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371 records returned

Apixaban: an emerging oral factor Xa inhibitorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Apixaban, an oral direct factor Xa inhibitor, is currently in late stage clinical development for the prevention and treatment of thromboembolic diseases. In comparison with current treatment standards for venous thromboembolism (VTE) prophylaxis, apixaban has shown decreased rates of clinically significant bleeding with mixed results in terms of non-inferiority for VTE events. Secondary treatment of VTE with apixaban is currently in phase III clinical study after earlier trials showed comparable safety and efficacy outcomes. The APPRAISE-1 trial, a phase II investigation of apixaban versus placebo ...
Source: Journal of Thrombosis and Thrombolysis - November 18, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Prevalence, clinical correlates and treatment of permanent atrial fibrillation among the elderly: insights from the first prospective population-based study in rural GreeceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To investigate the prevalence of permanent atrial fibrillation (AF), its clinical associated conditions and treatment status in the elderly population in rural Greece. 720 people (46.1% males) older than 65 years (mean age: 72.5 ± 5.7 years) living in four villages in rural Greece were screened with an electrocardiogram (response rate: 90.5%) for the presence of permanent AF. They underwent a physical examination, including blood pressure (BP) measurement, and body mass index (BMI) calculation, in addition to an interview about their medical history, physical activity, smoking h...
Source: Journal of Thrombosis and Thrombolysis - November 18, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Proceedings of the 10th National Conference on Anticoagulant TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11239-009-0427-yAuthors David A. Garcia, University of New Mexico Health Sciences Center, 1 University of New Mexico MSC Anticoagulation Clinic 10 5550 Albuquerque NM 87131 USA Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - November 18, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Impact of distal embolization on myocardial perfusion and survival among patients undergoing primary angioplasty with glycoprotein IIb–IIIa inhibitors: insights from the EGYPT cooperationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study showed among STEMI patients treated with Gp IIb–IIIa inhibitors, that distal embolization is independently associated with impaired myocardial perfusion and survival. Content Type Journal ArticleDOI 10.1007/s11239-009-0419-yAuthors Giuseppe De Luca, “Maggiore della Carità” Hospital, Eastern Piedmont University Division of Cardiology Novara ItalyC. Michael Gibson, Brigham & Women’s Hospital TIMI Study Group, Cardiovascular Division Boston MA USAFrancesco Bellandi, Prato Hospital Division of Cardiology Prato ItalyMarko Noc, University Medical Center Center for Intensive Internal Medicine Ljubljana S...
Source: Journal of Thrombosis and Thrombolysis - November 18, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

What you should know about the 2008 American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th) on Antithrombotic and Thrombolytic TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this article is to help answer ten common clinical questions frequently faced by anticoagulation management services. Content Type Journal ArticleDOI 10.1007/s11239-009-0415-2Authors Scott Kaatz, Henry Ford Hospital Department of Medicine Detroit MI 48202 USA Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - November 18, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Impact of diabetes on long-term outcome in STEMI patients undergoing primary angioplasty with glycoprotein IIb–IIIa inhibitors and BMS or DESEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study shows that among STEMI patients undergoing primary angioplasty with Gp IIb–IIIa inhibitors, diabetes is associated with worse long-term mortality, reinfarction, and IST, even with DES implantation, that, however, were able to equalize the outcome in terms of TVR as compared to non diabetic patients. Content Type Journal ArticleDOI 10.1007/s11239-009-0420-5Authors Giuseppe De Luca, Eastern Piedmont University Division of Cardiology, Ospedale “Maggiore della Carità” C.so Mazzini 18 28100 Novara ItalyRosario Sauro, “S.G. Moscati” Division of Cardiology Avellino ItalyAttilio Varricchio, “S.G. Mos...
