Journal of Thrombosis and HaemostasisThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30

1670 records returned

Join ISTHEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - October 20, 2009 Category: Hematology Tags: Announcements Source Type: journals

Enhanced post-clopidogrel platelet reactivity in diabetic patients is independently related to plasma fibrinogen level but not to glycemic controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - October 20, 2009 Category: Hematology Authors: B. GABORIT, C. FRÈRE, T. CUISSET, M.-C. ALESSI, A. DUTOUR Tags: Letters to the Editor Source Type: journals

Heparin-induced multiple electrode aggregometry: a potential tool for improvement of heparin-induced thrombocytopenia diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - October 20, 2009 Category: Hematology Authors: I. ELALAMY, V. GALEA, M. HATMI, G. T. GEROTZIAFAS Tags: Letters to the Editor Source Type: journals

Evaluation of anti-activated protein C antibody development in patients with severe sepsis from four clinical studies with drotrecogin alfa (activated)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The proportion of patients with anti-APC antibodies was low and was similar between DAA-treated and placebo-treated patients. No relationship between anti-APC antibody development and adverse reactions was observed. There was no evidence that the anti-APC antibodies detected represented a specific immune response to DAA therapy. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - October 20, 2009 Category: Hematology Authors: S. B. YAN, J. T. BRANDT, N. L. CORRELL, S. L. UM, J. S. BOURDAGE Tags: CLINICAL HAEMOSTASIS AND THROMBOSIS Source Type: journals

Socioeconomic inequalities in coronary heart disease risk in older age: contribution of established and novel coronary risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Socioeconomic inequalities in CHD persist in the elderly and are at least partly explained by behavioral risk factors; novel (inflammatory) coronary risk markers made some further contribution. Reducing inequalities in behavioral factors (especially cigarette smoking) could reduce these social inequalities by at least one-third. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - October 20, 2009 Category: Hematology Authors: S. E. RAMSAY, R. W. MORRIS, P. H. WHINCUP, O. PAPACOSTA, A. RUMLEY, L. LENNON, G. LOWE, S. G. WANNAMETHEE Tags: CARDIOVASCULAR MEDICINE Source Type: journals

Platelet functions beyond hemostasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article represents an integrated summary of presentations given at the Fourth Annual Platelet Colloquium in January 2009. The process of and factors mediating platelet[ndash]platelet and platelet[ndash]leukocyte interactions in inflammatory and immune responses are discussed, with the roles of P-selectin, chemokines and Src family kinases being highlighted. Also discussed are specific disorders characterized by local or systemic platelet activation, including coronary artery restenosis after percutaneous intervention, alloantibody-mediated transplant rejection, wound healing, and heparin-induced thrombocytopenia. (Sou...
Source: Journal of Thrombosis and Haemostasis - September 30, 2009 Category: Hematology Authors: S. S. SMYTH, R. P. MCEVER, A. S. WEYRICH, C. N. MORRELL, M. R. HOFFMAN, G. M. AREPALLY, P. A. FRENCH, H. L. DAUERMAN, R. C. BECKER Tags: Review Article Source Type: journals

Circulating inflammatory and hemostatic biomarkers are associated with risk of myocardial infarction and coronary death, but not angina pectoris, in older menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Circulating biomarkers of inflammation and hemostasis are associated with incident MI/CHD death but not incident angina uncomplicated by MI or CHD death in older men. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 23, 2009 Category: Hematology Authors: S. G. WANNAMETHEE, P. H. WHINCUP, A. G. SHAPER, A. RUMLEY, L. LENNON, G. D. O. LOWE Tags: CARDIOVASCULAR MEDICINE Source Type: journals

CorrigendumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 21, 2009 Category: Hematology Tags: Corrigendum Source Type: journals

Join ISTHEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 21, 2009 Category: Hematology Tags: Announcements Source Type: journals

