Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy
Tumors are highly complex and heterogenous ecosystems where malignant cells interact with healthy cells and the surrounding extracellular matrix (ECM). Solid tumors contain large ECM deposits that can constitu... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 24, 2024 Category: Research Authors: Rowie Borst, Linde Meyaard and M. Ines Pascoal Ramos Tags: Review Source Type: research
AZGP1 deficiency promotes angiogenesis in prostate cancer
Loss of AZGP1 expression is a biomarker associated with progression to castration resistance, development of metastasis, and poor disease-specific survival in prostate cancer. However, high expression of AZGP1... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 24, 2024 Category: Research Authors: Ru M. Wen, Zhengyuan Qiu, G. Edward W. Marti, Eric E. Peterson, Fernando Jose Garcia Marques, Abel Bermudez, Yi Wei, Rosalie Nolley, Nathan Lam, Alex LaPat Polasko, Chun-Lung Chiu, Dalin Zhang, Sanghee Cho, Grigorios Marios Karageorgos, Elizabeth McDonoug Tags: Research Source Type: research
Deciphering the importance of culture pH on CD22 CAR T-cells characteristics
Chimeric antigen receptor (CAR) T-cells have demonstrated significant efficacy in targeting hematological malignancies, and their use continues to expand. Despite substantial efforts spent on the optimization ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 24, 2024 Category: Research Authors: Michaela Prochazkova, Alexandra Dreyzin, Lipei Shao, Pam Garces, Yihua Cai, Rongye Shi, Alejandra Pelayo, Yong Soo Kim, Victoria Pham, Sue Ellen Frodigh, Shannon Fenton, Catherine Karangwa, Yan Su, Kathryn Martin, Nan Zhang, Steven L. Highfill & hellip; Tags: Research Source Type: research
Retraction Note: Palmitoyl transferases act as novel drug targets for pancreatic cancer
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 24, 2024 Category: Research Authors: Zhiqing Lin, Ziru Lv, Xin Liu and Keke Huang Tags: Retraction Note Source Type: research
Integrating spatial transcriptomics and single-cell RNA-sequencing reveals the alterations in epithelial cells during nodular formation in benign prostatic hyperplasia
Proliferative nodular formation represents a characteristic pathological feature of benign prostatic hyperplasia (BPH) and serves as the primary cause for prostate volume enlargement and consequent lower urina... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 23, 2024 Category: Research Authors: Xiawei Fei, Jican Liu, Junyan Xu, Hongyan Jing, Zhonglin Cai, Jiasheng Yan, Zhenqi Wu, Huifeng Li, Zhong Wang and Yanting Shen Tags: Research Source Type: research
Arginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine
Bacteria-based cancer therapy have demonstrated innovative strategies to combat tumors. Recent studies have focused on gram-negative bacterial outer membrane vesicles (OMVs) as a novel cancer immunotherapy str... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 22, 2024 Category: Research Authors: Suyang Wang, Chao-Cheng Chen, Ming-Hung Hu, Michelle Cheng, Hsin-Fang Tu, Ya-Chea Tsai, Jr-Ming Yang, T. C. Wu, Chuan-Hsiang Huang and Chien-Fu Hung Tags: Research Source Type: research
Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment
TAS-102 (Lonsurf ®) is an oral fluoropyrimidine consisting of a combination of trifluridine (a thymidine analog) and tipiracil (a thymidine phosphorylation inhibitor). The drug is effective in metastatic colorecta... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 22, 2024 Category: Research Authors: Alessandro Ottaiano, Mariachiara Santorsola, Monica Ianniello, Anna Ceccarelli, Marika Casillo, Francesco Sabbatino, Nadia Petrillo, Marco Cascella, Francesco Caraglia, Carmine Picone, Francesco Perri, Roberto Sirica, Silvia Zappavigna, Guglielmo Nasti, G Tags: Research Source Type: research
Correction to: COSMIC ‑based mutation database enhances identification efficiency of HLA‑I immunopeptidome