Source: Journal of Thrombosis and Thrombolysis - November 18, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Development of national performance measures on the prevention and treatment of venous thromboembolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Venous thromboembolism (VTE) remains a significant public health problem in the United States, particularly for hospitalized patients. Approximately two-thirds of all VTE events are associated with recent hospitalization. Despite the well-known risks of VTE, multiple studies have demonstrated underuse of VTE prophylaxis and clinicians often do not provide evidence-based care for those patients with confirmed VTE. In January 2005, the National Quality Forum initiated a project to develop national consensus standards on organization policies, preferred practices, and performance measures for the preve...
Source: Journal of Thrombosis and Thrombolysis - November 14, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Combined warfarin–aspirin therapy: what is the evidence for benefit and harm and which patients should (and should not) receive it?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this review are to describe the characteristics of patients who are receiving combined warfarin–aspirin therapy, to summarize the evidence for the therapeutic benefit and harm of combined warfarin–aspirin, and to provide practical guidelines as to which patients should (or should not) receive such treatment. Content Type Journal ArticleDOI 10.1007/s11239-009-0413-4Authors Marco P. Donadini, McMaster University and St Joseph’s Healthcare Department of Medicine Hamilton ON L8N 4A6 CanadaJames D. Douketis, McMaster University and St Joseph’s Healthcare Department of Medicine Room F-544, 50 Cha...
Source: Journal of Thrombosis and Thrombolysis - November 14, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

The financial viability of an anticoagulation clinic: a discussion from the anticoagulation forum meeting, May, 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11239-009-0417-0Authors Henry I. Bussey, The University of Texas at Austin College of Pharmacy Austin TX USA Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - November 13, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Angiotensin II up-regulates CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, angiotensin II increases the rate of CX3CR1-positive THP-1 cells. By extrapolating this in vitro observation to disease mechanisms, we speculate that angiotensin II induces up-regulation of CX3CR1 and promotes firm adhesion of circulation CX3CR1-positive monocytes on CX3CL1 expressing endothelial cells inducing vascular inflammation and atherogenesis. Content Type Journal ArticleDOI 10.1007/s11239-009-0424-1Authors Stavros Apostolakis, University of Crete Department of Clinical Virology, Faculty of Medicine Heraklion GreeceZacharenia Vlata, Institute of Molecular Biology and Biotechnology Departm...
Source: Journal of Thrombosis and Thrombolysis - November 13, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Assessment of validity of INR system for patients with liver disease associated with viral hepatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract International Normalized Ratio (INR), which standardizes prothrombin time (PT) during oral anticoagulation, has been extended to standardize PT in liver diseases and is included in all prognostic models of survival, the classification of CHILD-Pugh or Meld. However, the mechanisms of PT prolongation in liver diseases differ from those involved in oral anticoagulation. Our aim was to assess the validity of the INR system for patients with liver disease associated with viral hepatitis. We prospectively collected blood samples from 61 patients with liver disease associated with viral hepatitis; control...
Source: Journal of Thrombosis and Thrombolysis - November 13, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Heparin–platelet factor 4 antibodies in intensive care patients: an observational seroprevalence studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Heparin–platelet factor 4 (PF4) antibodies mediate heparin-induced thrombocytopenia (HIT) and, irrespective of thrombocytopenia, are associated with poorer outcomes in some patients. The prevalence of heparin-PF4 antibodies, including platelet-activating ones, in patients in the medical, neurotrauma, or shock-trauma intensive care unit (ICU) remains unclear. In this single-center, observational study, heparin-PF4 antibodies (IgG/A/M) were measured by ELISA in 185 adults (median APACHE II score, 16) admitted to the medical (n = 27), neurotrauma (n = 96), or shock-trauma (n ...