Variability of anti-PF4/heparin antibody results obtained by the rapid testing system ID-H/PF4-PaGIA: reply to a rebuttalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
See also Schneiter S, Colucci G, Sulzer I, Barizzi G, Lämmle B, Alberio L. Variability of anti-PF4/heparin antibody results obtained by the rapid testing system ID-H/PF4-PaGIA. This issue, pp 1649[ndash]55; Köchli A. Variability of anti-PF4/heparin antibody results obtained by the rapid testing system ID-H/PF4-PaGIA: a rebuttal. This issue, pp 1753[ndash]5. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 21, 2009 Category: Hematology Authors: G. COLUCCI, B. LÄMMLE, L. ALBERIO Tags: Letters to the Editor Source Type: journals

Variability of anti-PF4/heparin antibody results obtained by the rapid testing system ID-H/PF4-PaGIA: a rebuttalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
See also Schneiter S, Colucci G, Sulzer I, Barizzi G, Lämmle B, Alberio L. Variability of anti-PF4/heparin antibody results obtained by the rapid testing system ID-H/PF4-PaGIA. This issue, pp 1649[ndash]55; Colucci G, Lämmle B, Alberio L. Variability of anti-PF4/heparin antibody results obtained by the rapid testing system ID-H/PF4-PaGIA: reply to a rebuttal. This issue, pp 1755[ndash]6. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 21, 2009 Category: Hematology Authors: A. KÖCHLI Tags: Letters to the Editor Source Type: journals

Variability of anti-PF4/heparin antibody results obtained by the rapid testing system ID-H/PF4-PaGIAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Laboratories performing the assay should implement stringent internal quality controls in order to recognize potentially faulty ID-H/PF4-polymer lots, thus avoiding false negative results. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 21, 2009 Category: Hematology Authors: S. SCHNEITER, G. COLUCCI, I. SULZER, G. BARIZZI, B. LÄMMLE, L. ALBERIO Tags: CLINICAL HAEMOSTASIS AND THROMBOSIS Source Type: journals

Studies of mice lacking the GPIb-V-IX complex question the role of this receptor in atherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 8, 2009 Category: Hematology Authors: C. STRASSEL, B. HECHLER, A. BULL, C. GACHET, F. LANZA Tags: Letters to the Editor Source Type: journals

Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: IGF-1 attenuates post-injury carotid stenosis by exerting differential effects in the neointima and tunica media with regard to the key components of the response to injury. The data point to a novel role of IGF-1 as a potent vasculoprotective factor. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 8, 2009 Category: Hematology Authors: A. CITTADINI, M. G. MONTI, M. C. CASTIELLO, E. D'ARCO, G. GALASSO, D. SORRIENTO, L. SALDAMARCO, A. DE PAULIS, R. NAPOLI, G. IACCARINO, L. SACCÀ Tags: VASCULAR BIOLOGY Source Type: journals

Endothelial cell specific adhesion molecule (ESAM) localizes to platelet–platelet contacts and regulates thrombus formation in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings support a model in which ESAM localizes to platelet contacts following platelet activation in order to limit thrombus growth and stability so that the optimal hemostatic response occurs following vascular injury. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 8, 2009 Category: Hematology Authors: T. J. STALKER, J. WU, A. MORGANS, E. A. TRAXLER, L. WANG, M. S. CHATTERJEE, D. LEE, T. QUERTERMOUS, R. A. HALL, D. A. HAMMER, S. L. DIAMOND, L. F. BRASS Tags: PLATELETS Source Type: journals

Bacteria–platelet interactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 8, 2009 Category: Hematology Authors: D. COX Tags: PLATELETS Source Type: journals

Factor VIII gene (F8) mutations as predictors of outcome in immune tolerance induction of hemophilia A patients with high-responding inhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ITI success is influenced by F8 genotype. This knowledge should contribute to the stratification of prognosis, and to the clinical choices made for ITI in patients with high-responding inhibitors. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - September 8, 2009 Category: Hematology Authors: A. COPPOLA, M. MARGAGLIONE, E. SANTAGOSTINO, A. ROCINO, E. GRANDONE, P. M. MANNUCCI, G. DI MINNO Tags: CLINICAL HAEMOSTASIS AND THROMBOSIS Source Type: journals