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 22, 2024 Category: Research Authors: Fangzhou Wang, Zhenpeng Zhang, Mingsong Mao, Yudai Yang, Ping Xu and Shichun Lu Tags: Correction Source Type: research
Assessment of cephalometric parameters and correlation with the severity of the obstructive sleep apnea syndrome
In individuals diagnosed with obstructive sleep apnea syndrome (OSAS), variations in craniofacial structure have been inconsistently documented, showing differing degrees of alteration between obese and nonobe... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 22, 2024 Category: Research Authors: Eugenio Garofalo, Giuseppe Neri, Lucilla Maria Perri, Nicola Lombardo, Giovanna Piazzetta, Alessandro Antonelli, Eugenio Biamonte, Vincenzo Bosco, Caterina Battaglia, Corrado Pelaia, Francesco Manti, Annalisa Pitino, Giovanni Tripepi, Andrea Bruni, Michel Tags: Research Source Type: research
The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure
Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (SELENOT) emerged as a key regulator during rat cardiogenesis and acute cardiac protecti... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 20, 2024 Category: Research Authors: Anna De Bartolo, Teresa Pasqua, Naomi Romeo, Vittoria Rago, Ida Perrotta, Francesca Giordano, Maria Concetta Granieri, Alessandro Marrone, Rosa Mazza, Maria Carmela Cerra, Benjamin Lefranc, J érôme Leprince, Youssef Anouar, Tommaso Angelone and Carmine Tags: Research Source Type: research
Mutational landscape of inflammatory breast cancer
We report here the largest whole-exome sequencing (WES) study of clinic... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 18, 2024 Category: Research Authors: Fran çois Bertucci, Florence Lerebours, Michele Ceccarelli, Arnaud Guille, Najeeb Syed, Pascal Finetti, José Adélaïde, Steven Van Laere, Anthony Goncalves, Patrice Viens, Daniel Birnbaum, Emilie Mamessier, Céline Callens and Davide Bedognetti Tags: Research Source Type: research
Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancer
Ovarian cancer (OC) is characterized by its rapid growth and spread which, accompanied by a low 5-year survival rate, necessitates the development of improved treatments. In ovarian cancer, the selective overe... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 18, 2024 Category: Research Authors: Jing Guo, Xiaozhu Zeng, Yongjie Zhu, Dong Yang and Xudong Zhao Tags: Research Source Type: research
The development of chimeric antigen receptor T-cells against CD70 for renal cell carcinoma treatment
In this study, we investigated CD70 as a promising target for renal cell carcinoma (RCC) therapy and developed a potent chimeric antigen receptor T (CAR-T) cells for potential clinical testing. CD70, found to ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 18, 2024 Category: Research Authors: Qinghui Xiong, Haiying Wang, Qiushuang Shen, Yan Wang, Xiujie Yuan, Guangyao Lin and Pengfei Jiang Tags: Research Source Type: research
Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation
Patients with inflammatory bowel disease (IBD), dysbiosis, and immunosuppression who receive fecal microbiota transplantation (FMT) from healthy donors are at an increased risk of developing bacteremia. This s... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 18, 2024 Category: Research Authors: Hailan Zhao, Youlian Zhou, Jing Xu, Yong Zhang, Hong Wang, Chong Zhao, Hongli Huang, Jing Yang, Chen Huang, Yingfei Li, Lisheng Wang and Yuqiang Nie Tags: Research Source Type: research
Implications of ZNF334 gene in lymph node metastasis of lung SCC: potential bypassing of cellular senescence
The primary goal of this work is to identify biomarkers associated with lung squamous cell carcinoma and assess their potential for early detection of lymph node metastasis. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 18, 2024 Category: Research Authors: Khalil Khashei Varnamkhasti, Mehdi Moghanibashi and Sirous Naeimi Tags: Research Source Type: research