Source: Journal of Thrombosis and Thrombolysis - November 12, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

How to meet national quality initiatives: best practicesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11239-009-0406-3Authors Katherine Phillips Cabral, Maine Medical Center 22 Bramhall St. Portland ME 04102 USA Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - November 11, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Using low molecular weight heparin in special patient populationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Clinical trials evaluating low molecular weight heparin (LMWH) for the prevention and treatment of venous thromboembolism and acute coronary syndromes have led to their regulatory approval for these indications in the general population. However, certain patient populations have been excluded from these landmark clinical trials, including patients with renal insufficiency, obese patients and pregnant women. In these special populations, data on safety and efficacy is limited and typically based on pharmacokinetic studies often performed in healthy subjects, or small cohort studies which are generall...
Source: Journal of Thrombosis and Thrombolysis - November 10, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Is patient self-testing a good thing?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11239-009-0414-3Authors Lynn B. Oertel, Massachusetts General Hospital Anticoagulation Management Service Boston MA 02114 USAEdward N. Libby, University of New Mexico Cancer Center Division of Hematology & Oncology Albuquerque NM 87131 USA Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - November 9, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Impact on patient care: patient case through the continuum of careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hospitalized patients are at increased risk of venous thromboembolism and the Joint Commission has initiated practice measures to improve the rates of preventable events. The Joint Commission also initiated the National Patient Safety Goals for medication prescribing and administration, of which, goal 03.05.01 is specifically aimed at anticoagulation therapy. These measures and goals are consistent with the American College of Chest Physicians’ Consensus Guidelines on Antithrombotic and Thrombolytic Therapy. This narrative review uses a case-based approach that brings up practical clinical questio...
Source: Journal of Thrombosis and Thrombolysis - November 9, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Proceedings of the 10th National Conference on Anticoagulant TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11239-009-0416-1 Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - November 9, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Designing and implementing effective venous thromboembolism prevention protocols: lessons from collaborative effortsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hospital acquired venous thromboembolism (VTE) is a major source of morbidity and mortality, yet proven prevention measures are often underutilized. The lack of a validated VTE risk assessment model, difficulty integrating VTE risk assessment and prevention protocols into the routine process of care, and the lack of standardized metrics for VTE prophylaxis have all been barriers. Recently, a VTE risk assessment/prevention protocol has been validated, leading to portable strategies achieving breakthrough levels of adequate prophylaxis in a variety of inpatient settings. VTE prevention protocol design...
Source: Journal of Thrombosis and Thrombolysis - November 9, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

An embolus in the right atrium caught in the Chiari network and resistant to thrombolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Case report is presented, which describes a patient with thromboemboli trapped in the Chiari network within the right heart and resistant to thrombolysis. The right atrial masses were completely removed under cardiopulmonary bypass. Histological evaluation confirmed a mixed thromboemboli, with thrombus structures showing signs of organization and surrounded by a fibrous capsule. A heterozygous methylenetetrahydrofolate reductase gene polymorphism was found, and the plasma level of the plasminogen activator inhibitor type-1 (PAI-1) was 50% higher than the normal upper limit. In this presented case, t...
Source: Journal of Thrombosis and Thrombolysis - November 6, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

New oral anticoagulants: a practical guide for cliniciansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The search for an oral anticoagulant with acceptable efficacy and safety in the treatment and prevention of venous and arterial thromboembolism, but with practical advantages over warfarin, has been a focus of drug development for many years. Three oral agents, dabigatran, rivaroxaban, and apixaban, are nearing approval in the US. Their use in practice will be guided by the clinical trials available, as well as their pharmacokinetic and pharmacodynamic properties. Practitioners need to be fully aware of these characteristics in order to use these agents appropriately in clinical practice. This revie...
Source: Journal of Thrombosis and Thrombolysis - November 3, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Physician alerts to prevent venous thromboembolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Venous thromboembolism (VTE), which encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common but usually preventable complication of hospitalization associated with substantial mortality, morbidity, and health care costs. Despite published guidelines for the prevention of VTE among hospitalized patients, underutilization of prophylaxis continues to be a problem in the United States, Canada, and worldwide. Although much of the emphasis placed on prevention has focused on improving in-hospital prophylaxis, nearly 75% of patients develop VTE in the outpatient setting. Of these pa...