Glanzmann thrombasthenia: the need for epidemiological studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 27, 2009 Category: Hematology Authors: A. T. NURDEN Tags: PLATELETS Source Type: journals

Molecular and phenotypic determinants of the response to desmopressin in adult patients with mild hemophilia AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this cohort of patients with mild hemophilia A, a poor biologic response to desmopressin was frequently associated with the absence of detectable F8 mutations. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 27, 2009 Category: Hematology Authors: G. CASTAMAN, M. E. MANCUSO, S. H. GIACOMELLI, A. TOSETTO, E. SANTAGOSTINO, P. M. MANNUCCI, F. RODEGHIERO Tags: CLINICAL HAEMOSTASIS AND THROMBOSIS Source Type: journals

Prophylaxis of venous thromboembolism in the US: improving hospital performanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary. Venous thromboembolism (VTE) prevention has been recognized as the most important practice for improving patient safety in hospitals. To be effective, VTE prophylaxis must be appropriately prescribed with respect to type, dose and duration. Large-scale studies of medical discharge records have highlighted low rates of appropriate thromboprophylaxis in hospitalized medical patients, especially those with cancer or severe lung disease. Lack of prophylaxis and an insufficient duration are the most common forms of inappropriate prophylaxis. Multifaceted, active, quality improvement initiatives have been developed and ...
Source: Journal of Thrombosis and Haemostasis - August 25, 2009 Category: Hematology Authors: S. L. COHN Tags: Review Articles Source Type: journals

Join ISTHEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 23, 2009 Category: Hematology Tags: Annoucements Source Type: journals

A non-reactive glutamine residue of α2-antiplasmin promotes interactions with the factor XIII active site regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: D. B. CLEARY, P. G. DOIPHODE, T. M. SABO, M. C. MAURER Tags: Letters to the Editor Source Type: journals

Contribution of high factor VIII, IX and XI to the risk of recurrent venous thrombosis in factor V Leiden carriersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: W. M. LIJFERING, S. C. CHRISTIANSEN, F. R. ROSENDAAL, S. C. CANNEGIETER Tags: Letters to the Editor Source Type: journals

Reducing intra-individual variation in platelet aggregation: implications for platelet function testingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: A. J. PEACE, K. EGAN, G. F. KAVANAGH, A. F. TEDESCO, D. P. FOLEY, P. DICKER, M. C. BERNDT, D. KENNY Tags: Letters to the Editor Source Type: journals

Comparison between hirudin and citrate in monitoring the inhibitory effects of P2Y12 receptor antagonists with different platelet function testsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: C. A. C. M. PITTENS, H. J. BOUMAN, J. W. VAN WERKUM, J. M. TEN BERG, C. M. HACKENG Tags: Letters to the Editor Source Type: journals

P-selectin antagonism reduces thrombus formation in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: P-selectin antagonism with PSI-697 reduces ex vivo thrombus formation in humans. These findings provide further evidence that P-selectin antagonism may be a potential target for the prevention and treatment of cardiovascular disease. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: R. CHELLIAH, A. J. LUCKING, L. TATTERSALL, S. DAGA, N. J. BERESFORD-CLEARY, K. CORTAS, K. A. A. FOX, G. Z. FEUERSTEIN, T. M. CONNOLLY, D. E. NEWBY Tags: PLATELETS Source Type: journals

CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin αIIbβ3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Using gene knockout mice, we show for the first time that lack of Cib1 results in impaired thrombosis. CIB1 regulates these processes by affecting platelet spreading, but not platelet filopodia formation. These in vivo and in vitro results clearly show that CIB1 is a key regulator of thrombosis. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: M. U. NAIK, A. NIGAM, P. MANRAI, P. MILLILI, K. CZYMMEK, M. SULLIVAN, U. P. NAIK Tags: PLATELETS Source Type: journals

Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periodsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary. Background: Current guidelines state that platelet aggregation studies should be conducted within 4 h of venepuncture because of the decline in sensitivity to platelet agonists. This constrains studies of platelet activity in clinical situations where samples need to be transported or there are unavoidable delays prior to assessment. Objectives: The aim of the present study was to compare systematically the responses of platelets stored in the presence of either citrate or heparin, the two most widely used anti-coagulants, using a range of standard techniques. Methods: Blood was taken from healthy volunteers and e...
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: N. J. TRUSS, P. C. J. ARMSTRONG, E. LIVERANI, I. VOJNOVIC, T. D. WARNER Tags: PLATELETS Source Type: journals

Molecular defects in ITGA2B and ITGB3 genes in patients with Glanzmann thrombastheniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The severe type I GT was the most common subtype found in this study. Missense mutations were identified as the defects responsible for most GT patients. Carrier detection and genetic counseling in these families is a potentially effective alternative for decreasing the burden of severe type of GT. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: M. KANNAN, F. AHMAD, B. K. YADAV, R. KUMAR, V. P. CHOUDHRY, R. SAXENA Tags: PLATELETS Source Type: journals

Tumors, ticks and tissue factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: T. MCEACHRON, N. MACKMAN Tags: COAGULATION Source Type: journals

Factor IX binding to collagenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: D. GAILANI Tags: COAGULATION Source Type: journals

Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The decreased VWF:RCo seen with the P1467S sequence variation likely represents an artifact as a result of the use of ristocetin to measure VWF activity. The normal VWF function in other assays correlates with the lack of hemorrhagic symptoms, and suggests the need for more physiologically relevant assays of VWF function. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: V. H. FLOOD, K. D. FRIEDMAN, J. C. GILL, P. A. MORATECK, J. S. WREN, J. P. SCOTT, R. R. MONTGOMERY Tags: CLINICAL HAEMOSTASIS AND THROMBOSIS Source Type: journals

D-dimer levels and 15-day outcome in acute pulmonary embolism. Findings from the RIETE RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PE patients with D-dimer levels in the fourth quartile had an increased incidence of overall death, fatal PE and major bleeding within 15 days both before and after multivariate adjustment. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: J. L. LOBO, V. ZORRILLA, F. AIZPURU, E. GRAU, D. JIMÉNEZ, G. PALARETI, M. MONREAL Tags: CLINICAL HAEMOSTASIS AND THROMBOSIS Source Type: journals

Low protein C and incidence of ischemic stroke and coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this cohort study, low protein C was a risk factor for incident ischemic stroke but not coronary heart disease. Levels of protein C associated with stroke risk were not restricted to the traditional 'deficient' range for protein C (< 0.5 percentile), suggesting that other etiologies for a lower protein C, or genetic variants associated with more subtle changes in protein C, are playing a role in disease pathogenesis. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: A. R. FOLSOM, T. OHIRA, K. YAMAGISHI, M. CUSHMAN Tags: CARDIOVASCULAR MEDICINE Source Type: journals

The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this multicenter study, the detection of IgG antibodies that are directed against domain I of beta2GPI proved to be more strongly associated with thrombosis and obstetric complications than those detected using the standard anti-beta2GPI antibody assay. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: B. DE LAAT, V. PENGO, I. PABINGER, J. MUSIAL, A. E. VOSKUYL, I. E. M. BULTINK, A. RUFFATTI, B. ROZMAN, T. KVEDER, P. DE MOERLOOSE, F. BOEHLEN, J. RAND, Z. ULCOVA-GALLOVA, K. MERTENS, P. G. DE GROOT Tags: CARDIOVASCULAR MEDICINE Source Type: journals

Prothrombotic effects of diclofenac on arteriolar platelet activation and thrombosis in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: By decreasing levels of PGI2 without, at the same time, altering prothrombotic TxA2 levels, diclofenac can exert prothrombotic effects. However, this is not the case when an inflammatory situation is created by TNF-[alpha] treatment. These data may explain the enhanced risk of acute myocardial infarction observed in patients taking diclofenac. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: L. STRUTHMANN, N. HELLWIG, J. PIRCHER, H.-Y. SOHN, M. A. BUERKLE, V. KLAUSS, H. MANNELL, U. POHL, F. KRÖTZ Tags: VASCULAR BIOLOGY Source Type: journals

