells and pancreatic cancer cells. However, it is unclear why inflammatory stimuli can induce NF-[kappa]B activation in cancer cells.We used two human pancreatic cancer cells, Panc-1 and AsPC-1, as target cells. LPS was used as an inflammatory stimulus. To confirm the participation of TLR4/NF-[kappa]B signaling pathway, we used three different NF-[kappa]B inhibitors (PDTC, I[kappa]B...
Source: Journal of Surgical Oncology - August 30, 2009 Category: Cancer & Oncology Authors: Mio Ikebe, Yoshiki Kitaura, Masafumi Nakamura, Haruo Tanaka, Akio Yamasaki, Shuntaro Nagai, Junji Wada, Kosuke Yanai, Kenichiro Koga, Norihiro Sato, Makoto Kubo, Masao Tanaka, Hideya Onishi, Mitsuo Katano Source Type: journals

Palliative surgical treatment of primary cardiac angiosarcoma complicated with recurrent tamponadeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - August 30, 2009 Category: Cancer & Oncology Authors: Javier Gualis, Mario Castaño, Jesús Gómez-Plana, Pilar Mencía, David Alonso Source Type: journals

Survival analysis after pancreatic resection for ampullary and pancreatic head carcinoma: An analysis of clinicopathological factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, patients with ampullary carcinoma have a better prognosis and survival than those with pancreatic carcinoma. J. Surg. Oncol. © 2009 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - August 30, 2009 Category: Cancer & Oncology Authors: C.A.M. Sommerville, P. Limongelli, M. Pai, R. Ahmad, G. Stamp, N.A. Habib, R.C.N. Williamson, L.R. Jiao Source Type: journals

Early gallbladder cancer: Is further treatment necessary?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The goal of this study was to evaluate a series of patients with early gallbladder cancer, focusing on the selection of treatment and the role of Rokitansky Aschoff sinus infiltration.We performed a retrospective analysis of a prospective series of 371 patients with gallbladder cancer. Specimens were reviewed by an independent pathologist to confirm the diagnosis and depth of infiltration and to evaluate the presence of Rokitansky Aschoff sinus involvement.Forty-nine and 45 patients with muscular (pT1b) and mucosal (pT1a) infiltration gallbladder cancer tumors were studied respectively. Simple cholecystectomy was the treat...
Source: Journal of Surgical Oncology - August 30, 2009 Category: Cancer & Oncology Authors: Xabier de Aretxabala, Ivan Roa, Juan Hepp, Fernando Maluenda, Gerardo Mordojovich, Jorge Leon, Juan Carlos Roa Source Type: journals

Hyperbaric oxygen therapy for radiation-induced brain necrosis in a patient with primary central nervous system lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 45-year-old man who developed brain radionecrosis in the right frontal and left temporoparietal lobes after receiving whole brain radiotherapy and stereotactic radiosurgery for primary central nervous system lymphoma. Since high dose steroid treatment failed and he declined to undergo surgery, he was referred to hyperbaric oxygen (HBO) therapy. Both clinical and radiological findings improved after HBO therapy. Steroid requirements were also reduced. HBO therapy may have a potential value in treatment of brain radionecrosis. J. Surg. Oncol. © 2009 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - August 30, 2009 Category: Cancer & Oncology Authors: Yasemin Benderli Cihan, Günalp Uzun, [Scedil]enol Yildiz, Halil Dönmez Source Type: journals

Prognostic factors for extra-abdominal and abdominal wall desmoids: A 20-year experience at a single institutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous reports even large studies discussing the prognosis of desmoids have included tumors from intra- and extra-abdominal sites as well as incomplete resection. The purpose of this study was to explore prognostic factors associated with the recurrence free survival (RFS) rate in surgically treated extra-abdominal and abdominal wall desmoids.A total of 198 consecutive desmoid patients were treated with surgery over a 20-year period at a single institution. Of these, 151 patients with extra-abdominal and abdominal wall tumors were retrospectively reviewed. One hundred thirteen patients were referred for the primary tumor...
Source: Journal of Surgical Oncology - August 30, 2009 Category: Cancer & Oncology Authors: Kai Huang, Hong Fu, Ying-Qiang Shi, Ye Zhou, Chun-Yan Du Source Type: journals