Source: Journal of Thrombosis and Thrombolysis - November 3, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Update on heparin: what do we need to know?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Over the last 15 years, there has been a shift from unfractionated heparin to low-molecular-weight heparin or fondaparinux for many indications. Nonetheless, heparin continues to be used and it remains the drug of choice for selected indications and patients. This paper reviews when and how to use heparin and when low-molecular-weight heparin or fondaparinux may be a better choice. The paper also describes some of the new parenteral anticoagulants under development and provides perspective on how the introduction of rapid-acting oral thrombin or factor Xa inhibitors is likely to reduce or elimi...
Source: Journal of Thrombosis and Thrombolysis - November 3, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Warfarin anticoagulation reversal: management of the asymptomatic and bleeding patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The management of patients with supra-therapeutic INR in a common clinical problem. The risk of bleeding is influenced by the intensity, variability and duration of anticoagulation, patient age, presence of co-morbidities and concomitant drug therapy. For the asymptomatic patient, warfarin discontinuation is all that is usually required but for individuals at high risk of bleeding and those with INR > 10, oral vitamin K administration is recommended. In the presence of major bleeding, treatment with intravenous vitamin K and prothrombin complex concentrate is the most effective therapy....
Source: Journal of Thrombosis and Thrombolysis - November 2, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

To bridge or not to bridge: that is the question. The argument FOR bridging therapy in patients on oral anticoagulants requiring temporary interruption for elective proceduresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11239-009-0410-7Authors Alex C. Spyropoulos, Hamilton General Hospital, McMaster University Division of Hematology and Thromboembolism, Department of Medicine 6th Floor McMaster Clinic, Rm 609, 237 Barton Street East Hamilton ON L8L 2X2 Canada Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - November 2, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Stability validation of paraformaldehyde-fixed samples for the assessment of the platelet PECAM-1, P-selectin, and PAR-1 thrombin receptor by flow cytometryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Sample fixation for storage and/or transportation represents an unsolved challenge for multicenter clinical trials assessing serial changes in platelet activity, or monitoring various antiplatelet regimens. Whole blood flow cytometry represents a major advance in defining platelet function, although special training and expensive equipment is required. We sought to determine how fixation with 2% paraformaldehyde (PFA), and storage of blood samples over 1 week affects the flow cytometry readings for both intact and thrombin-activating four major surface platelet receptors. Whole blood platelet expres...
Source: Journal of Thrombosis and Thrombolysis - October 28, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Apixaban has similar affinity for human and rabbit factor Xa (FXa). Rabbits are commonly used in development of thrombosis disease models; however, unlike in other species, apixaban demonstrated poor oral bioavailability (F = 3%) and a high clearance rate (2.55 l/h/kg) in rabbits. Oxidative metabolism of [14C] apixaban by liver microsomes was approximately 20 times faster in rabbits than in rats or humans. Following an intravenous (IV) dose of 5 mg/kg, circulating levels of [14C] apixaban decreased from the earliest sampling time (5 min) to undetectable at 4 h. After an ...
Source: Journal of Thrombosis and Thrombolysis - October 22, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Reduced carriership of 4G allele of plasminogen activator inhibitor-1 4G/5G polymorphism in very young survivors of myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract There are limited and controversial data regarding the impact of 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene in the pathogenesis of premature myocardial infarction (MI). We explored whether 4G/5G polymorphism of the PAI-1 gene is associated with the development of MI ≤ 35 years of age. We recruited 201 consecutive patients who had survived their first acute MI ≤ 35 years of age (mean age = 32.2 ± 3.4 years). The control group consisted of 140 healthy individuals matched with cases for age and sex, without a fami...