Functional role of O-linked and N-linked glycosylation sites present on the activation peptide of factor XEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The carbohydrate chains of the FX activation peptide play an important role in restricting the specificity of zymogen recognition by both FVIIa and FIXa, thereby preventing the cofactor-independent activation of FX by these proteases. On the other hand, the carbohydrates contribute to the cofactor-dependent recognition of the zymogen by both extrinsic and intrinsic Xase complexes. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 18, 2009 Category: Hematology Authors: L. YANG, C. MANITHODY, A. R. REZAIE Tags: COAGULATION Source Type: journals

Splenic marginal zone antigen-presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Using FVIII-deficient mice as a model for patients with hemophilia A, and human pro-coagulant FVIII as a model for immunogenic self-derived protein therapeutics, our results highlight the importance of the spleen and MZ APCs in the initiation of immune responses to protein therapeutics. Identification of the receptors implicated in retention of protein therapeutics in the MZ may pave the way towards novel strategies aimed at reducing their immunogenicity. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 10, 2009 Category: Hematology Authors: A. NAVARRETE, S. DASGUPTA, S. DELIGNAT, G. CALIGIURI, O. D. CHRISTOPHE, J. BAYRY, A. NICOLETTI, S. V. KAVERI, S. LACROIX-DESMAZES Tags: CLINICAL HAEMOSTASIS AND THROMBOSIS Source Type: journals

von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in sizeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 10, 2009 Category: Hematology Authors: S.-Y. JIN, C. G. SKIPWITH, D. SHANG, X. L. ZHENG Tags: Letters to the Editor Source Type: journals

Replication of findings on the association of genetic variation in 24 hemostasis genes and risk of incident venous thrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 10, 2009 Category: Hematology Authors: N. L. SMITH, K. L. WIGGINS, A. P. REINER, L. A. LANGE, M. CUSHMAN, S. R. HECKBERT, T. LUMLEY, K. M. RICE, A. R. FOLSOM, B. M. PSATY Tags: Letters to the Editor Source Type: journals

Total knee arthroplasty in hemophilic arthropathy: efficiency of clotting factor usage in multijoint proceduresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 10, 2009 Category: Hematology Authors: F. J. A. SCHILD, E. P. MAUSER-BUNSCHOTEN, A. J. VERBOUT, A. C. VAN RINSUM, G. ROOSENDAAL Tags: Letters to the Editor Source Type: journals

Proteomic analysis of integrin αIIbβ3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study provides new insights into the molecular mechanism regulating [alpha]IIb[beta]3-mediated platelet spreading on fibrinogen. The novel platelet adapter Dok-3 and the structurally related Dok-1 are tyrosine phosphorylated in an Src kinase-independent manner downstream of [alpha]IIb[beta]3 in human platelets, leading to an interaction with Grb2 and SHIP-1. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 10, 2009 Category: Hematology Authors: Y. A. SENIS, R. ANTROBUS, S. SEVERIN, A. F. PARGUIÑA, I. ROSA, N. ZITZMANN, S. P. WATSON, A. GARCÍA Tags: PLATELETS Source Type: journals

Platelet glycoprotein VI as a mediator of metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 10, 2009 Category: Hematology Authors: R. W. FARNDALE Tags: PLATELETS Source Type: journals

IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: All IgG subclasses of anti-ADAMTS13 antibodies were detected in patients with acquired TTP, with IgG4, followed by IgG1, antibodies dominating the anti-ADAMTS13 immune response. Levels of IgG4 could be useful for the identification of patients at risk of disease recurrence. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 10, 2009 Category: Hematology Authors: S. FERRARI, G. C. MUDDE, M. RIEGER, A. VEYRADIER, J. A. KREMER HOVINGA, F. SCHEIFLINGER Tags: COAGULATION Source Type: journals

Clinical probability score and D-dimer estimation lack utility in the diagnosis of childhood pulmonary embolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The Wells clinical probability score and D-dimer estimation may lack utility in the determination of pre-test probability of PE in children. Validation of a pediatric clinical probability score, incorporating D-dimer estimation, by prospective study, would be difficult as a result of the rarity of childhood PE. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 10, 2009 Category: Hematology Authors: T. T. BISS, L. R. BRANDÃO, W. H. A. KAHR, A. K. C. CHAN, S. WILLIAMS Tags: CLINICAL HAEMOSTASIS AND THROMBOSIS Source Type: journals

Marked reduction of early stent thrombosis with pre-hospital initiation of high-dose Tirofiban in ST-segment elevation myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pre-hospital initiation of high-dose tirofiban reduces the 30-day incidence of stent thrombosis in STEMI patients treated with primary PCI and stenting. Early stent thrombosis and pre-hospital initiation of high-dose tirofiban were independent predictors of 30-day mortality. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - August 10, 2009 Category: Hematology Authors: A. A. C. M. HEESTERMANS, J. W. VAN WERKUM, C. HAMM, T. DILL, A. T. M. GOSSELINK, M. J. DE BOER, G. VAN HOUWELINGEN, J. C. A. HOORNTJE, P. C. KOOPMANS, J. M. TEN BERG, A. W. J. VAN 'T HOF Tags: CARDIOVASCULAR MEDICINE Source Type: journals

Staphylococcal superantigen-like 5 activates platelets and supports platelet adhesion under flow conditions, which involves glycoprotein Ibα and αIIbβ3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: SSL5 activates and aggregates platelets in a GPIb[alpha]-dependent manner, which could be important in colonization of the vascular bed and evasion of the immune system by S. aureus. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - July 27, 2009 Category: Hematology Authors: C. J. C. DE HAAS, C. WEETERINGS, M. M. VUGHS, P. G. DE GROOT, J. A. VAN STRIJP, T. LISMAN Tags: PLATELETS Source Type: journals

Molecular basis of thrombomodulin activation of slow thrombinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data show that TM binding alters the conformation of thrombin in a similar manner as Na+ coordination, resulting in an ordering of the Na+ binding loop and an opening of the adjacent S1 pocket. We conclude that other, more subtle subsite changes are unlikely to influence thrombin specificity toward macromolecular substrates. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - July 27, 2009 Category: Hematology Authors: T. E. ADAMS, W. LI, J. A. HUNTINGTON Tags: COAGULATION Source Type: journals

Evaluation of lyophilized platelets as an infusible hemostatic agent in experimental non-compressible hemorrhage in swineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This is the first reported study to evaluate rehydrated, lyophilized platelets as an infusible hemostatic agent for non-compressible hemorrhage. Stasix improved survival and reduced blood loss in a liver injury porcine model. However, evidence of thrombotic complications warrants further investigation prior to human use in the setting of traumatic hemorrhage. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - July 27, 2009 Category: Hematology Authors: J. S. HAWKSWORTH, E. A. ELSTER, D. FRYER, F. SHEPPARD, V. MORTHOLE, G. KRISHNAMURTHY, T. TOMORI, T. S. BROWN, D. K. TADAKI Tags: COAGULATION Source Type: journals

Factor IX mutants with enhanced catalytic activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The mutants showed no or marginally improved catalytic properties in FX activation by the intrinsic tenase complex (FIXa[ndash]FVIIIa[ndash]Ca2+[ndash]phospholipid). The combination of mutations Y94F and K98T hardly affected FX activation in the presence of FVIIIa, but yielded a FIX molecule that, in FIX-depleted plasma, had [sim] 2.5-fold higher clotting activity and [sim] 3.5-fold higher activity in a thrombin generation assay than plasma-derived FIX (pdFIX). Two FIXa mutants had considerably increased activities towards FX in the absence of FVIIIa. FIXa-Y94F/K98T/Y177F/I213V/E219G (FIXa-L) and FIXa-Y94F/A95...
Source: Journal of Thrombosis and Haemostasis - July 27, 2009 Category: Hematology Authors: R. HARTMANN, M. DOCKAL, W. KAMMLANDER, E. PANHOLZER, G. A. NICOLAES, C. FIEDLER, J. ROSING, F. SCHEIFLINGER Tags: COAGULATION Source Type: journals