Source: Journal of Thrombosis and Thrombolysis - October 21, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Newer anticoagulants in 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Several newer anticoagulants are under clinical development. Recently two of them, Dabigatran etexilate/Pradaxa®. and Rivaroxaban/Xarelto® obtained marketing authorization in Europe and Canada for the prevention of thromboembolic events following major orthopedic surgery such as total hip and knee replacement. The results of Phase III clinical studies in thromboprophylaxis in major orthopedic surgery are highlighted and discussed in detail. Ongoing Phase II and III clinical trials assess their efficacy in the secondary prevention and treatment of deep vein thrombosis and pulmonary embolism, and in ...
Source: Journal of Thrombosis and Thrombolysis - October 16, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Thrombolytic efficacy of recombinant human microplasmin in a canine model of copper coil-induced coronary artery thrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We investigated the in vitro fibrinolytic properties of microplasmin, the isolated proteinase domain of plasmin, and its thrombolytic efficacy in a coronary artery thrombosis model in dogs. The amidolytic and fibrinolytic activity of recombinant microplasmin was compared with natural human plasmin. The thrombolytic efficacy of microplasmin was studied in a canine model of copper coil induced coronary artery thrombosis. Animals were randomly assigned to one of six treatment regimens, each with five animals per cohort. Four treatment groups received an intravenous bolus of microplasmin followed by an ...
Source: Journal of Thrombosis and Thrombolysis - October 15, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Purtscher retinopathy as an initial presentation of thrombotic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11239-009-0399-yAuthors I. Tajunisah, University of Malaya Department of Ophthalmology, Faculty of Medicine 50603 Kuala Lumpur MalaysiaD. K. Patel, University of Malaya Department of Ophthalmology, Faculty of Medicine 50603 Kuala Lumpur MalaysiaV. Subrayan, University of Malaya Department of Ophthalmology, Faculty of Medicine 50603 Kuala Lumpur Malaysia Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - October 15, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Quantifying the effects of shear stress and shear exposure duration regulation on flow induced platelet activation and aggregationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A heightened flow shear stress magnitude or increased exposure duration at any shear stress magnitude enhances platelet activation. It has been suggested that increased circulating activated platelets are an indication of enhanced cardiovascular risk and that activated platelets can perpetuate cardiovascular diseases. However, the combined effects that shear stress and shear exposure duration have on platelet activation and aggregation are not clear. Our objective was to identify a new parameter (“shear stress-exposure time”) to predict platelet functional changes better than the absolute magnit...
Source: Journal of Thrombosis and Thrombolysis - October 15, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Are surgical patients at risk of venous thromboembolism currently meeting the Surgical Care Improvement Project performance measure for appropriate and timely prophylaxis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study assesses the current rate of achievement of SCIP-VTE-2 criteria using a retrospective data set of real-world surgical patients. The Premier Perspective™ database, which contains real-world data from >400 US hospitals, was queried (January 2004–December 2006) for in-patient hospital transactional billing records of surgical patients aged ≥18 years. The primary outcome was the proportion of patients achieving SCIP-VTE-2 requirements for appropriate and timely prophylaxis as per the SCIP-VTE-2 algorithm. Of the 149,785 patients included, 56.2% received appropriate prophylaxis and 52.7% achieved t...
Source: Journal of Thrombosis and Thrombolysis - September 30, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Platelet hyperactivity during exercise leading to iterative coronary stent thrombosis: clinical implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case where the initial acute coronary syndrome and the iterative stent thrombosis always occurred after intense and prolonged physical effort. For this patient the at rest response to platelet inhibition with antiplatelet treatments was assessed as adequate, but after exercise the patient developed platelet activation which could be the trigger of his stent thrombosis. Content Type Journal ArticleDOI 10.1007/s11239-009-0394-3Authors Olivier Ormezzano, Grenoble University Hospital Department of Cardiology Grenoble Cedex 09 FranceBenoit Polack, Grenoble University Hospital Haemostasis Unit Grenoble Cedex...
Source: Journal of Thrombosis and Thrombolysis - September 17, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Incidence rate of pulmonary embolism in Germany: data from the federal statistical officeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract With the introduction of Diagnosis Related Groups (DRG) for reimbursement in 2003 detailed description of the prevalence of pulmonary embolism (PE) in hospitalized patients in Germany was possible for the first time. Thus we estimated the incidence rate of PE in Germany. Detailed lists of all PE coded as I26 performed in 2005, 2006 and 2007 were provided by the Federal Statistical Office. In addition age- and gender-adjusted incidence rates were calculated for all cases for which PEs were coded. In 2005 a total of 67,351, in 2006 a total of 69,234 and in 2007 a total of 71,223 PEs (I26.0) were coded...
Source: Journal of Thrombosis and Thrombolysis - September 17, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Lipoma causing upper extremity deep vein thrombosis: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of lipoma in the right infraclavicular and axillary area compressing subclavian vein there by presenting with upper extremity deep venous thrombosis (UEDVT) and persistent symptoms of venous congestion. Patient was also found to be a heterozygous carrier of prothrombin 20210 gene mutation. Surgical excision of lipomatous tissue performed after 6 months of anticoagulation resulted in a complete resolution of symptoms. Content Type Journal ArticleDOI 10.1007/s11239-009-0395-2Authors Balavani Palamari, Mayo Clinic and Foundation for Education and Research Division of Cardiovascular Medicine 200 F...
Source: Journal of Thrombosis and Thrombolysis - September 3, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Effects of serum homocysteine and adiponectin levels on platelet aggregation in untreated patients with essential hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s11239-009-0390-7Authors Hakan Ekmekçi, Istanbul University Istanbul Medical Faculty, Bone Marrow Transplantation Unit, Department of Pediatric Haematology and Oncology Istanbul TurkeyÖzlem Balcı Ekmekçi, Istanbul University Istanbul Medical Faculty, Bone Marrow Transplantation Unit, Department of Pediatric Haematology and Oncology Istanbul TurkeySerap Erdine, Istanbul University Cerrahpasa Medical Faculty, Department of Cardiology Istanbul TurkeyHüseyin Sönmez, Istanbul University Cerrahpasa Medical Faculty, Department of Biochemistry Istanbul TurkeyYusup A...
Source: Journal of Thrombosis and Thrombolysis - August 28, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Monitoring unfractionated heparin in pediatric patients with congenital heart disease having cardiac catheterization or cardiac surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Determine the effect of age and congenital heart disease (CHD) on whole blood tests for monitoring unfractionated heparin (UFH) in children. Determine correlation with anti-Xa levels in children undergoing cardiac catheterization or cardiac surgery. A prospective cross-sectional study of 211 healthy children about to have minor surgery (median age 3.5 years) and 110 CHD patients (median age 2.1 years) undergoing cardiac catheterization or cardiac surgery. Commonly used whole blood tests (two activated clotting times and an activated partial thromboplastin time; ACT+, ACT-LR, and APTT, resp...
Source: Journal of Thrombosis and Thrombolysis - August 28, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Fructose-1,6-bisphosphate inhibits in vitro and ex vivo platelet aggregation induced by ADP and ameliorates coagulation alterations in experimental sepsis in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Sepsis is a systemic response to an infection that leads to a generalized inflammatory reaction. There is an intimate relationship between procoagulant and proinflammatory activities, and coagulation abnormalities are common in septic patients. Pharmaceutical studies have focused to the development of substances that act on coagulation abnormalities and on the link between coagulation and inflammation. Fructose-1,6-bisphosphate (FBP) is a high-energy glycolitic metabolite that in the past two decades has been shown therapeutic effects in great number of pathological situations, including sepsis. The...
Source: Journal of Thrombosis and Thrombolysis - August 24, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Cardiovascular risk factors and outcome in patients with retinal vein occlusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The pathogenesis and treatment of retinal vein occlusions (RVO) are largely unclear. Prevalence of cardiovascular risk factors and of thrombophilic abnormalities was evaluated in 117 patients (61 M, 56 F; mean age 51 ± 13 years) with a history of RVO (62 central, CRVO; 48 branch, BRVO; 7 both) and in 202 age- and sex-matched control subjects. Cardiovascular outcome after a mean 8.2 year follow-up was recorded for 90 patients. Arterial hypertension was significantly more frequent in patients than in controls (64.9 vs. 28.2%; adjusted OR 4.5 95% CI 2.4–7.9; P < 0.00...
Source: Journal of Thrombosis and Thrombolysis - August 24, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Pharmacogenetics and safety parameters for platelet P2Y12 receptor antagonistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11239-009-0385-4Authors Richard C. Becker, Duke University School of Medicine Durham USA Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - August 20, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Secondary prevention strategies for coronary heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Patients with established coronary heart disease (CHD) have a high risk of subsequent cardiovascular events, including myocardial infarction (MI), stroke, and death from cardiovascular disease. Adherence to evidence-based secondary prevention therapies for CHD has improved in recent years but still remains suboptimal. Mortality from CHD in the United States (US) has decreased substantially in recent decades. The decline in US deaths from CHD from 1980 through 2000 has been attributed to reductions in major risk factors and utilization of evidence-based medical therapies. It has been estimated that o...
Source: Journal of Thrombosis and Thrombolysis - August 19, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Comparison of pain and ecchymosis with low-molecular-weight heparin vs. unfractionated heparin in patients requiring bridging anticoagulation after warfarin interruption: a randomized trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s11239-009-0389-0Authors Erin Jamula, McMaster University Department of Medicine Hamilton CanadaKaren Woods, McMaster University Department of Medicine Hamilton CanadaMadeleine Verhovsek, McMaster University Department of Medicine Hamilton CanadaJames D. Douketis, McMaster University Department of Medicine Hamilton CanadaEllen McDonald, St. Joseph’s Healthcare Room F-544, 50 Charlton Ave Hamilton L8N 4A6 ON Canada Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - August 19, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Combined intraarterial and intravenous thrombolysis for severe cerebral venous sinus thrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To investigate the safety and efficacy of endovascular therapy with combined intra-arterial and intravenous thrombolysis for severe cerebral venous sinus thrombosis. Of the 28 consecutive patients with cerebral venous sinus thrombosis admitted to our hospital in recent 3 years, six patients underwent combined intra-arterial and intravenous thrombolysis. For each patient, local contact thrombolysis was performed with balloon catheter to break clot and urokinase infused for thrombolysis in sinus. At the same time, urokinase (100,000 IU/h) was infused intra-arterially via internal carotid art...
Source: Journal of Thrombosis and Thrombolysis - August 14, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We previously reported that acute cigarette smoking can cause a dysfunction of endothelium-dependent vasodilation in cerebral vessels, and that a reduction of oxidative stress by agents such as valsartan, fasudil, or apocynin prevented this impairment. Here, our aim was to investigate the comparative effects of two antiplatelet drugs used for stroke-prevention [a phosphodiesterase-3 inhibitor (cilostazol) and a cyclooxygenase inhibitor (aspirin)] on smoking-induced endothelial dysfunction in cerebral arterioles. In Sprague-Dawley rats, we used a closed cranial window preparation to measure the chang...
Source: Journal of Thrombosis and Thrombolysis - August 11, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Retinal vein occlusion: evaluation of “classic” and “emerging” risk factors and treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Retinal vein occlusion (RVO) is the second most common retinal vein disease and an important cause of blindness and visual morbidity. Systemic risk factors are commonly associated with RVO, while unclear it is the role of the thrombophilic and coagulation disorders. To evaluate “classic” and “emerging” risk factors, and to establish a good treatment for RVO. Fifty patients, 31 males and 19 females, with RVO were selected for our study. RVO patients were divided into two groups: those with central retinal vein occlusion (CRVO) and those with branch retinal vein occlusion (BRVO). All patients ...
Source: Journal of Thrombosis and Thrombolysis - August 11, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Tissue plasminogen activator antigen predicts medium-term left ventricular end-systolic volume after acute myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the relationships between VWF, t-PA antigen, matrix metalloproteinase (MMP)-2,-3, and -9, and B-type natriuretic peptide (BNP), and their predictive effect on serial change in LV volumes in a cohort of patients admitted with AMI. Plasma VWF, t-PA antigen, MMP-2,-3,-9, and BNP were measured at a mean 46 h after AMI in 100 patients (mean age 58.9 ± 12 years, 77% male) with depressed LVEF. Cardiac magnetic resonance (CMR) imaging was then performed. Biomarker measurement and CMR were repeated at 12 and 24 weeks. Plasma concentrations of VWF, BNP and MMP-9 were elevated while t-PA ant...
Source: Journal of Thrombosis and Thrombolysis - August 7, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Myocardial infarction due to late stent thrombosis following epileptic convulsive seizuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first case in the literature of acute myocardial infarction due to very late (5 years) drug-eluting stent (DES) thrombosis presenting with inferior ST-elevation myocardial infarction immediately after epileptic convulsive seizures in a patient with known coronary artery disease. A bare-metal stent had been implanted in the left anterior descending coronary artery in 2002, and a drug-eluting stent implanted in the right coronary artery in 2003. We discuss the possible pathogenetic mechanisms implied in convulsive epileptic crisis resulting in development of very late DES thrombosis. Content Type Jo...
Source: Journal of Thrombosis and Thrombolysis - August 4, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Incidence rates, clinical profile, and outcomes of patients with venous thromboembolism. The Worcester VTE studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract While there have been advances in prophylaxis and management of venous thromboembolism (VTE), there are a dearth of data from the perspective of a community-wide study, on the epidemiology, management, and outcomes of patients with a first episode of deep vein thrombosis (DVT) or pulmonary embolism (PE). The purpose of this population-based observational study was to describe trends in the incidence rates, clinical profile, management, and outcomes for patients with VTE. The medical records of Worcester (MA) metropolitan area residents with ICD-9 codes consistent with possible VTE during 1999, 2001,...
Source: Journal of Thrombosis and Thrombolysis - July 25, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Anti-coagulant activity of a metalloprotease: further characterization from the Indian cobra (Naja naja) venomEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A high molecular mass, non toxic metalloprotease the NN-PF3 with the bound Ca2+ and Zn2+ from the Naja naja venom has been studied further for its anticoagulant property. The molecular mass by MALDI-TOF mass spectrometry was 67.81 kDa. The NN-PF3 exhibited fibrin(ogen)olytic activity. In addition to fibrinogen, NN-PF3 hydrolyzed blood and plasma clot with the later hydrolyzed about one fold higher. The α polymer of fibrin was preferentially hydrolyzed over the α chain but the β chain and γ–γ dimer remained untouched. It was devoid of plasminogen activation property. It prolonged the activ...
Source: Journal of Thrombosis and Thrombolysis - July 25, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Severe bleeding secondary to misuse of fondaparinux: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of thigh haematoma by a 83-year-old woman under fondaparinux for a solear thrombosis. Then we discuss the indications of Unfractionated Heparin (UFH), Low-Molecular-Weight Heparins (LMWH) and Fondaparinux, which are the three classes of rapidly acting anticoagulant treatments nowadays available. As their efficacy is comparable, the choice between these classes relies on the risk of adverse effects, which depends on some patient’s characteristics. LMWH and fondaparinux are contra-indicated by the patients with a renal clearance under 30 ml/min. Only UFH are authorised during the whole pregnancy ...
Source: Journal of Thrombosis and Thrombolysis - July 23, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals